Na+ deposition in the fibrotic skin of systemic sclerosis patients detected by 23Na-magnetic resonance imaging

Rheumatology (United Kingdom)

Volumn 56, Issue 4, 2017, Pages 556-560

  Kopp, Christoph ^a   Beyer, Christian ^a   Linz, Peter ^a   Dahlmann, Anke ^a   Hammon, Matthias ^a   Jantsch, Jonathan ^b   Neubert, Patrick ^b   Rosenhauer, Daniela ^a   Müller, Dominik N ^c   Cavallaro, Alexander ^a   Eckardt, Kai Uwe ^a   Schett, Georg ^a   Luft, Friedrich C ^c,d   Uder, Michael ^a   Distler, Jörg H W ^a   Titze, Jens ^d  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

23Na MRI; Extracellular matrix; Fibrosis; Skin Na+; Systemic sclerosis

Indexed keywords

SODIUM 23; SODIUM ION; SODIUM;

ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FOLLOW UP; HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RODNAN SKIN SCORE; SCORING SYSTEM; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; TISSUE WATER; WATER CONTENT; COMPARATIVE STUDY; FEMALE; FIBROSIS; FOREARM; LOWER LIMB; MALE; METABOLISM; PATHOLOGY; PROCEDURES; SKIN;

CASE-CONTROL STUDIES; FEMALE; FIBROSIS; FOREARM; HUMANS; LOWER EXTREMITY; MAGNETIC RESONANCE IMAGING; MALE; SCLERODERMA, SYSTEMIC; SKIN; SODIUM; SODIUM ISOTOPES;

EID: 85017202252     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kew371     Document Type: Article

References (20)

1. Tyndall AJ, Bannert B, Vonk M et al. Causes and risk factors for death in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database. Ann Rheum Dis 2010;69:1809-15.
2. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007;117:557-67.
3. Wight TN, Potter-Perigo S. The extracellular matrix: an active or passive player in fibrosis? Am J Physiol Gastrointest Liver Physiol 2011;301:G950-5.
4. Søndergaard K, HeickendorffL, Risteli L et al. Increased levels of type I and III collagen and hyaluronan in scleroderma skin. Br J Dermatol 1997;136:47-53.
5. Bashey RI, Millan A, Jimenez SA. Increased biosynthesis of glycosaminoglycans by scleroderma fibroblasts in culture. Arthritis Rheum 1984;27:1040-5.
6. Titze J, Shakibaei M, Schafflhuber M et al. Glycosaminoglycan polymerization may enable osmotically inactive Na+ storage in the skin. Am J Physiol Heart Circ Physiol 2004;287:H203-8.
7. + by growth and by dietary salt restriction in rats. Am J Physiol Renal Physiol 2007;292:F1490-500.
8. Machnik A, Neuhofer W, Jantsch J et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 2009;15:545-52.
9. 23Na magnetic resonance imaging-determined tissue sodium in healthy subjects and hypertensive patients. Hypertension 2013;61:635-40.
10. 23Na magnetic resonance imaging of tissue sodium. Hypertension 2012;59:167-72.
11. Dahlmann A, Dörfelt K, Eicher F et al. Magnetic resonance-determined sodium removal from tissue stores in hemodialysis patients. Kidney Int 2015;87:434-41.
12. van den Hoogen F, Khanna D, Fransen J et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2013;72:1747-55.
13. LeRoy EC, Black C, Fleischmajer R et al. Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202-5.
14. Valentini G, Bencivelli W, Bombardieri S et al. European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. III. Assessment of the construct validity of the preliminary activity criteria. Ann Rheum Dis 2003;62:901-3.
15. + storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metabol 2015;21:493-501.
16. Xu W, Hong SJ, Zeitchek M et al. Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel (ENaC) in the skin. J Invest Dermatol 2015;135:796-806.
17. Ionescu R, Rednic S, Damjanov N et al. Repeated teaching courses of the modified Rodnan skin score in systemic sclerosis. Clin Exp Rheumatol 2010;28(2 Suppl 58): S37-41.
18. Czirják L, Nagy Z, Aringer M et al. The EUSTAR model for teaching and implementing the modified Rodnan skin score in systemic sclerosis. Ann Rheum Dis 2007;66:966-9.
19. Hesselstrand R, Scheja A, Wildt M, Akesson A. Highfrequency ultrasound of skin involvement in systemic sclerosis reflects oedema, extension and severity in early disease. Rheumatology 2008;47:84-7.
20. Brocks K, Stender I, Karlsmark T et al. Ultrasonic measurement of skin thickness in patients with systemic sclerosis. Acta Dermatol Venereol 2000;80:59-60.