Nanoparticle-integrated hydrogels as multifunctional composite materials for biomedical applications

Gels

Volumn 1, Issue 2, 2015, Pages 162-178

  Biondi, Marco ^a   Borzacchiello, Assunta ^b   Mayol, Laura ^a   Ambrosio, Luigi ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CNR   (Italy)

Author keywords

Biomedical applications; Hydrogels; Nanocomposite hydrogels; Nanocomposites; Nanoparticles

Indexed keywords

EID: 85016420937     PISSN: None     EISSN: 23102861     Source Type: Journal    
DOI: 10.3390/gels1020162     Document Type: Review

References (88)

1. Biondi, M.; Ungaro, F.; Quaglia, F.; Netti, P.A. Controlled drug delivery in tissue engineering. Adv. Drug Deliv. Rev. 2008, 60, 229–242.
2. Vashist, A.; Gupta, Y.K.; Ahmad, S. Recent advances in hydrogel based drug delivery systems for the human body. J. Mater. Chem. B 2014, 2, 147–166.
3. Biondi, M.; Indolfi, L.; Ungaro, F.; Quaglia, F.; La Rotonda, M.I.; Netti, P.A. Bioactivated collagen-based scaffolds embedding protein-releasing biodegradable microspheres: tuning of protein release kinetics. J. Mater. Sci. Mater. Med. 2009, 20, 2117–2128.
4. Mollica, F.; Biondi, M.; Muzzi, S.; Ungaro, F.; Quaglia, F.; La Rotonda, M.I.; Netti, P.A. Mathematical modelling of the evolution of protein distribution within single PLGA microspheres: prediction of local concentration profiles and release kinetics. J. Mater. Sci. Mater. Med. 2008, 19, 1587–1593.
5. Ungaro, F.; Biondi, M.; d’Angelo, I.; Indolfi, L.; Quaglia, F.; Netti, P.A.; La Rotonda, M.I. Microsphere-integrated collagen scaffolds for tissue engineering: effect of microsphere formulation and scaffold properties on protein release kinetics. J. Control. Release 2006, 113, 128–136.
6. Mayol, L.; Biondi, M.; Russo, L.; Malle, B.M.; Schwach-Abdellaoui, K.; Borzacchiello, A. Amphiphilic hyaluronic acid derivatives toward the design of micelles for the sustained delivery of hydrophobic drugs. Carbohydr. Polym. 2014, 102, 110–116.
7. Mayol, L.; Biondi, M.; Quaglia, F.; Fusco, S.; Borzacchiello, A.; Ambrosio, L.; La Rotonda, M.I. Injectable thermally responsive mucoadhesive gel for sustained protein delivery. Biomacromolecules 2011, 12, 28–33.
8. Mayol, L.; Quaglia, F.; Borzacchiello, A.; Ambrosio, L.; La Rotonda, M.I. A novel poloxamers/hyaluronic acid in situ forming hydrogel for drug delivery: Rheological, mucoadhesive and in vitro release properties. Eur. J. Pharm. Biopharm. 2008, 70, 199–206.
9. Borzacchiello, A.; Mayol, L.; Ramires, P.A.; Pastorello, A.; Di, B.C.; Ambrosio, L.; Milella, E. Structural and rheological characterization of hyaluronic acid-based scaffolds for adipose tissue engineering. Biomaterials 2007, 28, 4399–4408.
10. Guarnieri, D.; Battista, S.; Borzacchiello, A.; Mayol, L.; de, R.E.; Keene, D.R.; Muscariello, L.; Barbarisi, A.; Netti, P.A. Effects of fibronectin and laminin on structural, mechanical and transport properties of 3D collageneous network. J. Mater. Sci. Mater. Med. 2007, 18, 245–253.
11. Maltese, A.; Borzacchiello, A.; Mayol, L.; Bucolo, C.; Maugeri, F.; Nicolais, L.; Ambrosio, L. Novel polysaccharides-based viscoelastic formulations for ophthalmic surgery: Rheological characterization. Biomaterials 2006, 27, 5134–5142.
