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Volumn 18, Issue 4, 2017, Pages

Effects of a sativex-like combination of phytocannabinoids on disease progression in R6/2 mice, an experimental model of huntington’s disease

Author keywords

Basal ganglia; Cannabidiol; Huntington s disease; Neuroprotection; Phytocannabinoids; R6 2 mice; 9 tetrahydrocannabinol

Indexed keywords

CANNABICHROMENE; CANNABINOID; CHOLINE; FLUORODEOXYGLUCOSE F 18; GLUTAMIC ACID; LACTIC ACID; N ACETYLASPARTIC ACID; NABIXIMOLS; TAU PROTEIN; PLANT EXTRACT; TETRAHYDROCANNABINOL-CANNABIDIOL COMBINATION;

EID: 85016160980     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18040684     Document Type: Article
Times cited : (25)

References (40)
  • 2
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington’s disease
    • Zuccato, C.; Valenza, M.; Cattaneo, E. Molecular mechanisms and potential therapeutical targets in Huntington’s disease. Physiol. Rev. 2010, 90, 905–981. [CrossRef] [PubMed]
    • (2010) Physiol. Rev. , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3
  • 3
    • 77953894712 scopus 로고    scopus 로고
    • Huntington’s disease: Progress toward effective disease-modifying treatments and a cure
    • Johnson, C.D.; Davidson, B.L. Huntington’s disease: Progress toward effective disease-modifying treatments and a cure. Hum. Mol. Genet. 2010, 19, R98–R102. [CrossRef] [PubMed]
    • (2010) Hum. Mol. Genet. , vol.19 , pp. RR98-R102
    • Johnson, C.D.1    Davidson, B.L.2
  • 5
    • 52949136295 scopus 로고    scopus 로고
    • The endocannabinoid system in Huntington’s disease
    • Pazos, M.R.; Sagredo, O.; Fernández-Ruiz, J. The endocannabinoid system in Huntington’s disease. Curr. Pharm. Des. 2008, 14, 2317–2325. [CrossRef] [PubMed]
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 2317-2325
    • Pazos, M.R.1    Sagredo, O.2    Fernández-Ruiz, J.3
  • 7
    • 8444239705 scopus 로고    scopus 로고
    • Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo
    • Lastres-Becker, I.; Bizat, N.; Boyer, F.; Hantraye, P.; Fernández-Ruiz, J.; Brouillet, E. Potential involvement of cannabinoid receptors in 3-nitropropionic acid toxicity in vivo. Neuroreport 2004, 15, 2375–2379. [CrossRef] [PubMed]
    • (2004) Neuroreport , vol.15 , pp. 2375-2379
    • Lastres-Becker, I.1    Bizat, N.2    Boyer, F.3    Hantraye, P.4    Fernández-Ruiz, J.5    Brouillet, E.6
  • 8
    • 34547984234 scopus 로고    scopus 로고
    • Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    • Sagredo, O.; Ramos, J.A.; Decio, A.; Mechoulam, R.; Fernández-Ruiz, J. Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors. Eur. J. Neurosci. 2007, 26, 843–851. [CrossRef] [PubMed]
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 843-851
    • Sagredo, O.1    Ramos, J.A.2    Decio, A.3    Mechoulam, R.4    Fernández-Ruiz, J.5
  • 9
    • 84928044075 scopus 로고    scopus 로고
    • Neuroprotective properties of cannabigerol in Huntington’s disease: Studies in R6/2 mice and 3-nitropropionate-lesioned mice
    • Valdeolivas, S.; Navarrete, C.; Cantarero, I.; Bellido, M.L.; Muñoz, E.; Sagredo, O. Neuroprotective properties of cannabigerol in Huntington’s disease: Studies in R6/2 mice and 3-nitropropionate-lesioned mice. Neurotherapeutics 2015, 12, 185–199. [CrossRef] [PubMed]
    • (2015) Neurotherapeutics , vol.12 , pp. 185-199
    • Valdeolivas, S.1    Navarrete, C.2    Cantarero, I.3    Bellido, M.L.4    Muñoz, E.5    Sagredo, O.6
  • 14
    • 77955922748 scopus 로고    scopus 로고
    • Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington’s disease transgenic mice
    • Dowie, M.J.; Howard, M.L.; Nicholson, L.F.; Faull, R.L.; Hannan, A.J.; Glass, M. Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington’s disease transgenic mice. Neuroscience 2010, 170, 324–336. [CrossRef] [PubMed]
