Association between Dabigatran vs Warfarin and risk of osteoporotic fractures among patients with nonvalvular atrial fibrillation

JAMA - Journal of the American Medical Association

Volumn 317, Issue 11, 2017, Pages 1151-1158

  Lau, Wallis C Y ^a   Chan, Esther W ^a   Cheung, Ching Lung ^a   Sing, Chor Wing ^a   Man, Kenneth K C ^a   Lip, Gregory Y H ^b,c   Siu, Chung Wah ^d   Lam, Joanne K Y ^d   Lee, Alan C H ^d   Wong, Ian C K ^a,e  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c AALBORG UNIVERSITY   (Denmark)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DABIGATRAN; WARFARIN; ANTICOAGULANT AGENT; ANTITHROMBIN;

AGED; ARTICLE; ATRIAL FIBRILLATION; COHORT ANALYSIS; CONTROLLED STUDY; FALL RISK; FEMALE; FRAGILITY FRACTURE; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; LOW RISK PATIENT; MAJOR CLINICAL STUDY; MALE; RETROSPECTIVE STUDY; RISK ASSESSMENT; SPINE FRACTURE; CHEMICALLY INDUCED; FACTUAL DATABASE; FALLING; HIP FRACTURES; HONG KONG; OSTEOPOROTIC FRACTURES; POISSON DISTRIBUTION; PROPENSITY SCORE; RISK; SPINAL FRACTURES; STATISTICS AND NUMERICAL DATA; STROKE;

ACCIDENTAL FALLS; AGED; ANTICOAGULANTS; ANTITHROMBINS; ATRIAL FIBRILLATION; DABIGATRAN; DATABASES, FACTUAL; FEMALE; HIP FRACTURES; HONG KONG; HUMANS; MALE; OSTEOPOROTIC FRACTURES; POISSON DISTRIBUTION; PROPENSITY SCORE; RETROSPECTIVE STUDIES; RISK; SPINAL FRACTURES; STROKE; WARFARIN;

EID: 85016132395     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2017.1363     Document Type: Article

References (37)

