Inflammatory Markers and Frailty in Long-Term Care Residents

Journal of the American Geriatrics Society

Volumn 65, Issue 8, 2017, Pages 1777-1783

  Langmann, Gabrielle A ^a   Perera, Subashan ^a,b   Ferchak, Mary A ^a   Nace, David A ^a   Resnick, Neil M ^a   Greenspan, Susan L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

cytokines; falls; frailty; gait speed; inflammation; long term care; zoledronic acid

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PLACEBO; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; ZOLEDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; BONE DENSITY CONSERVATION AGENT; CYTOKINE; IMIDAZOLE DERIVATIVE;

AGED; ARTICLE; ASSISTED LIVING FACILITY; BATH; CLINICAL ASSESSMENT; COGNITION; COMORBIDITY; DAILY LIFE ACTIVITY; EATING; FALLING; FEMALE; FOOD PROCESSING; FRAILTY; FRIED FRAILTY INDEX; FUNCTIONAL STATUS; FUNCTIONAL STATUS ASSESSMENT; GAIT; GENETIC ASSOCIATION; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; NURSING HOME; NURSING HOME PHYSICAL PERFORMANCE TEST; OSTEOPOROSIS; OUTCOME ASSESSMENT; PATIENT HEALTH QUESTIONNAIRE 9; PHYSICAL PERFORMANCE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SENSITIVITY ANALYSIS; SHOPPING; SHORT PORTABLE MENTAL STATUS QUESTIONNAIRE; TOILETING; VERY ELDERLY; BLOOD; COMPLICATION; FRAIL ELDERLY; INFLAMMATION;

ACTIVITIES OF DAILY LIVING; AGED; BIOMARKERS; BONE DENSITY CONSERVATION AGENTS; CYTOKINES; DIPHOSPHONATES; FEMALE; FRAIL ELDERLY; HUMANS; IMIDAZOLES; INFLAMMATION; LONG-TERM CARE; OSTEOPOROSIS;

EID: 85016488492     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.14876     Document Type: Article

References (45)

1. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: Evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56A:M146–M156.
2. Fried LP, Hadley EC, Walston JD et al. From bedside to bench: Research agenda for frailty. Sci Aging Knowledge Environ 2005;2005:pe24.
3. Walston J, Hadley EC, Ferrucci L et al. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc 2006;54:991–1001.
4. Clegg A, Young J, Iliffe S et al. Frailty in elderly people. Lancet 2013;381:752–762.
5. Lipsitz LA. Dynamics of stability: The physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci 2002;57A:B115–B125.
6. Khan H, Kalogeropoulos AP, Georgiopoulou VV et al. Frailty and risk for heart failure in older adults: The health, aging, and body composition study. Am Heart J 2013;166:887–894.
7. Abellan van Kan G, Rolland Y, Houles M et al. The assessment of frailty in older adults. Clin Geriatr Med 2010;26:275–286.
8. Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal 2001;1:323–336.
9. Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci 2007;62A:738–743.
10. Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med 2011;27:17–26.
11. Woods NF, LaCroix AZ, Gray SL et al. Frailty: Emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 2005;53:1321–1330.
12. Leng SX, Xue QL, Tian J et al. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: Results from the Women's Health and Aging Studies I. Exp Gerontol 2009;44:511–516.
13. Collard RM, Boter H, Schoevers RA et al. Prevalence of frailty in community-dwelling older persons: A systematic review. J Am Geriatr Soc 2012;60:1487–1492.
14. Tom SE, Adachi JD, Anderson FA Jr et al. Frailty and fracture, disability, and falls: A multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc 2013;61:327–334.
15. Collerton J, Martin-Ruiz C, Davies K et al. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study. Mech Ageing Dev 2012;133:456–466.
16. Franceschi C, Bonafe M, Valensin S et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244–254.
17. Walston J, McBurnie MA, Newman A et al. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study. Arch Intern Med 2002;162:2333–2341.
18. Fried LP, Xue QL, Cappola AR et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: Implications for etiology and treatment. J Gerontol A Biol Sci Med Sci 2009;64A:1049–1057.
19. Li H, Manwani B, Leng SX. Frailty, inflammation, and immunity. Aging Dis 2011;2:466–473.
20. Leng S, Chaves P, Koenig K et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: A pilot study. J Am Geriatr Soc 2002;50:1268–1271.
21. Leng SX, Xue QL, Tian J et al. Inflammation and frailty in older women. J Am Geriatr Soc 2007;55:864–871.
22. Darvin K, Randolph A, Ovalles S et al. Plasma protein biomarkers of the geriatric syndrome of frailty. J Gerontol A Biol Sci Med Sci 2014;69A:182–186.
23. Cesari M, Penninx BW, Newman AB et al. Inflammatory markers and onset of cardiovascular events: Results from the Health ABC study. Circulation 2003;108:2317–2322.
24. Tracy RP. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Int J Obes Relat Metab Disord 2003;27(Suppl 3):S29–S34.
25. Soysal P, Stubbs B, Lucato P et al. Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev 2016;31:1–8.
26. Cauley JA, Danielson ME, Boudreau RM et al. Inflammatory markers and incident fracture risk in older men and women: The Health Aging and Body Composition Study. J Bone Miner Res 2007;22:1088–1095.
27. Barbour KE, Boudreau R, Danielson ME et al. Inflammatory markers and the risk of hip fracture: The Women's Health Initiative. J Bone Miner Res 2012;27:1167–1176.
28. Greenspan SL, Perera S, Ferchak MA et al. Efficacy and safety of single-dose zoledronic acid for osteoporosis in frail elderly women: A randomized clinical trial. JAMA Intern Med 2015;175:913–921.
29. Lyles KW, Colon-Emeric CS, Magaziner JS et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007;357:1799–1809.
30. Adami S, Bhalla AK, Dorizzi R et al. The acute-phase response after bisphosphonate administration. Calcif Tissue Int 1987;41:326–331.
31. Rossini M, Adami S, Viapiana O et al. Long-term effects of amino-bisphosphonates on circulating gammadelta T cells. Calcif Tissue Int 2012;91:395–399.
32. Greenspan S, Nace D, Perera S et al. Lessons learned from an osteoporosis clinical trial in frail long-term care residents. Clin Trials 2012;9:247–256.
33. Reuben DB, Siu AL. An objective measure of physical function of elderly outpatients. The Physical Performance Test. J Am Geriatr Soc 1990;38:1105–1112.
34. Pfeiffer E. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. J Am Geriatr Soc 1975;23:433–441.
35. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med 2001;16:606–613.
36. Rigler SK, Studenski S, Wallace D et al. Co-morbidity adjustment for functional outcomes in community-dwelling older adults. Clin Rehabil 2002;16:420–428.
37. Baylis D, Bartlett DB, Patel HP et al. Understanding how we age: Insights into inflammaging. Longev Healthspan 2013;2:8.
38. Michaud M, Balardy L, Moulis G et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc 2013;14:877–882.
39. Penninx BW, Kritchevsky SB, Newman AB et al. Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 2004;52:1105–1113.
40. Barbour KE, Lui LY, Ensrud KE et al. Inflammatory markers and risk of hip fracture in older white women: The Study of Osteoporotic Fractures. J Bone Miner Res 2014;29:2057–2064.
41. Theou O, Cann L, Blodgett J et al. Modifications to the frailty phenotype criteria: Systematic review of the current literature and investigation of 262 frailty phenotypes in the Survey of Health, Ageing, and Retirement in Europe. Ageing Res Rev 2015;21:78–94.
42. Aderka D, Engelmann H, Maor Y et al. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 1992;175:323–329.
43. Honda M, Yamamoto S, Cheng M et al. Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection. J Immunol 1992;148:2175–2180.
44. Van Zee KJ, Kohno T, Fischer E et al. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci USA 1992;89:4845–4849.
45. Marti CN, Khan H, Mann DL et al. Soluble tumor necrosis factor receptors and heart failure risk in older adults: Health, Aging, and Body Composition (Health ABC) Study. Circ Heart Fail 2014;7:5–11.