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Volumn 117, Issue 6, 2016, Pages 775-782

Fibrinogen in the initial resuscitation of severe trauma (FiiRST): a randomized feasibility trial

Author keywords

Fibrinogen concentrate; haemorrhage management; plasma fibrinogen; trauma; trauma coagulopathy

Indexed keywords

FIBRINOGEN; FIBRINOGEN CONCENTRATE; PLACEBO;

EID: 85016485777     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aew343     Document Type: Article
Times cited : (93)

References (43)
  • 1
    • 0028909841 scopus 로고
    • Epidemiology of trauma deaths
    • Sauaia, A, Moore, FA, Moore, EE, et al. Epidemiology of trauma deaths. J Trauma 38 (1995), 185–193.
    • (1995) J Trauma , vol.38 , pp. 185-193
    • Sauaia, A.1    Moore, F.A.2    Moore, E.E.3
  • 2
    • 0031947305 scopus 로고    scopus 로고
    • Lethal injuries and time to death in a level I trauma center
    • Acosta, JA, Yang, JC, Winchell, RJ, et al. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg 186 (1998), 528–533.
    • (1998) J Am Coll Surg , vol.186 , pp. 528-533
    • Acosta, J.A.1    Yang, J.C.2    Winchell, R.J.3
  • 4
    • 84926999068 scopus 로고    scopus 로고
    • Detailed description of all deaths in both the shock and traumatic brain injury hypertonic saline trials of the resuscitation outcomes consortium
    • Tisherman, SA, Schmicker, RH, Brasel, KJ, et al. Detailed description of all deaths in both the shock and traumatic brain injury hypertonic saline trials of the resuscitation outcomes consortium. Ann Surg 261 (2015), 586–590.
    • (2015) Ann Surg , vol.261 , pp. 586-590
    • Tisherman, S.A.1    Schmicker, R.H.2    Brasel, K.J.3
  • 5
    • 77954849520 scopus 로고    scopus 로고
    • Role of fibrinogen in trauma-induced coagulopathy
    • Fries, D, Martini, WZ., Role of fibrinogen in trauma-induced coagulopathy. Br J Anaesth 105 (2010), 116–121.
    • (2010) Br J Anaesth , vol.105 , pp. 116-121
    • Fries, D.1    Martini, W.Z.2
  • 7
    • 67650645257 scopus 로고    scopus 로고
    • The coagulopathy of trauma: a review of mechanisms
    • Hess, JR, Brohi, K, Dutton, RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma 65 (2008), 748–754.
    • (2008) J Trauma , vol.65 , pp. 748-754
    • Hess, J.R.1    Brohi, K.2    Dutton, R.P.3
  • 8
    • 85047377402 scopus 로고
    • Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates
    • Hiippala, ST, Myllyla, GJ, Vahtera, EM, Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 8 (1995), 359–360.
    • (1995) Anesth Analg , vol.8 , pp. 359-360
    • Hiippala, S.T.1    Myllyla, G.J.2    Vahtera, E.M.3
  • 9
    • 84863424619 scopus 로고    scopus 로고
    • Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes
    • Rourke, C, Curry, N, Khan, S, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 10 (2012), 1342–1351.
    • (2012) J Thromb Haemost , vol.10 , pp. 1342-1351
    • Rourke, C.1    Curry, N.2    Khan, S.3
  • 10
    • 43349088932 scopus 로고    scopus 로고
    • The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an Army Combat Support Hospital
    • Stinger, HK, Spinella, PC, Perkins, JG, et al. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an Army Combat Support Hospital. J Trauma 64 (2008), S79–S85.
    • (2008) J Trauma , vol.64 , pp. S79-S85
    • Stinger, H.K.1    Spinella, P.C.2    Perkins, J.G.3
  • 11
    • 79958044332 scopus 로고    scopus 로고
    • The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion
    • Nienaber, U, Innerhofer, P, Westermann, I, et al. The impact of fresh frozen plasma vs coagulation factor concentrates on morbidity and mortality in trauma-associated haemorrhage and massive transfusion. Injury 42 (2011), 697–701.
    • (2011) Injury , vol.42 , pp. 697-701
    • Nienaber, U.1    Innerhofer, P.2    Westermann, I.3
  • 12
    • 77950681467 scopus 로고    scopus 로고
