메뉴 건너뛰기




Volumn 60, Issue 6, 2017, Pages 1138-1151

Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice

Author keywords

Acute myocardial infarction; Cardiovascular death; Diet; Endothelial dysfunction; Metabolic syndrome; Mice; Nitrate; Nitric oxide; Nitrite

Indexed keywords

ACETYLCHOLINE; ADENOSINE PHOSPHATE; ADIPONECTIN; ARGININE; CARBOHYDRATE; FAT; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRATE; NITRITE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; SIRTUIN 1; SODIUM NITRATE; TRIACYLGLYCEROL; WATER; NITRIC ACID DERIVATIVE; NITRIC OXIDE;

EID: 85016090848     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-017-4259-6     Document Type: Article
Times cited : (67)

References (49)
  • 1
    • 79956280344 scopus 로고    scopus 로고
    • The Metabolic Syndrome
    • Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscaldo J, (eds), Mc Graw Hill Education, New York
    • Eckel R (2015) The Metabolic Syndrome. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscaldo J (eds) Harrison's Principles of Internal Medicine. Mc Graw Hill Education, New York, pp 2449–2454
    • (2015) Harrison's Principles of Internal Medicine , pp. 2449-2454
    • Eckel, R.1
  • 2
    • 84883311618 scopus 로고    scopus 로고
    • Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010
    • PID: 23810877
    • Beltran-Sanchez H, Harhay MO, Harhay MM, McElligott S (2013) Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999-2010. J Am Coll Cardiol 62:697–703
    • (2013) J Am Coll Cardiol , vol.62 , pp. 697-703
    • Beltran-Sanchez, H.1    Harhay, M.O.2    Harhay, M.M.3    McElligott, S.4
  • 3
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • COI: 1:CAS:528:DC%2BD1MXht1OrtrrK, PID: 19805654
    • Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 4
    • 77957198071 scopus 로고    scopus 로고
    • The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    • PID: 20863953
    • Mottillo S, Filion KB, Genest J et al (2010) The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 56:1113–1132
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1113-1132
    • Mottillo, S.1    Filion, K.B.2    Genest, J.3
  • 5
    • 0742266631 scopus 로고    scopus 로고
    • The metabolic syndrome and chronic kidney disease in U.S. adults
    • PID: 14757614
    • Chen J, Muntner P, Hamm LL et al (2004) The metabolic syndrome and chronic kidney disease in U.S. adults. Ann Intern Med 140:167–174
    • (2004) Ann Intern Med , vol.140 , pp. 167-174
    • Chen, J.1    Muntner, P.2    Hamm, L.L.3
  • 6
    • 84868110731 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of cancer: a systematic review and meta-analysis
    • PID: 23093685
    • Esposito K, Chiodini P, Colao A, Lenzi A, Giugliano D (2012) Metabolic syndrome and risk of cancer: a systematic review and meta-analysis. Diabetes Care 35:2402–2411
    • (2012) Diabetes Care , vol.35 , pp. 2402-2411
    • Esposito, K.1    Chiodini, P.2    Colao, A.3    Lenzi, A.4    Giugliano, D.5
  • 7
    • 84892925036 scopus 로고    scopus 로고
    • Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study
    • COI: 1:CAS:528:DC%2BC2cXjt1CksA%3D%3D, PID: 24191289
    • Garg PK, Biggs ML, Carnethon M et al (2014) Metabolic syndrome and risk of incident peripheral artery disease: the cardiovascular health study. Hypertension 63:413–419
    • (2014) Hypertension , vol.63 , pp. 413-419
    • Garg, P.K.1    Biggs, M.L.2    Carnethon, M.3
  • 8
    • 28044446543 scopus 로고    scopus 로고
    • The metabolic syndrome as a predictor of nonalcoholic fatty liver disease
    • COI: 1:CAS:528:DC%2BD2MXht1yntLrN, PID: 16287793
    • Hamaguchi M, Kojima T, Takeda N et al (2005) The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. Ann Intern Med 143:722–728
    • (2005) Ann Intern Med , vol.143 , pp. 722-728
    • Hamaguchi, M.1    Kojima, T.2    Takeda, N.3
  • 9
    • 33644876824 scopus 로고    scopus 로고
    • Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study
