메뉴 건너뛰기




Volumn 540, Issue 7633, 2016, Pages 433-437

A 17-gene stemness score for rapid determination of risk in acute leukaemia

(30)  Ng, Stanley W K a   Mitchell, Amanda b   Kennedy, James A b,c,d   Chen, Weihsu C b   McLeod, Jessica b   Ibrahimova, Narmin b   Arruda, Andrea b   Popescu, Andreea b   Gupta, Vikas b,c,d   Schimmer, Aaron D b,c,d   Schuh, Andre C b,c,d   Yee, Karen W b,c,d   Bullinger, Lars e   Herold, Tobias f,g   Görlich, Dennis h   Büchner, Thomas h   Hiddemann, Wolfgang f,g   Berdel, Wolfgang E h   Wörmann, Bernhard i   Cheok, Meyling j   more..


Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; BIOLOGICAL MARKER; TUMOR MARKER; TRANSCRIPTOME;

EID: 85016147467     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20598     Document Type: Article
Times cited : (614)

References (53)
  • 1
    • 84873580363 scopus 로고    scopus 로고
    • Acute myeloid leukaemia in adults
    • Ferrara, F. & Schiffer, C. A. Acute myeloid leukaemia in adults. Lancet 381, 484-495 (2013)
    • (2013) Lancet , vol.381 , pp. 484-495
    • Ferrara, F.1    Schiffer, C.A.2
  • 2
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: Determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom medical research council trials
    • Grimwade, D. et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials. Blood 116, 354-365 (2010)
    • (2010) Blood , vol.116 , pp. 354-365
    • Grimwade, D.1
  • 3
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner, H. et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 115, 453-474 (2010)
    • (2010) Blood , vol.115 , pp. 453-474
    • Döhner, H.1
  • 4
    • 79960256952 scopus 로고    scopus 로고
    • Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: Evaluation of the proposed reporting system
    • Röllig, C. et al. Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: evaluation of the proposed reporting system. J. Clin. Oncol. 29, 2758-2765 (2011)
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2758-2765
    • Röllig, C.1
  • 5
    • 84922429991 scopus 로고    scopus 로고
    • Resistance prediction in AML: Analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center
    • Walter, R. B. et al. Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center. Leukemia 29, 312-320 (2015)
    • (2015) Leukemia , vol.29 , pp. 312-320
    • Walter, R.B.1
  • 6
    • 84896125494 scopus 로고    scopus 로고
    • Evolution of the cancer stem cell model
    • Kreso, A. & Dick, J. E. Evolution of the cancer stem cell model. Cell Stem Cell 14, 275-291 (2014)
    • (2014) Cell Stem Cell , vol.14 , pp. 275-291
    • Kreso, A.1    Dick, J.E.2
  • 7
    • 77749294821 scopus 로고    scopus 로고
    • Identification of therapeutic targets for quiescent, chemotherapyresistant human leukemia stem cells
    • Saito, Y. et al. Identification of therapeutic targets for quiescent, chemotherapyresistant human leukemia stem cells. Sci. Transl. Med. 2, 17ra9 (2010)
    • (2010) Sci. Transl. Med. , vol.2 , pp. 17ra9
    • Saito, Y.1
  • 8
    • 84916891627 scopus 로고    scopus 로고
    • Sirt1 activation by a c-myc oncogenic network promotes the maintenance and drug resistance of human flt3-itd acute myeloid leukemia stem cells
    • Li, L. et al. SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. Cell Stem Cell 15, 431-446 (2014)
    • (2014) Cell Stem Cell , vol.15 , pp. 431-446
    • Li, L.1
  • 9
    • 84942531832 scopus 로고    scopus 로고
    • Bet inhibitor resistance emerges from leukaemia stem cells
    • Fong, C. Y. et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature 525, 538-542 (2015)
    • (2015) Nature , vol.525 , pp. 538-542
    • Fong, C.Y.1
  • 10
    • 84958635003 scopus 로고    scopus 로고
    • MIR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
    • Lechman, E. R. et al. miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells. Cancer Cell 29, 214-228 (2016)
    • (2016) Cancer Cell , vol.29 , pp. 214-228
    • Lechman, E.R.1
  • 11
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert, K. et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nature Med. 17, 1086-1093 (2011)
    • (2011) Nature Med. , vol.17 , pp. 1086-1093
    • Eppert, K.1
  • 12
    • 78650950098 scopus 로고    scopus 로고
    • Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in nod/scid/il2r c-deficient mice
    • Sarry, J. E. et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R c-deficient mice. J. Clin. Invest. 121, 384-395 (2011)