12. Fisher, O.Z.; Khademhosseini, A.; Langer, R.; Peppas, N.A. Bioinspired materials for controlling stem cell fate. Acc. Chem. Res. 2010, 43, 419–428.
13. Slaughter, B.V.; Khurshid, S.S.; Fisher, O.Z.; Khademhosseini, A.; Peppas, N.A. Hydrogels in regenerative medicine Adv. Mater. 2009, 21, 3307–3329.
14. Kloxin, A.M.; Kloxin, C.J.; Bowman, C.N.; Anseth, K.S. Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination. Adv. Mater. 2010, 22, 3484–3494.
15. Borzacchiello, A.; Mayol, L.; Garskog, O.; Dahlqvist, A.; Ambrosio, L. Evaluation of injection augmentation treatment of hyaluronic acid based materials on rabbit vocal folds viscoelasticity. J. Mater. Sci. Mater. Med. 2005, 16, 553–557.
16. Borzacchiello, A.; Mayol, L.; Schiavinato, A.; Ambrosio, L. Effect of hyaluronic acid amide derivative on equine synovial fluid viscoelasticity. J. Biomed. Mater. Res. A 2010, 92, 1162–1170.
17. Annabi, N.; Tamayol, A.; Uquillas, J.A.; Akbari, M.; Bertassoni, L.E.; Cha, C.; Camci-Unal, G.; Dokmeci, M.R.; Peppas, N.A.; Khademhosseini, A. 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Adv. Mater. 2014, 26, 85–123.
18. Goenka, S.; Sant, V.; Sant, S. Graphene-based nanomaterials for drug delivery and tissue engineering. J. Control. Release 2014, 173, 75–88.
19. Schexnailder, P.J.; Gaharwar, A.K.; Bartlett, R.L.; Seal, B.L.; Schmidt, G. Tuning cell adhesion by incorporation of charged silicate nanoparticles as cross-linkers to polyethylene oxide. Macromol. Biosci. 2010, 10, 1416–1423.
20. Cha, C.; Shin, S.R.; Annabi, N.; Dokmeci, M.R.; Khademhosseini, A. Carbon-based nanomaterials: Multifunctional materials for biomedical engineering. ACS Nano 2013, 7, 2891–2897.
21. Kuilla, T.; Bhadra, S.; Yao, D.H.; Kim, N.H.; Bose, S.; Lee, J.H. Recent advances in graphene based polymer composites. Prog. Polym. Sci. 2010, 35, 1350–1375.
22. Ma, P.C.; Siddiqui, N.A.; Marom, G.; Kim, J.K. Dispersion and functionalization of carbon nanotubes for polymer-based nanocomposites: A review. Compos. Part A-Appl. Sci. Manuf. 2010, 41, 1345–1367.
23. Mottaghitalab, F.; Farokhi, M.; Zaminy, A.; Kokabi, M.; Soleimani, M.; Mirahmadi, F.; Shokrgozar, M.A.; Sadeghizadeh, M. A Biosynthetic Nerve Guide Conduit Based on Silk/SWNT/Fibronectin Nanocomposite for Peripheral Nerve Regeneration. PLoS ONE. 2013, 8, doi:10.1371/annotation/939b3723-6e52-48ce-9853-e11e368c9f64.
24. Huang, Y.C.; Hsu, S.H.; Kuo, W.C.; Chang-Chien, C.L.; Cheng, H.; Huang, Y.Y. Effects of laminin-coated carbon nanotube/chitosan fibers on guided neurite growth. J. Biomed. Mater. Res. Part A 2011, 99A, 86–93.
25. Makharza, S.; Cirillo, G.; Bachmatiuk, A.; Ibrahim, I.; Ioannides, N.; Trzebicka, B.; Hampel, S.; Rummeli, M.H. Graphene oxide-based drug delivery vehicles: Functionalization, characterization, and cytotoxicity evaluation. J. Nanopart. Res. 2013, 15, doi:10.1007/s11051-013-2099-y.