    • ®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate
    • ®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care, 14, 2010, R55.
    • (2010) Crit Care , vol.14 , pp. R55
    • Schöchl, H.1    Nienaber, U.2    Hofer, G.3
  • 13
    • 79952197748 scopus 로고    scopus 로고
    • Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy
    • Schöchl, H, Nienaber, U, Maegele, M, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Crit Care, 15, 2011, R83.
    • (2011) Crit Care , vol.15 , pp. R83
    • Schöchl, H.1    Nienaber, U.2    Maegele, M.3
  • 14
    • 84855195876 scopus 로고    scopus 로고
    • Observational study of fibrinogen concentrate in massive hemorrhage
    • Weiss, G, Lison, S, Glaser, M, et al. Observational study of fibrinogen concentrate in massive hemorrhage. Blood Coagul Fibrinolysis 22 (2011), 727–734.
    • (2011) Blood Coagul Fibrinolysis , vol.22 , pp. 727-734
    • Weiss, G.1    Lison, S.2    Glaser, M.3
  • 15
    • 84875234519 scopus 로고    scopus 로고
    • Administration of fibrinogen concentrate in exsanguinating trauma pa1tients is associated with improved survival at 6 hours but not at discharge
    • Wafaisade, A, Lefering, R, Maegele, M, et al. Administration of fibrinogen concentrate in exsanguinating trauma pa1tients is associated with improved survival at 6 hours but not at discharge. J Trauma Acute Care Surg 74 (2013), 387–395.
    • (2013) J Trauma Acute Care Surg , vol.74 , pp. 387-395
    • Wafaisade, A.1    Lefering, R.2    Maegele, M.3
  • 16
    • 84886933280 scopus 로고    scopus 로고
    • Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study
    • Schlimp, CJ, Voelckel, W, Inaba, K, Maegele, M, Schöchl, H., Impact of fibrinogen concentrate alone or with prothrombin complex concentrate (+/− fresh frozen plasma) on plasma fibrinogen level and fibrin-based clot strength (FIBTEM) in major trauma: a retrospective study. Scand J Trauma Resusc Emerg Med, 21, 2013, 74.
    • (2013) Scand J Trauma Resusc Emerg Med , vol.21 , pp. 74
    • Schlimp, C.J.1    Voelckel, W.2    Inaba, K.3    Maegele, M.4    Schöchl, H.5
  • 17
    • 84876280594 scopus 로고    scopus 로고
    • Management of bleeding and coagulopathy following major trauma: an updated European guideline
    • Spahn, DR, Bouillon, B, Cerny, V, et al. Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care, 17, 2013, R76.
    • (2013) Crit Care , vol.17 , pp. R76
    • Spahn, D.R.1    Bouillon, B.2    Cerny, V.3
  • 18
    • 81255160694 scopus 로고    scopus 로고
    • Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma
    • Nascimento, B, Rizoli, S, Rubenfeld, G, et al. Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma. Transfus Med 21 (2011), 394–401.
    • (2011) Transfus Med , vol.21 , pp. 394-401
    • Nascimento, B.1    Rizoli, S.2    Rubenfeld, G.3
  • 20
    • 84936802105 scopus 로고    scopus 로고
    • Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial
    • Curry, N, Rourke, C, Davenport, R, et al. Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial. Br J Anaesth 115 (2015), 76–83.
    • (2015) Br J Anaesth , vol.115 , pp. 76-83
    • Curry, N.1    Rourke, C.2    Davenport, R.3
  • 21
    • 67049116011 scopus 로고    scopus 로고
    • Cryoprecipitate: the current state of knowledge
    • Callum, JL, Karkouti, K, Lin, Y., Cryoprecipitate: the current state of knowledge. Transfus Med Rev 23 (2009 Jul), 177–188.
    • (2009) Transfus Med Rev , vol.23 , pp. 177-188
    • Callum, J.L.1    Karkouti, K.2    Lin, Y.3
  • 23
    • 80053959247 scopus 로고    scopus 로고
    • Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review
    • Kozek-Langenecker, S, Sørensen, B, Hess, JR, Spahn, DR., Clinical effectiveness of fresh frozen plasma compared with fibrinogen concentrate: a systematic review. Crit Care, 15, 2011, R239.
