An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

Cell Reports

Volumn 19, Issue 1, 2017, Pages 50-59

  Iefremova, Vira ^a   Manikakis, George ^a   Krefft, Olivia ^a   Jabali, Ammar ^a   Weynans, Kevin ^a   Wilkens, Ruven ^a   Marsoner, Fabio ^a   Brändl, Björn ^b   Müller, Franz Josef ^b   Koch, Philipp ^a   Ladewig, Julia ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

brain organoids; disease modeling; induced pluripotent stem cells; Lissencephaly; Miller Dieker Syndrome; neurodevelopmental disorders; ventricular zone niche signaling

Indexed keywords

14 3 3 EPSILON PROTEIN; BETA CATENIN; CELL ADHESION MOLECULE; LIS1 PROTEIN; MULTIPROTEIN COMPLEX; NERVE CELL ADHESION MOLECULE; UNCLASSIFIED DRUG; WNT PROTEIN; 1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; CADHERIN; MICROTUBULE ASSOCIATED PROTEIN; PAFAH1B1 PROTEIN, HUMAN; PROTEIN 14 3 3; YWHAE PROTEIN, HUMAN;

ARTICLE; BRAIN CORTEX; BRAIN REGION; CHILD; CONTROLLED STUDY; CYTOPLASM; FEMALE; GLIA CELL; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; INFANT; MALE; MICROTUBULE ORGANIZING CENTER; MILLER DIEKER SYNDROME; NERVOUS SYSTEM DEVELOPMENT; PROTEIN EXPRESSION; RADIAL GLIA CELL; VENTRICULAR ZONE; WNT SIGNALING PATHWAY; ABNORMALITIES; AGYRIA; BIOLOGICAL MODEL; CELL COMMUNICATION; CELL DIVISION; CHROMOSOME 17; CHROMOSOME DELETION; GENE EXPRESSION; GENETICS; HETEROZYGOTE; MACROGLIA; METABOLISM; ORGANOID; PATHOLOGY; STEM CELL NICHE; TISSUE ENGINEERING; WNT SIGNALING;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 14-3-3 PROTEINS; BETA CATENIN; CADHERINS; CELL COMMUNICATION; CELL DIVISION; CEREBRAL CORTEX; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 17; CLASSICAL LISSENCEPHALIES AND SUBCORTICAL BAND HETEROTOPIAS; EPENDYMOGLIAL CELLS; GENE EXPRESSION; HETEROZYGOTE; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; ORGANOIDS; STEM CELL NICHE; TISSUE ENGINEERING; WNT SIGNALING PATHWAY;

EID: 85016941182     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.047     Document Type: Article

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