Roles of Reactive Oxygen Species in Physiology and Pathology

Atherosclerosis: Risks, Mechanisms, and Therapies

Volumn , Issue , 2015, Pages 379-392

  Song, Ping ^a   Zou, Ming Hui ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Antioxidants; Atherosclerosis; Mitochondria; NAD(P)H oxidase; Reactive oxygen species; Signal transduction

Indexed keywords

EID: 85015867480     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118828533.ch30     Document Type: Chapter

References (70)

1. Finkel, T. Oxidant signals and oxidative stress. Curr Opin Cell Biol 15:247-254; 2003.
2. Song, P.; Wu, Y.; Xu, J. et al. Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregu-lating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner. Circulation 116:1585-1595; 2007.
3. Scherz-Shouval, R.; Shvets, E.; Fass, E.; Shorer, H.; Gil, L.; Elazar, Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26:1749-1760; 2007.
4. Kalyanaraman, B.; Darley-Usmar, V.; Davies, K. J. et al. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med 52:1-6; 2012.
5. Zou, M. H.; Shi, C.; Cohen, R. A. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 109:817-826; 2002.
6. Widlansky, M. E; Gutterman, D. D. Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal 15:1517-1530; 2011.
7. Cadenas, E.; Davies, K. J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29:222-230; 2000.
8. Murphy, M. P. How mitochondria produce reactive oxygen species. Biochem J 417:1-13; 2009.
9. Jezek, P.; Hlavata, L. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. The international journal of biochemistry & cell biology 37:2478-2503; 2005.
10. Shen, G. X. Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase. Canadian journal of physiology and pharmacology 88:241-248; 2010.
11. Devarajan, A.; Bourquard, N.; Hama, S. et al. Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis. Antioxid Redox Signal 14:341-351; 2011.
12. Lambeth, J. D. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 4:181-189; 2004.
13. Leto, T. L.; Morand, S.; Hurt, D.; Ueyama, T. Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal 11:2607-2619; 2009.
14. Song, P.; Zou, M. H. Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radic Biol Med 52:1607-1619; 2012.
15. Niu, X. L.; Madamanchi, N. R.; Vendrov, A. E. et al. Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation 121:549-559; 2010.
16. Stanic, B.; Katsuyama, M.; Miller, F. J., Jr. An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. Arterioscler Thromb Vasc Biol 30:2234-2241; 2010.
17. Kroviarski, Y.; Debbabi, M.; Bachoual, R. et al. Phosphorylation of NADPH oxidase activator 1 (NOXA1) on serine 282 by MAP kinases and on serine 172 by protein kinase C and protein kinase A prevents NOX1 hyperactivation. FASEB J 24:2077-2092; 2010.
18. Lee, M. Y.; San Martin, A.; Mehta, P. K. et al. Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol 29:480-487; 2009.
19. Yogi, A.; Mercure, C.; Touyz, J. et al. Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension. Hypertension 51:500-506; 2008.
20. Prosser, B. L.; Ward, C. W.; Lederer, W. J. X-ROS signaling: rapid mechano-chemo transduction in heart. Science 333:1440-1445; 2011.
21. Zhang, M.; Song, P.; Xu, J. et al. Activation of NAD(P)H oxidases by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 31:125-132; 2011.
22. Gupte, S. A.; Kaminski, P. M.; George, S. et al. Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction. Am J Physiol Heart Circ Physiol 296: H1048-H1057; 2009.
23. Chen, Z.; Keaney, J. F., Jr.; Schulz, E. et al. Decreased neointimal formation in Nox2- deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci USA 101:13014-13019; 2004.
24. Wang, S.; Zhang, M.; Liang, B. et al. AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes. Circ Res 106:1117-1128; 2010.
25. Touyz, R. M.; Mercure, C.; He, Y. et al. Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase. Hypertension 45:530-537; 2005.
26. Chen, H.; Song, Y. S.; Chan, P. H. Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab 29:1262-1272; 2009.
27. Violi, F.; Sanguigni, V.; Carnevale, R. et al. Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study. Circulation 120:1616-1622; 2009.
28. Ueno, N.; Takeya, R.; Miyano, K. et al. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem 280:23328-23339; 2005.
29. Cheng, G.; Ritsick, D.; Lambeth, J. D. Nox3 regulation by NOXO1, p47phox, and p67phox. J Biol Chem 279:34250-34255; 2004.
30. Paffenholz, R.; Bergstrom, R. A.; Pasutto, F. et al. Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev 18:486-491; 2004.
31. Craige, S. M.; Chen, K.; Pei, Y. et al. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation 124:731-740; 2011.
32. Clempus, R. E.; Sorescu, D.; Dikalova, A. E. et al. Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype. Arterioscler Thromb Vasc Biol 27:42-48; 2007.
33. Lyle, A. N.; Deshpande, N. N.; Taniyama, Y. et al. Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res 105:249-259; 2009.
34. Martyn, K. D.; Frederick, L. M.; von Loehneysen, K.; Dinauer, M. C.; Knaus, U. G. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal 18:69-82; 2006.