    • (2011) Crit Care , vol.15 , pp. R239
    • Kozek-Langenecker, S.1    Sørensen, B.2    Hess, J.R.3    Spahn, D.R.4
  • 24
    • 84899959003 scopus 로고    scopus 로고
    • Efficacy and safety of fibrinogen concentrate in trauma patients—a systematic review
    • Aubron, C, Reade, MC, Fraser, JF, Cooper, DJ., Efficacy and safety of fibrinogen concentrate in trauma patients—a systematic review. J Crit Care 29 (2014), 471.e11–471.e17.
    • (2014) J Crit Care , vol.29 , pp. 471.e11-471.e17
    • Aubron, C.1    Reade, M.C.2    Fraser, J.F.3    Cooper, D.J.4
  • 25
    • 81455159199 scopus 로고    scopus 로고
    • Design and preliminary results of a pilot randomized controlled trial on a 1:1:1 transfusion strategy: the trauma formula-driven versus laboratory-guided study
    • Nascimento, B, Rizoli, S, Rubenfeld, G, et al. Design and preliminary results of a pilot randomized controlled trial on a 1:1:1 transfusion strategy: the trauma formula-driven versus laboratory-guided study. J Trauma 71 (2011), S418–S426.
    • (2011) J Trauma , vol.71 , pp. S418-S426
    • Nascimento, B.1    Rizoli, S.2    Rubenfeld, G.3
  • 27
    • 84859777714 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults
    • Warmuth, M, Mad, P, Wild, C., Systematic review of the efficacy and safety of fibrinogen concentrate substitution in adults. Acta Anaesthesiol Scand 56 (2011), 539–548.
    • (2011) Acta Anaesthesiol Scand , vol.56 , pp. 539-548
    • Warmuth, M.1    Mad, P.2    Wild, C.3
  • 29
    • 77951289861 scopus 로고    scopus 로고
    • Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery
    • Solomon, C, Pichlmaier, U, Schoechl, H, et al. Recovery of fibrinogen after administration of fibrinogen concentrate to patients with severe bleeding after cardiopulmonary bypass surgery. Br J Anaesth 104 (2010), 555–562.
    • (2010) Br J Anaesth , vol.104 , pp. 555-562
    • Solomon, C.1    Pichlmaier, U.2    Schoechl, H.3
  • 30
    • 84871544047 scopus 로고    scopus 로고
    • Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery
    • Rahe-Meyer, N, Solomon, C, Hanke, A, et al. Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery. Anesthesiology 118 (2013), 40–50.
    • (2013) Anesthesiology , vol.118 , pp. 40-50
    • Rahe-Meyer, N.1    Solomon, C.2    Hanke, A.3
  • 31
    • 84873642154 scopus 로고    scopus 로고
    • Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: Results from a randomized, placebo-controlled trial
    • Rahe-Meyer, N, Hanke, A, Schmidt, DS, Hagl, C, Pichlmaier, M., Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: Results from a randomized, placebo-controlled trial. J Thorac Cardiovasc Surg 145 (2013), S178–S185.
    • (2013) J Thorac Cardiovasc Surg , vol.145 , pp. S178-S185
    • Rahe-Meyer, N.1    Hanke, A.2    Schmidt, D.S.3    Hagl, C.4    Pichlmaier, M.5
  • 32
    • 84878279368 scopus 로고    scopus 로고
    • Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery
    • Solomon, C, Hagl, C, Rahe-Meyer, N., Time course of haemostatic effects of fibrinogen concentrate administration in aortic surgery. Br J Anaesth 110 (2013), 947–956.
    • (2013) Br J Anaesth , vol.110 , pp. 947-956
    • Solomon, C.1    Hagl, C.2    Rahe-Meyer, N.3
  • 33
    • 40749143135 scopus 로고    scopus 로고
    • Efficacy and tolerability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding
    • Danés, AF, Cuenca, LG, Bueno, SR, Mendarte Barrenechea, L, Ronsano, JBM., Efficacy and tolerability of human fibrinogen concentrate administration to patients with acquired fibrinogen deficiency and active or in high-risk severe bleeding. Vox Sang 94 (2008), 221–226.
    • (2008) Vox Sang , vol.94 , pp. 221-226
    • Danés, A.F.1    Cuenca, L.G.2    Bueno, S.R.3    Mendarte Barrenechea, L.4    Ronsano, J.B.M.5
  • 34
    • 85011049050 scopus 로고    scopus 로고
