메뉴 건너뛰기




Volumn 5, Issue 2, 2015, Pages 192-210

Systemic metabolomic changes in blood samples of lung cancer patients identified by gas chromatography Time-Of-Flight mass spectrometry

Author keywords

Blood; Lung cancer; Mass spectrometry; Metabolomics

Indexed keywords

ETHANOLAMINE; GLUTAMIC ACID; GLYCEROL; HISTIDINE; LACTIC ACID; LYSINE; MALTOSE; PALMITIC ACID; TRYPTOPHAN;

EID: 85016919890     PISSN: None     EISSN: 22181989     Source Type: Journal    
DOI: 10.3390/metabo5020192     Document Type: Article
Times cited : (70)

References (48)
  • 3
    • 44249086425 scopus 로고    scopus 로고
    • Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship
    • Molina, J.R.; Yang, P.; Cassivi, S.D.; Schild, S.E.; Adjei, A.A. Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 2008, 83, 584-594.
    • (2008) Mayo Clin. Proc , vol.83 , pp. 584-594
    • Molina, J.R.1    Yang, P.2    Cassivi, S.D.3    Schild, S.E.4    Adjei, A.A.5
  • 5
    • 84856940527 scopus 로고    scopus 로고
    • Lung cancer screening with low-dose computed tomography: Costs, national expenditures, and cost-effectiveness
    • Goulart, B.H.; Bensink, M.E.; Mummy, D.G.; Ramsey, S.D. Lung cancer screening with low-dose computed tomography: Costs, national expenditures, and cost-effectiveness. J. Natl. Compr. Canc. Netw. 2012, 10, 267-275.
    • (2012) J. Natl. Compr. Canc. Netw , vol.10 , pp. 267-275
    • Goulart, B.H.1    Bensink, M.E.2    Mummy, D.G.3    Ramsey, S.D.4
  • 7
    • 84858766991 scopus 로고    scopus 로고
    • A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by ct screening
    • Bigbee, W.L.; Gopalakrishnan, V.; Weissfeld, J.L.; Wilson, D.O.; Dacic, S.; Lokshin, A.E.; Siegfried, J.M. A multiplexed serum biomarker immunoassay panel discriminates clinical lung cancer patients from high-risk individuals found to be cancer-free by ct screening. J. Thorac. Oncol. 2012, 7, 698-708.
    • (2012) J. Thorac. Oncol , vol.7 , pp. 698-708
    • Bigbee, W.L.1    Gopalakrishnan, V.2    Weissfeld, J.L.3    Wilson, D.O.4    Dacic, S.5    Lokshin, A.E.6    Siegfried, J.M.7
  • 11
    • 33845314350 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
    • Denkert, C.; Budczies, J.; Kind, T.; Weichert, W.; Tablack, P.; Sehouli, J.; Niesporek, S.; Konsgen, D.; Dietel, M.; Fiehn, O. Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res. 2006, 66, 10795-10804.
    • (2006) Cancer Res , vol.66 , pp. 10795-10804
    • Denkert, C.1    Budczies, J.2    Kind, T.3    Weichert, W.4    Tablack, P.5    Sehouli, J.6    Niesporek, S.7    Konsgen, D.8    Dietel, M.9    Fiehn, O.10
  • 12
    • 77049086563 scopus 로고    scopus 로고
    • Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer
    • Urayama, S.; Zou, W.; Brooks, K.; Tolstikov, V. Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer. Rapid Commun. Mass Spectrom. 2010, 24, 613-620.
    • (2010) Rapid Commun. Mass Spectrom , vol.24 , pp. 613-620
    • Urayama, S.1    Zou, W.2    Brooks, K.3    Tolstikov, V.4
  • 13
    • 84859783281 scopus 로고    scopus 로고
    • Identification of metabolic biomarkers to diagnose epithelial ovarian cancer using a uplc/qtof/ms platform
    • Fan, L.; Zhang, W.; Yin, M.; Zhang, T.; Wu, X.; Zhang, H.; Sun, M.; Li, Z.; Hou, Y.; Zhou, X.; et al. Identification of metabolic biomarkers to diagnose epithelial ovarian cancer using a uplc/qtof/ms platform. Acta Oncol. 2012, 51, 473-479.
    • (2012) Acta Oncol , vol.51 , pp. 473-479
