Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: Influence of gastritis

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Nasrollahzadeh, Dariush ^a,b   Aghcheli, Karim ^b   Sotoudeh, Masoud ^b   Shakeri, Ramin ^b   Persson, E Christina ^c   Islami, Farhad ^b,d   Kamangar, Farin ^b,c,e   Abnet, Christian C ^c   Boffetta, Paolo ^f,g   Engstrand, Lars ^h   Dawsey, Sanford M ^c   Malekzadeh, Reza ^b   Ye, Weimin ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c NATIONAL CANCER INSTITUTE   (United States)

^d INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^e MORGAN STATE UNIVERSITY   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g INTERNATIONAL PREVENTION RESEARCH INSTITUTE   (France)

^h SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; CYTOTOXIN ASSOCIATED GENE A ANTIBODY; GASTRIN 17; PEPSINOGEN I; PEPSINOGEN II; UNCLASSIFIED DRUG; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CAGA PROTEIN, HELICOBACTER PYLORI; GASTRIN; PEPSINOGEN;

ADULT; AGED; ARTICLE; ATROPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENDOSCOPY; FEMALE; GASTRIC FUNDUS ATROPHY; GASTRIN 17 BLOOD LEVEL; GASTRITIS; HELICOBACTER PYLORI; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; NONATROPHIC PANGASTRITIS; PEPSINOGEN I BLOOD LEVEL; PEPSINOGEN II BLOOD LEVEL; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; STOMACH FUNDUS; VALIDITY; AREA UNDER THE CURVE; ATROPHIC GASTRITIS; BLOOD; MASS SCREENING; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY;

HELICOBACTER PYLORI;

ANTIGENS, BACTERIAL; AREA UNDER CURVE; BACTERIAL PROTEINS; FEMALE; GASTRIC FUNDUS; GASTRINS; GASTRITIS; GASTRITIS, ATROPHIC; HELICOBACTER PYLORI; HUMANS; MALE; MASS SCREENING; MIDDLE AGED; PEPSINOGEN A; PEPSINOGEN C; REFERENCE VALUES;

EID: 80055113418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026957     Document Type: Article

References (46)