26. Frankland, S.J.V.; Caglar, A.; Brenner, D.W.; Griebel, M. Molecular simulation of the influence of chemical cross-links on the shear strength of carbon nanotube-polymer interfaces. J. Phys. Chem. B 2002, 106, 3046–3048.
27. Shin, S.R.; Bae, H.; Cha, J.M.; Mun, J.Y.; Chen, Y.C.; Tekin, H.; Shin, H.; Farshchi, S.; Dokmeci, M.R.; Tang, S.; et al. Carbon nanotube reinforced hybrid microgels as scaffold materials for cell encapsulation. ACS Nano 2012, 6, 362–372.
28. Shin, S.R.; Jung, S.M.; Zalabany, M.; Kim, K.; Zorlutuna, P.; Kim, S.B.; Nikkhah, M.; Khabiry, M.; Azize, M.; Kong, J.; et al. Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators. ACS Nano 2013, 7, 2369–2380.
29. Li, C.X.; Mezzenga, R. Functionalization of Multiwalled Carbon Nanotubes and Their pH-Responsive Hydrogels with Amyloid Fibrils. Langmuir 2012, 28, 10142–10146.
30. Liu, X.; Kruger, P.; Maibach, H.; Colditz, P.B.; Roberts, M.S. Using skin for drug delivery and diagnosis in the critically ill. Adv. Drug Deliv. Rev. 2014, 77, 40–49.
31. Giri, A.; Bhowmick, M.; Pal, S.; Bandyopadhyaya, A. Polymer hydrogel from carboxymethyl guar gum and carbon nanotube for sustained trans-dermal release of diclofenac sodium. Int. J. Biol. Macromol. 2011, 49, 885–893.
32. Liu, H.W.; Hu, S.H.; Chen, Y.W.; Chen, S.Y. Characterization and drug release behavior of highly responsive chip-like electrically modulated reduced graphene oxide-poly(vinyl alcohol) membranes. J. Mater. Chem. 2012, 22, 17311–17320.
33. Liu, J.Q.; Chen, C.F.; He, C.C.; Zhao, L.; Yang, X.J.; Wang, H.L. Synthesis of graphene peroxide and its application in fabricating super extensible and highly resilient nanocomposite hydrogels. ACS Nano 2012, 6, 8194–8202.
34. Liao, K.H.; Lin, Y.S.; Macosko, C.W.; Haynes, C.L. Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts. ACS Appl. Mater. Interfaces 2011, 3, 2607–2615.
35. Chang, Y.L.; Yang, S.T.; Liu, J.H.; Dong, E.; Wang, Y.W.; Cao, A.N.; Liu, Y.F.; Wang, H.F. In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicol. Lett. 2011, 200, 201–210.
36. Zhang, X.Y.; Hu, W.B.; Li, J.; Tao, L.; Wei, Y. A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond. Toxicol. Res. 2012, 1, 62–68.
37. Zhang, Y.B.; Ali, S.F.; Dervishi, E.; Xu, Y.; Li, Z.R.; Casciano, D.; Biris, A.S. Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano 2010, 4, 3181–3186.
38. Park, S.; Mohanty, N.; Suk, J.W.; Nagaraja, A.; An, J.H.; Piner, R.D.; Cai, W.W.; Dreyer, D.R.; Berry, V.; Ruoff, R.S. Biocompatible, Robust free-standing paper composed of a TWEEN/graphene composite. Adv.Mater. 2010, 22, 1736–1740.
39. Agarwal, S.; Zhou, X.Z.; Ye, F.; He, Q.Y.; Chen, G.C.K.; Soo, J.; Boey, F.; Zhang, H.; Chen, P. Interfacing live cells with nanocarbon substrates. Langmuir 2010, 26, 2244–2247.
40. Wang, K.; Ruan, J.; Song, H.; Zhang, J.L.; Wo, Y.; Guo, S.W.; Cui, D.X. Biocompatibility of Graphene Oxide. Nanoscale Rese. Lett. 2011, 6, doi:10.1007/s11671-010-9751-6.