    • PID: 16344402
    • Hanley AJ, Karter AJ, Williams K et al (2005) Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study. Circulation 112:3713–3721
    • (2005) Circulation , vol.112 , pp. 3713-3721
    • Hanley, A.J.1    Karter, A.J.2    Williams, K.3
  • 10
    • 0025321355 scopus 로고
    • Biosynthesis and metabolism of endothelium-derived nitric oxide
    • COI: 1:CAS:528:DyaK3MXitFakug%3D%3D, PID: 2188578
    • Ignarro LJ (1990) Biosynthesis and metabolism of endothelium-derived nitric oxide. Annu Rev Pharmacol Toxicol 30:535–560
    • (1990) Annu Rev Pharmacol Toxicol , vol.30 , pp. 535-560
    • Ignarro, L.J.1
  • 11
    • 0027752805 scopus 로고
    • The l-arginine-nitric oxide pathway
    • COI: 1:CAS:528:DyaK2cXhsF2ntrw%3D, PID: 7504210
    • Moncada S, Higgs A (1993) The l-arginine-nitric oxide pathway. N Engl J Med 329:2002–2012
    • (1993) N Engl J Med , vol.329 , pp. 2002-2012
    • Moncada, S.1    Higgs, A.2
  • 12
    • 33750689471 scopus 로고    scopus 로고
    • Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development
    • COI: 1:CAS:528:DC%2BD28XhtFymur3J, PID: 17093251
    • Murad F (2006) Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med 355:2003–2011
    • (2006) N Engl J Med , vol.355 , pp. 2003-2011
    • Murad, F.1
  • 13
    • 67649877883 scopus 로고    scopus 로고
    • Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice
    • COI: 1:CAS:528:DC%2BD1MXnsF2is7k%3D, PID: 19430166
    • Tsutsui M, Shimokawa H, Otsuji Y, Ueta Y, Sasaguri Y, Yanagihara N (2009) Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice. Circ J 73:986–993
    • (2009) Circ J , vol.73 , pp. 986-993
    • Tsutsui, M.1    Shimokawa, H.2    Otsuji, Y.3    Ueta, Y.4    Sasaguri, Y.5    Yanagihara, N.6
  • 14
    • 78049280211 scopus 로고    scopus 로고
    • Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases
    • COI: 1:CAS:528:DC%2BC3cXhtlKhs7zN, PID: 20826180
    • Tsutsui M, Shimokawa H, Otsuji Y, Yanagihara N (2010) Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases. Pharmacol Ther 128:499–508
    • (2010) Pharmacol Ther , vol.128 , pp. 499-508
    • Tsutsui, M.1    Shimokawa, H.2    Otsuji, Y.3    Yanagihara, N.4
  • 15
    • 84924056460 scopus 로고    scopus 로고
    • Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice
    • COI: 1:CAS:528:DC%2BC28Xislalurk%3D, PID: 25704017
    • Tsutsui M, Tanimoto A, Tamura M et al (2015) Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice. J Pharmacol Sci 127:42–52
    • (2015) J Pharmacol Sci , vol.127 , pp. 42-52
    • Tsutsui, M.1    Tanimoto, A.2    Tamura, M.3
  • 16
    • 79551484534 scopus 로고    scopus 로고
    • Review focus on inorganic nitrite and nitrate in cardiovascular health and disease
    • COI: 1:CAS:528:DC%2BC3MXhsVSmu70%3D, PID: 21183508
    • Kevil CG, Lefer DJ (2011) Review focus on inorganic nitrite and nitrate in cardiovascular health and disease. Cardiovasc Res 89:489–491
    • (2011) Cardiovasc Res , vol.89 , pp. 489-491
    • Kevil, C.G.1    Lefer, D.J.2
  • 17
    • 38849162730 scopus 로고    scopus 로고
    • The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    • COI: 1:CAS:528:DC%2BD1cXhs1Khsrw%3D, PID: 18167491
    • Lundberg JO, Weitzberg E, Gladwin MT (2008) The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7:156–167
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 156-167
    • Lundberg, J.O.1    Weitzberg, E.2    Gladwin, M.T.3
  • 18
    • 84901819805 scopus 로고    scopus 로고
    • Nitrite reduction and cardiovascular protection
    • COI: 1:CAS:528:DC%2BC2cXislCgsrs%3D, PID: 24486197
    • Omar SA, Webb AJ (2014) Nitrite reduction and cardiovascular protection. J Mol Cell Cardiol 73:57–69
    • (2014) J Mol Cell Cardiol , vol.73 , pp. 57-69
    • Omar, S.A.1    Webb, A.J.2
  • 19
    • 75149163814 scopus 로고    scopus 로고
    • Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate
    • COI: 1:CAS:528:DC%2BC3cXht12ltb8%3D, PID: 19748594