35. Tong, X.; Hou, X.; Jourd'heuil, D. et al. Upregulation of Nox4 by TGFß1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat. Circ Res 107:975-983; 2010.
36. Diaz, B.; Shani, G.; Pass, I.; Anderson, D.; Quintavalle, M.; Courtneidge, S. A. Tks5- dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2:ra53; 2009.
37. 2 drives DNA oxidation resulting in 8-OHdG as urinary biomarker and hemangioendothelioma formation. Antioxid Redox Signal 12:933-943; 2010.
38. Chen, K.; Kirber, M. T.; Xiao, H.; Yang, Y.; Keaney, J. F., Jr. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol 181:1129-1139; 2008.
39. Ismail, S.; Sturrock, A.; Wu, P. et al. NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-1 and insulin-like growth factor binding protein-3. Am J Physiol Lung Cell Mol Physiol 296:L489-L499; 2009.
40. Lener, B.; Koziel, R.; Pircher, H. et al. The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. Biochem J 423:363-374; 2009.
41. Wang, M.; Zhang, J.; Walker, S. J.; Dworakowski, R.; Lakatta, E. G.; Shah, A. M. Involvement of NADPH oxidase in age-associated cardiac remodeling. J Mol Cell Cardiol 48:765-772; 2010.
42. Zhang, M.; Brewer, A. C.; Schroder, K. et al. NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci USA 107:18121-18126; 2010.
43. Schroder, K.; Zhang, M.; Benkhoff, S. et al. Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res 110:1217-1225; 2012.
44. Montezano, A. C.; Burger, D.; Paravicini, T. M. et al. Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells. Circ Res 106:1363-1373; 2010.
45. Jay, D. B.; Papaharalambus, C. A.; Seidel-Rogol, B.; Dikalova, A. E.; Lassegue, B.; Griendling, K. K. Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med 45:329-335; 2008.
46. 2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem 279:18583-18591; 2004.
47. Serrander, L.; Jaquet, V.; Bedard, K. et al. NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie 89:1159-1167; 2007.
48. Jagnandan, D.; Church, J.E.; Banfi, B.; Stuehr, D. J.; Marrero, M. B.; Fulton, D. J. Novel mechanism of activation of NADPH oxidase 5. calcium sensitization via phosphorylation. J Biol Chem 282:6494-6507; 2007.
49. El Jamali, A.; Valente, A. J.; Lechleiter, J. D. et al. Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl. Free Radic Biol Med 44:868-881; 2008.
50. Guzik, T. J.; Chen, W.; Gongora, M. C. et al. Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease. J Am Coll Cardiol 52:1803-1809; 2008.
51. Moreno, J. C.; Bikker, H.; Kempers, M. J. et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med 347:95-102; 2002.
52. Kundu, T. K.; Velayutham, M.; Zweier, J. L. Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation. Biochemistry 51:2930-2939; 2012.
53. Bravard, A.; Bonnard, C.; Durand, A. et al. Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice. Am J Physiol Endocrinol Metab 300:E581-591; 2011.
54. Bonnard, C.; Durand, A.; Peyrol, S. et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 118:789-800; 2008.
55. Su, J.; Lucchesi, P. A.; Gonzalez-Villalobos, R. A. et al. Role of advanced glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice. Arterioscler Thromb Vasc Biol 28:1432-1438; 2008.
56. Rhee, S. G.; Chae, H. Z.; Kim, K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med 38:1543-1552; 2005.
57. Kern, J. C.; Kehrer, J. P. Free radicals and apoptosis: relationships with glutathione, thioredoxin, and the BCL family of proteins. Frontiers in bioscience: a journal and virtual library 10:1727-1738; 2005.
58. D'Autreaux, B.; Toledano, M. B. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8:813-824; 2007.
59. 2-mediated activation of NFkappaB-inducing kinase. J Biol Chem 281:1495-1505; 2006.
60. Milenkovic, M.; De Deken, X.; Jin, L. et al. Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult. The Journal of endocrinology 192:615-626; 2007.
61. Zou, M. H.; Cohen, R.; Ullrich, V. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium 11:89-97; 2004.
62. Alom-Ruiz, S. P.; Anilkumar, N.; Shah, A. M. Reactive oxygen species and endothelial activation. Antioxid Redox Signal 10:1089-1100; 2008.
63. Kisucka, J.; Chauhan, A. K.; Patten, I. S. et al. Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis. Circ Res 103:598-605; 2008.
64. Park, J. G.; Yoo, J. Y.; Jeong, S. J. et al. Peroxiredoxin 2 deficiency exacerbates atherosclerosis in apolipoprotein E-deficient mice. Circ Res 109:739-749; 2011.
65. Dong, Y.; Zhang, M.; Liang, B. et al. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation 121:792-803; 2010.
66. Vendrov, A. E.; Madamanchi, N. R.; Niu, X. L. et al. NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. J Biol Chem 285:26545-26557; 2010.
67. Mitra, S.; Deshmukh, A.; Sachdeva, R. et al. Oxidized low-density lipoprotein and atherosclerosis implications in antioxidant therapy. The American journal of the medical sciences 342:135-142; 2011.
68. Qiao, M.; Zhao, Q.; Lee, C. F. et al. Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 29:1779-1786; 2009.
69. Hulsmans, M.; De Keyzer, D.; Holvoet, P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. FASEB J 25:2515-2527; 2011.
70. Fang, Y.; Shi, C.; Manduchi, E. et al. MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro. Proc Natl Acad Sci U S A 107:13450-13455; 2010.