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Volumn 16, Issue 4, 2017, Pages 1646-1658

Optimization and Application of Direct Infusion Nanoelectrospray HRMS Method for Large-Scale Urinary Metabolic Phenotyping in Molecular Epidemiology

Author keywords

direct infusion mass spectrometry; high throughput analysis; metabolic profiling; molecular epidemiology

Indexed keywords

ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR RISK; CHINA; CROSS-SECTIONAL STUDY; DATA MINING; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; JAPAN; LARGE SCALE PRODUCTION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MOLECULAR EPIDEMIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITY CONTROL; QUANTITATIVE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY; UNITED KINGDOM; UNITED STATES; URINALYSIS; URINE SAMPLING; CHEMISTRY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; NANOTECHNOLOGY; PROCEDURES; URINE;

EID: 85017108555     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/acs.jproteome.6b01003     Document Type: Article
Times cited : (41)

References (46)
  • 1
    • 84903983520 scopus 로고    scopus 로고
    • Design and Analysis of Metabolomics Studies in Epidemiologic Research: A Primer on -Omic Technologies
    • Tzoulaki, I.; Ebbels, T. M. D.; Valdes, A.; Elliott, P.; Ioannidis, J. P. A. Design and Analysis of Metabolomics Studies in Epidemiologic Research: A Primer on -Omic Technologies Am. J. Epidemiol. 2014, 180 (2) 129-139 10.1093/aje/kwu143
    • (2014) Am. J. Epidemiol. , vol.180 , Issue.2 , pp. 129-139
    • Tzoulaki, I.1    Ebbels, T.M.D.2    Valdes, A.3    Elliott, P.4    Ioannidis, J.P.A.5
  • 4
    • 84906861310 scopus 로고    scopus 로고
    • High-throughput discovery metabolomics
    • Fuhrer, T.; Zamboni, N. High-throughput discovery metabolomics Curr. Opin. Biotechnol. 2015, 31, 73-78 10.1016/j.copbio.2014.08.006
    • (2015) Curr. Opin. Biotechnol. , vol.31 , pp. 73-78
    • Fuhrer, T.1    Zamboni, N.2
  • 5
    • 84907294794 scopus 로고    scopus 로고
    • Development of a metabolomic approach based on urine samples and direct infusion mass spectrometry
    • Gonzalez-Dominguez, R.; Castilla-Quintero, R.; Garcia-Barrera, T.; Gomez-Ariza, J. L. Development of a metabolomic approach based on urine samples and direct infusion mass spectrometry Anal. Biochem. 2014, 465, 20-27 10.1016/j.ab.2014.07.016
    • (2014) Anal. Biochem. , vol.465 , pp. 20-27
    • Gonzalez-Dominguez, R.1    Castilla-Quintero, R.2    Garcia-Barrera, T.3    Gomez-Ariza, J.L.4
  • 6
    • 84874393708 scopus 로고    scopus 로고
    • Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: A review
    • Draper, J.; Lloyd, A. J.; Goodacre, R.; Beckmann, M. Flow infusion electrospray ionisation mass spectrometry for high throughput, non-targeted metabolite fingerprinting: a review Metabolomics 2013, 9 (1) 4-29 10.1007/s11306-012-0449-x
    • (2013) Metabolomics , vol.9 , Issue.1 , pp. 4-29
    • Draper, J.1    Lloyd, A.J.2    Goodacre, R.3    Beckmann, M.4
  • 7
    • 0029994086 scopus 로고    scopus 로고
    • Using direct electrospray mass spectrometry in taxonomy and secondary metabolite profiling of crude fungal extracts
    • Smedsgaard, J.; Frisvad, J. C. Using direct electrospray mass spectrometry in taxonomy and secondary metabolite profiling of crude fungal extracts J. Microbiol. Methods 1996, 25 (1) 5-17 10.1016/0167-7012(95)00073-9
    • (1996) J. Microbiol. Methods , vol.25 , Issue.1 , pp. 5-17
    • Smedsgaard, J.1    Frisvad, J.C.2
  • 8
    • 84878275118 scopus 로고    scopus 로고
    • Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow
    • Kirwan, J. A.; Broadhurst, D. I.; Davidson, R. L.; Viant, M. R. Characterising and correcting batch variation in an automated direct infusion mass spectrometry (DIMS) metabolomics workflow Anal. Bioanal. Chem. 2013, 405 (15) 5147-5157 10.1007/s00216-013-6856-7
    • (2013) Anal. Bioanal. Chem. , vol.405 , Issue.15 , pp. 5147-5157
    • Kirwan, J.A.1    Broadhurst, D.I.2    Davidson, R.L.3    Viant, M.R.4
  • 9
    • 85010931968 scopus 로고    scopus 로고
