Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis

American Journal of Respiratory and Critical Care Medicine

Volumn 195, Issue 10, 2017, Pages 1384-1393

  Chalmers, James D ^a   Moffitt, Kelly L ^b   Suarez Cuartin, Guillermo ^c   Sibila, Oriol ^c   Finch, Simon ^a   Furrie, Elizabeth ^a   Dicker, Alison ^a   Wrobel, Karolina ^a   Elborn, J Stuart ^b,d   Walker, Brian ^b   Martin, S Lorraine ^b   Marshall, Sara E ^a   Huang, Jeffrey T J ^a   Fardon, Thomas C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Biomarker; Bronchiectasis; Exacerbations; Inflammation; Neutrophils

Indexed keywords

ANTIBIOTIC AGENT; DESMOSINE; INTERLEUKIN 1BETA; INTERLEUKIN 8; LEUKOCYTE ELASTASE; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR; BIOLOGICAL MARKER;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; BACTERIAL LOAD; BLOOD SAMPLING; BRONCHIECTASIS; CAUSE OF DEATH; CLINICAL ASSESSMENT; CLINICAL OUTCOME; COHORT ANALYSIS; DISEASE EXACERBATION; DISEASE SEVERITY; ENTEROBACTERIACEAE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROMETRY; FOLLOW UP; FORCED EXPIRATORY VOLUME; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HOSPITAL ADMISSION; HUMAN; IMMUNOASSAY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LONG TERM CARE; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSEUDOMONAS AERUGINOSA; QUALITY OF LIFE; SENSITIVITY ANALYSIS; SPIROMETRY; SPUTUM ANALYSIS; ST. GEORGE RESPIRATORY QUESTIONNAIRE; DISEASE COURSE; LUNG; METABOLISM; MIDDLE AGED; NEUTROPHIL; PATHOPHYSIOLOGY; REGISTER; SEVERITY OF ILLNESS INDEX; SPUTUM; UNITED KINGDOM;

AGED; BIOMARKERS; BRONCHIECTASIS; COHORT STUDIES; DESMOSINE; DISEASE PROGRESSION; FEMALE; HUMANS; LEUKOCYTE ELASTASE; LUNG; MALE; MIDDLE AGED; NEUTROPHILS; PROSPECTIVE STUDIES; REGISTRIES; SEVERITY OF ILLNESS INDEX; SPUTUM; UNITED KINGDOM;

EID: 85017339471     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201605-1027OC     Document Type: Article

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