Mitochondrial replacement techniques - Implications for the clinical community

New England Journal of Medicine

Volumn 374, Issue 12, 2016, Pages 1103-1106

  Falk, Marni J ^a   Decherney, Alan ^b   Kahn, Jeffrey P ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE;

CRISPR CAS SYSTEM; FERTILIZATION IN VITRO; GENE MUTATION; HETEROPLASMY; HUMAN; INHERITANCE; LIVE BIRTH; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL GENOME; MITOCHONDRIAL REPLACEMENT THERAPY; NONHUMAN; PERSONALIZED MEDICINE; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; REVIEW; ANIMAL; FEMALE; MALE; MITOCHONDRIAL DISEASES; MUTATION; ORGANIZATION; UNITED STATES;

ANIMALS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; INSTITUTE OF MEDICINE (U.S.); MALE; MITOCHONDRIAL DISEASES; MITOCHONDRIAL REPLACEMENT THERAPY; MUTATION; UNITED STATES;

EID: 84962321766     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMp1600893     Document Type: Review

References (5)

1. Hashimoto M, Bacman SR, Peralta S, et al. MitoTALEN: a general approach to reduce mutant mtDNA loads and restore oxidative phosphorylation function in mitochondrial diseases. Mol Ther 2015; 23: 1592-9.
2. Tachibana M, Sparman M, Sritanaudomchai H, et al. Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature 2009; 461: 367-72.
3. National Academies of Sciences, Engineering, and Medicine. Mitochondrial replacement techniques: ethical, social, and policy considerations. Washington, DC: National Academies Press, 2016.
4. Engelstad K, Sklerov M, Kriger J, et al. Attitudes towards prevention of mtDNArelated diseases through oocyte mitochondrial replacement therapy. Hum Reprod (in press).
5. Mitalipov S, Amato P, Parry S, Falk MJ. Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases. Cell Rep 2014; 7: 935-7.