Euploidy rates in donor egg cycles significantly differ between fertility centers

Human Reproduction

Volumn 32, Issue 4, 2017, Pages 743-749

  Munne S ^a   Alikani, M ^b   Ribustello, L ^a   Colls, P ^a   Martínez Ortiz, Pedro A ^c   Mcculloh, D H ^d  

^a Reprogenetics LLC   (United States)

^b Reproductive Science Center of New Jersey   (United States)

^c UNIVERSITY OF ALICANTE   (Spain)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

aneuploidy; ART; donor oocytes; euploidy; mosaicism; PGS

Indexed keywords

ADULT; ARTICLE; BLASTOCYST; CHROMOSOME ABERRATION; CLINICAL ARTICLE; COHORT ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; DONOR; EUPLOIDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEALTH CARE FACILITY; HORMONAL REGULATION; HUMAN; INFERTILITY THERAPY; OOCYTE DONATION; PH; PLOIDY; RETROSPECTIVE STUDY; TEMPERATURE; EMBRYO DISPOSITION; EMBRYOLOGY; FERTILITY; PRACTICE GUIDELINE; PREIMPLANTATION GENETIC DIAGNOSIS; STANDARDS;

ADULT; CHROMOSOME ABERRATIONS; COMPARATIVE GENOMIC HYBRIDIZATION; EMBRYO DISPOSITION; FEMALE; FERTILITY; HUMANS; OOCYTE DONATION; PLOIDIES; PRACTICE GUIDELINES AS TOPIC; PREIMPLANTATION DIAGNOSIS; REPRODUCTIVE TECHNIQUES, ASSISTED; RETROSPECTIVE STUDIES;

EID: 85016953367     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dex031     Document Type: Article

References (52)

