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Volumn 129, Issue 11, 2017, Pages 1420-1427

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE INHIBITOR;

EID: 85015822266     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-09-731893     Document Type: Review
Times cited : (530)

References (103)
  • 2
    • 0041411106 scopus 로고    scopus 로고
    • Diagnosis and treatment of systemic mastocytosis: State of the art
    • Valent P, Akin C, Sperr WR, et al. Diagnosis and treatment of systemic mastocytosis: state of the art. Br J Haematol. 2003;122(5):695-717.
    • (2003) Br J Haematol. , vol.122 , Issue.5 , pp. 695-717
    • Valent, P.1    Akin, C.2    Sperr, W.R.3
  • 3
    • 51649115383 scopus 로고    scopus 로고
    • Mast cells and mastocytosis
    • Metcalfe DD. Mast cells and mastocytosis. Blood. 2008;112(4):946-956.
    • (2008) Blood , vol.112 , Issue.4 , pp. 946-956
    • Metcalfe, D.D.1
  • 4
    • 0021804366 scopus 로고
    • Bone marrow findings in systemic mastocytosis
    • Horny HP, Parwaresch MR, Lennert K. Bone marrow findings in systemic mastocytosis. Hum Pathol. 1985;16(8):808-814.
    • (1985) Hum Pathol. , vol.16 , Issue.8 , pp. 808-814
    • Horny, H.P.1    Parwaresch, M.R.2    Lennert, K.3
  • 5
    • 0034986344 scopus 로고    scopus 로고
    • Diagnosis of mastocytosis: General histopathological aspects, morphological criteria, and immunohistochemical findings
    • Horny HP, Valent P. Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings. Leuk Res. 2001;25(7):543-551.
    • (2001) Leuk Res. , vol.25 , Issue.7 , pp. 543-551
    • Horny, H.P.1    Valent, P.2
  • 6
    • 0025921178 scopus 로고
    • Classification and diagnosis of mastocytosis: Current status
    • Metcalfe DD. Classification and diagnosis of mastocytosis: current status. J Invest Dermatol. 1991;96(3):2S-4S.
    • (1991) J Invest Dermatol. , vol.96 , Issue.3 , pp. 2S-4S
    • Metcalfe, D.D.1
  • 7
    • 0029986256 scopus 로고    scopus 로고
    • Biology, classification and treatment of human mastocytosis
    • Valent P. Biology, classification and treatment of human mastocytosis. Wien Klin Wochenschr. 1996;108(13):385-397.
    • (1996) Wien Klin Wochenschr. , vol.108 , Issue.13 , pp. 385-397
    • Valent, P.1
  • 8
    • 0034983045 scopus 로고    scopus 로고
    • Diagnostic criteria and classification of mastocytosis: A consensus proposal
    • Valent P, Horny HP, Escribano L, et al. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001;25(7):603-625.
    • (2001) Leuk Res. , vol.25 , Issue.7 , pp. 603-625
    • Valent, P.1    Horny, H.P.2    Escribano, L.3
  • 11
    • 34249333084 scopus 로고    scopus 로고
    • Standards and standardization in mastocytosis: Consensus statements on diagnostics, treatment recommendations and response criteria
    • Valent P, Akin C, Escribano L, et al. Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria. Eur J Clin Invest. 2007;37(6):435-453.
    • (2007) Eur J Clin Invest. , vol.37 , Issue.6 , pp. 435-453
    • Valent, P.1    Akin, C.2    Escribano, L.3
  • 12
    • 0000675424 scopus 로고
    • Rare forms of urticaria
    • Nettleship E, Tay W. Rare forms of urticaria. Br Med J. 1869;2:323-324.
    • (1869) Br Med J. , vol.2 , pp. 323-324
    • Nettleship, E.1    Tay, W.2
  • 13
    • 0001424675 scopus 로고
    • Urticaria pigmentosa; A report of a case with autopsy
    • Ellis JM. Urticaria pigmentosa; a report of a case with autopsy. Arch Pathol (Chic). 1949;48(5): 426-435.
    • (1949) Arch Pathol (Chic) , vol.48 , Issue.5 , pp. 426-435
    • Ellis, J.M.1
  • 14
    • 0000124580 scopus 로고
    • The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases
    • Caplan RM. The natural course of urticaria pigmentosa. Analysis and follow-up of 112 cases. Arch Dermatol. 1963;87:146-157.
    • (1963) Arch Dermatol. , vol.87 , pp. 146-157
    • Caplan, R.M.1
  • 16
    • 77955642537 scopus 로고    scopus 로고
    • Pathogenesis, classification and treatment of mastocytosis: State of the art in 2010 and future perspectives
    • Arock M, Valent P. Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives. Expert Rev Hematol. 2010;3(4):497-516.
    • (2010) Expert Rev Hematol. , vol.3 , Issue.4 , pp. 497-516
    • Arock, M.1    Valent, P.2
  • 17
    • 84935119657 scopus 로고    scopus 로고
    • Mast cells, mastocytosis, and related disorders
    • Theoharides TC, Valent P, Akin C. Mast cells, mastocytosis, and related disorders. N Engl J Med. 2015;373(2):163-172.
    • (2015) N Engl J Med. , vol.373 , Issue.2 , pp. 163-172
    • Theoharides, T.C.1    Valent, P.2    Akin, C.3
  • 18
    • 0028856070 scopus 로고
    • Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder
    • Nagata H, Worobec AS, Oh CK, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder. Proc Natl Acad Sci USA. 1995;92(23): 10560-10564.