    • Milkowski A, Garg HK, Coughlin JR, Bryan NS (2010) Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. Nitric Oxide 22:110–119
    • (2010) Nitric Oxide , vol.22 , pp. 110-119
    • Milkowski, A.1    Garg, H.K.2    Coughlin, J.R.3    Bryan, N.S.4
  • 20
    • 84880686365 scopus 로고    scopus 로고
    • Novel aspects of dietary nitrate and human health
    • COI: 1:CAS:528:DC%2BC3sXhsVSqtLvK, PID: 23642194
    • Weitzberg E, Lundberg JO (2013) Novel aspects of dietary nitrate and human health. Annu Rev Nutr 33:129–159
    • (2013) Annu Rev Nutr , vol.33 , pp. 129-159
    • Weitzberg, E.1    Lundberg, J.O.2
  • 21
    • 37649023552 scopus 로고    scopus 로고
    • Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
    • COI: 1:CAS:528:DC%2BD2sXhsVSksLvJ, PID: 18025468
    • Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ (2007) Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A 104:19144–19149
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19144-19149
    • Bryan, N.S.1    Calvert, J.W.2    Elrod, J.W.3    Gundewar, S.4    Ji, S.Y.5    Lefer, D.J.6
  • 22
    • 46649108907 scopus 로고    scopus 로고
    • Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
    • COI: 1:CAS:528:DC%2BD1cXosFWntLs%3D, PID: 18501719
    • Bryan NS, Calvert JW, Gundewar S, Lefer DJ (2008) Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Free Radic Biol Med 45:468–474
    • (2008) Free Radic Biol Med , vol.45 , pp. 468-474
    • Bryan, N.S.1    Calvert, J.W.2    Gundewar, S.3    Lefer, D.J.4
  • 23
    • 67650535289 scopus 로고    scopus 로고
    • Orally administered nitrite attenuates cardiac allograft rejection in rats
    • PID: 19628069
    • Zhan J, Nakao A, Sugimoto R et al (2009) Orally administered nitrite attenuates cardiac allograft rejection in rats. Surgery 146:155–165
    • (2009) Surgery , vol.146 , pp. 155-165
    • Zhan, J.1    Nakao, A.2    Sugimoto, R.3
  • 24
    • 84873254843 scopus 로고    scopus 로고
    • Effect of blood nitrite and nitrate levels on murine platelet function
    • COI: 1:CAS:528:DC%2BC3sXivVOks7s%3D, PID: 23383344
    • Park JW, Piknova B, Huang PL, Noguchi CT, Schechter AN (2013) Effect of blood nitrite and nitrate levels on murine platelet function. PLoS One 8:e55699
    • (2013) PLoS One , vol.8
    • Park, J.W.1    Piknova, B.2    Huang, P.L.3    Noguchi, C.T.4    Schechter, A.N.5
  • 25
    • 0036244941 scopus 로고    scopus 로고
    • A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC
    • COI: 1:CAS:528:DC%2BD38XjvFegsLs%3D, PID: 11971952
    • Usui S, Hara Y, Hosaki S, Okazaki M (2002) A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC. J Lipid Res 43:805–814
    • (2002) J Lipid Res , vol.43 , pp. 805-814
    • Usui, S.1    Hara, Y.2    Hosaki, S.3    Okazaki, M.4
  • 26
    • 84908327773 scopus 로고    scopus 로고
    • Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse
    • COI: 1:CAS:528:DC%2BC2cXhs1KlsLjF, PID: 25265498
    • Uchida T, Furuno Y, Tanimoto A et al (2014) Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse. J Mol Cell Cardiol 77:29–41
    • (2014) J Mol Cell Cardiol , vol.77 , pp. 29-41
    • Uchida, T.1    Furuno, Y.2    Tanimoto, A.3
  • 27
    • 84921817732 scopus 로고    scopus 로고
    • Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation
    • COI: 1:CAS:528:DC%2BC2cXhs1SisrnK, PID: 25149188
    • Satoh K, Satoh T, Kikuchi N et al (2014) Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Circ Res 115:738–750
    • (2014) Circ Res , vol.115 , pp. 738-750
    • Satoh, K.1    Satoh, T.2    Kikuchi, N.3
  • 28
    • 84881478467 scopus 로고    scopus 로고
    • Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing
    • COI: 1:CAS:528:DC%2BC3sXpvVyhsr4%3D, PID: 23571675
    • Kim SW, Suda W, Kim S et al (2013) Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing. DNA Res 20:241–253
    • (2013) DNA Res , vol.20 , pp. 241-253
    • Kim, S.W.1    Suda, W.2    Kim, S.3
  • 29
    • 84907225684 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in liver cirrhosis