    • A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics
    • Southam, A. D.; Weber, R. J.; Engel, J.; Jones, M. R.; Viant, M. R. A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics Nat. Protoc. 2017, 12 (2) 255-273 10.1038/nprot.2016.156
    • (2017) Nat. Protoc. , vol.12 , Issue.2 , pp. 255-273
    • Southam, A.D.1    Weber, R.J.2    Engel, J.3    Jones, M.R.4    Viant, M.R.5
  • 10
    • 84941263818 scopus 로고    scopus 로고
    • Direct infusion mass spectrometry metabolomics dataset: A benchmark for data processing and quality control
    • Kirwan, J. A.; Weber, R. J.; Broadhurst, D. I.; Viant, M. R. Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control Sci. Data 2014, 1, 140012 10.1038/sdata.2014.12
    • (2014) Sci. Data , vol.1 , pp. 140012
    • Kirwan, J.A.1    Weber, R.J.2    Broadhurst, D.I.3    Viant, M.R.4
  • 11
    • 27944492417 scopus 로고    scopus 로고
    • Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma
    • Boernsen, K. O.; Gatzek, S.; Imbert, G. Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma Anal. Chem. 2005, 77 (22) 7255-7264 10.1021/ac0508604
    • (2005) Anal. Chem. , vol.77 , Issue.22 , pp. 7255-7264
    • Boernsen, K.O.1    Gatzek, S.2    Imbert, G.3
  • 12
    • 84857355911 scopus 로고    scopus 로고
    • Development of a nano-electrospray MSn method for the analysis of serotonin and related compounds in urine using a LTQ-orbitrap mass spectrometer
    • Moriarty, M.; Lehane, M.; O'Connell, B.; Keeley, H.; Furey, A. Development of a nano-electrospray MSn method for the analysis of serotonin and related compounds in urine using a LTQ-orbitrap mass spectrometer Talanta 2012, 90, 1-11 10.1016/j.talanta.2011.11.085
    • (2012) Talanta , vol.90 , pp. 1-11
    • Moriarty, M.1    Lehane, M.2    O'Connell, B.3    Keeley, H.4    Furey, A.5
  • 13
    • 84897689938 scopus 로고    scopus 로고
    • High-throughput and high-sensitivity quantitative analysis of serum unsaturated fatty acids by chip-based nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry: Early stage diagnostic biomarkers of pancreatic cancer
    • Zhang, Y. P.; Qiu, L.; Wang, Y. M.; Qin, X. Z.; Li, Z. L. High-throughput and high-sensitivity quantitative analysis of serum unsaturated fatty acids by chip-based nanoelectrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry: Early stage diagnostic biomarkers of pancreatic cancer Analyst 2014, 139 (7) 1697-1706 10.1039/c3an02130k
    • (2014) Analyst , vol.139 , Issue.7 , pp. 1697-1706
    • Zhang, Y.P.1    Qiu, L.2    Wang, Y.M.3    Qin, X.Z.4    Li, Z.L.5
  • 14
    • 77958062885 scopus 로고    scopus 로고
    • Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer
    • Lin, L.; Yu, Q. A.; Yan, X. M.; Hang, W.; Zheng, J. X.; Xing, J. C.; Huang, B. L. Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer Analyst 2010, 135 (11) 2970-2978 10.1039/c0an00265h
    • (2010) Analyst , vol.135 , Issue.11 , pp. 2970-2978
    • Lin, L.1    Yu, Q.A.2    Yan, X.M.3    Hang, W.4    Zheng, J.X.5    Xing, J.C.6    Huang, B.L.7
  • 15
    • 84858841249 scopus 로고    scopus 로고
    • Evaluation of Direct Infusion-Multiple Reaction Monitoring Mass Spectrometry for Quantification of Heat Shock Proteins
    • Xiang, Y.; Koomen, J. M. Evaluation of Direct Infusion-Multiple Reaction Monitoring Mass Spectrometry for Quantification of Heat Shock Proteins Anal. Chem. 2012, 84 (4) 1981-1986 10.1021/ac203011j
    • (2012) Anal. Chem. , vol.84 , Issue.4 , pp. 1981-1986
    • Xiang, Y.1    Koomen, J.M.2
  • 16
    • 4744360988 scopus 로고    scopus 로고
    • Charge competition and the linear dynamic range of detection in electrospray ionization mass spectrometry
    • Tang, K. Q.; Page, J. S.; Smith, R. D. Charge competition and the linear dynamic range of detection in electrospray ionization mass spectrometry J. Am. Soc. Mass Spectrom. 2004, 15 (10) 1416-1423 10.1016/j.jasms.2004.04.034
    • (2004) J. Am. Soc. Mass Spectrom. , vol.15 , Issue.10 , pp. 1416-1423
    • Tang, K.Q.1    Page, J.S.2    Smith, R.D.3
  • 17
    • 20044366919 scopus 로고    scopus 로고