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.23 , pp. 10560-10564
    • Nagata, H.1    Worobec, A.S.2    Oh, C.K.3
  • 19
    • 0009013631 scopus 로고    scopus 로고
    • Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: Establishment of clonality in a human mast cell neoplasm
    • Longley BJ, Tyrrell L, Lu SZ, et al. Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm. Nat Genet. 1996;12(3):312-314.
    • (1996) Nat Genet. , vol.12 , Issue.3 , pp. 312-314
    • Longley, B.J.1    Tyrrell, L.2    Lu, S.Z.3
  • 20
    • 0035010149 scopus 로고    scopus 로고
    • Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis
    • Fritsche-Polanz R, Jordan JH, Feix A, et al. Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis. Br J Haematol. 2001;113(2): 357-364.
    • (2001) Br J Haematol. , vol.113 , Issue.2 , pp. 357-364
    • Fritsche-Polanz, R.1    Jordan, J.H.2    Feix, A.3
  • 21
    • 0031682307 scopus 로고    scopus 로고
    • Diagnostic value of immunostaining for tryptase in patients with mastocytosis
    • Horny HP, Sillaber C, Menke D, et al. Diagnostic value of immunostaining for tryptase in patients with mastocytosis. Am J Surg Pathol. 1998; 22(9):1132-1140.
    • (1998) Am J Surg Pathol. , vol.22 , Issue.9 , pp. 1132-1140
    • Horny, H.P.1    Sillaber, C.2    Menke, D.3
  • 22
    • 0032523149 scopus 로고    scopus 로고
    • Indolent systemic mast cell disease in adults: Immunophenotypic characterization of bone marrow mast cells and its diagnostic implications
    • Escribano L, Orfao A, Díaz-Agustin B, et al. Indolent systemic mast cell disease in adults: immunophenotypic characterization of bone marrow mast cells and its diagnostic implications. Blood. 1998;91(8):2731-2736.
    • (1998) Blood , vol.91 , Issue.8 , pp. 2731-2736
    • Escribano, L.1    Orfao, A.2    Díaz-Agustin, B.3
  • 23
    • 0033932870 scopus 로고    scopus 로고
    • Serum tryptase and the laboratory diagnosis of systemic mastocytosis
    • Schwartz LB, Irani AM. Serum tryptase and the laboratory diagnosis of systemic mastocytosis. Hematol Oncol Clin North Am. 2000;14(3): 641-657.
    • (2000) Hematol Oncol Clin North Am. , vol.14 , Issue.3 , pp. 641-657
    • Schwartz, L.B.1    Irani, A.M.2
  • 24
    • 0034983239 scopus 로고    scopus 로고
    • Morphologic properties of neoplastic mast cells: Delineation of stages of maturation and implication for cytological grading of mastocytosis
    • Sperr WR, Escribano L, Jordan JH, et al. Morphologic properties of neoplastic mast cells: delineation of stages of maturation and implication for cytological grading of mastocytosis. Leuk Res. 2001;25(7):529-536.
    • (2001) Leuk Res. , vol.25 , Issue.7 , pp. 529-536
    • Sperr, W.R.1    Escribano, L.2    Jordan, J.H.3
  • 25
    • 0032846837 scopus 로고    scopus 로고
    • Recent advances in mastocytosis research. Summary of the Vienna Mastocytosis meeting 1998
    • Valent P, Escribano L, Parwaresch RM, et al. Recent advances in mastocytosis research. Summary of the Vienna Mastocytosis Meeting 1998. Int Arch Allergy Immunol. 1999;120(1):1-7.
    • (1999) Int Arch Allergy Immunol. , vol.120 , Issue.1 , pp. 1-7
    • Valent, P.1    Escribano, L.2    Parwaresch, R.M.3
  • 26
    • 84974560145 scopus 로고    scopus 로고
    • The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
    • Arber DA, Orazi A, Hasserjian R, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405.
    • (2016) Blood , vol.127 , Issue.20 , pp. 2391-2405
    • Arber, D.A.1    Orazi, A.2    Hasserjian, R.3
  • 28
    • 84953637134 scopus 로고    scopus 로고
    • Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; The American Academy of Allergy, Asthma & Immunology; And the European Academy of Allergology and Clinical Immunology
    • Hartmann K, Escribano L, Grattan C, et al. Cutaneous manifestations in patients with mastocytosis: consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology. J Allergy Clin Immunol. 2016;137(1):35-45.
    • (2016) J Allergy Clin Immunol. , vol.137 , Issue.1 , pp. 35-45
    • Hartmann, K.1    Escribano, L.2    Grattan, C.3
  • 29
    • 84905257819 scopus 로고    scopus 로고
    • Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): A consensus proposal
    • Valent P, Sotlar K, Sperr WR, et al. Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal. Ann Oncol. 2014; 25(9):1691-1700.
    • (2014) Ann Oncol. , vol.25 , Issue.9 , pp. 1691-1700
    • Valent, P.1    Sotlar, K.2    Sperr, W.R.3
  • 30
    • 67651120132 scopus 로고    scopus 로고
    • Systemic mastocytosis in 342 consecutive adults: Survival studies and prognostic factors
    • Lim KH, Tefferi A, Lasho TL, et al. Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Blood. 2009; 113(23):5727-5736.
    • (2009) Blood , vol.113 , Issue.23 , pp. 5727-5736
    • Lim, K.H.1    Tefferi, A.2    Lasho, T.L.3
  • 31
    • 69349102308 scopus 로고    scopus 로고
    • Prognosis in adult indolent systemic mastocytosis: A long-term study of the Spanish Network on Mastocytosis in a series of 145 patients
    • Escribano L, Alvarez-Twose I, Sánchez-Muñoz L, et al. Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients. J Allergy Clin Immunol. 2009;124(3): 514-521.