1. Almeida PA, Bolton VN. The effect of temperature fluctuations on the cytoskeletal organization and chromosomal constitution of the human oocyte. Zygote 1995; 3: 357-365.
2. Alvarez Sedo C, Miguens M, Andreucci S, Ortiz N, Lorenzi D, Papier S, Nodar F. Correlation between cytoplamic oocyte maturation and chromosomal aneuploidies-impact on fertilization, embryo quality and pregnancy. JBRA Assist Reprod 2015; 19: 59-65.
3. Ata B, Kaplan B, Danzer H, Glassner M, Opsahl M, Tan SL, Munné S. Array CGH analysis shows that aneuploidy is not related with the number of embryos generated. Reprod Biomed Online 2012; 24: 614-620.
4. Baart EB, Martini E, Eijkemans MJ, Van Opstal D, Beckers NG, Verhoeff A, Macklon NS, Fauser BC. Milder ovarian stimulation for in-vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 2007; 22: 980-988.
5. Badenas J, Santalo J, Calafell JM, Estop AM, Egozcue J. Effect of the degree of maturation of mouse oocytes at fertilization: a source of chromosome imbalance. Gamete Res 1989; 24: 205-218.
6. Baker VL, Brown MB, Luke B, Smith GW, Ireland JJ. Gonadotropin dose is negatively correlated with live birth rate: analysis of more than 650, 000 assisted reproductive technology cycles. Fertil Steril 2015; 104: 1145-1152.
7. Capalbo A, Wright G, Elliott T, Ubaldi FM, Rienzi L, Nagy PZ. FISH reanalysis of inner cell mass and trophectoderm samples of previously array-CGH screened blastocysts shows high accuracy of diagnosis and no major diagnostic impact of mosaicism at the blastocyst stage. Human Reprod 2013; 28: 2298-2307.
8. Capalbo A, TreffNR, Cimadomo D, Tao X, Upham K, Ubaldi FM, Rienzi L, Scott RT Jr. Comparison of array comparative genomic hybridization and quantitative real-Time PCR-based aneuploidy screening of blastocyst biopsies. Eur J Hum Genet 2015; 23: 901.
9. Colls P, Escudero T, Fischer J, Cekleniak N, Ben-Ozer S, Meyer B, Damien M, Grifo J, Hershlag A, Munné S. Validation of array comparative genome hybridization for diagnosis of translocations in preimplantation human embryos. Reprod Biomed Online 2012; 24: 621-629.
10. De Vincentiis S, De Martino E, Buffone MG, Brugo-Olmedo S. Use of metaphase I oocytes matured in vitro is associated with embryo multinucleation. Fertil Steril 2013; 99: 414-421.
11. Dubey A, Dayal MB, Frankfurter D, Balazy P, Peak D, Gindoff PR. The influence of sperm morphology on preimplantation genetic diagnosis cycles outcome. Fertil Steril 2008; 89: 1665-1669.
12. Fiorentino F, Biricik A, Bono S, Spizzichino L, Cotroneo E, Cottone G, Kokocinski F, Michel CE. Development and validation of a nextgeneration sequencing-based protocol for 24-chromosome aneuploidy screening of embryos. Fertil Steril 2014; 101: 1375-1382.
13. Frattarelli JL, Miller KA, Miller BT, Elkind-Hirsch Scott RT. Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles. Fertil Steril 2008; 90: 97-103.
14. Forman EJ, Li X, Ferry KM, Scott K, Treff NR, Scott RTJr. Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting. Fertil Steril 2012; 98: 644-649.
15. Goldman KN, Kramer Y, Hodes-Wertz B, Noyes N, McCaffrey C, Grifo JA. Long-Term cryopreservation of human oocytes does not increase embryonic aneuploidy. Fertil Steril 2015; 103: 662-668.
16. Greco E, Minasi MG, Fiorentino F. Healthy babies after intrauterine transfer of mosaic aneuploid blastocysts. N. Engl J Med 2015; 373: 2089-2090.
17. Gutiérrez-Mateo C, Colls P, Sánchez-García J, Escudero T, Prates R, Wells D, Munné S. Validation of microarray comparative genomic hybridization for comprehensive chromosome analysis of embryos. Fertil Steril 2011; 95: 953-958.
18. Hassold T, Jacobs PA, Kline J, Stein Z, Warburton D. Effect of maternal age on autosomal trisomies. Ann Hum Genet 1980; 44: 29-36.
19. Hickman C, Wells D, Gwinnett D, Wilkinson T, Christiansen S, Oliana O, Abramov B, Carby A, Lavery S. Euploid rate sensitivity to laboratory culture environment: a blind, prospective, randomised, sibling study. Hum Reprod 2016; 31: i216-i217; P-203.
20. Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voig RC, Thomas S, Thomas BF, Hassold TJ. Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Curr Biol 2003; 13: 546-553.
21. Kligman I, Benadiva C, Alikani M, Munné S. The presence of multinucleated blastomeres in human embryos correlates with chromosomal abnormalities. Human Reprod 1996; 11: 1492-1498.
22. Konstantinidis M, Prates P, Goodall N, Fischer J, Tecson V, Lemma T, Chu B, Jordan A, Armenti E, Wells D, et al. Live births following Karyomapping of human blastocysts: experience from clinical application of the method. Reprod Biomed Online 2015; 31: 394-403.
23. Kung A, Munné S, Bankowski B, Coates A, Wells D. Validation of nextgeneration sequencing for comprehensive chromosome screening of embryos. Reprod Biomed Online 2015; 31: 760-769.
24. Larsen K, Holm J, Budtz E, Endahl L. Interpreting parameters in the logistic regression model with random effects. Biometrics 2000; 56: 909-914.
25. Magli MC, Gianaroli L, Ferrareti AP. Chromosomal abnormalities in embryos. Mol Cell Endocrinol 2001; 22: S29-S34.
