Vitamin B12 intake and related biomarkers: Associations in a Dutch elderly population

Journal of Nutrition, Health and Aging

Volumn 21, Issue 10, 2017, Pages 1268-1276

  van Wijngaarden, J P ^a   Dhonukshe Rutten, R A M ^a   Brouwer Brolsma, E M ^a   Enneman, A W ^b   Swart, K M A ^c   van Dijk, S C ^b   in 't Veld P H ^a   van Schoor, N M ^c   van der Velde, N ^b,d   de Jonge, R ^b   Lips, P ^c   Uitterlinden, A G ^b   de Groot, L C P G M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

elderly; holotranscobalamin; homocysteine; methylmalonic acid; nutrient intake; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; HOLOTRANSCOBALAMIN; HOMOCYSTEINE; METHYLMALONIC ACID; TRANSCOBALAMIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

AGED; ARTICLE; ATROPHIC GASTRITIS; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYANOCOBALAMIN DEFICIENCY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; BLOOD; ETHNIC GROUP; METABOLISM; SWEDEN;

AGED; BIOMARKERS; CROSS-SECTIONAL STUDIES; ETHNIC GROUPS; FEMALE; HUMANS; MALE; SWEDEN; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 85015933666     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-017-0911-6     Document Type: Article

References (48)