    • (2009) J Allergy Clin Immunol. , vol.124 , Issue.3 , pp. 514-521
    • Escribano, L.1    Alvarez-Twose, I.2    Sánchez-Muñoz, L.3
  • 32
    • 70449706224 scopus 로고    scopus 로고
    • Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies
    • Pardanani A, Lim KH, Lasho TL, et al. Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies. Blood. 2009; 114(18):3769-3772.
    • (2009) Blood , vol.114 , Issue.18 , pp. 3769-3772
    • Pardanani, A.1    Lim, K.H.2    Lasho, T.L.3
  • 33
    • 74949103091 scopus 로고    scopus 로고
    • WHO subvariants of indolent mastocytosis: Clinical details and prognostic evaluation in 159 consecutive adults
    • Pardanani A, Lim KH, Lasho TL, et al. WHO subvariants of indolent mastocytosis: clinical details and prognostic evaluation in 159 consecutive adults. Blood. 2010;115(1):150-151.
    • (2010) Blood , vol.115 , Issue.1 , pp. 150-151
    • Pardanani, A.1    Lim, K.H.2    Lasho, T.L.3
  • 35
    • 84920459044 scopus 로고    scopus 로고
    • Chronic mast cell leukemia: A novel leukemia-variant with distinct morphological and clinical features
    • Valent P, Sotlar K, Sperr WR, Reiter A, Arock M, Horny HP. Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features. Leuk Res. 2015;39(1):1-5.
    • (2015) Leuk Res. , vol.39 , Issue.1 , pp. 1-5
    • Valent, P.1    Sotlar, K.2    Sperr, W.R.3    Reiter, A.4    Arock, M.5    Horny, H.P.6
  • 36
    • 84930573118 scopus 로고    scopus 로고
    • KIT mutation analysis in mast cell neoplasms: Recommendations of the European Competence Network on Mastocytosis
    • Arock M, Sotlar K, Akin C, et al. KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis. Leukemia. 2015; 29(6):1223-1232.
    • (2015) Leukemia , vol.29 , Issue.6 , pp. 1223-1232
    • Arock, M.1    Sotlar, K.2    Akin, C.3
  • 37
    • 45949102957 scopus 로고    scopus 로고
    • Unique effects of KIT D816V in BaF3 cells: Induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens
    • Mayerhofer M, Gleixner KV, Hoelbl A, et al. Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens. J Immunol. 2008;180(8):5466-5476.
    • (2008) J Immunol. , vol.180 , Issue.8 , pp. 5466-5476
    • Mayerhofer, M.1    Gleixner, K.V.2    Hoelbl, A.3
  • 38
    • 29144489542 scopus 로고    scopus 로고
    • Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation
    • Zappulla JP, Dubreuil P, Desbois S, et al. Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation. J Exp Med. 2005;202(12):1635-1641.
    • (2005) J Exp Med. , vol.202 , Issue.12 , pp. 1635-1641
    • Zappulla, J.P.1    Dubreuil, P.2    Desbois, S.3
  • 39
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; Kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y, Zeng S, Metcalfe DD, et al. The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood. 2002;99(5):1741-1744.
    • (2002) Blood , vol.99 , Issue.5 , pp. 1741-1744
    • Ma, Y.1    Zeng, S.2    Metcalfe, D.D.3
  • 40
    • 0043169405 scopus 로고    scopus 로고
    • Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit
    • Akin C, Brockow K, D'Ambrosio C, et al. Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit. Exp Hematol. 2003;31(8):686-692.
    • (2003) Exp Hematol. , vol.31 , Issue.8 , pp. 686-692
    • Akin, C.1    Brockow, K.2    D'Ambrosio, C.3
  • 41
    • 1842579440 scopus 로고    scopus 로고
    • A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib
    • Akin C, Fumo G, Yavuz AS, Lipsky PE, Neckers L, Metcalfe DD. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood. 2004;103(8): 3222-3225.
    • (2004) Blood , vol.103 , Issue.8 , pp. 3222-3225
    • Akin, C.1    Fumo, G.2    Yavuz, A.S.3    Lipsky, P.E.4    Neckers, L.5    Metcalfe, D.D.6
  • 42
    • 76649094569 scopus 로고    scopus 로고
    • Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    • Bodemer C, Hermine O, Palmérini F, et al. Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol. 2010; 130(3):804-815.
    • (2010) J Invest Dermatol. , vol.130 , Issue.3 , pp. 804-815
    • Bodemer, C.1    Hermine, O.2    Palmérini, F.3
  • 43
    • 32844455834 scopus 로고    scopus 로고
    • A novel K509I mutation of KIT identified in familial mastocytosis-in vitro and in vivo responsiveness to imatinib therapy
    • Zhang LY, Smith ML, Schultheis B, et al. A novel K509I mutation of KIT identified in familial mastocytosis-in vitro and in vivo responsiveness to imatinib therapy. Leuk Res. 2006;30(4): 373-378.
    • (2006) Leuk Res. , vol.30 , Issue.4 , pp. 373-378
    • Zhang, L.Y.1    Smith, M.L.2    Schultheis, B.3
  • 44
    • 84862252300 scopus 로고    scopus 로고
    • Complete response after imatinib mesylate therapy in a patient with well-differentiated systemic mastocytosis
    • Alvarez-Twose I, González P, Morgado JM, et al. Complete response after imatinib mesylate therapy in a patient with well-differentiated systemic mastocytosis. J Clin Oncol. 2012; 30(12):e126-e129.
    • (2012) J Clin Oncol. , vol.30 , Issue.12 , pp. e126-e129
    • Alvarez-Twose, I.1    González, P.2    Morgado, J.M.3
  • 45
    • 84908024600 scopus 로고    scopus 로고
    • Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412
    • de Melo Campos P, Machado-Neto JA, Scopim-Ribeiro R, et al. Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412. Leuk Res. 2014;38(10):1245-1251.
