Predictive significance of CCL21 and CXCL13 levels in the minor salivary glands of patients with Sjögren's syndrome

Clinical and Experimental Rheumatology

Volumn 35, Issue 2, 2017, Pages 234-240

  Lee, Kyung Eun ^a   Kang, Ji Hyoun ^a   Yim, Yi Rang ^a   Kim, Ji Eun ^a   Lee, Jeong Won ^a   Wen, Lihui ^a   Park, Dong Jin ^a   Kim, Tae Jong ^a   Park, Yong Wook ^a   Yoon, Kyung Chul ^a   Lee, Ji Shin ^a   Lee, Shin Seok ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Chemokine; Disease activity; Salivary gland; Sj gren's syndrome

Indexed keywords

C REACTIVE PROTEIN; CXCL13 CHEMOKINE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; SECONDARY LYMPHOID TISSUE CHEMOKINE; BIOLOGICAL MARKER; CCL21 PROTEIN, HUMAN; CXCL13 PROTEIN, HUMAN;

ADULT; ARTHRALGIA; ARTICLE; ASSESSMENT OF HUMANS; AUTOIMMUNE THYROIDITIS; CARPAL TUNNEL SYNDROME; COMPUTER ASSISTED TOMOGRAPHY; DISEASE ACTIVITY; ECHOCARDIOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; EUROPEAN LEAGUE AGAINST RHEUMATISM SS DISEASE ACTIVITY INDEX; FEMALE; FIBROSING ALVEOLITIS; GASTROSCOPY; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN TISSUE; HYPOTHYROIDISM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERSTITIAL LUNG DISEASE; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHOTOSENSITIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; PSYCHOSIS; RAYNAUD PHENOMENON; SALIVARY GLAND; SALIVARY GLAND BIOPSY; SJOEGREN SYNDROME; SYNDROME CREST; URINALYSIS; BIOPSY; CHEMISTRY; METABOLISM; MINOR SALIVA GLAND; PROGNOSIS; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; SJOGREN'S SYNDROME; UPREGULATION;

ADULT; BIOMARKERS; BIOPSY; BLOOD SEDIMENTATION; CHEMOKINE CCL21; CHEMOKINE CXCL13; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; SALIVARY GLANDS, MINOR; SEVERITY OF ILLNESS INDEX; SJOGREN'S SYNDROME; UP-REGULATION;

EID: 85018171714     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. FERRO F, VAGELLI R, BRUNI C et al.: One year in review 2016: Sjögren's syndrome. Clin Exp Rheumatol 2016; 34: 161-71.
2. KASSAN SS, MOUTSOPOULOS HM: Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med 2004; 164: 1275-84.
3. TAKEMURA S, BRAUN A, CROWSON C et al.: Lymphoid neogenesis in rheumatoid synovitis. J Immunol 2001; 167: 1072-80.
4. ARMENGOL MP, JUAN M, LUCAS-MARTIN A et al.: Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol 2001; 159: 861-73.
5. VINUESA CG, SANZ I, COOK MC: Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol 2009; 9: 845-57.
6. ALOISI F, PUJOL-BORRELL R: Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006; 6: 205-17.
7. CORSIERO E, BOMBARDIERI M, MANZO A, BUGATTI S, UGUCCIONI M, PITZALIS C: Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Immunol Lett 2012; 145: 62-7.
8. van de PAVERT SA, MEBIUS RE: New insights into the development of lymphoid tissues. Nat Rev Immunol 2010; 10: 664-74.
9. MacKAY CR: Chemokines: immunology's high impact factors. Nat Immunol 2001; 2: 95-101.
10. LINK A, VOGT TK, FAVRE S et al.: Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol 2007; 8: 1255-65.
11. CUPEDO T, MEBIUS RE: Role of chemokines in the development of secondary and tertiary lymphoid tissues. Semin Immunol 2003; 15: 243-8.
12. AMFT N, CURNOW SJ, SCHEEL-TOELLNER D et al.: Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum 2001; 44: 2633-41.
13. BARONE F, BOMBARDIERI M, MANZO A et al.: Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome. Arthritis Rheum 2005; 52: 1773-84.
14. VITALI C, BOMBARDIERI S, JONSSON R et al.: Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-8.
15. DANIELS TE, WHITCHER JP: Association of patterns of labial salivary gland inflammation with keratoconjunctivitis sicca. Analysis of 618 patients with suspected Sjögren's syndrome. Arthritis Rheum 1994; 37: 869-77.
16. SEROR R, RAVAUD P, BOWMAN SJ et al.: EULAR Sjögren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren's syndrome. Ann Rheum Dis 2010; 69: 1103-9.
17. VITALI C, PALOMBI G, BALDINI C et al.: Sjögren's Syndrome Disease Damage Index and disease activity index: scoring systems for the assessment of disease damage and disease activity in Sjögren's syndrome, derived from an analysis of a cohort of Italian patients. Arthritis Rheum 2007; 56: 2223-31.
18. LUTHER SA, BIDGOL A, HARGREAVES DC et al.: Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 2002; 169: 424-33.
19. CORNEC D, DEVAUCHELLE-PENSEC V, TOBON GJ, PERS JO, JOUSSE-JOULIN S, SARAUX A: B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment. J Autoimmun 2012; 39: 161-7.
20. RISSELADA AP, LOOIJE MF, KRUIZE AA, BIJLSMA JW, van ROON JA: The role of ectopic germinal centers in the immunopathology of primary Sjögren's syndrome: a systematic review. Semin Arthritis Rheum 2013; 42: 368-76.
21. JONSSON MV, SKARSTEIN K, JONSSON R, BRUN JG: Serological implications of germinal center-like structures in primary Sjögren's syndrome. J Rheumatol 2007; 34: 2044-9.
22. THEANDER E, VASAITIS L, BAECKLUND E et al.: Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndrome. Ann Rheum Dis 2011; 70: 1363-8.
23. BARONE F, BOMBARDIERI M, ROSADO MM et al.: CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjögren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization. J Immunol 2008; 180: 5130-40.
24. NOCTURNE G, SEROR R, FOGEL O et al.: CXCL13 and CCL11 Serum Levels and Lymphoma and Disease Activity in Primary Sjögren's Syndrome. Arthritis Rheumatol 2015; 67: 3226-33.
25. KRAMER JM, KLIMATCHEVA E, ROTHSTEIN TL: CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis. J Leukoc Biol 2013; 94: 1079-89.
26. BOMBARDIERI M, BARONE F, PITTONI V et al.: Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate. Arthritis Res Ther 2004; 6: R447-56.