26. Magli MC, Gianaroli L, Ferrareti AP, Lappi M, Ruberti A, Farfalli V. Embryo morphology and development are dependent on the chromosome complement. Fertil Steril 2007; 87: 534-541.
27. Magli MC, Gianaroli L, Ferraretti AP, Gordts S, Fredericks V, Crippa A. Paternal contribution to aneuploidy in preimplantation embryos. Reprod Biomed Online 2009; 18: 536-542.
28. McArthur SJ, Leigh D, Marshall JT, de Boer KA, Jansen RP. Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertil Steril 2005; 84: 1628-1636.
29. McKiernan SH, Bavister BD. Environmental variables influencing in vitro development of hamster 2-cell embryos to the blastocyst stage. Biol Reprod 1990; 43: 404-413.
30. Munné S, Weier HUG, Grifo J, Cohen J. Chromosome mosaicism in human embryos. Biol Reprod 1994; 51: 373-379.
31. Munné S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates and maternal age are correlated with chromosome abnormalities. Fertil Steril 1995; 64: 382-391.
32. Munné S, Magli C, Adler A, Wright G, de Boer K, Mortimer D, Tucker M, Cohen J, Gianaroli L. Treatment-related chromosome abnormalities in human embryos. Human Reprod 1997; 12: 780-784.
33. Munné S, Ary J, Zouves C, Escudero T, Barnes F, Cinioglu C, Ary B, Cohen J. Wide range of chromosome abnormalities in the embryos of young egg donors. Reprod Biomed Online 2006; 12: 340-346.
34. Munné S. Chromosome abnormalities and their relationship to morphology and development of human embryos. Reprod Biomed Online 2006; 12: 234-253.
35. Munné S, Chen S, Colls P, Garrisi J, Zheng X, Cekleniak N, Lenzi M, Hughes P, Fischer J, Garrisi M, et al. Maternal age, morphology, development and chromosome abnormalities in over 6000 cleavage-stage embryos. Reprod Biomed Online 2007; 14: 628-634.
36. Munné S, Alikani M. Culture-induced chromosome abnormalities: the canary in the mine. Reprod Biomed Online 2011; 22: 506-508.
37. Pickering SJ, Braude PR, Jhonson MH, Cant A, Currie J. Transient cooling to room temperature can cause irreversible disruption of the meiotic spindle in the human oocyte. Fertil Steril 1990; 54: 102-108.
38. Rabinowitz M, Ryan A, Gemelos G, Hill M, Baner J, Cinnioglu C, Banjevic M, Potter D, Petrov DA, Demko Z. Origins and rates of aneuploidy in human blastomeres. Fertil Steril 2012; 97: 395-401.
39. Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C. Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos. Fertil Steril 2010; 94: 1380-1386.
40. Rubio R, Mercader A, Alama P, Cesar L, Rodrigo L, Labarta E, Melo M, Pellicer A, Remohi J. Prospective cohort study in high responder oocyte donors using two hormonal stimulation protocols: impact on embryo aneuploidy and development. Hum Reprod 2010; 25: 2290-2297.
41. Sachdev NM, Ribustello L, Liu E, McCulloh DH, Grifo J, Munne S. The rate of mosaic embryos from donor egg as detected by next generation sequencing (NGS) varies by IVF laboratory. Fertil Steril 2016; 106: e156-e157.
42. Sánchez-Castro M, Jiménez-Macedo AR, Sandalinas M, Blanco J. Prognostic value of sperm fluorescence in situ hybridization analysis over PGD. Hum Reprod 2009; 24: 1516-1521.
43. Santaló J, Badenes J, Calafell JM, Català V, Munné S, Egozcue J, Estop AM. The genetic risk of in vitro fertilization techniques. J Assist Reprod Genet 1992; 9: 462-474.
44. Scott RT Jr, Upham KM, Forman EJ, Zhao T, Treff NR. Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril 2013; 100: 697-703.
45. Silber S, Escudero T, Lenahan K, Sadowy S, Abdelhadi I, Kilani Z, Munné S. Chromosomal abnormalities in embryos derived from TESE. Fertil Steril 2003; 79: 30-38.
46. Sunkara SK, Rittenberg V, Raine-Fenning N, Bhattacharya S, Zamora J, Coomarasamy A. Association between the number of eggs and live birth in IVF treatment: an analysis of 400, 135 treatment cycles. Hum Reprod 2011; 26: 1768-1774.
47. Susiarjo M, Hassold TJ, Freeman E, Hunt PA. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet 2007; 3: e5.
48. Treff NR, Su J, Tao X, Levy B, Scott RT Jr. Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Fertil Steril 2010; 94: 2017-2021.
49. Treff NR, Ferry KM, Zhao T, Ferry KM, Su J, Taylor D, Scott RT. Development and validation of an accurate quantitative real-Time polymerase chain reaction-based assay for human blastocyst comprehensive chromosomal aneuploidy screening. Fertil Steril 2012; 97: 819-824.
50. Weghofer A, Munné S, Brannath W, Chen S, Tomkin G, Cekleniak N, Garrisi M, Barad D, Cohen J, Gleicher N. The impact of LH-containing gonadotropins on diploidy rates in preimplantation embryos: long protocol stimulation. Hum Reprod 2008; 23: 499-503.
51. Weghofer A, Munné S, Brannath W, Chen S, Barad D, Cohen J, Gleicher N. The impact of LH-containing gonadotropin stimulation on euploidy rates in preimplantation embryos: antagonist cycles. Fertil Steril 2009; 92: 937-942.
52. Wells D, Kaur K, Rico A, Grifo J, Anderson S, Sherlock J, Taylor JC, Munné S. Clinical utilization of a rapid low-pass whole-genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation. J Med Genet 2014; 51: 553-562.