    • (2014) Leuk Res. , vol.38 , Issue.10 , pp. 1245-1251
    • De Melo-Campos, P.1    Machado-Neto, J.A.2    Scopim-Ribeiro, R.3
  • 46
    • 55249107643 scopus 로고    scopus 로고
    • Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade
    • Harir N, Boudot C, Friedbichler K, et al. Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood. 2008;112(6):2463-2473.
    • (2008) Blood , vol.112 , Issue.6 , pp. 2463-2473
    • Harir, N.1    Boudot, C.2    Friedbichler, K.3
  • 47
    • 84856396314 scopus 로고    scopus 로고
    • The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils
    • Blatt K, Herrmann H, Mirkina I, et al. The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils. PLoS One. 2012;7(1):e29925.
    • (2012) PLoS One , vol.7 , Issue.1 , pp. e29925
    • Blatt, K.1    Herrmann, H.2    Mirkina, I.3
  • 48
    • 33746611521 scopus 로고    scopus 로고
    • Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
    • Gabillot-Carré M, Lepelletier Y, Humbert M, et al. Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells. Blood. 2006; 108(3):1065-1072.
    • (2006) Blood , vol.108 , Issue.3 , pp. 1065-1072
    • Gabillot-Carré, M.1    Lepelletier, Y.2    Humbert, M.3
  • 49
    • 73549084274 scopus 로고    scopus 로고
    • Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: Subcellular distribution and role of the transforming oncoprotein KIT D816V
    • Baumgartner C, Cerny-Reiterer S, Sonneck K, et al. Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V. Am J Pathol. 2009;175(6):2416-2429.
    • (2009) Am J Pathol. , vol.175 , Issue.6 , pp. 2416-2429
    • Baumgartner, C.1    Cerny-Reiterer, S.2    Sonneck, K.3
  • 50
    • 34948836275 scopus 로고    scopus 로고
    • The tyrosine kinase FES is an essential effector of KITD816V proliferation signal
    • Voisset E, Lopez S, Dubreuil P, De Sepulveda P. The tyrosine kinase FES is an essential effector of KITD816V proliferation signal. Blood. 2007; 110(7):2593-2599.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2593-2599
    • Voisset, E.1    Lopez, S.2    Dubreuil, P.3    De Sepulveda, P.4
  • 51
    • 84959359802 scopus 로고    scopus 로고
    • Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth
    • Peter B, Winter GE, Blatt K, et al. Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth. Leukemia. 2016;30(2):464-472.
    • (2016) Leukemia , vol.30 , Issue.2 , pp. 464-472
    • Peter, B.1    Winter, G.E.2    Blatt, K.3
  • 52
    • 76349119028 scopus 로고    scopus 로고
    • Experience with everolimus (RAD001), an oral mammalian target of rapamycin inhibitor, in patients with systemic mastocytosis
    • Parikh SA, Kantarjian HM, Richie MA, Cortes JE, Verstovsek S. Experience with everolimus (RAD001), an oral mammalian target of rapamycin inhibitor, in patients with systemic mastocytosis. Leuk Lymphoma. 2010;51(2): 269-274.
    • (2010) Leuk Lymphoma. , vol.51 , Issue.2 , pp. 269-274
    • Parikh, S.A.1    Kantarjian, H.M.2    Richie, M.A.3    Cortes, J.E.4    Verstovsek, S.5
  • 53
    • 84865062086 scopus 로고    scopus 로고
    • Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis
    • Traina F, Visconte V, Jankowska AM, et al. Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis. PLoS One. 2012;7(8):e43090.
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e43090
    • Traina, F.1    Visconte, V.2    Jankowska, A.M.3
  • 54
    • 79952336888 scopus 로고    scopus 로고
    • Clonal analysis of NRAS activating mutations in KITD816V systemic mastocytosis
    • Wilson TM, Maric I, Simakova O, et al. Clonal analysis of NRAS activating mutations in KITD816V systemic mastocytosis. Haematologica. 2011;96(3):459-463.
    • (2011) Haematologica , vol.96 , Issue.3 , pp. 459-463
    • Wilson, T.M.1    Maric, I.2    Simakova, O.3
  • 55
    • 84887658376 scopus 로고    scopus 로고
    • Comprehensive mutational profiling in advanced systemic mastocytosis
    • Schwaab J, Schnittger S, Sotlar K, et al. Comprehensive mutational profiling in advanced systemic mastocytosis. Blood. 2013;122(14): 2460-2466.
    • (2013) Blood , vol.122 , Issue.14 , pp. 2460-2466
    • Schwaab, J.1    Schnittger, S.2    Sotlar, K.3
  • 56
    • 84896535727 scopus 로고    scopus 로고
    • ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases
    • Damaj G, Joris M, Chandesris O, et al. ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. PLoS One. 2014;9(1): e85362.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e85362
    • Damaj, G.1    Joris, M.2    Chandesris, O.3
  • 57
    • 80051879352 scopus 로고    scopus 로고
    • KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: Role of Lyn and Btk activation and disruption by dasatinib and bosutinib
    • Gleixner KV, Mayerhofer M, Cerny-Reiterer S, et al. KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. Blood. 2011;118(7):1885-1898.
