Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

Molecular Therapy

Volumn 25, Issue 7, 2017, Pages 1580-1587

  O'Loughlin, Aisling J ^a   Mäger, Imre ^a,b   de Jong, Olivier G ^a   Varela, Miguel A ^a   Schiffelers, Raymond M ^c   El Andaloussi, Samir ^a,d   Wood, Matthew J A ^a   Vader, Pieter ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

delivery; exosomes; extracellular vesicles; RNA interference; siRNA

Indexed keywords

CHOLESTEROL; SMALL INTERFERING RNA; ELAV LIKE PROTEIN 1; ELAVL1 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG STRUCTURE; EMBRYO; EXOSOME; GENE; GENE SILENCING; HUMAN; HUMAN CELL; HUR GENE; INCUBATION TIME; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; TEMPERATURE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; FIBROBLAST; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; METABOLISM; NERVE CELL; NUCLEOTIDE SEQUENCE; PATHOLOGY; PERMEABILITY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL LINE; CELL LINE, TUMOR; CHOLESTEROL; DRUG DELIVERY SYSTEMS; ELAV-LIKE PROTEIN 1; EXTRACELLULAR VESICLES; FIBROBLASTS; GENE EXPRESSION; HEK293 CELLS; HUMANS; MICE; NEOPLASM PROTEINS; NEURONS; PERMEABILITY; RNA, SMALL INTERFERING; TEMPERATURE;

EID: 85017141800     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2017.03.021     Document Type: Article

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