    • Fan, L.1    Zhang, W.2    Yin, M.3    Zhang, T.4    Wu, X.5    Zhang, H.6    Sun, M.7    Li, Z.8    Hou, Y.9    Zhou, X.10
  • 16
    • 79960438225 scopus 로고    scopus 로고
    • Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry
    • Yu, L.; Aa, J.; Xu, J.; Sun, M.; Qian, S.; Cheng, L.; Yang, S.; Shi, R. Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry. J. Gastroenterol. Hepatol. 2011, 26, 1290-1297.
    • (2011) J. Gastroenterol. Hepatol , vol.26 , pp. 1290-1297
    • Yu, L.1    Aa, J.2    Xu, J.3    Sun, M.4    Qian, S.5    Cheng, L.6    Yang, S.7    Shi, R.8
  • 17
    • 78650314877 scopus 로고    scopus 로고
    • Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: A case control study
    • Maeda, J.; Higashiyama, M.; Imaizumi, A.; Nakayama, T.; Yamamoto, H.; Daimon, T.; Yamakado, M.; Imamura, F.; Kodama, K. Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: A case control study. BMC Cancer 2010, 10, 690.
    • (2010) BMC Cancer , vol.10 , pp. 690
    • Maeda, J.1    Higashiyama, M.2    Imaizumi, A.3    Nakayama, T.4    Yamamoto, H.5    Daimon, T.6    Yamakado, M.7    Imamura, F.8    Kodama, K.9
  • 19
    • 79952215103 scopus 로고    scopus 로고
    • Prognostic impact of amp-activated protein kinase expression in ovarian carcinoma: Correlation of protein expression and gc/tof-ms-based metabolomics
    • Buckendahl, A.C.; Budczies, J.; Fiehn, O.; Darb-Esfahani, S.; Kind, T.; Noske, A.; Weichert, W.; Sehouli, J.; Braicu, E.; Dietel, M.; et al. Prognostic impact of amp-activated protein kinase expression in ovarian carcinoma: Correlation of protein expression and gc/tof-ms-based metabolomics. Oncol. Rep. 2011, 25, 1005-1012.
    • (2011) Oncol. Rep , vol.25 , pp. 1005-1012
    • Buckendahl, A.C.1    Budczies, J.2    Fiehn, O.3    Darb-Esfahani, S.4    Kind, T.5    Noske, A.6    Weichert, W.7    Sehouli, J.8    Braicu, E.9    Dietel, M.10
  • 22
    • 79952527112 scopus 로고    scopus 로고
    • Stable sotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer
    • Lane, A.N.; Fan, T.W.; Bousamra, M., 2nd; Higashi, R.M.; Yan, J.; Miller, D.M. Stable sotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer. OMICS 2011, 15, 173-182.
    • (2011) OMICS , vol.15 , pp. 173-182
    • Lane, A.N.1    Fan, T.W.2    Bousamra, M.3    Higashi, R.M.4    Yan, J.5    Miller, D.M.6
  • 24
    • 0028354319 scopus 로고
    • Exponentially weighted moving principal components-analysis and projections to latent structures
    • Wold, S. Exponentially weighted moving principal components-analysis and projections to latent structures. Chemometr. Intell. Lab. Syst. 1994, 23, 149-161.
    • (1994) Chemometr. Intell. Lab. Syst , vol.23 , pp. 149-161
    • Wold, S.1
  • 25
    • 72449186517 scopus 로고    scopus 로고
    • Fiehnlib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • Kind, T.; Wohlgemuth, G.; Lee do, Y.; Lu, Y.; Palazoglu, M.; Shahbaz, S.; Fiehn, O. Fiehnlib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem. 2009, 81, 10038-10048.
    • (2009) Anal. Chem , vol.81 , pp. 10038-10048
    • Kind, T.1    Wohlgemuth, G.2    Lee do, Y.3    Lu, Y.4    Palazoglu, M.5    Shahbaz, S.6    Fiehn, O.7
  • 26
    • 79960981890 scopus 로고    scopus 로고
    • Applying in-silico retention index and mass spectra matching for identification of unknown metabolites in accurate mass gc-tof mass spectrometry