    • (2011) Blood , vol.118 , Issue.7 , pp. 1885-1898
    • Gleixner, K.V.1    Mayerhofer, M.2    Cerny-Reiterer, S.3
  • 58
    • 38749092150 scopus 로고    scopus 로고
    • Systemic mastocytosis associated with chronic idiopathic myelofibrosis: A distinct subtype of systemic mastocytosis associated with a clonal hematological non-mast cell lineage disorder carrying the activating point mutations KITD816V and JAK2V617F
    • Sotlar K, Bache A, Stellmacher F, Bültmann B, Valent P, Horny HP. Systemic mastocytosis associated with chronic idiopathic myelofibrosis: a distinct subtype of systemic mastocytosis associated with a clonal hematological non-mast cell lineage disorder carrying the activating point mutations KITD816V and JAK2V617F. J Mol Diagn. 2008;10(1):58-66.
    • (2008) J Mol Diagn. , vol.10 , Issue.1 , pp. 58-66
    • Sotlar, K.1    Bache, A.2    Stellmacher, F.3    Bültmann, B.4    Valent, P.5    Horny, H.P.6
  • 59
    • 84865696666 scopus 로고    scopus 로고
    • Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations
    • Broesby-Olsen S, Kristensen TK, Møller MB, Bindslev-Jensen C, Vestergaard H; Mastocytosis Centre, Odense University Hospital (MastOUH). Adult-onset systemic mastocytosis in monozygotic twins with KIT D816V and JAK2 V617F mutations. J Allergy Clin Immunol. 2012;130(3):806-808.
    • (2012) J Allergy Clin Immunol. , vol.130 , Issue.3 , pp. 806-808
    • Broesby-Olsen, S.1    Kristensen, T.K.2    Møller, M.B.3    Bindslev-Jensen, C.4    Vestergaard, H.5
  • 60
    • 84860827822 scopus 로고    scopus 로고
    • 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: Role of FASdemethylation and FAS re-expression, and synergism with FAS-ligand
    • Ghanim V, Herrmann H, Heller G, et al. 5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FASdemethylation and FAS re-expression, and synergism with FAS-ligand. Blood. 2012; 119(18):4242-4252.
    • (2012) Blood , vol.119 , Issue.18 , pp. 4242-4252
    • Ghanim, V.1    Herrmann, H.2    Heller, G.3
  • 61
    • 84946500898 scopus 로고    scopus 로고
    • Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia
    • Wedeh G, Cerny-Reiterer S, Eisenwort G, et al. Identification of bromodomain-containing protein-4 as a novel marker and epigenetic target in mast cell leukemia. Leukemia. 2015;29(11): 2230-2237.
    • (2015) Leukemia , vol.29 , Issue.11 , pp. 2230-2237
    • Wedeh, G.1    Cerny-Reiterer, S.2    Eisenwort, G.3
  • 62
    • 33947579975 scopus 로고    scopus 로고
    • Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: Inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412
    • Aichberger KJ, Mayerhofer M, Gleixner KV, et al. Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412. Blood. 2007;109(7):3031-3041.
    • (2007) Blood , vol.109 , Issue.7 , pp. 3031-3041
    • Aichberger, K.J.1    Mayerhofer, M.2    Gleixner, K.V.3
  • 63
    • 1642541150 scopus 로고    scopus 로고
    • 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells
    • Fumo G, Akin C, Metcalfe DD, Neckers L. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells. Blood. 2004;103(3):1078-1084.
    • (2004) Blood , vol.103 , Issue.3 , pp. 1078-1084
    • Fumo, G.1    Akin, C.2    Metcalfe, D.D.3    Neckers, L.4
  • 64
    • 34547111574 scopus 로고    scopus 로고
    • Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells
    • Kondo R, Gleixner KV, Mayerhofer M, et al. Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells. Blood. 2007;110(2): 661-669.
    • (2007) Blood , vol.110 , Issue.2 , pp. 661-669
    • Kondo, R.1    Gleixner, K.V.2    Mayerhofer, M.3
  • 65
    • 33745899005 scopus 로고    scopus 로고
    • CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders
    • Santos DD, Hatjiharissi E, Tournilhac O, et al. CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's macroglobulinemia and mast cell disorders. Clin Lymphoma Myeloma. 2006;6(6):478-483.
    • (2006) Clin Lymphoma Myeloma. , vol.6 , Issue.6 , pp. 478-483
    • Santos, D.D.1    Hatjiharissi, E.2    Tournilhac, O.3
  • 66
    • 33845782440 scopus 로고    scopus 로고
    • Effects of the CD33-targeted drug gemtuzumab ozogamicin (Mylotarg) on growth and mediator secretion in human mast cells and blood basophils
    • Krauth MT, Böhm A, Agis H, et al. Effects of the CD33-targeted drug gemtuzumab ozogamicin (Mylotarg) on growth and mediator secretion in human mast cells and blood basophils. Exp Hematol. 2007;35(1):108-116.
    • (2007) Exp Hematol. , vol.35 , Issue.1 , pp. 108-116
    • Krauth, M.T.1    Böhm, A.2    Agis, H.3
  • 67
    • 79953331926 scopus 로고    scopus 로고
    • Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis
    • Sotlar K, Cerny-Reiterer S, Petat-Dutter K, et al. Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis. Mod Pathol. 2011;24(4):585-595.
    • (2011) Mod Pathol. , vol.24 , Issue.4 , pp. 585-595
    • Sotlar, K.1    Cerny-Reiterer, S.2    Petat-Dutter, K.3
  • 68
    • 84887816251 scopus 로고    scopus 로고
    • CD30 expression by bone marrow mast cells from different diagnostic variants of systemic mastocytosis
    • Morgado JM, Perbellini O, Johnson RC, et al. CD30 expression by bone marrow mast cells from different diagnostic variants of systemic mastocytosis. Histopathology. 2013;63(6): 780-787.
    • (2013) Histopathology , vol.63 , Issue.6 , pp. 780-787
    • Morgado, J.M.1    Perbellini, O.2    Johnson, R.C.3
  • 69
    • 84905233373 scopus 로고    scopus 로고
    • CD52 is a molecular target in advanced systemic mastocytosis
    • Hoermann G, Blatt K, Greiner G, et al. CD52 is a molecular target in advanced systemic mastocytosis. FASEB J. 2014;28(8):3540-3551.
