D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress

Free Radical Biology and Medicine

Volumn 108, Issue , 2017, Pages 354-361

  Sciegienka, Sebastian J ^a   Solst, Shane R ^a   Falls, Kelly C ^a   Schoenfeld, Joshua D ^a   Klinger, Adrienne R ^a   Ross, Natalie L ^a   Rodman, Samuel N ^a   Spitz, Douglas R ^a   Fath, Melissa A ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Breast cancer; D penicillamine; Hydrogen peroxide; Lung cancer; Oxidative metabolism; Transition metal ions

Indexed keywords

BUTHIONINE SULFOXIMINE; CARBOPLATIN; CATALASE; COPPER SULFATE; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROPEROXIDE; PENICILLAMINE; THIOREDOXIN REDUCTASE; ANTINEOPLASTIC AGENT; AURANOFIN; CHELATING AGENT; COPPER;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; BREAST EPITHELIUM CELL; CANCER CELL; CANCER CHEMOTHERAPY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; H1299 CANCER CELL LINE; HUMAN; HUMAN CELL; IONIZING RADIATION; LIMIT OF QUANTITATION; LUNG CANCER; LUNG CANCER CELL LINE; MDA-MB-231 CELL LINE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RATE CONSTANT; STEADY STATE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; CHEMISTRY; DRUG EFFECTS; EPITHELIUM CELL; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; RADIATION; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AURANOFIN; BREAST NEOPLASMS; BUTHIONINE SULFOXIMINE; CARBOPLATIN; CATALASE; CELL LINE, TUMOR; CHELATING AGENTS; COPPER; EPITHELIAL CELLS; FEMALE; HUMANS; HYDROGEN PEROXIDE; LUNG NEOPLASMS; OXIDATIVE STRESS; PENICILLAMINE; RADIATION; THIOREDOXIN-DISULFIDE REDUCTASE;

EID: 85017320419     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2017.04.001     Document Type: Article

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