Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia

Journal of Traditional Medicines

Volumn 30, Issue 4, 2013, Pages 164-175

  Nogami, A ^a   Takasaki, Kotaro ^a   Kubota, Kaori ^a   Yamaguchi, Kazuko ^a   Kawasaki, Chihiro ^a   Nakamura, Kazuya ^a   Fujikawa, Risako ^a   Uchida, Naoki ^b   Katsurabayashi, Shutaro ^a   Mishima, Kenichi ^a   Nishimura, Ryoji ^a   Fujiwara, Michihiro ^a   Iwasaki, Katsunori ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acetylcholine; Apoptosis; Dementia; Memory; Yokukansan

Indexed keywords

EID: 85016164862     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.30.164     Document Type: Article

References (27)

1. González-Concepcón, J.J., Geil, K., Jiménz-Velázquez, I.Z., Ramos-Romey, C.: Atypical antipsychotics in the management of behavioral symptoms associated with dementia. Bol. Asoc. Med. P R., 101(1), 51-53, 2009.
2. Rogers, S.L., Friedhoff, L.T.: The efficacy and safety of donepezil in patients with Alzheimer's disease: results of a US multicenter, randomized, double-blind, placebo-controlled trial. The Donepezil Study Group. Dementia, 7(6), 293-303, 1996.
3. Iwasaki, K., Satoh-Nakagawa, T., Maruyama, M., Monma, Y., Nemoto, M., Tomita, N., Tanji, H., Fujiwara, H., Seki, T., Fujii, M., Arai, H., Sasaki, H.: A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J. Clin. Psychiatry, 66(2), 248-252, 2005.
4. Mizukami, K., Asada, T., Kinoshita, T., Tanaka, K., Sonohara, K., Nakai, R., Yamaguchi, K., Hanyu, H., Kanaya, K., Takao, T., Okada, M., Kudo, S., Kotoku, H., Iwakiri, M., Kurita, H., Miyamura, T., Kawasaki, Y., Omori, K., Shiozaki, K., Odawara, T., Suzuki, T., Yamada, S., Nakamura, Y., Toba, K.: A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. Int J Neuropsychopharmacol., 12(2), 191-199, 2009.
5. Miyaoka, T., Furuya, M., Yasuda, H., Hayashida, M., Nishida, A., Inagaki, T., Horiguchi, J.: Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. Prog. Neuropsychopharmacol. Biol. Psychiatry, 32, 761-764, 2008.
6. Monji, A., Takita, M., Samejima, T., Takaishi, T., Hashimoto, K., Matsunaga, H., Oda, M., Sumida, Y., Mizoguchi, Y., Kato, T., Horikawa, H., Kanba, S.: Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry, 33, 308-311, 2009.
7. Egashira, N., Iwasaki, K., Ishibashi, A., Hayakawa, K., Okuno, R., Abe, M., Uchida, N., Mishima, K., Takasaki, K., Nishimura, R., Oishi, R., Fujiwara, M.: Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT) 2A receptors in the prefrontal cortex. Prog Neuropsychopharmacol. Biol. Psychiatry, 32(6), 1516-1520, 2008.
8. Terawaki, K., Ikarashi, Y., Sekiguchi, K., Nakai, Y., Kase, Y.: Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells. J Ethnopharmacol, 127(2), 306-312, 2010.
9. Uchida, N., Egashira, N., Iwasaki, K., Ishibashi, A., Tashiro, R., Nogami, A., Manome, N., Abe, M., Takasaki, K., Mishima, K., Takata, J., Oishi, R., Nishimura, R., Fujiwara, M.: Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents. Biol Pharm Bull., 32(3), 372-375, 2009.
10. Hayashi, Y., Ishida, Y., Inoue, T., Udagawa, M., Takeuchi, K., Yoshimuta, H., Kiue, K., Ninomiya, Y., Kawano, J., Sameshima, T., Kawahara, T., Goto, I., Shudo, K., Kurayama, S., Nakamura, J., Okahara, K., Mitsuyama, Y.: Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice. Prog. Neuropsychopharmacol. Biol. Psychiatry, 34(3), 541-545, 2010.
11. Baskys, A., Hou, A.C.: Vascular dementia: pharmacological treatment approaches and perspectives. Clin. Interv. Aging, 2(3), 327-335, 2007.