    • (2014) FASEB J. , vol.28 , Issue.8 , pp. 3540-3551
    • Hoermann, G.1    Blatt, K.2    Greiner, G.3
  • 70
    • 84954515495 scopus 로고    scopus 로고
    • Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis
    • Blatt K, Cerny-Reiterer S, Schwaab J, et al. Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis. Blood. 2015;126(26):2832-2841.
    • (2015) Blood , vol.126 , Issue.26 , pp. 2832-2841
    • Blatt, K.1    Cerny-Reiterer, S.2    Schwaab, J.3
  • 71
    • 84937023038 scopus 로고    scopus 로고
    • Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells
    • Pardanani A, Lasho T, Chen D, et al. Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells. Leukemia. 2015;29(7): 1605-1608.
    • (2015) Leukemia , vol.29 , Issue.7 , pp. 1605-1608
    • Pardanani, A.1    Lasho, T.2    Chen, D.3
  • 72
    • 85015869910 scopus 로고    scopus 로고
    • Successful treatment of systemic mastocytosis associated with AML-M2, t(8:21) in a child using MRC-based AML chemotherapy along with gemtuzumab
    • Jeong DK, Fauman K, Ross C, Akin C, Mody R. Successful treatment of systemic mastocytosis associated with AML-M2, t(8:21) in a child using MRC-based AML chemotherapy along with gemtuzumab. J Allergy Clin Immunol. 2007; 119(S1):207.
    • (2007) J Allergy Clin Immunol. , vol.119 , Issue.S1 , pp. 207
    • Jeong, D.K.1    Fauman, K.2    Ross, C.3    Akin, C.4    Mody, R.5
  • 73
    • 84959553201 scopus 로고    scopus 로고
    • Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia
    • Alvarez-Twose I, Martínez-Barranco P, Gotlib J, et al. Complete response to gemtuzumab ozogamicin in a patient with refractory mast cell leukemia. Leukemia. 2016;30(8):1753-1756.
    • (2016) Leukemia , vol.30 , Issue.8 , pp. 1753-1756
    • Alvarez-Twose, I.1    Martínez-Barranco, P.2    Gotlib, J.3
  • 74
    • 84953407413 scopus 로고    scopus 로고
    • Expression of programmed cell death ligand-1 in mastocytosis correlates with disease severity
    • Rabenhorst A, Leja S, Schwaab J, et al. Expression of programmed cell death ligand-1 in mastocytosis correlates with disease severity. J Allergy Clin Immunol. 2016;137(1):314-318.
    • (2016) J Allergy Clin Immunol. , vol.137 , Issue.1 , pp. 314-318
    • Rabenhorst, A.1    Leja, S.2    Schwaab, J.3
  • 75
    • 78951476130 scopus 로고    scopus 로고
    • Targeting of leukemia-initiating cells to develop curative drug therapies: Straightforward but nontrivial concept
    • Valent P. Targeting of leukemia-initiating cells to develop curative drug therapies: straightforward but nontrivial concept. Curr Cancer Drug Targets. 2011;11(1):56-71.
    • (2011) Curr Cancer Drug Targets. , vol.11 , Issue.1 , pp. 56-71
    • Valent, P.1
  • 76
    • 84943557479 scopus 로고    scopus 로고
    • Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells
    • Pelosi E, Castelli G, Testa U. Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells. Blood Cells Mol Dis. 2015;55(4):336-346.
    • (2015) Blood Cells Mol Dis. , vol.55 , Issue.4 , pp. 336-346
    • Pelosi, E.1    Castelli, G.2    Testa, U.3
  • 77
    • 85015911806 scopus 로고    scopus 로고
    • Identification of a neoplastic stem cell in human mast cell leukemia
    • Eisenwort G, Peter B, Blatt K, et al. Identification of a neoplastic stem cell in human mast cell leukemia. Blood. 2014;124(21):817.
    • (2014) Blood , vol.124 , Issue.21 , pp. 817
    • Eisenwort, G.1    Peter, B.2    Blatt, K.3
  • 78
    • 0026570013 scopus 로고
    • Response to interferon alfa-2b in a patient with systemic mastocytosis
    • Kluin-Nelemans HC, Jansen JH, Breukelman H, et al. Response to interferon alfa-2b in a patient with systemic mastocytosis. N Engl J Med. 1992; 326(9):619-623.
    • (1992) N Engl J Med. , vol.326 , Issue.9 , pp. 619-623
    • Kluin-Nelemans, H.C.1    Jansen, J.H.2    Breukelman, H.3
  • 79
    • 0036454699 scopus 로고    scopus 로고
    • Treatment of adult systemic mastocytosis with interferon-alpha: Results of a multicentre phase II trial on 20 patients
    • Casassus P, Caillat-Vigneron N, Martin A, et al. Treatment of adult systemic mastocytosis with interferon-alpha: results of a multicentre phase II trial on 20 patients. Br J Haematol. 2002;119(4): 1090-1097.
    • (2002) Br J Haematol. , vol.119 , Issue.4 , pp. 1090-1097
    • Casassus, P.1    Caillat-Vigneron, N.2    Martin, A.3
  • 80
    • 73349111582 scopus 로고    scopus 로고
    • Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine
    • Lim KH, Pardanani A, Butterfield JH, Li CY, Tefferi A. Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine. Am J Hematol. 2009;84(12):790-794.