    • (2011) J. Clin. Invest , vol.121 , pp. 384-395
    • Sarry, J.E.1
  • 13
    • 84879421185 scopus 로고    scopus 로고
    • The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment
    • Laurenti, E. et al. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nature Immunol. 14, 756-763 (2013)
    • (2013) Nature Immunol , vol.14 , pp. 756-763
    • Laurenti, E.1
  • 14
    • 78651486442 scopus 로고    scopus 로고
    • Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    • Novershtern, N. et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144, 296-309 (2011)
    • (2011) Cell , vol.144 , pp. 296-309
    • Novershtern, N.1
  • 15
    • 58149240152 scopus 로고    scopus 로고
    • Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling
    • Verhaak, R. G. et al. Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica 94, 131-134 (2009)
    • (2009) Haematologica , vol.94 , pp. 131-134
    • Verhaak, R.G.1
  • 16
    • 77950537175 scopus 로고    scopus 로고
    • Regularization paths for generalized linear models via coordinate descent
    • Friedman, J., Hastie, T. & Tibshirani, R. Regularization paths for generalized linear models via coordinate descent. J. Stat. Softw. 33, 1-22 (2010)
    • (2010) J. Stat. Softw. , vol.33 , pp. 1-22
    • Friedman, J.1    Hastie, T.2    Tibshirani, R.3
  • 17
    • 79952934063 scopus 로고    scopus 로고
    • Regularization paths for Cox's proportional hazards model via coordinate descent
    • Simon, N., Friedman, J., Hastie, T. & Tibshirani, R. Regularization paths for Cox's proportional hazards model via coordinate descent. J. Stat. Softw. 39, 1-13 (2011)
    • (2011) J. Stat. Softw. , vol.39 , pp. 1-13
    • Simon, N.1    Friedman, J.2    Hastie, T.3    Tibshirani, R.4
  • 18
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N. Engl. J. Med. 368, 2059-2074 (2013)
    • (2013) N. Engl. J. Med. , vol.368 , pp. 2059-2074
  • 19
    • 57449103508 scopus 로고    scopus 로고
    • An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia
    • Metzeler, K. H. et al. An 86-probe-set gene-expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood 112, 4193-4201 (2008)
    • (2008) Blood , vol.112 , pp. 4193-4201
    • Metzeler, K.H.1
  • 20
    • 84955451182 scopus 로고    scopus 로고
    • Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
    • Grimwade, D., Ivey, A. & Huntly, B. J. Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood 127, 29-41 (2016)
    • (2016) Blood , vol.127 , pp. 29-41
    • Grimwade, D.1    Ivey, A.2    Huntly, B.J.3
  • 21
    • 84973879698 scopus 로고    scopus 로고
    • Genomic classification and prognosis in acute myeloid leukemia
    • Papaemmanuil, E. et al. Genomic classification and prognosis in acute myeloid leukemia. N. Engl. J. Med. 374, 2209-2221 (2016)
    • (2016) N. Engl. J. Med. , vol.374 , pp. 2209-2221
    • Papaemmanuil, E.1
  • 22
    • 84934442835 scopus 로고    scopus 로고
    • Data-driven phenotypic dissection of AML reveals progenitorlike cells that correlate with prognosis
    • Levine, J. H. et al. Data-driven phenotypic dissection of AML reveals progenitorlike cells that correlate with prognosis. Cell 162, 184-197 (2015)
    • (2015) Cell , vol.162 , pp. 184-197
    • Levine, J.H.1
  • 23
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • Gentles, A. J., Plevritis, S. K., Majeti, R. & Alizadeh, A. A. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. J. Am. Med. Assoc. 304, 2706-2715 (2010)
    • (2010) J. Am. Med. Assoc. , vol.304 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 24
    • 84943616457 scopus 로고    scopus 로고
    • An lsc epigenetic signature is largely mutation independent and implicates the hoxa cluster in AML pathogenesis
    • Jung, N., Dai, B., Gentles, A. J., Majeti, R. & Feinberg, A. P. An LSC epigenetic signature is largely mutation independent and implicates the HOXA cluster in AML pathogenesis. Nature Commun. 6, 8489 (2015)
    • (2015) Nature Commun. , vol.6 , pp. 8489
    • Jung, N.1    Dai, B.2    Gentles, A.J.3    Majeti, R.4    Feinberg, A.P.5
  • 25
    • 40449100030 scopus 로고    scopus 로고
    • Direct multiplexed measurement of gene expression with color-coded probe pairs
    • Geiss, G. K. et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nature Biotechnol. 26, 317-325 (2008)
    • (2008) Nature Biotechnol , vol.26 , pp. 317-325
    • Geiss, G.K.1
  • 26
    • 84867099700 scopus 로고    scopus 로고