    • Massive haemorrhage protocol: what's the best protocol?
    • Callum, JL, Nascimento, B, Alam, A., Massive haemorrhage protocol: what's the best protocol?. ISBT Science Series 11 (2016), 297–306.
    • (2016) ISBT Science Series , vol.11 , pp. 297-306
    • Callum, J.L.1    Nascimento, B.2    Alam, A.3
  • 35
    • 84866563389 scopus 로고    scopus 로고
    • National audit of the use of fibrinogen concentrate to correct hypofibrinogenaemia
    • Gollop, ND, Chilcott, J, Benton, A, et al. National audit of the use of fibrinogen concentrate to correct hypofibrinogenaemia. Transfus Med 22 (2012), 350–355.
    • (2012) Transfus Med , vol.22 , pp. 350-355
    • Gollop, N.D.1    Chilcott, J.2    Benton, A.3
  • 36
    • 84872773471 scopus 로고    scopus 로고
    • The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma
    • Innerhofer, P, Westermann, I, Tauber, H, et al. The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. Injury 44 (2013), 209–216.
    • (2013) Injury , vol.44 , pp. 209-216
    • Innerhofer, P.1    Westermann, I.2    Tauber, H.3
  • 37
    • 67749122125 scopus 로고    scopus 로고
    • Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study
    • Karlsson, M, Ternström, L, Hyllner, M, et al. Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. Thromb Haemost 102 (2009), 137–144.
    • (2009) Thromb Haemost , vol.102 , pp. 137-144
    • Karlsson, M.1    Ternström, L.2    Hyllner, M.3
  • 38
    • 65349156418 scopus 로고    scopus 로고
    • Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial
    • Fenger-Eriksen, C, Jensen, TM, Kristensen, BS, et al. Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial. J Thromb Haemost 7 (2009), 795–802.
    • (2009) J Thromb Haemost , vol.7 , pp. 795-802
    • Fenger-Eriksen, C.1    Jensen, T.M.2    Kristensen, B.S.3
  • 39
    • 84942592736 scopus 로고    scopus 로고
    • Fibrinogen concentrate administration inhibits endogenous fibrinogen synthesis in pigs after traumatic hemorrhage
    • discussion 547–8
    • Martini, WZ, Dubick, MA., Fibrinogen concentrate administration inhibits endogenous fibrinogen synthesis in pigs after traumatic hemorrhage. J Trauma Acute Care Surg 79 (2015), 540–547 discussion 547–8.
    • (2015) J Trauma Acute Care Surg , vol.79 , pp. 540-547
    • Martini, W.Z.1    Dubick, M.A.2
  • 40
    • 84876142253 scopus 로고    scopus 로고
    • Use of prothrombin complex concentrates and fibrinogen concentrates in the perioperative setting: a systematic review
    • Lin, DM, Murphy, LS, Tran, M-H., Use of prothrombin complex concentrates and fibrinogen concentrates in the perioperative setting: a systematic review. Transfus Med Rev 27 (2013), 91–104.
    • (2013) Transfus Med Rev , vol.27 , pp. 91-104
    • Lin, D.M.1    Murphy, L.S.2    Tran, M.-H.3
  • 41
    • 84931274743 scopus 로고    scopus 로고
    • Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data
    • Solomon, C, Groner, A, Ye, J, Pendrak, I., Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data. Thromb Haemost 113 (2015), 759–771.
    • (2015) Thromb Haemost , vol.113 , pp. 759-771
    • Solomon, C.1    Groner, A.2    Ye, J.3    Pendrak, I.4
  • 42
    • 84938780644 scopus 로고    scopus 로고
    • Impact of age on the clinical outcomes of major trauma
    • Hildebrand, F, Pape, HC, Horst, K, et al. Impact of age on the clinical outcomes of major trauma. Eur J Trauma Emerg Surg 42 (2016), 317–332.
    • (2016) Eur J Trauma Emerg Surg , vol.42 , pp. 317-332
    • Hildebrand, F.1    Pape, H.C.2    Horst, K.3
  • 43
    • 0037151796 scopus 로고    scopus 로고
    • Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis
    • Fergusson, D., Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. Br Med J 325 (2002), 652–654.
    • (2002) Br Med J , vol.325 , pp. 652-654
    • Fergusson, D.1


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