    • (2009) Am J Hematol. , vol.84 , Issue.12 , pp. 790-794
    • Lim, K.H.1    Pardanani, A.2    Butterfield, J.H.3    Li, C.Y.4    Tefferi, A.5
  • 81
    • 0345167915 scopus 로고    scopus 로고
    • Cladribine therapy for systemic mastocytosis
    • Kluin-Nelemans HC, Oldhoff JM, Van Doormaal JJ, et al. Cladribine therapy for systemic mastocytosis. Blood. 2003;102(13):4270-4276.
    • (2003) Blood , vol.102 , Issue.13 , pp. 4270-4276
    • Kluin-Nelemans, H.C.1    Oldhoff, J.M.2    Van Doormaal, J.J.3
  • 82
    • 84940099838 scopus 로고    scopus 로고
    • Longterm efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis
    • quiz 1050
    • Barete S, Lortholary O, Damaj G, et al. Longterm efficacy and safety of cladribine (2-CdA) in adult patients with mastocytosis. Blood. 2015; 126(8):1009-1016, quiz 1050.
    • (2015) Blood , vol.126 , Issue.8 , pp. 1009-1016
    • Barete, S.1    Lortholary, O.2    Damaj, G.3
  • 83
    • 84905257818 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation for advanced systemic mastocytosis
    • Ustun C, Reiter A, Scott BL, et al. Hematopoietic stem-cell transplantation for advanced systemic mastocytosis. J Clin Oncol. 2014;32(29): 3264-3274.
    • (2014) J Clin Oncol. , vol.32 , Issue.29 , pp. 3264-3274
    • Ustun, C.1    Reiter, A.2    Scott, B.L.3
  • 84
    • 84981311900 scopus 로고    scopus 로고
    • Consensus opinion on allogeneic hematopoietic cell transplantation in advanced systemic mastocytosis
    • Ustun C, Gotlib J, Popat U, et al. Consensus opinion on allogeneic hematopoietic cell transplantation in advanced systemic mastocytosis. Biol Blood Marrow Transplant. 2016;22(8):1348-1356.
    • (2016) Biol Blood Marrow Transplant. , vol.22 , Issue.8 , pp. 1348-1356
    • Ustun, C.1    Gotlib, J.2    Popat, U.3
  • 85
    • 18844478996 scopus 로고    scopus 로고
    • PKC412-A protein kinase inhibitor with a broad therapeutic potential
    • Fabbro D, Ruetz S, Bodis S, et al. PKC412-a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 2000;15(1): 17-28.
    • (2000) Anticancer Drug Des. , vol.15 , Issue.1 , pp. 17-28
    • Fabbro, D.1    Ruetz, S.2    Bodis, S.3
  • 86
    • 80051475544 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in the treatment of systemic mastocytosis
    • Ustun C, DeRemer DL, Akin C. Tyrosine kinase inhibitors in the treatment of systemic mastocytosis. Leuk Res. 2011;35(9):1143-1152.
    • (2011) Leuk Res. , vol.35 , Issue.9 , pp. 1143-1152
    • Ustun, C.1    DeRemer, D.L.2    Akin, C.3
  • 87
    • 22144455380 scopus 로고    scopus 로고
    • Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
    • Growney JD, Clark JJ, Adelsperger J, et al. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood. 2005;106(2): 721-724.
    • (2005) Blood , vol.106 , Issue.2 , pp. 721-724
    • Growney, J.D.1    Clark, J.J.2    Adelsperger, J.3
  • 88
    • 30444446680 scopus 로고    scopus 로고
    • PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816Vmutated variant of KIT: Comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
    • Gleixner KV, Mayerhofer M, Aichberger KJ, et al. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816Vmutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood. 2006;107(2):752-759.
    • (2006) Blood , vol.107 , Issue.2 , pp. 752-759
    • Gleixner, K.V.1    Mayerhofer, M.2    Aichberger, K.J.3
  • 89
    • 27144506215 scopus 로고    scopus 로고
    • Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
    • Gotlib J, Berubé C, Growney JD, et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood. 2005;106(8):2865-2870.
    • (2005) Blood , vol.106 , Issue.8 , pp. 2865-2870
    • Gotlib, J.1    Berubé, C.2    Growney, J.D.3
  • 90
    • 70350333277 scopus 로고    scopus 로고
    • Midostaurin (PKC412) inhibits immunoglobulin E-dependent activation and mediator release in human blood basophils and mast cells
    • Krauth MT, Mirkina I, Herrmann H, Baumgartner C, Kneidinger M, Valent P. Midostaurin (PKC412) inhibits immunoglobulin E-dependent activation and mediator release in human blood basophils and mast cells. Clin Exp Allergy. 2009; 39(11):1711-1720.
    • (2009) Clin Exp Allergy. , vol.39 , Issue.11 , pp. 1711-1720
    • Krauth, M.T.1    Mirkina, I.2    Herrmann, H.3    Baumgartner, C.4    Kneidinger, M.5    Valent, P.6
  • 91
    • 84976517053 scopus 로고    scopus 로고
    • Efficacy and safety of midostaurin in advancedsystemic mastocytosis
    • Gotlib J, Kluin-Nelemans HC, George TI, et al. Efficacy and safety of midostaurin in advancedsystemic mastocytosis. N Engl J Med. 2016;374(26):2530-2541.
    • (2016) N Engl J Med. , vol.374 , Issue.26 , pp. 2530-2541
    • Gotlib, J.1    Kluin-Nelemans, H.C.2    George, T.I.3
  • 92
    • 84976480011 scopus 로고    scopus 로고
    • Midostaurin in advanced systemic mastocytosis
    • Chandesris MO, Damaj G, Canioni D, et al; CEREMAST Study Group. Midostaurin in advanced systemic mastocytosis. N Engl J Med. 2016;374(26):2605-2607.