    • COI: 1:CAS:528:DC%2BC2cXhsVyhurvE, PID: 25079328
    • Qin N, Yang F, Li A et al (2014) Alterations of the human gut microbiome in liver cirrhosis. Nature 513:59–64
    • (2014) Nature , vol.513 , pp. 59-64
    • Qin, N.1    Yang, F.2    Li, A.3
  • 30
    • 84930675333 scopus 로고    scopus 로고
    • Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters
    • PID: 25992554
    • Lecomte V, Kaakoush NO, Maloney CA et al (2015) Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters. PLoS One 10:e0126931
    • (2015) PLoS One , vol.10
    • Lecomte, V.1    Kaakoush, N.O.2    Maloney, C.A.3
  • 32
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • PID: 17183312
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027–1031
    • (2006) Nature , vol.444 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 33
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • Vrieze A, Van Nood E, Holleman F et al (2012) Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913–916.e917
    • (2012) Gastroenterology 143 , vol.e917 , pp. 913-916
    • Vrieze, A.1    Van Nood, E.2    Holleman, F.3
  • 34
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • COI: 1:CAS:528:DC%2BC3sXhtFait7rM, PID: 23671105
    • Everard A, Belzer C, Geurts L et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 110:9066–9071
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 9066-9071
    • Everard, A.1    Belzer, C.2    Geurts, L.3
  • 35
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • COI: 1:CAS:528:DC%2BC2cXpsVSltro%3D, PID: 23804561
    • Shin NR, Lee JC, Lee HY et al (2014) An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 63:727–735
    • (2014) Gut , vol.63 , pp. 727-735
    • Shin, N.R.1    Lee, J.C.2    Lee, H.Y.3
  • 36
    • 84864395103 scopus 로고    scopus 로고
    • Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity
    • PID: 22844426
    • Gauffin Cano P, Santacruz A, Moya A, Sanz Y (2012) Bacteroides uniformis CECT 7771 ameliorates metabolic and immunological dysfunction in mice with high-fat-diet induced obesity. PLoS One 7:e41079
    • (2012) PLoS One , vol.7
    • Gauffin Cano, P.1    Santacruz, A.2    Moya, A.3    Sanz, Y.4
  • 37
    • 23044483861 scopus 로고    scopus 로고
    • Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms
    • COI: 1:CAS:528:DC%2BD2MXntVSiurs%3D, PID: 16024729
    • Morishita T, Tsutsui M, Shimokawa H et al (2005) Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A 102:10616–10621
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10616-10621
    • Morishita, T.1    Tsutsui, M.2    Shimokawa, H.3
  • 38
    • 44049102229 scopus 로고    scopus 로고
    • Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms
    • COI: 1:CAS:528:DC%2BD1cXkvFSjtL8%3D, PID: 18413498
    • Nakata S, Tsutsui M, Shimokawa H et al (2008) Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms. Circulation 117:2211–2223
    • (2008) Circulation , vol.117 , pp. 2211-2223
    • Nakata, S.1    Tsutsui, M.2    Shimokawa, H.3
  • 39
    • 0345117404 scopus 로고    scopus 로고
    • Globular adiponectin upregulates nitric oxide production in vascular endothelial cells
    • COI: 1:CAS:528:DC%2BD3sXptVyqs7g%3D, PID: 14551684
    • Hattori Y, Suzuki M, Hattori S, Kasai K (2003) Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46:1543–1549
    • (2003) Diabetologia , vol.46 , pp. 1543-1549
    • Hattori, Y.1    Suzuki, M.2    Hattori, S.3    Kasai, K.4
  • 40
    • 77949828624 scopus 로고    scopus 로고
    • eNOS plays a major role in adiponectin synthesis in adipocytes
    • COI: 1:CAS:528:DC%2BC3cXksl2qurs%3D, PID: 20124507
    • Koh EH, Kim M, Ranjan KC et al (2010) eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab 298:E846–E853
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E846-E853
    • Koh, E.H.1    Kim, M.2    Ranjan, K.C.3
  • 41
    • 14844327755 scopus 로고    scopus 로고
    • Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity?
