The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle

Journal of Physiology

Volumn 595, Issue 5, 2017, Pages 1657-1670

  Hwee, Darren T ^a   Cheng, Arthur J ^b   Hartman, James J ^a   Hinken, Aaron C ^a   Lee, Ken ^a   Durham, Nickie ^a   Russell, Alan J ^a   Malik, Fady I ^a   Westerblad, Håkan ^b   Jasper, Jeffrey R ^a  

^a Cytokinetics Inc   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Ca2 + sensitivity; skeletal muscle; troponin C

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM ION; CK 2066260; ENZYME ACTIVATOR; TROPONIN C; UNCLASSIFIED DRUG; CALCIUM; IMIDAZOLE DERIVATIVE; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CALCIUM SENSITIVITY; CALCIUM TRANSPORT; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; FLEXOR DIGITORUM BREVIS MUSCLE; FLOW RATE; FREQUENCY MODULATION; MOUSE; MUSCLE EXCITATION; MUSCLE FIBRIL; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; MUSCLE STRENGTH; MUSCLE WEAKNESS; NONHUMAN; PHYSICAL SENSITIVITY; RAT; SKELETAL MUSCLE; ANIMAL; BOVINE; C57BL MOUSE; DRUG EFFECTS; FAST MUSCLE FIBER; HINDLIMB; LEPORIDAE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CALCIUM; CATTLE; FEMALE; HINDLIMB; IMIDAZOLES; MICE, INBRED C57BL; MUSCLE FIBERS, FAST-TWITCH; MYOFIBRILS; PYRAZINES; RABBITS; RATS, SPRAGUE-DAWLEY; TROPONIN C;

EID: 85016609100     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/JP273248     Document Type: Article

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