    • (2016) N Engl J Med. , vol.374 , Issue.26 , pp. 2605-2607
    • Chandesris, M.O.1    Damaj, G.2    Canioni, D.3
  • 93
    • 85015854839 scopus 로고    scopus 로고
    • Durable responses and improved quality of life with midostaurin (PKC412) in advanced systemic mastocytosis (SM): Updated stage 1 results of the global D2201 trial
    • Gotlib J, Kluin-Nelemans HC, George TI, et al. Durable responses and improved quality of life with midostaurin (PKC412) in advanced systemic mastocytosis (SM): updated stage 1 results of the global D2201 trial. Blood. 2013; 122:106.
    • (2013) Blood , vol.122 , pp. 106
    • Gotlib, J.1    Kluin-Nelemans, H.C.2    George, T.I.3
  • 94
    • 68649118339 scopus 로고    scopus 로고
    • Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis
    • Vega-Ruiz A, Cortes JE, Sever M, et al. Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis. Leuk Res. 2009; 33(11):1481-1484.
    • (2009) Leuk Res. , vol.33 , Issue.11 , pp. 1481-1484
    • Vega-Ruiz, A.1    Cortes, J.E.2    Sever, M.3
  • 95
    • 78649504351 scopus 로고    scopus 로고
    • Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: A phase 2a study
    • Paul C, Sans B, Suarez F, et al. Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study. Am J Hematol. 2010;85(12):921-925.
    • (2010) Am J Hematol. , vol.85 , Issue.12 , pp. 921-925
    • Paul, C.1    Sans, B.2    Suarez, F.3
  • 96
    • 84951567087 scopus 로고    scopus 로고
    • Nilotinib in patients with systemic mastocytosis: Analysis of the phase 2, open-label, single-arm nilotinib registration study
    • Hochhaus A, Baccarani M, Giles FJ, et al. Nilotinib in patients with systemic mastocytosis: analysis of the phase 2, open-label, single-arm nilotinib registration study. J Cancer Res Clin Oncol. 2015;141(11):2047-2060.
    • (2015) J Cancer Res Clin Oncol. , vol.141 , Issue.11 , pp. 2047-2060
    • Hochhaus, A.1    Baccarani, M.2    Giles, F.J.3
  • 97
    • 85149153049 scopus 로고    scopus 로고
    • Imatinib in systemic mastocytosis: A phase IV clinical trial in patients lacking exon 17 KIT mutations and review of the literature
    • [published online ahead of print 19 July 2016]
    • Alvarez-Twose I, Matito A, Morgado JM, et al. Imatinib in systemic mastocytosis: a phase IV clinical trial in patients lacking exon 17 KIT mutations and review of the literature [published online ahead of print 19 July 2016]. Oncotarget. doi:10.18632/oncotarget.10711.
    • Oncotarget
    • Alvarez-Twose, I.1    Matito, A.2    Morgado, J.M.3
  • 98
    • 84879188238 scopus 로고    scopus 로고
    • How I treat patients with indolent and smoldering mastocytosis (rare conditions but difficult to manage)
    • Pardanani A. How I treat patients with indolent and smoldering mastocytosis (rare conditions but difficult to manage). Blood. 2013;121(16): 3085-3094.
    • (2013) Blood , vol.121 , Issue.16 , pp. 3085-3094
    • Pardanani, A.1
  • 99
    • 84929129792 scopus 로고    scopus 로고
    • Current treatment options in patients with mastocytosis: Status in 2015 and future perspectives
    • Arock M, Akin C, Hermine O, Valent P. Current treatment options in patients with mastocytosis: status in 2015 and future perspectives. Eur J Haematol. 2015;94(6):474-490.
    • (2015) Eur J Haematol. , vol.94 , Issue.6 , pp. 474-490
    • Arock, M.1    Akin, C.2    Hermine, O.3    Valent, P.4
  • 100
    • 78650673033 scopus 로고    scopus 로고
    • How I treat patients with advanced systemic mastocytosis
    • Valent P, Sperr WR, Akin C. How I treat patients with advanced systemic mastocytosis. Blood. 2010;116(26):5812-5817.
    • (2010) Blood , vol.116 , Issue.26 , pp. 5812-5817
    • Valent, P.1    Sperr, W.R.2    Akin, C.3
  • 101
    • 82055186230 scopus 로고    scopus 로고
    • Severe life-threatening or disabling anaphylaxis in patients with systemic mastocytosis: A single-center experience
    • Wimazal F, Geissler P, Shnawa P, Sperr WR, Valent P. Severe life-threatening or disabling anaphylaxis in patients with systemic mastocytosis: a single-center experience. Int Arch Allergy Immunol. 2012;157(4):399-405.
    • (2012) Int Arch Allergy Immunol. , vol.157 , Issue.4 , pp. 399-405
    • Wimazal, F.1    Geissler, P.2    Shnawa, P.3    Sperr, W.R.4    Valent, P.5
  • 102
    • 0345772088 scopus 로고    scopus 로고
    • Aggressive systemic mastocytosis and related mast cell disorders: Current treatment options and proposed response criteria
    • Valent P, Akin C, Sperr WR, et al. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk Res. 2003; 27(7):635-641.
    • (2003) Leuk Res. , vol.27 , Issue.7 , pp. 635-641
    • Valent, P.1    Akin, C.2    Sperr, W.R.3
  • 103
    • 84878423607 scopus 로고    scopus 로고
    • International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis
    • Gotlib J, Pardanani A, Akin C, et al. International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis. Blood. 2013;121(13):2393-2401.
    • (2013) Blood , vol.121 , Issue.13 , pp. 2393-2401
    • Gotlib, J.1    Pardanani, A.2    Akin, C.3


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