41. Akhavan, O.; Ghaderi, E.; Akhavan, A. Size-dependent genotoxicity of graphene nanoplatelets in human stem cells. Biomaterials 2012, 33, 8017–8025.
42. Merino, S.; Martin, C.; Kostarelos, K.; Prato, M.; Vazquez, E. Nanocomposite hydrogels: 3D polymer-nanoparticle synergies for on-demand drug delivery. ACS Nano 2015, 9, 4686–4697.
43. Brayden, D.J.; Cryan, S.A.; Dawson, K.A.; O’Brien, P.J.; Simpson, J.C. High-content analysis for drug delivery and nanoparticle applications. Drug Discov. Today 2015, 20, 942–957.
44. Salcher, A.; Nikolic, M.S.; Casado, S.; Velez, M.; Weller, H.; Juarez, B.H. CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres. J. Mater. Chem. 2010, 20, 1367–1374.
45. Li, G.L.; Mohwald, H.; Shchukin, D.G. Precipitation polymerization for fabrication of complex core-shell hybrid particles and hollow structures. Chem. Soc. Rev. 2013, 42, 3628–3646.
46. Schluter, A.D.; Halperin, A.; Kroger, M.; Vlassopoulos, D.; Wegner, G.; Zhang, B.Z. Dendronized polymers: Molecular objects between conventional linear polymers and colloidal particles. ACS Macro Lett. 2014, 3, 991–998.
47. Irfan, M.; Seiler, M. Encapsulation using hyperbranched polymers: From research and technologies to emerging applications. Ind. Eng. Chem. Res. 2010, 49, 1169–1196.
48. Liu, T.; Wu, T.; Liu, H.X.; Ke, B.; Huang, H.X.; Jiang, Z.Y.; Xie, M.Q. Ultraviolet-crosslinked hydrogel sustained-release hydrophobic antibiotics with long-term antibacterial activity and limited cytotoxicity. J. Appl. Polym. Sci. 2014, 131, doi:10.1002/app.40438.
49. Mayol, L.; Serri, C.; Menale, C.; Crispi, S.; Piccolo, M.T.; Mita, L.; Giarra, S.; Forte, M.; Saija, A.; Biondi, M.; et al. Curcumin loaded PLGA-poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells. Eur. J. Pharm. Biopharm. 2015, 93, 37–45.
50. Ju, C.Y.; Sun, J.; Zi, P.; Jin, X.; Zhang, C. Thermosensitive micelles-hydrogel hybrid system based on poloxamer 407 for localized delivery of paclitaxel. J. Pharm. Sci. 2013, 102, 2707–2717.
51. Joshi, N.; Grinstaff, M. Applications of dendrimers in tissue engineering. Curr. Top. Med. Chem. 2008, 8, 1225–1236.
52. Zhong, S.; Yung, L.Y. Enhanced biological stability of collagen with incorporation of PAMAM dendrimer. J. Biomed. Mater. Res. A 2009, 91, 114–122.
53. Zhang, H.B.; Patel, A.; Gaharwar, A.K.; Mihaila, S.M.; Iviglia, G.; Mukundan, S.; Bae, H.; Yang, H.; Khademhosseini, A. Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties. Biomacromolecules 2013, 14, 1299–1310.
54. Oral, E.; Peppas, N.A. Responsive and recognitive hydrogels using star polymers. J. Biomed. Mater. Res. Part A 2004, 68A, 439–447.
55. Sontjens, S.H.M.; Nettles, D.L.; Carnahan, M.A.; Setton, L.A.; Grinstaff, M.W. Biodendrimer-based hydrogel scaffolds for cartilage tissue repair.Biomacromolecules 2006, 7, 310–316.
56. Postnova, I.; Silant'ev, V.; Kim, M.H.; Song, G.Y.; Kim, I.; Ha, C.S.; Shchipunov, Y. Hyperbranched polyglycerol hydrogels prepared through biomimetic mineralization. Coll. Surf. B Biointerfaces 2013, 103, 31–37.