    • Statistical total correlation spectroscopy: An exploratory approach for latent biomarker identification from metabolic H-1 NMR data sets
    • Cloarec, O.; Dumas, M. E.; Craig, A.; Barton, R. H.; Trygg, J.; Hudson, J.; Blancher, C.; Gauguier, D.; Lindon, J. C.; Holmes, E.; Nicholson, J. Statistical total correlation spectroscopy: An exploratory approach for latent biomarker identification from metabolic H-1 NMR data sets Anal. Chem. 2005, 77 (5) 1282-1289 10.1021/ac048630x
    • (2005) Anal. Chem. , vol.77 , Issue.5 , pp. 1282-1289
    • Cloarec, O.1    Dumas, M.E.2    Craig, A.3    Barton, R.H.4    Trygg, J.5    Hudson, J.6    Blancher, C.7    Gauguier, D.8    Lindon, J.C.9    Holmes, E.10    Nicholson, J.11
  • 18
    • 84871285922 scopus 로고    scopus 로고
    • Subset Optimization by Reference Matching (STORM): An Optimized Statistical Approach for Recovery of Metabolic Biomarker Structural Information from 1H NMR Spectra of Biofluids
    • Posma, J. M.; Garcia-Perez, I.; De Iorio, M.; Lindon, J. C.; Elliott, P.; Holmes, E.; Ebbels, T. M. D.; Nicholson, J. K. Subset Optimization by Reference Matching (STORM): An Optimized Statistical Approach for Recovery of Metabolic Biomarker Structural Information from 1H NMR Spectra of Biofluids Anal. Chem. 2012, 84 (24) 10694-10701 10.1021/ac302360v
    • (2012) Anal. Chem. , vol.84 , Issue.24 , pp. 10694-10701
    • Posma, J.M.1    Garcia-Perez, I.2    De Iorio, M.3    Lindon, J.C.4    Elliott, P.5    Holmes, E.6    Ebbels, T.M.D.7    Nicholson, J.K.8
  • 19
    • 84942902349 scopus 로고    scopus 로고
    • Bile Acid Profiling and Quantification in Biofluids Using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry
    • Sarafian, M. H.; Lewis, M. R.; Pechlivanis, A.; Ralphs, S.; McPhail, M. J. W.; Patel, V. C.; Dumas, M. E.; Holmes, E.; Nicholson, J. K. Bile Acid Profiling and Quantification in Biofluids Using Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry Anal. Chem. 2015, 87 (19) 9662-9670 10.1021/acs.analchem.5b01556
    • (2015) Anal. Chem. , vol.87 , Issue.19 , pp. 9662-9670
    • Sarafian, M.H.1    Lewis, M.R.2    Pechlivanis, A.3    Ralphs, S.4    McPhail, M.J.W.5    Patel, V.C.6    Dumas, M.E.7    Holmes, E.8    Nicholson, J.K.9
  • 20
    • 84948467411 scopus 로고    scopus 로고
    • Development and Validation of a High-Throughput Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Approach for Screening of Oxylipins and Their Precursors
    • Wolfer, A. M.; Gaudin, M.; Taylor-Robinson, S. D.; Holmes, E.; Nicholson, J. K. Development and Validation of a High-Throughput Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Approach for Screening of Oxylipins and Their Precursors Anal. Chem. 2015, 87 (23) 11721-11731 10.1021/acs.analchem.5b02794
    • (2015) Anal. Chem. , vol.87 , Issue.23 , pp. 11721-11731
    • Wolfer, A.M.1    Gaudin, M.2    Taylor-Robinson, S.D.3    Holmes, E.4    Nicholson, J.K.5
  • 22
    • 84930607602 scopus 로고    scopus 로고
    • High-Throughput Microbore UPLC-MS Metabolic Phenotyping of Urine for Large-Scale Epidemiology Studies
    • Gray, N.; Lewis, M. R.; Plumb, R. S.; Wilson, I. D.; Nicholson, J. K. High-Throughput Microbore UPLC-MS Metabolic Phenotyping of Urine for Large-Scale Epidemiology Studies J. Proteome Res. 2015, 14 (6) 2714-2721 10.1021/acs.jproteome.5b00203
    • (2015) J. Proteome Res. , vol.14 , Issue.6 , pp. 2714-2721
    • Gray, N.1    Lewis, M.R.2    Plumb, R.S.3    Wilson, I.D.4    Nicholson, J.K.5
  • 24
    • 0024591825 scopus 로고
    • The Atherosclerosis Risk in Communities (Aric) Study - Design and Objectives
    • Williams, O. D. The Atherosclerosis Risk in Communities (Aric) Study-Design and Objectives Am. J. Epidemiol. 1989, 129 (4) 687-702 10.1093/oxfordjournals.aje.a115184
    • (1989) Am. J. Epidemiol. , vol.129 , Issue.4 , pp. 687-702
    • Williams, O.D.1
  • 27
    • 85017181896 scopus 로고    scopus 로고
    • FDA Guidance for Industry, Bioanalytical Method Validation
    • FDA Guidance for Industry, Bioanalytical Method Validation. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm368107.pdf.
