Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2

Experimental Dermatology

Volumn 26, Issue 6, 2017, Pages 536-541

  Fischer, Johannes ^a   Degenhardt, Franziska ^a   Hofmann, Andrea ^a   Redler, Silke ^a   Basmanav, F Buket ^a   Heilmann Heimbach, Stefanie ^a   Hanneken, Sandra ^b   Giehl, Kathrin A ^c   Wolff, Hans ^c   Moebus, Susanne ^d   Kruse, Roland ^e   Lutz, Gerhard ^f   Blaumeiser, Bettina ^g   Böhm, Markus ^h   Garcia Bartels, Natalie ⁱ   Blume Peytavi, Ulrike ⁱ   Petukhova, Lynn ^j   Christiano, Angela M ^j   Nöthen, Markus M ^a   Betz, Regina C ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e Dermatological Practice   (Germany)

^f Dermatological Practice   (Germany)

^g ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^h UNIVERSITY OF MÜNSTER   (Germany)

ⁱ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^j Columbia University ^*  (United States)

more..

Author keywords

alopecia areata; copy number variants; genetic complex disorder; MCHR2; molecular genetics

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR; HYPOPHYSIS HORMONE; HYPOTHALAMUS HORMONE; MCHR2 PROTEIN, HUMAN; MELANIN; MELANIN-CONCENTRATING HORMONE;

ADULT; ALOPECIA AREATA; ARTICLE; CENTRAL EUROPEAN; CHROMOSOME 16P; CHROMOSOME 20P; CHROMOSOME 4Q; CHROMOSOME 6Q; CHROMOSOME 9P; COHORT ANALYSIS; COPY NUMBER VARIATION; FEMALE; GENE LOCUS; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PIGMENTATION; QUALITY CONTROL; SIGNAL TRANSDUCTION; BELGIUM; CHROMOSOMAL MAPPING; EUROPE; GENETICS; GERMANY; METABOLISM; NETHERLANDS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALOPECIA AREATA; BELGIUM; CHROMOSOME MAPPING; COHORT STUDIES; DNA COPY NUMBER VARIATIONS; EUROPE; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GERMANY; HUMANS; HYPOTHALAMIC HORMONES; MALE; MELANINS; NETHERLANDS; PIGMENTATION; PITUITARY HORMONES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PITUITARY HORMONE; SIGNAL TRANSDUCTION;

EID: 85017140015     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/exd.13123     Document Type: Article

References (39)

1. Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton LJ III. Mayo Clin Proc. 1995;70:628–633.
2. Mirzoyev SA, Schrum AG, Davis MD, Torgerson RR. J Invest Dermatol. 2014;134:1141–1142.
3. Petukhova L, Christiano AM. J Investig Dermatol Symp Proc. 2013;16:S16–S22.
4. Jackow C, Puffer N, Hordinsky M, Nelson J, Tarrand J, Duvic M. J Am Acad Dermatol. 1998;38:418–425.
5. Blaumeiser B, van der Goot I, Fimmers R, et al. J Am Acad Dermatol. 2006;54:627–632.
6. Betz RC, Petukhova L, Ripke S, et al. Nat Commun. 2015;6:5966.
7. Jagielska D, Redler S, Brockschmidt FF, et al. J Invest Dermatol. 2012;132:2192–2197.
8. Petukhova L, Duvic M, Hordinsky M, et al. Nature. 2010;466:113–117.
9. Olsson LM, Nerstedt A, Lindqvist AK, et al. Antioxid Redox Signal. 2012;16:71–78.
10. Fellermann K, Stange DE, Schaeffeler E, et al. Am J Hum Genet. 2006;79:439–448.
11. Craddock N, Hurles ME, Cardin N, et al. Nature. 2010;464:713–720.
12. McKinney C, Merriman TR. Hum Mol Genet. 2012;21:2370–2376.
13. Yang Y, Chung EK, Wu YL, et al. Am J Hum Genet. 2007;80:1037–1054.
14. de Cid R, Riveira-Munoz E, Zeeuwen PL, et al. Nat Genet. 2009;41:211–215.
15. Pedrosa E, Carretero-Iglesia L, Boada A, et al. J Invest Dermatol. 2011;131:1830–1837.
16. Huffmeier U, Bergboer JG, Becker T, et al. J Invest Dermatol. 2010;130:979–984.
17. Brown SJ, Kroboth K, Sandilands A, et al. J Invest Dermatol. 2012;132:98–104.
18. Wichmann HE, Gieger C, Illig T. Gesundheitswesen. 2005;67(Suppl 1):S26–S30.
19. Krawczak M, Nikolaus S, von Eberstein H, Croucher PJ, El Mokhtari NE, Schreiber S. Community Genet. 2006;9:55–61.
20. Schmermund A, Mohlenkamp S, Stang A, et al. Am Heart J. 2002;144:212–218.
21. Degenhardt F, Priebe L, Herms S, et al. Am J Med Genet B Neuropsychiatr Genet. 2012;159B:263–273.
22. Colella S, Yau C, Taylor JM, et al. Nucleic Acids Res. 2007;35:2013–2025.
23. Wang K, Li M, Hadley D, et al. Genome Res. 2007;17:1665–1674.
24. Kent WJ, Sugnet CW, Furey TS, et al. Genome Res. 2002;12:996–1006.
25. Purcell S, Neale B, Todd-Brown K, et al. Am J Hum Genet. 2007;81:559–575.
26. MacDonald JR, Ziman R, Yuen RK, Feuk L, Scherer SW. Nucleic Acids Res. 2014;42:D986–D992.
27. Pinto D, Marshall C, Feuk L, Scherer SW. Hum Mol Genet. 2007;16(Spec No. 2):R168–R173.
28. Coe BP, Witherspoon K, Rosenfeld JA, et al. Nat Genet. 2014;46:1063–1071.
29. Uddin M, Thiruvahindrapuram B, Walker S, et al. Genet Med. 2014;17:747–752.
30. Cooper GM, Coe BP, Girirajan S, et al. Nat Genet. 2011;43:838–846.
31. Chee MJ, Pissios P, Prasad D, Maratos-Flier E. Endocrinology. 2014;155:81–88.
32. Mizusawa K, Kobayashi Y, Yamanome T, Saito Y, Takahashi A. Gen Comp Endocrinol. 2013;181:229–234.
33. Rogozin IB. Genet Res Int. 2014;2014:516508.
34. Gilhar A, Etzioni A, Paus R. N Engl J Med. 2012;366:1515–1525.
35. Paus R, Nickoloff BJ, Ito T. Trends Immunol. 2005;26:32–40.
36. McElwee KJ, Gilhar A, Tobin DJ, et al. Exp Dermatol. 2013;22:609–626.
37. Paus R, Slominski A, Czarnetzki BM. Yale J Biol Med. 1993;66:541–554.
38. Rosengren Pielberg G, Golovko A, Sundstrom E, et al. Nat Genet. 2008;40:1004–1009.
39. Moskvina V, Holmans P, Schmidt KM, Craddock N. Ann Hum Genet. 2005;69:566–576.