    • The european leukemianet AML working party consensus statement on allogeneic hsct for patients with AML in remission: An integrated-risk adapted approach
    • Cornelissen, J. J. et al. The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach. Nature Rev. Clin. Oncol. 9, 579-590 (2012)
    • (2012) Nature Rev. Clin. Oncol. , vol.9 , pp. 579-590
    • Cornelissen, J.J.1
  • 27
    • 77954569665 scopus 로고    scopus 로고
    • Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways
    • Kohlmann, A. et al. Gene expression profiling in AML with normal karyotype can predict mutations for molecular markers and allows novel insights into perturbed biological pathways. Leukemia 24, 1216-1220 (2010)
    • (2010) Leukemia , vol.24 , pp. 1216-1220
    • Kohlmann, A.1
  • 28
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
    • Castaigne, S. et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet 379, 1508-1516 (2012)
    • (2012) Lancet , vol.379 , pp. 1508-1516
    • Castaigne, S.1
  • 29
    • 84905560676 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: A meta-analysis of individual patient data from randomised controlled trials
    • Hills, R. K. et al. Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials. Lancet Oncol. 15, 986-996 (2014)
    • (2014) Lancet Oncol. , vol.15 , pp. 986-996
    • Hills, R.K.1
  • 30
    • 84940545016 scopus 로고    scopus 로고
    • Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia
    • Klco, J. M. et al. Association between mutation clearance after induction therapy and outcomes in acute myeloid leukemia. J. Am. Med. Assoc. 314, 811-822 (2015)
    • (2015) J. Am. Med. Assoc. , vol.314 , pp. 811-822
    • Klco, J.M.1
  • 31
    • 46249088370 scopus 로고    scopus 로고
    • Lumi: A pipeline for processing Illumina microarray
    • Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547-1548 (2008)
    • (2008) Bioinformatics , vol.24 , pp. 1547-1548
    • Du, P.1    Kibbe, W.A.2    Lin, S.M.3
  • 32
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015)
    • (2015) Nucleic Acids Res. , vol.43 , pp. 47
    • Ritchie, M.E.1
  • 33
    • 84872023313 scopus 로고    scopus 로고
    • Pert: A method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions
    • Qiao, W. et al. PERT: a method for expression deconvolution of human blood samples from varied microenvironmental and developmental conditions. PLOS Comput. Biol. 8, e1002838 (2012)
    • (2012) PLOS Comput. Biol. , vol.8 , pp. 1002838
    • Qiao, W.1
  • 34
    • 1342288026 scopus 로고    scopus 로고
    • Affy-analysis of affymetrix genechip data at the probe level
    • Gautier, L., Cope, L., Bolstad, B. M. & Irizarry, R. A. affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20, 307-315 (2004)
    • (2004) Bioinformatics , vol.20 , pp. 307-315
    • Gautier, L.1    Cope, L.2    Bolstad, B.M.3    Irizarry, R.A.4
  • 35
    • 85028360383 scopus 로고    scopus 로고
    • Gcrma: Background adjustment using sequence information
    • Wu, J., Irizarry, R., MacDonald, J. & Gentry, J. Gcrma: background adjustment using sequence information. R package version 2.36.0 (2016)
    • (2016) R Package Version , vol.2 , pp. 36-37
    • Wu, J.1    Irizarry, R.2    MacDonald, J.3    Gentry, J.4
  • 36
    • 29144535372 scopus 로고    scopus 로고
    • Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
    • Dai, M. et al. Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Nucleic Acids Res. 33, e175 (2005)
    • (2005) Nucleic Acids Res. , vol.33 , pp. 175
    • Dai, M.1
  • 37
    • 84884244117 scopus 로고    scopus 로고
    • RNA-seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
    • Macrae, T. et al. RNA-seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells. PLoS ONE 8, e72884 (2013)
    • (2013) PLoS ONE , vol.8 , pp. 72884
    • Macrae, T.1
  • 38
    • 84899136028 scopus 로고    scopus 로고
    • Determining cell-of-origin subtypes of diffuse large b-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue
    • Scott, D. W. et al. Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue. Blood 123, 1214-1217 (2014)
    • (2014) Blood , vol.123 , pp. 1214-1217
    • Scott, D.W.1
  • 39
    • 84897400979 scopus 로고    scopus 로고
    • Analytical validation of the pam50-based prosigna breast cancer prognostic gene signature assay and ncounter analysis system using formalin-fixed paraffin-embedded breast tumor specimens
    • Nielsen, T. et al. Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens. BMC Cancer 14, 177 (2014)