  • 28
    • 84867341623 scopus 로고    scopus 로고
    • The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans
    • Dunn, W. B.; Wilson, I. D.; Nicholls, A. W.; Broadhurst, D. The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans Bioanalysis 2012, 4 (18) 2249-2264 10.4155/bio.12.204
    • (2012) Bioanalysis , vol.4 , Issue.18 , pp. 2249-2264
    • Dunn, W.B.1    Wilson, I.D.2    Nicholls, A.W.3    Broadhurst, D.4
  • 29
    • 54949129419 scopus 로고    scopus 로고
    • ProteoWizard: Open source software for rapid proteomics tools development
    • Kessner, D.; Chambers, M.; Burke, R.; Agus, D.; Mallick, P. ProteoWizard: open source software for rapid proteomics tools development Bioinformatics 2008, 24 (21) 2534-2536 10.1093/bioinformatics/btn323
    • (2008) Bioinformatics , vol.24 , Issue.21 , pp. 2534-2536
    • Kessner, D.1    Chambers, M.2    Burke, R.3    Agus, D.4    Mallick, P.5
  • 30
    • 0042553279 scopus 로고
    • Smoothing and Differentiation of Data by Simplified Least Squares Procedures
    • Savitzky, A.; Golay, M. J. E. Smoothing and Differentiation of Data by Simplified Least Squares Procedures Anal. Chem. 1964, 36 (8) 1627-1639 10.1021/ac60214a047
    • (1964) Anal. Chem. , vol.36 , Issue.8 , pp. 1627-1639
    • Savitzky, A.1    Golay, M.J.E.2
  • 31
    • 79961135005 scopus 로고    scopus 로고
    • R Development Core Team. R Foundation for Statistical Computing: Vienna, Austria
    • R Development Core Team. R: A Language and Environment for Statistical Computing; R Foundation for Statistical Computing: Vienna, Austria, 2011.
    • (2011) R: A Language and Environment for Statistical Computing
  • 32
    • 34249335649 scopus 로고    scopus 로고
    • OPLS discriminant analysis: Combining the strengths of PLS-DA and SIMCA classification
    • Bylesjo, M.; Rantalainen, M.; Cloarec, O.; Nicholson, J. K.; Holmes, E.; Trygg, J. OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification J. Chemom. 2006, 20 (8-10) 341-351 10.1002/cem.1006
    • (2006) J. Chemom. , vol.20 , Issue.810 , pp. 341-351
    • Bylesjo, M.1    Rantalainen, M.2    Cloarec, O.3    Nicholson, J.K.4    Holmes, E.5    Trygg, J.6
  • 36
    • 34548550429 scopus 로고    scopus 로고
    • Quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays
    • Viswanathan, C. T.; Bansal, S.; Booth, B.; DeStefano, A. J.; Rose, M. J.; Sailstad, J.; Shah, V. P.; Skelly, J. P.; Swann, P. G.; Weiner, R. Quantitative bioanalytical methods validation and implementation: Best practices for chromatographic and ligand binding assays Pharm. Res. 2007, 24 (10) 1962-1973 10.1007/s11095-007-9291-7
    • (2007) Pharm. Res. , vol.24 , Issue.10 , pp. 1962-1973
    • Viswanathan, C.T.1    Bansal, S.2    Booth, B.3    DeStefano, A.J.4    Rose, M.J.5    Sailstad, J.6    Shah, V.P.7    Skelly, J.P.8    Swann, P.G.9    Weiner, R.10
  • 38
    • 84867950499 scopus 로고    scopus 로고
    • Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules
    • Jones, B. R.; Schultz, G. A.; Eckstein, J. A.; Ackermann, B. L. Surrogate matrix and surrogate analyte approaches for definitive quantitation of endogenous biomolecules Bioanalysis 2012, 4 (19) 2343-2356 10.4155/bio.12.200
    • (2012) Bioanalysis , vol.4 , Issue.19 , pp. 2343-2356
    • Jones, B.R.1    Schultz, G.A.2    Eckstein, J.A.3    Ackermann, B.L.4
  • 39
    • 67249106875 scopus 로고    scopus 로고
    • Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: Investigation of borate preservation
    • Smith, L. M.; Maher, A. D.; Want, E. J.; Elliott, P.; Stamler, J.; Hawkes, G. E.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. Large-scale human metabolic phenotyping and molecular epidemiological studies via 1H NMR spectroscopy of urine: investigation of borate preservation Anal. Chem. 2009, 81 (12) 4847-56 10.1021/ac9004875
    • (2009) Anal. Chem. , vol.81 , Issue.12 , pp. 4847-4856
    • Smith, L.M.1    Maher, A.D.2    Want, E.J.3    Elliott, P.4    Stamler, J.5    Hawkes, G.E.6    Holmes, E.7    Lindon, J.C.8    Nicholson, J.K.9
  • 40
    • 34548146614 scopus 로고    scopus 로고
    • Within-Day Reproducibility of an HPLC-MS-Based Method for Metabonomic Analysis: Application to Human Urine
    • Gika, H. S.; Theodoridis, G. A.; Wingate, J. E.; Wilson, I. D. Within-Day Reproducibility of an HPLC-MS-Based Method for Metabonomic Analysis: Application to Human Urine J. Proteome Res. 2007, 6, 3291-3303 10.1021/pr070183p
    • (2007) J. Proteome Res. , vol.6 , pp. 3291-3303
    • Gika, H.S.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4
  • 41
    • 33645671556 scopus 로고    scopus 로고
    • Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: The INTERMAP study
    • Dumas, M. E.; Maibaum, E. C.; Teague, C.; Ueshima, H.; Zhou, B. F.; Lindon, J. C.; Nicholson, J. K.; Stamler, J.; Elliott, P.; Chan, Q.; Holmes, E. Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP study Anal. Chem. 2006, 78 (7) 2199-2208 10.1021/ac0517085
    • (2006) Anal. Chem. , vol.78 , Issue.7 , pp. 2199-2208
    • Dumas, M.E.1    Maibaum, E.C.2    Teague, C.3    Ueshima, H.4    Zhou, B.F.5    Lindon, J.C.6    Nicholson, J.K.7    Stamler, J.8    Elliott, P.9    Chan, Q.10    Holmes, E.11
  • 42
    • 41849083955 scopus 로고    scopus 로고
    • High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: Validation study
    • Barton, R. H.; Nicholson, J. K.; Elliott, P.; Holmes, E. High-throughput 1H NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study International Journal of Epidemiology 2008, 37, 31-40 10.1093/ije/dym284
    • (2008) International Journal of Epidemiology , vol.37 , pp. 31-40
    • Barton, R.H.1    Nicholson, J.K.2    Elliott, P.3    Holmes, E.4
  • 44
    • 84856762345 scopus 로고    scopus 로고
    • A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: The INTERMAP Study
    • Loo, R. L.; Chan, Q.; Brown, I. J.; Robertson, C. E.; Stamler, J.; Nicholson, J. K.; Holmes, E.; Elliott, P. A comparison of self-reported analgesic use and detection of urinary ibuprofen and acetaminophen metabolites by means of metabonomics: the INTERMAP Study Am. J. Epidemiol. 2012, 175 (4) 348-58 10.1093/aje/kwr292
    • (2012) Am. J. Epidemiol. , vol.175 , Issue.4 , pp. 348-358
    • Loo, R.L.1    Chan, Q.2    Brown, I.J.3    Robertson, C.E.4    Stamler, J.5    Nicholson, J.K.6    Holmes, E.7    Elliott, P.8
  • 45
    • 84938818771 scopus 로고    scopus 로고
    • Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses
    • Thevenot, E. A.; Roux, A.; Xu, Y.; Ezan, E.; Junot, C. Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical Analyses J. Proteome Res. 2015, 14 (8) 3322-3335 10.1021/acs.jproteome.5b00354
    • (2015) J. Proteome Res. , vol.14 , Issue.8 , pp. 3322-3335
    • Thevenot, E.A.1    Roux, A.2    Xu, Y.3    Ezan, E.4    Junot, C.5


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