1. Uemura N, Okamoto S, Yamamoto S, Matsumura N, Yamaguchi S, et al. (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 345: 784-789.
2. Ye W, Held M, Lagergren J, Engstrand L, Blot WJ, et al. (2004) Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia. J Natl Cancer Inst 96: 388-396.
3. Ren JS, Kamangar F, Qiao YL, Taylor PR, Liang H, et al. (2009) Serum pepsinogens and risk of gastric and oesophageal cancers in the General Population Nutrition Intervention Trial cohort. Gut 58: 636-642.
4. Gritti I, Banfi G, Roi GS, (2000) Pepsinogens: physiology, pharmacology pathophysiology and exercise. Pharmacol Res 41: 265-281.
5. Graham DY, Nurgalieva ZZ, El-Zimaity HM, Opekun AR, Campos A, et al. (2006) Noninvasive versus histologic detection of gastric atrophy in a Hispanic population in North America. Clin Gastroenterol Hepatol 4: 306-314.
6. Vaananen H, Vauhkonen M, Helske T, Kaariainen I, Rasmussen M, et al. (2003) Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study. Eur J Gastroenterol Hepatol 15: 885-891.
7. Adamu MA, Weck MN, Rothenbacher D, Brenner H, (2011) Incidence and risk factors for the development of chronic atrophic gastritis: five year follow-up of a population-based cohort study. Int J Cancer 128: 1652-1658.
8. Miki K, Ichinose M, Shimizu A, Huang SC, Oka H, et al. (1987) Serum pepsinogens as a screening test of extensive chronic gastritis. Gastroenterol Jpn 22: 133-141.
9. McColl KE, el-Omar E, Gillen D, Banerjee S, (1997) The role of Helicobacter pylori in the pathophysiology of duodenal ulcer disease and gastric cancer. Semin Gastrointest Dis 8: 142-155.
10. Sipponen P, Marshall BJ, (2000) Gastritis and gastric cancer. Western countries. Gastroenterol Clin North Am 29: 579-592, v-vi.
11. Correa P, (1992) Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52: 6735-6740.
12. Brenner H, Rothenbacher D, Weck MN, (2007) Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value. Int J Cancer 121: 2782-2786.
13. Islami F, Kamangar F, Aghcheli K, Fahimi S, Semnani S, et al. (2004) Epidemiologic features of upper gastrointestinal tract cancers in Northeastern Iran. Br J Cancer 90: 1402-1406.
14. Mahboubi E, Kmet J, Cook PJ, Day NE, Ghadirian P, et al. (1973) Oesophageal cancer studies in the Caspian Littoral of Iran: the Caspian cancer registry. Br J Cancer 28: 197-214.
15. Semnani S, Sadjadi A, Fahimi S, Nouraie M, Naeimi M, et al. (2006) Declining incidence of esophageal cancer in the Turkmen Plain, eastern part of the Caspian Littoral of Iran: a retrospective cancer surveillance. Cancer Detect Prev 30: 14-19.
16. Saidi F, Sepehr A, Fahimi S, Farahvash MJ, Salehian P, et al. (2000) Oesophageal cancer among the Turkomans of northeast Iran. Br J Cancer 83: 1249-1254.
17. Watabe H, Mitsushima T, Yamaji Y, Okamoto M, Wada R, et al. (2005) Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study. Gut 54: 764-768.
18. Broutet N, Plebani M, Sakarovitch C, Sipponen P, Megraud F, (2003) Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics. Br J Cancer 88: 1239-1247.
19. Nardone G, Rocco A, Staibano S, Mezza E, Autiero G, et al. (2005) Diagnostic accuracy of the serum profile of gastric mucosa in relation to histological and morphometric diagnosis of atrophy. Aliment Pharmacol Ther 22: 1139-1146.
20. Storskrubb T, Aro P, Ronkainen J, Sipponen P, Nyhlin H, et al. (2008) Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study. Scand J Gastroenterol 43: 1448-1455.
21. Kang JM, Kim N, Yoo JY, Park YS, Lee DH, et al. (2008) The role of serum pepsinogen and gastrin test for the detection of gastric cancer in Korea. Helicobacter 13: 146-156.
22. Haj-Sheykholeslami A, Rakhshani N, Amirzargar A, Rafiee R, Shahidi SM, et al. (2008) Serum pepsinogen I, pepsinogen II, and gastrin 17 in relatives of gastric cancer patients: comparative study with type and severity of gastritis. Clin Gastroenterol Hepatol 6: 174-179.
23. He CY, Sun LP, Gong YH, Xu Q, Dong NN, et al. (2011) Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs. J Gastroenterol Hepatol 26: 1039-1046.
24. Iijima K, Koike T, Abe Y, Ara N, Uno K, et al. (2009) Alteration of correlation between serum pepsinogen concentrations and gastric acid secretion after H. pylori eradication. J Gastroenterol 44: 819-825.
25. Chang YW, Oh HC, Jang JY, Hwangbo Y, Lee JW, et al. (2008) IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H. pylori eradication in gastroduodenal phenotypes. Scand J Gastroenterol 43: 1184-1193.
26. Abnet CC, Zheng W, Ye W, Kamangar F, Ji BT, et al. (2011) Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort. Br J Cancer.
27. Mardh E, Mardh S, Mardh B, Borch K, (2002) Diagnosis of gastritis by means of a combination of serological analyses. Clin Chim Acta 320: 17-27.
28. Knight T, Wyatt J, Wilson A, Greaves S, Newell D, et al. (1996) Helicobacter pylori gastritis and serum pepsinogen levels in a healthy population: development of a biomarker strategy for gastric atrophy in high risk groups. Br J Cancer 73: 819-824.
29. Sipponen P, Ranta P, Helske T, Kaariainen I, Maki T, et al. (2002) Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study. Scand J Gastroenterol 37: 785-791.
30. Shimatani T, Inoue M, Iwamoto K, Hyogo H, Yokozaki M, et al. (2005) Gastric acidity in patients with follicular gastritis is significantly reduced, but can be normalized after eradication for Helicobacter pylori. Helicobacter 10: 256-265.
31. Imagawa S, Yoshihara M, Ito M, Yoshida S, Wada Y, et al. (2008) Evaluation of gastric cancer risk using topography of histological gastritis: a large-scaled cross-sectional study. Dig Dis Sci 53: 1818-1823.
32. Song HJ, Jang SJ, Yun SC, Park YS, Kim MJ, et al. (2010) Low Levels of Pepsinogen I and Pepsinogen I/II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic Mucosectomy. Gut Liver 4: 475-480.
33. Shiotani A, Iishi H, Uedo N, Kumamoto M, Nakae Y, et al. (2005) Histologic and serum risk markers for noncardia early gastric cancer. Int J Cancer 115: 463-469.
34. Bodger K, Wyatt JI, Heatley RV, (2001) Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy. Helicobacter 6: 216-224.
35. Di Mario F, Moussa AM, Cavallaro LG, Caruana P, Merli R, et al. (2004) Clinical usefulness of serum pepsinogen II in the management of Helicobacter pylori infection. Digestion 70: 167-172.
36. Gatta L, Di Mario F, Vaira D, Rugge M, Franze A, et al. (2011) Quantification of serum levels of pepsinogens and gastrin to assess eradication of Helicobacter pylori. Clin Gastroenterol Hepatol 9: 440-442.
37. Ricci C, Vakil N, Rugge M, Gatta L, Perna F, et al. (2004) Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori. American Journal of Gastroenterology 99: 1910-1915.
38. Malekzadeh R, Sotoudeh M, Derakhshan MH, Mikaeli J, Yazdanbod A, et al. (2004) Prevalence of gastric precancerous lesions in Ardabil, a high incidence province for gastric adenocarcinoma in the northwest of Iran. J Clin Pathol 57: 37-42.
39. Pakseresht M, Forman D, Malekzadeh R, Yazdanbod A, West RM, et al. (2011) Dietary habits and gastric cancer risk in north-west Iran. Cancer Causes Control 22: 725-736.
40. Weck MN, Gao L, Brenner H, (2009) Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease. Epidemiology 20: 569-574.
41. Gao L, Weck MN, Nieters A, Brenner H, (2009) Inverse association between a pro-inflammatory genetic profile and Helicobacter pylori seropositivity among patients with chronic atrophic gastritis: enhanced elimination of the infection during disease progression? Eur J Cancer 45: 2860-2866.
42. Parente F, Lazzaroni M, Sangaletti O, Baroni S, Bianchi Porro G, (1985) Cigarette smoking, gastric acid secretion, and serum pepsinogen I concentrations in duodenal ulcer patients. Gut 26: 1327-1332.
43. Kikuchi S, Kurosawa M, Sakiyama T, Tenjin H, (2002) Long-term effect of smoking on serum pepsinogen values. J Epidemiol 12: 351-356.
44. Tatemichi M, Kabuto M, Tsugane S, (2001) Effect of smoking on serum pepsinogen I level depends on serological status of Helicobacter pylori. Jpn J Cancer Res 92: 243-248.
45. Dixon MF, Genta RM, Yardley JH, Correa P, (1996) Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 20: 1161-1181.
46. Pepe M, Longton G, Janes H, (2009) Estimation and Comparison of Receiver Operating Characteristic Curves. Stata J 9: 1.