    • COI: 1:CAS:528:DC%2BD2MXht1Omt7g%3D
    • Bouskila M, Pajvani UB, Scherer PE (2005) Adiponectin: a relevant player in PPARgamma-agonist-mediated improvements in hepatic insulin sensitivity? Int J Obes 29(Suppl 1):S17–S23
    • (2005) Int J Obes , vol.29 , pp. S17-S23
    • Bouskila, M.1    Pajvani, U.B.2    Scherer, P.E.3
  • 42
    • 33745183847 scopus 로고    scopus 로고
    • Functions of AMP-activated protein kinase in adipose tissue
    • COI: 1:CAS:528:DC%2BD28XnsVyju70%3D, PID: 16709632
    • Daval M, Foufelle F, Ferre P (2006) Functions of AMP-activated protein kinase in adipose tissue. J Physiol 574:55–62
    • (2006) J Physiol , vol.574 , pp. 55-62
    • Daval, M.1    Foufelle, F.2    Ferre, P.3
  • 43
    • 0037333159 scopus 로고    scopus 로고
    • Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment
    • COI: 1:CAS:528:DC%2BD3sXhs1WktL4%3D, PID: 12620753
    • Sniderman AD, Furberg CD, Keech A et al (2003) Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment. Lancet 361:777–780
    • (2003) Lancet , vol.361 , pp. 777-780
    • Sniderman, A.D.1    Furberg, C.D.2    Keech, A.3
  • 45
    • 84974851147 scopus 로고    scopus 로고
    • Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice
    • PID: 27255361
    • Windelov JA, Pedersen J, Holst JJ (2016) Use of anesthesia dramatically alters the oral glucose tolerance and insulin secretion in C57Bl/6 mice. Physiol Rep 4:e12824
    • (2016) Physiol Rep , vol.4
    • Windelov, J.A.1    Pedersen, J.2    Holst, J.J.3
  • 46
    • 0035902547 scopus 로고    scopus 로고
    • Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase
    • COI: 1:CAS:528:DC%2BD3MXlslOmtLg%3D, PID: 11457755
    • Duplain H, Burcelin R, Sartori C et al (2001) Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 104:342–345
    • (2001) Circulation , vol.104 , pp. 342-345
    • Duplain, H.1    Burcelin, R.2    Sartori, C.3
  • 48
    • 84864244872 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance, and roles of inflammation - mechanisms and therapeutic targets
    • COI: 1:CAS:528:DC%2BC38XhtVCrsLnP, PID: 22815343
    • Romeo GR, Lee J, Shoelson SE (2012) Metabolic syndrome, insulin resistance, and roles of inflammation - mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol 32:1771–1776
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1771-1776
    • Romeo, G.R.1    Lee, J.2    Shoelson, S.E.3
  • 49
    • 84883478660 scopus 로고    scopus 로고
    • Gut microbiota from twins discordant for obesity modulate metabolism in mice
    • PID: 24009397
    • Ridaura VK, Faith JJ, Rey FE et al (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214
    • (2013) Science , vol.341 , pp. 1241214
    • Ridaura, V.K.1    Faith, J.J.2    Rey, F.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.