57. Hench, L.L.; Polak, J.M. Third-generation biomedical materials. Science 2002, 295, 1014–1017.
58. Hoppe, A.; Guldal, N.S.; Boccaccini, A.R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials 2011, 32, 2757–2774.
59. Khan, F.; Ahmad, S.R. Polysaccharides and their derivatives for versatile tissue engineering application. Macromol. Biosci. 2013, 13, 395–421.
60. Zhu, J.M. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 2010, 31, 4639–4656.
61. Barbucci, R.; Rappuoli, R.; Borzacchiello, A.; Ambrosio, L. Synthesis, chemical and rheological characterization of new hyaluronic acid-based hydrogels. J. Biomater. Sci.-Polym. Ed. 2000, 11, 383–399.
62. Lapcik, L.; Lapcik, L.; de Smedt, S.; Demeester, J.; Chabrecek, P. Hyaluronan: Preparation, structure, properties, and applications. Chem. Rev. 1998, 98, 2663–2684.
63. Borzacchiello, A.; Russo, L.; Malle, B.M.; Schwach-Abdellaoui, K.; Ambrosio, L. Hyaluronic acid based hydrogels for regenerative medicine applications. BioMed Res. Int. 2015, 2015, doi:10.1155/2015/871218.
64. Fusco, S.; Borzacchiello, A.; Miccio, L.; Pesce, G.; Rusciano, G.; Sasso, A.; Netti, P.A. High frequency viscoelastic behaviour of low molecular weight hyaluronic acid water solutions. Biorheology 2007, 44, 403–418.
65. Nejadnik, M.R.; Yang, X.; Bongio, M.; Alghamdi, H.S.; van den Beucken, J.J.; Huysmans, M.C.; Jansen, J.A.; Hilborn, J.; Ossipov, D.; Leeuwenburgh, S.C. Self-healing hybrid nanocomposites consisting of bisphosphonated hyaluronan and calcium phosphate nanoparticles. Biomaterials 2014, 35, 6918–6929.
66. Valles-Lluch, A.; Poveda-Reyes, S.; Amoros, P.; Beltran, D.; Monleon, P.M. Hyaluronic acid-silica nanohybrid gels. Biomacromolecules 2013, 14, 4217–4225.
67. Mayol, L.; De Stefano, D.; Campani, V.; De Falco, F.; Ferrari, E.; Cencetti, C.; Matricardi, P.; Maiuri, L.; Carnuccio, R.; Gallo, A.; et al. Design and characterization of a chitosan physical gel promoting wound healing in mice. J. Mater. Sci. Mater. Med. 2014, 25, 1483–1493.
68. Aranaz, I.; Gutierrez, M.C.; Ferrer, M.L.; del, M.F. Preparation of chitosan nanocompositeswith a macroporous structure by unidirectional freezing and subsequent freeze-drying. Mar. Drugs 2014, 12, 5619–5642.
69. Gutierrez, M.C.; Jobbagy, M.; Ferrer, M.L.; del Monte, F. Enzymatic synthesis of amorphous calcium phosphate—Chitosan nanocomposites and their processing into hierarchical structures. Chem. Mater. 2008, 20, 11–13.
70. Gaharwar, A.K.; Dammu, S.A.; Canter, J.M.; Wu, C.J.; Schmidt, G. Highly extensible, tough, and elastomeric nanocomposite hydrogels from poly(ethylene glycol) and hydroxyapatite nanoparticles. Biomacromolecules 2011, 12, 1641–1650.
71. Gaharwar, A.K.; Rivera, C.; Wu, C.J.; Chan, B.K.; Schmidt, G. Photocrosslinked nanocomposite hydrogels from PEG and silica nanospheres: Structural, mechanical and cell adhesion characteristics. Mater. Sci. Eng. C Mater. Biol. Appl. 2013, 33, 1800–1807.
72. Gaharwar, A.K.; Rivera, C.P.; Wu, C.J.; Schmidt, G. Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles. Acta Biomater. 2011, 7, 4139–4148.