1. Hoey, L, Strain, J, McNulty, H. Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. Am J Clin Nutr 2009;89;1981S-1996S. 10.3945/ajcn.2009.27230C
2. Nexo, E, Hoffmann-Lucke, E. Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility. Am J Clin Nutr 2011;94;359S-365S. 10.3945/ajcn.111.013458
3. Allen, L. Vitamin B-12. Adv Nutr 2012;3;54–55. 10.3945/an.111.001370
4. Yetley, E, Pfeiffer, C, Phinney, K et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011;94;313S-321S. 10.3945/ajcn.111.013243
5. Valente, E, Scott, J, Ueland, P et al. Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B(1)(2) status in the elderly. Clin Chem 2011;57;856–863. 10.1373/clinchem.2010.158154
6. Refsum, H, Smith, A, Ueland, P et al. (Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50;3–32. 10.1373/ clinchem.2003.021634)
7. Bor, M, Lydeking-Olsen, E, Moller, J et al. A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. Am J Clin Nutr 2006;83;52–58.
8. Bor, M, von Castel-Roberts, K, Kauwell, G et al. Daily intake of 4 to 7 microg dietary vitamin B-12 is associated with steady concentrations of vitamin B-12-related biomarkers in a healthy young population. Am J Clin Nutr 2010;91;571–577. 10.3945/ajcn.2009.28082
9. Tucker, K, Rich, S, Rosenberg, I et al. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr 2000;71;514–522.
10. Kwan, L, Bermudez, O, Tucker, K. Low vitamin B-12 intake and status are more prevalent in Hispanic older adults of Caribbean origin than in neighborhood-matched non-Hispanic whites. J Nutr 2002;132;2059–2064.
11. Howard, J, Azen, C, Jacobsen, D et al. Dietary intake of cobalamin in elderly people who have abnormal serum cobalamin, methylmalonic acid and homocysteine levels. Eur J Clin Nutr 1998;52;582–587.
12. Dullemeijer, C, Souverein, OW, Doets, EL et al. Systematic review with doseresponse meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly. Am J Clin Nutr 2012;10.3945/ajcn.112.033951
13. Bailey, R, Carmel, R, Green, R et al. Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr 2011;94;552–561. 10.3945/ajcn.111.015222
14. Vogiatzoglou, A, Oulhaj, A, Smith, A et al. Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem 2009;55;2198–2206. 10.1373/clinchem.2009.128678
15. Lindenbaum, J, Rosenberg, I, Wilson, P et al. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr 1994;60;2–11.
16. van Asselt, D, de Groot, L, van Staveren, W et al. Role of cobalamin intake and atrophic gastritis in mild cobalamin deficiency in older Dutch subjects. Am J Clin Nutr 1998;68;328–334.
17. Allen, L. How common is vitamin B-12 deficiency? Am J Clin Nutr 2009;89;693S-696S. 10.3945/ajcn.2008.26947A
18. Lindenbaum, J, Healton, EB, Savage, DG et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318;1720–1728. 10.1056/NEJM198806303182604
19. Yetley, EA, Pfeiffer, CM, Phinney, KW et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011;94;313S-321S. 10.3945/ajcn.111.013243
20. Bailey, RL, Carmel, R, Green, R et al. Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr 2011;94;552–561. 10.3945/ajcn.111.015222
21. Carmel, R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: A critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. American Journal of Clinical Nutrition 2011;4;348S-358S.
22. van Wijngaarden, JP, Dhonukshe-Rutten, RA, van Schoor, NM et al. Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence. BMC Geriatr 2011;11;80. 10.1186/1471-2318-11-80
23. Feunekes, GI, Van Staveren, WA, De Vries, JH et al. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. Am J Clin Nutr 1993;58;489–496.
24. Verkleij-Hagoort, AC, de Vries, JH, Stegers, MP et al. Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads. Eur J Clin Nutr 2007;61;610–615. 10.1038/sj.ejcn.1602581
25. Siebelink, E, Geelen, A, de Vries, JH. Self-reported energy intake by FFQ compared with actual energy intake to maintain body weight in 516 adults. Br J Nutr 2011;106;274–281. 10.1017/S0007114511000067
26. van Driel, LM, Eijkemans, MJ, de Jonge, R et al. Body mass index is an important determinant of methylation biomarkers in women of reproductive ages. J Nutr 2009;139;2315–2321. 10.3945/jn.109.109710
27. Heil, SG, de Jonge, R, de Rotte, MC et al. (Screening for metabolic vitamin B12 deficiency by holotranscobalamin in patients suspected of vitamin B12 deficiency: a multicentre study. Ann Clin Biochem 2012;49;184–189. 10.1258/acb.2011.011039)
28. Selhub, J, Jacques, PF, Dallal, G et al. (The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr Bull 2008;29;S67–73.)
29. Desquilbet, L, Mariotti, F. Dose-response analyses using restricted cubic spline functions in public health research. Stat Med 2010;29;1037–1057. 10.1002/sim.3841
30. Goldberg, GR, Black, AE, Jebb, SA et al. Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. erivation of cut-off limits to identify under-recording. Eur J Clin Nutr 1991;45;569–581.
31. Nasrollahzadeh, D, Aghcheli, K, Sotoudeh, M et al. Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis. PLoS One 2011;6;e26957. 10.1371/journal.pone.0026957
32. Ocke, M, Buurma-Rethans, E, de Boer, E et al. (2 Diet of community-dwelling older adults: Dutch National Food Consumption Survey Older adults 2010-2012. RIVM, 2013)
33. Dullemeijer, C, Souverein, O, Doets, E et al. Systematic review with doseresponse meta-analyses between vitamin B-12 intake and European Micronutrient Recommendations Aligned’s prioritized biomarkers of vitamin B-12 including randomized controlled trials and observational studies in adults and elderly persons. Am J Clin Nutr 2013;97;390–402. 10.3945/ajcn.112.033951
34. Clarke, R, Grimley Evans, J, Schneede, J et al. Vitamin B12 and folate deficiency in later life. Age Ageing 2004;33;34–41.
35. Refsum, H, Nurk, E, Smith, AD et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 2006;136;1731S-1740S.
36. Bailey, RL, Durazo-Arvizu, RA, Carmel, R et al. Modeling a methylmalonic acidderived change point for serum vitamin B-12 for adults in NHANES. Am J Clin Nutr 2013;98;460–467. 10.3945/ajcn.113.061234
37. Obeid, R, Herrmann, W. Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid. Clin Chem Lab Med 2007;45;1746–1750. 10.1515/CCLM.2007.361
38. Clarke, R, Refsum, H, Birks, J et al. Screening for vitamin B-12 and folate deficiency in older persons. Am J Clin Nutr 2003;77;1241–1247.
39. Carmel, R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr 2011;94;348S-358S. 10.3945/ajcn.111.013441
40. Green, R. Indicators for assessing folate and vitamin B-12 status and for monitoring the efficacy of intervention strategies. Am J Clin Nutr 2011;94;666S-672S. 10.3945/ajcn.110.009613
41. Smith, AD, Refsum, H. Do we need to reconsider the desirable blood level of vitamin B12? J Intern Med 271;179-182. 10.1111/j.1365-2796.2011.02485.x
42. Herrmann, W, Obeid, R. Utility and limitations of biochemical markers of vitamin B12 deficiency. Eur J Clin Invest 2013;43;231–237. 10.1111/eci.12034
43. Lewerin, C, Jacobsson, S, Lindstedt, G et al. Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: Implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy. Scand J Gastroenterol 2008;43;1050–1056. 10.1080/00365520802078341
44. Weck, MN, Brenner, H. Prevalence of chronic atrophic gastritis in different parts of the world. Cancer Epidemiol Biomarkers Prev 2006;15;1083–1094. 10.1158/1055-9965.EPI-05-0931
45. Green, TJ, Venn, BJ, Skeaff, CM et al. Serum vitamin B12 concentrations and atrophic gastritis in older New Zealanders. Eur J Clin Nutr 2005;59;205–210. 10.1038/sj.ejcn.1602059
46. Korstanje, A, den Hartog, G, Biemond, I et al. The serological gastric biopsy: a non-endoscopical diagnostic approach in management of the dyspeptic patient: significance for primary care based on a survey of the literature. Scand J Gastroenterol Suppl 2002;22–26.
47. de Bree, A, van der Put, N, Mennen, L et al. Prevalences of hyperhomocysteinemia, unfavorable cholesterol profile and hypertension in European populations. Eur J Clin Nutr 2005;59;480–488. 10.1038/sj.ejcn.1602097
48. Ganguli, M, Lytle, M, Reynolds, M et al. Random versus volunteer selection for a community-based study. J Gerontol A Biol Sci Med Sci 1998;53;M39–46.