    • (2010) Neuroscience , vol.170 , pp. 324-336
    • Dowie, M.J.1    Howard, M.L.2    Nicholson, L.F.3    Faull, R.L.4    Hannan, A.J.5    Glass, M.6
  • 15
    • 79955663620 scopus 로고    scopus 로고
    • THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis
    • Sastre-Garriga, J.; Vila, C.; Clissold, S.; Montalban, X. THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis. Expert Rev. Neurother. 2011, 11, 627–637. [PubMed]
    • (2011) Expert Rev. Neurother. , vol.11 , pp. 627-637
    • Sastre-Garriga, J.1    Vila, C.2    Clissold, S.3    Montalban, X.4
  • 16
    • 79951751577 scopus 로고    scopus 로고
    • Role of cannabinoids in multiple sclerosis
    • Zajicek, J.P.; Apostu, V.I. Role of cannabinoids in multiple sclerosis. CNS Drugs 2011, 25, 187–201. [CrossRef] [PubMed]
    • (2011) CNS Drugs , vol.25 , pp. 187-201
    • Zajicek, J.P.1    Apostu, V.I.2
  • 17
    • 65449146377 scopus 로고    scopus 로고
    • Emerging strategies for exploiting cannabinoid receptor agonists as medicines
    • Pertwee, R.G. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br. J. Pharmacol. 2009, 156, 397–411. [CrossRef] [PubMed]
    • (2009) Br. J. Pharmacol. , vol.156 , pp. 397-411
    • Pertwee, R.G.1
  • 18
    • 79960062773 scopus 로고    scopus 로고
    • Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease
    • Sagredo, O.; Pazos, M.R.; Satta, V.; Ramos, J.A.; Pertwee, R.G.; Fernández-Ruiz, J. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease. J. Neurosci. Res. 2011, 89, 1509–1518. [CrossRef] [PubMed]
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1509-1518
    • Sagredo, O.1    Pazos, M.R.2    Satta, V.3    Ramos, J.A.4    Pertwee, R.G.5    Fernández-Ruiz, J.6
  • 19
    • 0038201773 scopus 로고    scopus 로고
    • Effects of cannabinoids in the rat model of Huntington’s disease generated by an intrastriatal injection of malonate
    • Lastres-Becker, I.; Bizat, N.; Boyer, F.; Hantraye, P.; Brouillet, E.; Fernández-Ruiz, J. Effects of cannabinoids in the rat model of Huntington’s disease generated by an intrastriatal injection of malonate. Neuroreport 2003, 14, 813–816. [CrossRef] [PubMed]
    • (2003) Neuroreport , vol.14 , pp. 813-816
    • Lastres-Becker, I.1    Bizat, N.2    Boyer, F.3    Hantraye, P.4    Brouillet, E.5    Fernández-Ruiz, J.6
  • 20
    • 84862077856 scopus 로고    scopus 로고
    • Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: Role of CB1 and CB2 receptors
    • Valdeolivas, S.; Satta, V.; Pertwee, R.G.; Fernández-Ruiz, J.; Sagredo, O. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: Role of CB1 and CB2 receptors. ACS Chem. Neurosci. 2012, 3, 400–406. [PubMed]
    • (2012) ACS Chem. Neurosci. , vol.3 , pp. 400-406
    • Valdeolivas, S.1    Satta, V.2    Pertwee, R.G.3    Fernández-Ruiz, J.4    Sagredo, O.5
  • 24
    • 33644843611 scopus 로고    scopus 로고
    • Metabolic characterization of the R6/2 transgenic mouse model of Huntington’s disease by high-resolution MAS 1H NMR spectroscopy
    • Tsang, T.M.; Woodman, B.; McLoughlin, G.A.; Griffin, J.L.; Tabrizi, S.J.; Bates, G.P.; Holmes, E. Metabolic characterization of the R6/2 transgenic mouse model of Huntington’s disease by high-resolution MAS 1H NMR spectroscopy. J. Proteome Res. 2006, 5, 483–492. [PubMed]
    • (2006) J. Proteome Res. , vol.5 , pp. 483-492
    • Tsang, T.M.1    Woodman, B.2    McLoughlin, G.A.3    Griffin, J.L.4    Tabrizi, S.J.5    Bates, G.P.6    Holmes, E.7
  • 26
    • 84871457873 scopus 로고    scopus 로고
    • Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington’s disease
