Metabolism of nutritive sweeteners in humans

Fructose, High Fructose Corn Syrup, Sucrose and Health

Volumn , Issue , 2014, Pages 35-50

  Tappy, Luc ^a   Egli, Leonie ^b   Tran, Christel ^c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Aldolase B; De novo lipogenesis; Energy expenditure; Fructokinase; Fructose; Gluconeogenesis; Glucose; Hereditary fructose intolerance; High fructose corn syrup; Lactic acid production; Sucrose

Indexed keywords

EID: 85017159540     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4899-8077-9_3     Document Type: Chapter

References (58)

1. Temussi PA. Sweet, bitter and umami receptors: a complex relationship. Trends Biochem Sci. 2009;34(6): 296-302.
2. Mintz SW. Sweetness and power. The place of sugar in modern history. New York: Penguin Books; 1985. ISBN ISBN 978-0-14-009233-2.
3. White JS. Straight talk about high-fructose corn syrup: what it is and what it ain't. Am J Clin Nutr. 2008; 88(6):1716S-21.
4. Brunzell JD. Use of fructose, xylitol, or sorbitol as a sweetener in diabetes mellitus. Diabetes Care. 1978;1(4): 223-30.
5. Schoch W. Effect of hydrogen ion concentration on sucrose inversion in determination of sugar content of forage and sugar beets. Mitt Lebensmittelunters Hyg. 1951;42(3):242-50.
6. Drozdowski LA, Thomson AB. Intestinal sugar transport. World J Gastroenterol. 2006;12(11):1657-70.
7. Wright EM, Turk E, Martin MG. Molecular basis for glucose-galactose malabsorption. Cell Biochem Biophys. 2002;36(2-3):115-21.
8. Douard V, Ferraris RP. The role of fructose transporters in diseases linked to excessive fructose intake. J Physiol. 2013;591(Pt 2):401-14.
9. Kellett GL, Brot-Laroche E. Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes. 2005; 54(10):3056-62.
10. Gorboulev V, Schurmann A, Vallon V, Kipp H, Jaschke A, Klessen D, Friedrich A, Scherneck S, Rieg T, Cunard R, et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012;61(1):187-96.
11. Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, et al. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem. 2009;284(8):5056-66.
12. DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91.
13. Holloway PA, Parsons DS. Absorption and metabolism of fructose by rat jejunum. Biochem J. 1984;222(1): 57-64.
14. Latulippe ME, Skoog SM. Fructose malabsorption and intolerance: effects of fructose with and without simultaneous glucose ingestion. Crit Rev Food Sci Nutr. 2011;51(7):583-92.
15. Mueckler M. Facilitative glucose transporters. Eur J Biochem. 1994;219(3):713-25.
16. Thorens B, Mueckler M. Glucose transporters in the 21st century. Am J Physiol Endocrinol Metab. 2010; 298(2):E141-5.
17. Wilson JE. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol. 2003;206(Pt 12):2049-57.
18. Postic C, Shiota M, Magnuson MA. Cell-specifi c roles of glucokinase in glucose homeostasis. RPHR. 2001;56: 195-217.
19. Herman RH, Zakim D. Fructose metabolism. IV. Enzyme defi ciencies: essential fructosuria, fructose intolerance, and glycogen-storage disease. Am J Clin Nutr. 1968;21(6):693-8.
20. Diggle CP, Shires M, Leitch D, Brooke D, Carr IM, Markham AF, Hayward BE, Asipu A, Bonthron DT. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem. 2009;57(8):763-74.
21. Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr. 1993;58:S754-65.
22. Espinoza J, Clark SB, Hritz A, Rosensweig NS. Regulation of rat proximal intestinal glycolytic enzyme activity by ileal perfusion with glucose. Gastroenterology. 1976;71(2):295-8.
23. Rajas F, Bruni N, Montano S, Zitoun C, Mithieux G. The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology. 1999;117(1):132-9.
24. Bjorkman O, Crump M, Phillips RW. Intestinal metabolism of orally administered glucose and fructose in Yucatan miniature swine. J Nutr. 1984;114(8):1413-20.
25. Bismut H, Hers HG, Van Schaftingen E. Conversion of fructose to glucose in the rabbit small intestine. A reappraisal of the direct pathway. Eur J Biochem. 1993;213(2):721-6.
26. Haidari M, Leung N, Mahbub F, Uffelman KD, Kohen-Avramoglu R, Lewis GF, Adeli K. Fasting and postprandial overproduction of intestinally derived lipoproteins in an animal model of insulin resistance. Evidence that chronic fructose feeding in the hamster is accompanied by enhanced intestinal de novo lipogenesis and ApoB48-containing lipoprotein overproduction. J Biol Chem. 2002;277(35):31646-55.
27. Halse R, Bonavaud SM, Armstrong JL, McCormack JG, Yeaman SJ. Control of glycogen synthesis by glucose, glycogen, and insulin in cultured human muscle cells. Diabetes. 2001;50(4):720-6.