    • (2014) BMC Cancer , vol.14 , pp. 177
    • Nielsen, T.1
  • 40
    • 85016150640 scopus 로고    scopus 로고
    • R Development Core Team. A Language and Environment for Statistical Computing (R Foundation for Statistical Computing
    • R Development Core Team. A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2014)
    • (2014)
  • 41
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    • Cheson, B. D. et al. Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia. J. Clin. Oncol. 21, 4642-4649 (2003)
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4642-4649
    • Cheson, B.D.1
  • 42
    • 0000120995 scopus 로고
    • A class of K-sample tests for comparing the cumulative incidence of a competing risk
    • Gray, R. J. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann. Stat. 16, 1141-1154 (1988)
    • (1988) Ann.Stat. , vol.16 , pp. 1141-1154
    • Gray, R.J.1
  • 43
    • 1542532754 scopus 로고    scopus 로고
    • A proportional hazards model for the subdistribution of a competing risk
    • Fine, J. P. & Gray, R. J. A proportional hazards model for the subdistribution of a competing risk. J. Am. Stat. Assoc. 94, 496-509 (1999)
    • (1999) J.Am.Stat. Assoc. , vol.94 , pp. 496-509
    • Fine, J.P.1    Gray, R.J.2
  • 44
    • 84878105433 scopus 로고    scopus 로고
    • Cmprsk: Subdistribution analysis of competing risks
    • Gray, B. cmprsk: subdistribution analysis of competing risks. R package version 2.2-7 (2014)
    • (2014) R Package Version , vol.2 , pp. 2-7
    • Gray, B.1
  • 45
    • 85016164910 scopus 로고    scopus 로고
    • RiskRegression: Risk regression for survival analysis
    • Gerds, T. A. & Scheike, T. H. riskRegression: risk regression for survival analysis. R package version 0.0.8 (2016)
    • (2016) R Package Version , pp. 0-8
    • Gerds, T.A.1    Scheike, T.H.2
  • 46
    • 84875215709 scopus 로고    scopus 로고
    • Investigation of the freely available easy-to-use software 'EZR' for medical statistics
    • Kanda, Y. Investigation of the freely available easy-to-use software 'EZR' for medical statistics. Bone Marrow Transplant. 48, 452-458 (2013)
    • (2013) Bone Marrow Transplant , vol.48 , pp. 452-458
    • Kanda, Y.1
  • 47
    • 84950449668 scopus 로고
    • Evaluation of response-time data involving transient states: An illustration using heart transplant data
    • Mantel, N. & Byar, D. Evaluation of response-time data involving transient states: an illustration using heart transplant data. J. Am. Stat. Assoc. 69, 81-86 (1974)
    • (1974) J. Am. Stat. Assoc. , vol.69 , pp. 81-86
    • Mantel, N.1    Byar, D.2
  • 48
    • 0001646484 scopus 로고
    • Cox's regression model for counting processes: A large sample study
    • Andersen, P. & Gill, R. D. Cox's regression model for counting processes: a large sample study. Ann. Stat. 10, 1100-1120 (1982)
    • (1982) Ann. Stat. , vol.10 , pp. 1100-1120
    • Andersen, P.1    Gill, R.D.2
  • 49
    • 0021343213 scopus 로고
    • A non-parametric graphical representation of the relationship between survival and the occurrence of an event: Application to responder versus non-responder bias
    • Simon, R. & Makuch, R. W. A non-parametric graphical representation of the relationship between survival and the occurrence of an event: application to responder versus non-responder bias. Stat. Med. 3, 35-44 (1984)
    • (1984) Stat.Med. , vol.3 , pp. 35-44
    • Simon, R.1    Makuch, R.W.2
  • 51
    • 84864806171 scopus 로고    scopus 로고
    • Jr. Rms: Regression modeling strategies
    • Harrell, F. E. Jr. rms: regression modeling strategies. R package version 4.4-1 (2016)
    • (2016) R Package Version , vol.4 , pp. 1-4
    • Harrell, F.E.1
  • 52
    • 79952709519 scopus 로고    scopus 로고
    • Proc: An open-source package for R and S+ to analyze and compare ROC curves
    • Robin, X. et al. pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 12, 77 (2011)
    • (2011) BMC Bioinformatics , vol.12 , pp. 77
    • Robin, X.1
  • 53
    • 79959716798 scopus 로고    scopus 로고
    • PredictABEL: An R psackage for the assessment of risk prediction models
    • Kundu, S., Aulchenko, Y. S., van Duijn, C. M. & Janssens, A. C. PredictABEL: an R psackage for the assessment of risk prediction models. Eur. J. Epidemiol. 26, 261-264 (2011).
    • (2011) Eur. J. Epidemiol , vol.26 , pp. 261-264
    • Kundu, S.1    Aulchenko, Y.S.2    Van Duijn, C.M.3    Janssens, A.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.