    • Kumari, S.; Stevens, D.; Kind, T.; Denkert, C.; Fiehn, O. Applying in-silico retention index and mass spectra matching for identification of unknown metabolites in accurate mass gc-tof mass spectrometry. Anal. Chem. 2011, 83, 5895-5902.
    • (2011) Anal. Chem , vol.83 , pp. 5895-5902
    • Kumari, S.1    Stevens, D.2    Kind, T.3    Denkert, C.4    Fiehn, O.5
  • 27
    • 34247163207 scopus 로고    scopus 로고
    • Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry
    • Kind, T.; Fiehn, O. Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinf. 2007, 8, 105.
    • (2007) BMC Bioinf , vol.8 , pp. 105
    • Kind, T.1    Fiehn, O.2
  • 28
    • 84881089210 scopus 로고    scopus 로고
    • Exploratory investigation of plasma metabolomics in human lung adenocarcinoma
    • Wen, T.; Gao, L.; Wen, Z.; Wu, C.; Tan, C.S.; Toh, W.Z.; Ong, C.N. Exploratory investigation of plasma metabolomics in human lung adenocarcinoma. Mol. Biosyst. 2013, 9, 2370-2378.
    • (2013) Mol. Biosyst , vol.9 , pp. 2370-2378
    • Wen, T.1    Gao, L.2    Wen, Z.3    Wu, C.4    Tan, C.S.5    Toh, W.Z.6    Ong, C.N.7
  • 36
    • 80052324373 scopus 로고    scopus 로고
    • Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer
    • Wedge, D.C.; Allwood, J.W.; Dunn, W.; Vaughan, A.A.; Simpson, K.; Brown, M.; Priest, L.; Blackhall, F.H.; Whetton, A.D.; Dive, C.; et al. Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal. Chem. 2011, 83, 6689-6697.
    • (2011) Anal. Chem , vol.83 , pp. 6689-6697
    • Wedge, D.C.1    Allwood, J.W.2    Dunn, W.3    Vaughan, A.A.4    Simpson, K.5    Brown, M.6    Priest, L.7    Blackhall, F.H.8    Whetton, A.D.9    Dive, C.10
  • 37
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM)
    • Fan, T.W.; Lane, A.N.; Higashi, R.M.; Farag, M.A.; Gao, H.; Bousamra, M.; Miller, D.M. Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotope-resolved metabolomics (SIRM). Mol. Cancer 2009, 8, 41.
    • (2009) Mol. Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 38
    • 84858983547 scopus 로고    scopus 로고
    • Kegg for integration and interpretation of large-scale molecular data sets
    • Kanehisa, M.; Goto, S.; Sato, Y.; Furumichi, M.; Tanabe, M. Kegg for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 2012, 40, D109-D114.
    • (2012) Nucleic Acids Res , vol.40 , pp. D109-D114
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3    Furumichi, M.4    Tanabe, M.5
  • 39
    • 75549090213 scopus 로고    scopus 로고
    • Kegg for representation and analysis of molecular networks involving diseases and drugs
    • Kanehisa, M.; Goto, S.; Furumichi, M.; Tanabe, M.; Hirakawa, M. Kegg for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010, 38, D355-D360.
    • (2010) Nucleic Acids Res , vol.38 , pp. D355-D360
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3    Tanabe, M.4    Hirakawa, M.5
  • 40
    • 84861002231 scopus 로고    scopus 로고
    • Metamapp: Mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity
    • Barupal, D.K.; Haldiya, P.K.; Wohlgemuth, G.; Kind, T.; Kothari, S.L.; Pinkerton, K.E.; Fiehn, O. Metamapp: Mapping and visualizing metabolomic data by integrating information from biochemical pathways and chemical and mass spectral similarity. BMC Bioinf. 2012, 13, 99.
    • (2012) BMC Bioinf , vol.13 , pp. 99
    • Barupal, D.K.1    Haldiya, P.K.2    Wohlgemuth, G.3    Kind, T.4    Kothari, S.L.5    Pinkerton, K.E.6    Fiehn, O.7
  • 41
    • 0027497292 scopus 로고
