Live birth derived from oocyte spindle transfer to prevent mitochondrial disease

Reproductive BioMedicine Online

Volumn 34, Issue 4, 2017, Pages 361-368

  Zhang, John ^a,b   Liu, Hui ^b   Luo, Shiyu ^c   Lu, Zhuo ^b   Chávez Badiola, Alejandro ^a   Liu, Zitao ^b   Yang, Mingxue ^b   Merhi, Zaher ^d   Silber, Sherman J ^e   Munné, Santiago ^f   Konstandinidis, Michalis ^f   Wells, Dagan ^f   Huang, Taosheng ^c  

^a New Hope Fertility Center   (Mexico)

^b New Hope Fertility Center   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ST LUKE S HOSPITAL   (United States)

^f Reprogenetics LLC   (United States)

Author keywords

Cytoplasm; Leigh syndrome; Meiotic spindle; Mitochondria; Nuclear transfer; Oocyte

Indexed keywords

MITOCHONDRIAL DNA;

ADULT; ARTICLE; BLASTOCYST; CASE REPORT; CYTOPLASM; DNA SEQUENCE; EMBRYO TRANSFER; FEMALE; GENE MUTATION; HUMAN; INFERTILITY; INTRACYTOPLASMIC SPERM INJECTION; LEIGH DISEASE; LIVE BIRTH; MALE; MITOCHONDRIAL GENOME; MITOCHONDRIAL REPLACEMENT THERAPY; MUTATIONAL LOAD; NEWBORN; OOCYTE DONATION; OOCYTE SPINDLE TRANSFER; SPONTANEOUS ABORTION; CHEMISTRY; GENETICS; HETEROZYGOTE; IN VITRO FERTILIZATION; MATERNAL INHERITANCE; MITOCHONDRION; OOCYTE; PEDIGREE; PREGNANCY; PREIMPLANTATION GENETIC DIAGNOSIS; ULTRASTRUCTURE;

DNA, MITOCHONDRIAL; FEMALE; FERTILIZATION IN VITRO; HETEROZYGOTE; HUMANS; LEIGH DISEASE; LIVE BIRTH; MATERNAL INHERITANCE; MITOCHONDRIA; MITOCHONDRIAL REPLACEMENT THERAPY; OOCYTE DONATION; OOCYTES; PEDIGREE; PREGNANCY; PREIMPLANTATION DIAGNOSIS; SEQUENCE ANALYSIS, DNA;

EID: 85016757008     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2017.01.013     Document Type: Article

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