73. Schexnailder, P.; Schmidt, G. Nanocomposite polymer hydrogels. Coll. Polym. Sci. 2009, 287, 1–11.
74. Barani, H.; Montazer, M.; Samadi, N.; Toliyat, T. In situ synthesis of nano silver/lecithin on wool: Enhancing nanoparticles diffusion. Coll. Surf. B Biointerfaces 2012, 92, 9–15.
75. Dallas, P.; Sharma, V.K.; Zboril, R. Silver polymeric nanocomposites as advanced antimicrobial agents: Classification, synthetic paths, applications, and perspectives. Adv. Coll. Interface Sci. 2011, 166, 119–135.
76. Palza, H. Antimicrobial polymers with metal nanoparticles. Int J Mol Sci. 2015, 16, 2099-2116.
77. Ma, Y.Q.; Yi, J.Z.; Zhang, L.M. A facile approach to incorporate silver nanoparticles into dextran-based hydrogels for antibacterial and catalytical application. J. Macromol. Sci. Part A-Pure Appl. Chem. 2009, 46, 643–648.
78. Vimala, K.; Sivudu, K.S.; Mohan, Y.M.; Sreedhar, B.; Raju, K.M. Controlled silver nanoparticles synthesis in semi-hydrogel networks of poly(acrylamide) and carbohydrates: A rational methodology for antibacterial application. Carbohydr. Polym. 2009, 75, 463–471.
79. Bardajee, G.R.; Hooshyar, Z.; Rezanezhad, H. A novel and green biomaterial based silver nanocomposite hydrogel: Synthesis, characterization and antibacterial effect. J. Inorg. Biochem. 2012, 117, 367–373.
80. Mohan, Y.M.; Lee, K.; Premkumar, T.; Geckeler, K.E. Hydrogel networks as nanoreactors: A novel approach to silver nanoparticles for antibacterial applications.Polymer 2007, 48, 158–164.
81. Wei, Q.B.; Fu, F.; Zhang, Y.Q.; Tang, L. Preparation, characterization, and antibacterial properties of pH-responsive P(MMA-co-MAA)/silver nanocomposite hydrogels. J. Polym. Res. 2014, 21, doi:10.1007/s10965-013-0349-4.
82. Juby, K.A.; Dwivedi, C.; Kumar, M.; Kota, S.; Misra, H.S.; Bajaj, P.N. Silver nanoparticle-loaded PVA/gum acacia hydrogel: Synthesis, characterization and antibacterial study. Carbohydr. Polym. 2012, 89, 906–913.
83. Dvir, T.; Timko, B.P.; Brigham, M.D.; Naik, S.R.; Karajanagi, S.S.; Levy, O.; Jin, H.W.; Parker, K.K.; Langer, R.; Kohane, D.S. Nanowired three-dimensional cardiac patches. Nat. Nanotechnol. 2011, 6, 720–725.
84. Liu, H.; Webster, T.J. Mechanical properties of dispersed ceramic nanoparticles in polymer composites for orthopedic applications. Int J Nanomedicine. 2010, 5, 299–313.
85. Gaharwar, A.K.; Wong, J.E.; Müller-Schulte, D.; Bahadur, D.; Richtering, W. Magnetic nanoparticles encapsulated within a thermoresponsive polymer. J Nanosci Nanotechnol. 2009, 9, 5355-5361.
86. Wang, C.; Cheng, L.; Liu, Z. Upconversion Nanoparticles for Photodynamic Therapy and Other Cancer Therapeutics. Theranostics. 2013, 3, 317–330.
87. Matteini, P.; Ratto, F.; Rossi, F.; Centi, S.; Dei, L.; Pini, R. Chitosan films doped with gold nanorods as laser-activatable hybrid bioadhesives. Adv. Mater. 2010, 22, 4313–4316.
88. Matteini, P.; Martina, M.R.; Giambastiani, G.; Tatini, F.; Cascella, R.; Ratto, F.; Cecchi, C.; Caminati, G.; Dei, L.; Pini, R. Light-responsive nanocomposite sponges for on demand chemical release with high spatial and dosage control. J. Mater. Chem. B 2013, 1, 1096–1100.