Transmembrane TNF-dependent uptake of anti-TNF antibodies

mAbs

Volumn 9, Issue 4, 2017, Pages 680-695

  Deora, Arun ^a   Hegde, Subramanya ^a   Lee, Jacqueline ^a   Choi, Chee Ho ^a   Chang, Qing ^a   Lee, Cheryl ^a   Eaton, Lucia ^a   Tang, Hua ^a   Wang, Dongdong ^a,d   Lee, David ^a,b   Michalak, Mark ^a   Tomlinson, Medha ^a   Tao, Qingfeng ^a   Gaur, Nidhi ^a,c   Harvey, Bohdan ^a   McLoughlin, Shaun ^a   Labkovsky, Boris ^a   Ghayur, Tariq ^a  

^a ABBVIE INC   (United States)

^b Mersana Therapeutics Inc   (United States)

^c Berg LLC   (United States)

^d BioAnalytix Inc   (United States)

Author keywords

Anti drug antibodies (ADA); anti TNFs; clathrin; endocytosis; membrane TNF; tetanus toxin; TmTNF reverse signaling; Transmembrane TNF

Indexed keywords

CLATHRIN HEAVY CHAIN; HLA DR ANTIGEN; MEMBRANE PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ANTIBODY; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; ANTIBODY;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANIMAL CELL; BIOTINYLATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MEMBRANE TRANSPORT; MONOCYTE; MOUSE; NONHUMAN; PROTEIN ISOLATION; SIZE EXCLUSION CHROMATOGRAPHY; T LYMPHOCYTE; TRANSIENT TRANSFECTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; HEK293 CELL LINE; MACROPHAGE; METABOLISM;

ANIMALS; ANTIBODIES; CELL MEMBRANE; DENDRITIC CELLS; HEK293 CELLS; HUMANS; MACROPHAGES; MICE; MONOCYTES; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85017522495     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2017.1304869     Document Type: Article

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