    • Heikkinen, T.; Lehtimäki, K.; Vartiainen, N.; Puoliväli, J.; Hendricks, S.J.; Glaser, J.R.; Bradaia, A.; Wadel, K.; Touller, C.; Kontkanen, O.; et al. Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington’s disease. PLoS ONE 2012, 7, e50717. [CrossRef] [PubMed]
    • (2012) Plos ONE , vol.7
    • Heikkinen, T.1    Lehtimäki, K.2    Vartiainen, N.3    Puoliväli, J.4    Hendricks, S.J.5    Glaser, J.R.6    Bradaia, A.7    Wadel, K.8    Touller, C.9    Kontkanen, O.10
  • 29
    • 84969240461 scopus 로고    scopus 로고
    • Novel metabolite biomarkers of Huntington’s disease as detected by High-Resolution Mass Spectrometry
    • Graham, S.F.; Kumar, P.; Bahado-Singh, R.O.; Robinson, A.; Mann, D.; Green, B.D. Novel metabolite biomarkers of Huntington’s disease as detected by High-Resolution Mass Spectrometry. J. Proteome Res. 2016, 15, 1592–1601. [PubMed]
    • (2016) J. Proteome Res. , vol.15 , pp. 1592-1601
    • Graham, S.F.1    Kumar, P.2    Bahado-Singh, R.O.3    Robinson, A.4    Mann, D.5    Green, B.D.6
  • 30
    • 33645969007 scopus 로고    scopus 로고
    • Contribution of reduced and oxidized glutathione to signals detected by magnetic resonance spectroscopy as indicators of local brain redox state
    • Satoh, T.; Yoshioka, Y. Contribution of reduced and oxidized glutathione to signals detected by magnetic resonance spectroscopy as indicators of local brain redox state. Neurosci. Res. 2006, 55, 34–39. [CrossRef] [PubMed]
    • (2006) Neurosci. Res. , vol.55 , pp. 34-39
    • Satoh, T.1    Yoshioka, Y.2
  • 31
    • 72849149551 scopus 로고    scopus 로고
    • A pilot study using nabilone for symptomatic treatment in Huntington’s disease
    • Curtis, A.; Mitchell, I.; Patel, S.; Ives, N.; Rickards, H. A pilot study using nabilone for symptomatic treatment in Huntington’s disease. Mov. Disord. 2009, 24, 2254–2259. [CrossRef] [PubMed]
    • (2009) Mov. Disord. , vol.24 , pp. 2254-2259
    • Curtis, A.1    Mitchell, I.2    Patel, S.3    Ives, N.4    Rickards, H.5
  • 32
    • 33750837262 scopus 로고    scopus 로고
    • Nabilone could treat chorea and irritability in Huntington’s disease
    • Curtis, A.; Rickards, H. Nabilone could treat chorea and irritability in Huntington’s disease. J. Neuropsychiatry Clin. Neurosci. 2006, 18, 553–554. [CrossRef] [PubMed]
    • (2006) J. Neuropsychiatry Clin. Neurosci. , vol.18 , pp. 553-554
    • Curtis, A.1    Rickards, H.2
  • 33
    • 0345237253 scopus 로고    scopus 로고
    • Nabilone increases choreatic movements in Huntington’s disease
    • Müller-Vahl, K.R.; Schneider, U.; Emrich, H.M. Nabilone increases choreatic movements in Huntington’s disease. Mov. Disord. 1999, 14, 1038–1040. [CrossRef]
    • (1999) Mov. Disord. , vol.14 , pp. 1038-1040
    • Müller-Vahl, K.R.1    Schneider, U.2    Emrich, H.M.3
  • 35
    • 84881317019 scopus 로고    scopus 로고
    • Decreased expression of GLT-1 in the R6/2 model of Huntington’s disease does not worsen disease progression
    • Petr, G.T.; Schultheis, L.A.; Hussey, K.C.; Sun, Y.; Dubinsky, J.M.; Aoki, C.; Rosenberg, P.A. Decreased expression of GLT-1 in the R6/2 model of Huntington’s disease does not worsen disease progression. Eur. J. Neurosci. 2013, 38, 2477–2490. [CrossRef] [PubMed]
    • (2013) Eur. J. Neurosci. , vol.38 , pp. 2477-2490
    • Petr, G.T.1    Schultheis, L.A.2    Hussey, K.C.3    Sun, Y.4    Dubinsky, J.M.5    Aoki, C.6    Rosenberg, P.A.7
  • 36
    • 84860162121 scopus 로고    scopus 로고
    • Evaluation of the safety and tolerability profile of Sativex: Is it reassuring enough?
    • Wade, D. Evaluation of the safety and tolerability profile of Sativex: Is it reassuring enough? Expert Rev. Neurother. 2012, 12, 9–14. [PubMed]
    • (2012) Expert Rev. Neurother. , vol.12 , pp. 9-14
    • Wade, D.1
  • 39


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.