12. Iwasaki, K., Egashira, N., Hatip-Al-Khatib, I., Akiyoshi, Y., Arai, T., Takagaki, Y., Watanabe, T., Mishima, K., Fujiwara, M.: Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Brain Res., 1097(1), 216-223, 2006.
13. Olton, D.S., Samuelson, R.J.: Remembrance of places past:spatial memory in rats. J. Exp. Psychol., Anim. Behav. Processes, 2, 97-116, 1976.
14. Iwasaki, K., Chung, E.H., Egashira, N., Hatip-Al-Khatib, I., Mishima, K., Egawa, T., Irie, K., Fujiwara, M.: Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats. Brain Res., 995(1), 131-139, 2004.
15. Pulsinelli, W.A., Brierley, J.B.: A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke, 10(3), 267-272, 1979.
16. Nogami, A., Takasaki, K., Sakata, Y., Uchida, N., Yamaguchi, K., Kawasaki, C., Shindo, T., Katsurabayashi, S., Mishima, K., Nishimura, R., Fujiwara, M., Iwasaki, K.: Effects of Yokukansan on the anxiety-like behavior in model rat of cerebrovascular dementia. J Nat Med., 65(2), 275-281, 2011.
17. Campanozzi, M.D., Casali, E., Neviani, F., Martini, E., Neri, M.: Evaluation of the slopes of cognitive impairment and disability in Alzheimer's disease (AD) patients treated with acetylcholinesterase inhibitors (AChEl). Arch. Gerontol. Geriatr, 44, 91-96, 2007.
18. Román, G.C., Salloway, S., Black, S.E., Royall, D.R., Decarli, C., Weiner, M.W., Moline, M., Kumar, D., Schindler, R., Posner, H.: Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size. Stroke, 41(6), 1213-1221, 2010.
19. Lippa, A.S., Pelham, R.W., Beer, B., Critchett, D.J., Dean, R.L., Bartus, R.T.: Brain cholinergic dysfunction and memory in aged rats. Neurobiol Aging, 1(1), 13-19, 1980.
20. Chung, E., Iwasaki, K., Mishima, K., Egashira, N., Fujiwara, M.: Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat. Life Sci., 72(4-5), 609-619, 2002.
21. Uchida, N., Takasaki, K., Sakata, Y., Nogami, A., Oishi, H., Watanabe, T., Shindo, T., Egashira, N., Kubota, K., Katsurabayashi, S., Mishima, K., Fujiwara, M., Nishimura, R., Iwasaki, K.: Cholinergic Involvement and Synaptic Dynamin 1 Expression in Yokukansan-mediated Improvement of Spatial Memory in a Rat Model of Early Alzheimer's Disease. Phytother Res., 27(7), 966-972, 2013.
22. Irie, K., Mishima, K., Ishibashi, D., Egashira, N., Iwasaki, K., Fujiwara, M.: Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia. Life Sci., 72(4-5), 621-629, 2002.
23. Hatip-Al-Khatib, I., Iwasaki, K., Egashira, N., Ishibashi, D., Mishima, K., Fujiwara, M.: Comparison of single- and repeated-ischemia-induced changes in expression of flip and flop splice variants of AMPA receptor subtypes GluR1 and GluR2 in the rats hippocampus CA1 subregion. J. Pharmacol. Sci., 103(1), 83-91, 2007.
24. Sugimoto, H., Iimura, Y., Yamanishi, Y., Yamatsu, K.: Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds. J Med Chem., 38, 4821-4829, 1995.
25. Kawakami, Z., Kanno, H., Ueki, T., Terawaki, K., Tabuchi, M., Ikarashi, Y., Kase, Y.: Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. Neuroscience, 159(4), 1397-1407, 2009.
26. Terasawa, K., Shimada, Y., Kita, T., Yamamoto, T., Tosa, H., Tanaka, N., Saito, Y., Kanaki, E., Goto, S., Mizushima, N., Fujioka, M., Takase, S., Seki, H., Kimura, I., Ogawa, T., Nakamura, S., Araki, G., Maruyama, I., Maruyama, Y., Takaori, S.: Choto-san in the treatment of vascular dementia: a double-blind, placebo-controlled study. Phytomedicine, 4(1), 15-22, 1997.
27. Goto, H., Satoh, N., Hayashi, Y., Hikiami, H., Nagata, Y., Obi, R., Shimada, Y.: A chinese herbal medicine, tokishakuyakusan, reduces the worsening of impairments and independence after stroke: a 1-year randomized, controlled trial. Evid Based Complement Alternat Med., 2011, 194046, 2011.