Increase in middle east respiratory syndrome-coronavirus cases in Saudi Arabia linked to hospital outbreak with continued circulation of recombinant virus, July 1-August 31, 2015

Open Forum Infectious Diseases

Volumn 3, Issue 3, 2016, Pages

  Assiri, Abdullah M ^a   Biggs, Holly M ^b   Abedi, Glen R ^b   Lu, Xiaoyan ^b   Bin Saeed, Abdulaziz ^a,c   Abdalla, Osman ^a   Mohammed, Mutaz ^a   Al Abdely, Hail M ^a   Algarni, Homoud S ^a   Alhakeem, Raafat F ^a   Almasri, Malak M ^a   Alsharef, Ali A ^a   Nooh, Randa ^a   Erdman, Dean D ^b   Gerber, Susan I ^b   Watson, John T ^b  

^a MINISTRY OF HEALTH   (Saudi Arabia)

^b NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES   (United States)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Coronavirus infections; Disease outbreaks; Infectious disease transmission; Middle East respiratory syndrome coronavirus; Saudi Arabia

Indexed keywords

ADULT; AGED; ARTICLE; CASE FATALITY RATE; EPIDEMIC; FEMALE; GENE DELETION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MORTALITY; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; QUESTIONNAIRE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAUDI ARABIA; SEQUENCE ANALYSIS; VERY ELDERLY; VIRUS RECOMBINANT; VIRUS TRANSMISSION;

EID: 85016008333     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofw165     Document Type: Article

References (15)

1. Alraddadi BM, Watson JT, Almarashi A, et al. Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans. Emerg Infect Dis 2015; 22:49-55.
2. Oboho IK, Tomczyk SM, Al-Asmari AM, et al. 2014 MERS-CoV outbreak in Jeddah-a link to health care facilities. N Engl J Med 2015; 372:846-54.
3. Drosten C, Meyer B, Muller MA, et al. Transmission of MERS-coronavirus in household contacts. N Engl J Med 2014; 371:828-35.
4. Sabir JS, Lam TT, AhmedMM, et al. Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. Science 2016; 351:81-4.
5. Balkhy HH, Alenazi TH, Alshamrani MM, et al. Notes from the field: nosocomial outbreak of Middle East respiratory syndrome in a large tertiary care hospital-Riyadh, Saudi Arabia, 2015. MMWR Morb Mortal Wkly Rep 2016; 65:163-4.
6. World Health Organization. Laboratory testing for Middle East respiratory syndrome coronavirus (MERS-CoV), interim guidance, updated June 2015. Available at: http://apps.who.int/iris/bitstream/10665/176982/1/WHO_MERS_LAB_15. 1_eng.pdf. Accessed 26 October 2015.
7. Assiri AM, Midgley CM, Abedi GR, et al. Epidemiology of a novel recombinant MERS-CoV in humans in Saudi Arabia. J Infect Dis 2016; 214:712-21.
8. Saudi Arabia Ministry of Health. MERS-CoV Statistics, Command and Control Center. Available at: http://www.moh.gov.sa/en/CCC/PressReleases/Pages/statistics-2016-07-5-001.aspx. Accessed 5 July 2016.
9. Assiri A, McGeer A, Perl TM, et al. Hospital outbreak of Middle East respiratory syndrome coronavirus. N Engl J Med 2013; 369:407-16.
10. Wang Y, Liu D, Shi W, et al. Origin and possible genetic recombination of the Middle East respiratory syndrome coronavirus from the first imported case in China: phylogenetics and coalescence analysis. MBio 2015; 6:e01280-15.
11. Lamers MM, Raj VS, Shafei M, et al. Deletion variants of Middle East respiratory syndrome coronavirus from humans, Jordan, 2015. Emerg Infect Dis 2016; 22:716-9.
12. van Boheemen S, de GraafM, Lauber C, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio 2012; 3:e00473-12.
13. Scobey T, Yount BL, Sims AC, et al. Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus. Proc Natl Acad Sci USA 2013; 110:16157-62.
14. Cotten M, Watson SJ, Zumla AI, et al. Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus. MBio 2014; 5; e01062-13.
15. Muller MA, Meyer B, Corman VM, et al. Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study. Lancet Infect Dis 2015; 15:629.