    • Protein and amino acid metabolism in cancer cachexia: Investigative techniques and therapeutic interventions
    • Pisters, P.W.; Pearlstone, D.B. Protein and amino acid metabolism in cancer cachexia: Investigative techniques and therapeutic interventions. Crit. Rev. Clin. Lab Sci. 1993, 30, 223-272.
    • (1993) Crit. Rev. Clin. Lab Sci , vol.30 , pp. 223-272
    • Pisters, P.W.1    Pearlstone, D.B.2
  • 42
    • 84897015133 scopus 로고    scopus 로고
    • Clinical utility of a plasma-based mirna signature classifier within computed tomography lung cancer screening: A correlative mild trial study
    • Sozzi, G.; Boeri, M.; Rossi, M.; Verri, C.; Suatoni, P.; Bravi, F.; Roz, L.; Conte, D.; Grassi, M.; Sverzellati, N.; et al. Clinical utility of a plasma-based mirna signature classifier within computed tomography lung cancer screening: A correlative mild trial study. J. Clin. Oncol. 2014, 32, 768-773.
    • (2014) J. Clin. Oncol , vol.32 , pp. 768-773
    • Sozzi, G.1    Boeri, M.2    Rossi, M.3    Verri, C.4    Suatoni, P.5    Bravi, F.6    Roz, L.7    Conte, D.8    Grassi, M.9    Sverzellati, N.10
  • 43
    • 0942265392 scopus 로고    scopus 로고
    • Process for the integrated extraction, identification and quantification of metabolites, proteins and rna to reveal their co-regulation in biochemical networks
    • Weckwerth, W.; Wenzel, K.; Fiehn, O. Process for the integrated extraction, identification and quantification of metabolites, proteins and rna to reveal their co-regulation in biochemical networks. Proteomics 2004, 4, 78-83.
    • (2004) Proteomics , vol.4 , pp. 78-83
    • Weckwerth, W.1    Wenzel, K.2    Fiehn, O.3
  • 44
    • 41049100247 scopus 로고    scopus 로고
    • Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry
    • Fiehn, O. Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry. Trends Anal. Chem. 2008, 27, 261-269.
    • (2008) Trends Anal. Chem , vol.27 , pp. 261-269
    • Fiehn, O.1
  • 45
    • 33947216093 scopus 로고    scopus 로고
    • A comprehensive urinary metabolomic approach for identifying kidney cancer
    • Kind, T.; Tolstikov, V.; Fiehn, O.; Weiss, R.H. A comprehensive urinary metabolomic approach for identifying kidney cancer. Anal. Biochem. 2007, 363, 185-195.
    • (2007) Anal. Biochem , vol.363 , pp. 185-195
    • Kind, T.1    Tolstikov, V.2    Fiehn, O.3    Weiss, R.H.4
  • 46
    • 36348979386 scopus 로고    scopus 로고
    • Setupx-A public study design database for metabolomic projects
    • Scholz, M.; Fiehn, O. Setupx-A public study design database for metabolomic projects. Pac. Symp. Biocomput. 2007, 363, 169-180.
    • (2007) Pac. Symp. Biocomput , vol.363 , pp. 169-180
    • Scholz, M.1    Fiehn, O.2
  • 47
    • 33846515112 scopus 로고    scopus 로고
    • Partial least squares: A versatile tool for the analysis of high-dimensional genomic data
    • Boulesteix, A.L.; Strimmer, K. Partial least squares: A versatile tool for the analysis of high-dimensional genomic data. Brief Bioinform 2007, 8, 32-44.
    • (2007) Brief Bioinform , vol.8 , pp. 32-44
    • Boulesteix, A.L.1    Strimmer, K.2
  • 48
    • 84953639872 scopus 로고    scopus 로고
    • (accessed on 31 March 2015)
    • R Development Core Team. The R Stats Package. Available online: https://stat.ethz.ch/R-manual/R-patched/library/stats/html/00Index.html (accessed on 31 March 2015).
    • The R Stats Package


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.