1. Sugiyama T, Kugimiya F, Kono S, Kim YT, Oda H. Warfarin use and fracture risk: An evidence-based mechanistic insight. Osteoporos Int. 2015;26(3): 1231-1232.
2. Caraballo PJ, Heit JA, Atkinson EJ, et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med. 1999;159(15):1750-1756.
3. Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF. Risk of osteoporotic fracture in elderly patients taking warfarin: Results from the National Registry of Atrial Fibrillation 2. Arch Intern Med. 2006;166(2):241-246.
4. Rejnmark L, Vestergaard P, Mosekilde L. Fracture risk in users of oral anticoagulants: A nationwide case-control study. Int J Cardiol. 2007; 118(3):338-344.
5. Fusaro M, Dalle Carbonare L, Dusso A, et al. Differential effects of dabigatran and warfarin on bone volume and structure in rats with normal renal function. PLoS One. 2015;10(8):e0133847.
6. Panula J, Pihlajamäki H, Mattila VM, et al. Mortality and cause of death in hip fracture patients aged 65 or older: A population-based study. BMC Musculoskelet Disord. 2011;12:105.
7. Hospital Authority. Introduction. http://www .ha.org.hk/visitor/ha-visitor-index.asp?.Content-ID =10008&Lang=ENG&Dimension=100&Parent -ID=10004. Accessed September 8, 2016.
8. Hospital Authority. Hospital Authority Statistical Report 2014-2015. http://www.ha.org.hk/haho/ho /stat/HASR1415-2.pdf. Accessed September 8, 2016.
9. Wong AYS, Root A, Douglas IJ, et al. Cardiovascular outcomes associated with use of clarithromycin: Population based study. BMJ. 2016; 352:h6926.
10. Chan EW, LauWC, Leung WK, et al. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology. 2015;149(3):586-595.e3.
11. Wong AY, Wong IC, Chui CS, et al. Association between acute neuropsychiatric events and Helicobacter pylori therapy containing clarithromycin. JAMA Intern Med. 2016; 176(6):828-834.
12. Chan EW, LauWC, Siu CW, et al. Effect of suboptimal anticoagulation treatment with antiplatelet therapy and warfarin on clinical outcomes in patients with nonvalvular atrial fibrillation: A population-wide cohort study. Heart Rhythm. 2016;13(8):1581-1588.
13. Chui CS, Chan EW, Wong AY, Root A, Douglas IJ, Wong IC. Association between oral fluoroquinolones and seizures: A self-controlled case series study. Neurology. 2016;86(18):1708-1715.
14. Man KK, Chan EW, Coghill D, et al. Methylphenidate and the risk of trauma. Pediatrics. 2015;135(1):40-48.
15. Chui CS, Man KK, Cheng CL, et al. An investigation of the potential association between retinal detachment and oral fluoroquinolones: A self-controlled case series study. J Antimicrob Chemother. 2014;69(9):2563-2567.
16. Man KK, Ip P, Hsia Y, et al. ADHD drug prescribing trend is increasing among children and adolescents in Hong Kong [published online July 3, 2014]. J Atten Disord. doi:10.1177/1087054714536047
17. Hippisley-Cox J, Coupland C. Predicting risk of osteoporotic fracture in men and women in England andWales: Prospective derivation and validation of QFractureScores. BMJ. 2009;339: B4229.
18. Austin PC. Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples. Stat Med. 2009;28(25):3083-3107.
19. Austin PC. Some methods of propensity-score matching had superior performance to others: Results of an empirical investigation and Monte Carlo simulations. Biom J. 2009;51(1):171-184.
20. Stuart EA, Lee BK, Leacy FP. Prognostic score-based balance measures can be a useful diagnostic for propensity score methods in comparative effectiveness research. J Clin Epidemiol. 2013;66(8)(suppl):S84-S90.e81
21. Pasternak B, Svanström H, Melbye M, Hviid A. Association between oral fluoroquinolone use and retinal detachment. JAMA. 2013;310(20):2184-2190.
22. Gage BF, Birman-Deych E, Kerzner R, Radford MJ, Nilasena DS, RichMW. Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med. 2005;118(6):612-617.
23. Stürmer T, Rothman KJ, Avorn J, Glynn RJ. Treatment effects in the presence of unmeasured confounding: Dealing with observations in the tails of the propensity score distribution-a simulation study. Am J Epidemiol. 2010;172(7):843-854.
24. Tufano A, Coppola A, Contaldi P, Franchini M, Minno GD. Oral anticoagulant drugs and the risk of osteoporosis: new anticoagulants better than old?. Semin Thromb Hemost. 2015;41(4):382-388.
25. Szulc P, Arlot M, Chapuy MC, Duboeuf F, Meunier PJ, Delmas PD. Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res. 1994;9 (10):1591-1595.
26. Ivaska KK, Gerdhem P, Akesson K, Garnero P, Obrant KJ. Effect of fracture on bone turnover markers: A longitudinal study comparing marker levels before and after injury in 113 elderly women. J Bone Miner Res. 2007;22(8):1155-1164.
27. January CT, Wann LS, Alpert JS, et al; ACC/AHA Task Force Members. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):e199-e267.
28. Feskanich D, Weber P, WillettWC, Rockett H, Booth SL, Colditz GA. Vitamin K intake and hip fractures in women: A prospective study. Am J Clin Nutr. 1999;69(1):74-79.
29. Pilon D, Castilloux AM, Dorais M, LeLorier J. Oral anticoagulants and the risk of osteoporotic fractures among elderly. Pharmacoepidemiol Drug Saf. 2004;13(5):289-294.
30. Misra D, Zhang Y, Peloquin C, Choi HK, Kiel DP, Neogi T. Incident long-term warfarin use and risk of osteoporotic fractures: Propensity-score matched cohort of elders with new onset atrial fibrillation. Osteoporos Int. 2014;25(6):1677-1684.
31. Woo C, Chang LL, Ewing SK, Bauer DC; Osteoporotic Fractures in Men Study Group. Single-point assessment of warfarin use and risk of osteoporosis in elderly men. J AmGeriatr Soc. 2008;56(7):1171-1176.
32. Jamal SA, BrownerWS, Bauer DC, Cummings SR; Study of Osteoporotic Fractures Research Group.Warfarin use and risk for osteoporosis in elderly women. Ann Intern Med. 1998;128(10): 829-832.
33. Sato Y, Honda Y, Jun I. Long-term oral anticoagulation therapy and the risk of hip fracture in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation. Cerebrovasc Dis. 2010;29(1):73-78.
34. Benzinger P, Rapp K, König HH, et al. Risk of osteoporotic fractures following stroke in older persons. Osteoporos Int. 2015;26(4):1341-1349.
35. Leslie WD, Lix LM; Manitoba Bone Density Program. Absolute fracture risk assessment using lumbar spine and femoral neck bone density measurements: Derivation and validation of a hybrid system. J Bone Miner Res. 2011;26(3):460-467.
36. Henau K, Van Eycken E, Silversmit G, Pukkala E. Regional variation in incidence for smoking and alcohol related cancers in Belgium. Cancer Epidemiol. 2015;39(1):55-65.
37. Ip TP, Cheung SK, Cheung TC, et al; OSHK Task Group for Formulation of 2013 OSHK Guideline for Clinical Management of Postmenopausal Osteoporosis in Hong Kong; Osteoporosis Society of Hong Kong. The Osteoporosis Society of Hong Kong (OSHK): 2013 OSHK guideline for clinical management of postmenopausal osteoporosis in Hong Kong. Hong Kong Med J. 2013;19(suppl 2):1-40.