A C3(H20) recycling pathway is a component of the intracellular complement system

Journal of Clinical Investigation

Volumn 127, Issue 3, 2017, Pages 970-981

  Elvington, Michelle ^a   Liszewski, M Kathryn ^a   Bertram, Paula ^a   Kulkarni, Hrishikesh S ^a   Atkinson, John P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B RECEPTOR; MEMBRANE COFACTOR PROTEIN; METHYLAMINE; C3 PROTEIN, HUMAN; COMPLEMENT COMPONENT C3;

ARTICLE; CD4+ T LYMPHOCYTE; CELL STIMULATION; COMPLEMENT SYSTEM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; WESTERN BLOTTING; CELL LINE; CYTOLOGY; FEMALE; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; PROTEIN DEGRADATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; COMPLEMENT C3; FEMALE; HUMANS; LYMPHOCYTE ACTIVATION; MALE; PROTEOLYSIS;

EID: 85015879754     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI89412     Document Type: Article

References (40)

1. Walport MJ. Complement. Second of two parts. N Engl J Med. 2001;344(15):1140-1144.
2. Walport MJ. Complement. First of two parts. N Engl J Med. 2001;344(14):1058-1066.
3. Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785-797.
4. Liszewski MK, et al. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity. 2013;39(6):1143-1157.
5. Baudino L, et al. C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci USA. 2014;111(4):1503-1508.
6. Tam JC, Bidgood SR, McEwan WA, James LC. Intracellular sensing of complement C3 activates cell autonomous immunity. Science. 2014;345(6201):1256070.
7. Martin M, et al. Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes. Cell Death Differ. 2016;23(5):903-911.
8. Cardone J, et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol. 2010;11(9):862-871.
9. Le Friec G, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13(12):1213-1221.
10. Liszewski MK, Kemper C, Price JD, Atkinson JP. Emerging roles and new functions of CD46. Springer Semin Immunopathol. 2005;27(3):345-358.
11. Kolev M, et al. Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses. Immunity. 2015;42(6):1033-1047.
12. Arbore G, Kemper C. A novel complementmetabolism-inflammasome axis as a key regulator of immune cell effector function. Eur J Immunol. 2016;46(7):1563-1573.
13. Pangburn MK, Schreiber RD, Müller-Eberhard HJ. Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3. J Exp Med. 1981;154(3):856-867.
14. Brade V, Hall RE, Colten HR. Biosynthesis of pro-C3, a precursor of the third component of complement. J Exp Med. 1977;146(3):759-765.
15. Meilinger M, et al. Metabolism of activated complement component C3 is mediated by the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor. J Biol Chem. 1999;274(53):38091-38096.
16. Tack BF, Harrison RA, Janatova J, Thomas ML, Prahl JW. Evidence for presence of an internal thiolester bond in third component of human complement. Proc Natl Acad Sci USA. 1980;77(10):5764-5768.
17. Nishida N, Walz T, Springer TA. Structural transitions of complement component C3 and its activation products. Proc Natl Acad Sci USA. 2006;103(52):19737-19742.
18. Janssen BJ, et al. Structures of complement component C3 provide insights into the function and evolution of immunity. Nature. 2005;437(7058):505-511.
19. Chen ZA, et al. Structure of complement C3(H2O) revealed by quantitative cross-linking/mass spectrometry and modeling. Mol Cell Proteomics. 2016;15(8):2730-2743.
20. Moestrup SK, Gliemann J, Pallesen G. Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res. 1992;269(3):375-382.
21. Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro-and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011;1813(5):878-888.
22. Pangburn MK, Müller-Eberhard HJ. Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement. J Exp Med. 1980;152(4):1102-1114.
23. Bu G. The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family. Int Rev Cytol. 2001;209:79-116.
24. Turner NA, Sartain SE, Hui SK, Moake JL. Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies. PLoS One. 2015;10(3):e0121994.
25. Ault BH, et al. Human factor H deficiency. Mutations in framework cysteine residues and block in H protein secretion and intracellular catabolism. J Biol Chem. 1997;272(40):25168-25175.
26. Vtvicka V, Reed W, Hoover ML, Ross GD. Complement factors H and I synthesized by B cell lines function to generate a growth factor activity from C3. J Immunol. 1993;150(9):4052-4060.
27. Rayes J, et al. The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status. Blood. 2014;123(1):121-125.
28. Liszewski MK, Tedja I, Atkinson JP. Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domains. J Biol Chem. 1994;269(14):10776-10779.
29. Ghannam A, Fauquert JL, Thomas C, Kemper C, Drouet C. Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation. Mol Immunol. 2014;58(1):98-107.
30. Tanaka T, Narazaki M, Ogata A, Kishimoto T. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin Immunol. 2014;26(1):88-96.
31. Kopf M, Herren S, Wiles MV, Pepys MB, Kosco-Vilbois MH. Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component. J Exp Med. 1998;188(10):1895-1906.
32. Ghannam A, et al. Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells. J Immunol. 2008;181(7):5158-5166.
33. Katz Y, Singer L, Wetsel RA, Schlesinger M, Fishelson Z. Inherited complement C3 deficiency: a defect in C3 secretion. Eur J Immunol. 1994;24(7):1517-1522.
34. Singer L, Whitehead WT, Akama H, Katz Y, Fishelson Z, Wetsel RA. Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (ASP549 to ASN) impairs C3 secretion. J Biol Chem. 1994;269(45):28494-28499.
35. Reis ES, Falcão DA, Isaac L. Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H. Scand J Immunol. 2006;63(3):155-168.
36. Botto M, Lissandrini D, Sorio C, Walport MJ. Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes. J Immunol. 1992;149(4):1348-1355.
37. Einstein LP, et al. Biosynthesis of the third component of complement (C3) in vitro by monocytes from both normal and homozygous C3-deficient humans. J Clin Invest. 1977;60(5):963-969.
38. Nickells MW, Atkinson JP. Characterization of CR1-and membrane cofactor proteinlike proteins of two primates. J Immunol. 1990;144(11):4262-4268.
39. Wang G, Liszewski MK, Chan AC, Atkinson JP. Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol. 2000;164(4):1839-1846.
40. Seya T, Okada M, Nishino H, Atkinson JP. Regulation of proteolytic activity of complement factor I by pH: C3b/C4b receptor (CR1) and membrane cofactor protein (MCP) have different pH optima for factor I-mediated cleavage of C3b. J Biochem. 1990;107(2):310-315.