28. Kelley D, Mitrakou A, Marsh H, Schwenk F, Benn J, Sonnenberg G, Arcangeli M, Aoki T, Sorensen J, Berger M, et al. Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest. 1988;81:1563-71.
29. Radziuk J, Pye S. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes Metab Res Rev. 2001;17:250-72.
30. Petersen KF, Cline GW, Gerard DP, Magnusson I, Rothman DL, Shulman GI. Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans. Metabolism. 2001;50(5):598-601.
31. Tappy L, Schneiter P. Measurement of substrate oxidation in man. Diabetes Metab. 1997;23(5):435-42.
32. Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol metab. 2004;287(2):E199-206.
33. Schneeberger D, Tappy L, Temler E, Jéquier E. Effects of muscarinic blockade on insulin secretion and on glucoseinduced thermogenesis in lean and obese human subjects. Eur J Clin Invest. 1991;21:608-15.
34. Delarue J, Normand S, Pachiaudi C, Beylot M, Lamisse F, Riou JP. The contribution of naturally labelled 13C fructose to glucose appearance in humans. Diabetologia. 1993;36:338-45.
35. Tran C, Jacot-Descombes D, Lecoultre V, Fielding BA, Carrel G, Le KA, Schneiter P, Bortolotti M, Frayn KN, Tappy L. Sex differences in lipid and glucose kinetics after ingestion of an acute oral fructose load. Br J Nutr. 2010;104(8):1139-47.
36. Parks EJ, Skokan LE, Timlin MT, Dingfelder CS. Dietary sugars stimulate fatty acid synthesis in adults. J Nutr. 2008;138(6):1039-46.
37. Sun SZ, Empie MW. Fructose metabolism in humans-what isotopic tracer studies tell us. Nutr Metab (Lond). 2012;9(1):89.
38. Nilsson LH, Hultman E. Liver and muscle glycogen in man after glucose and fructose infusion. Scand J Clin Lab Invest. 1974;33:5-10.
39. Hultman E, Nilson LH. Factors infl uencing carbohydrate metabolism in man. Nutr Metabol. 1975;18 Suppl 1:45-64.
40. Lecoultre V, Benoit R, Carrel G, Schutz Y, Millet GP, Tappy L, Schneiter P. Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fl uxes and oxidation compared with an equimolar intake of glucose. Am J Clin Nutr. 2010;92(5):1071-9.
41. Björkman O, Gunnarsson R, Hagström E, Felig P, Wahren J. Splanchnic and renal exchange of infused fructose in insulin-defi cient type 1 diabetic patients and healthy controls. J Clin Invest. 1989;83:52-9.
42. Tounian P, Schneiter P, Henry S, Jequier E, Tappy L. Effects of infused fructose on endogenous glucose production, gluconeogenesis, and glycogen metabolism. Am J Physiol (Endocr Metab). 1994;267(5 Pt 1):E710-7.
43. Bjorkman O, Felig P. Role of the kidney in the metabolism of fructose in 60-h fasted humans. Diabetes. 1982;31 (6 Pt 1):516-20.
44. Keller U. The sugar substitutes fructose and sorbite: an unnecessary risk in parenteral nutrition. Schweiz Med Wochenschr. 1989;119(4):101-6.
45. Van den Berghe G. Inborn errors of fructose metabolism. Ann Rev Nutr. 1994;14:41-58.
46. Lecoultre V, Egli L, Theytaz F, Schneiter P: Diabetes Care. 2013;36:e149-e150.
47. Flatt JP. The biochemistry of energy expenditure. In: Bray G, editor. Recent advances in obesity research II. 0th ed. London: John Libbey; 1980. p. 211-8.
48. Tappy L, Lecoultre V, Egli L, Schneider PM: BMC Nutr Metab. 2013; 10:54. doi: 10.1186/1743-7075-10-54.
49. Wakil SJ, Abu-Elheiga LA. Fatty acid metabolism: target for metabolic syndrome. J Lipid Res. 2009; 50(Suppl):S138-43.
50. Guo ZK, Cella LK, Baum C, Ravussin E, Schoeller DA. De novo lipogenesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry. Int J Obesity. 2000;24:932-7.
51. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol. 1983; 55(2):628-34.
52. Acheson KJ, Schutz Y, Bessard T, Anantharaman K, Flatt JP, Jequier E. Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr. 1988;48(2):240-7.
53. Hellerstein MK. De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr. 1999;53 Suppl 1:S53-65.
54. Egli L, Lecoultre V, Theytaz F, Campos V, Hodson L, Schneiter P, Mittendorfer B, Patterson BW, Fielding BA, Gerber PA, et al. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes. 2013;62(7):2259-65.
55. McDevitt RM, Bott SJ, Harding M, Coward WA, Bluck LJ, Prentice AM. De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr. 2001;74(6):737-46.
56. Steinman B, Santer R. Disorders of fructose metabolism. In: Saudubray JM, Van Den Berghe G, Walter JH, editors. Inborn metabolic diseases. 5th ed. Heidelberg: Springer; 2012. p. 159-62.
57. Bouteldja N, Timson DJ. The biochemical basis of hereditary fructose intolerance. J Inherit Metab Dis. 2010;33(2):105-12.
58. Richardson RM, Little JA, Patten RL, Goldstein MB, Halperin ML. Pathogenesis of acidosis in hereditary fructose intolerance. Metabolism. 1979;28(11):1133-8.