A novel K509I mutation of KIT identified in familial mastocytosis - In vitro and in vivo responsiveness to imatinib therapy

Leukemia Research

Volumn 30, Issue 4, 2006, Pages 373-378

  Zhang, Ling Yan ^a   Smith, Matthew L ^b   Schultheis, Beate ^c   Fitzgibbon, Jude ^b   Lister, T Andrew ^b   Melo, Junia V ^c   Cross, Nicholas C P ^a   Cavenagh, Jamie D ^b  

^a WESSEX REGIONAL GENETICS LABORATORY   (United Kingdom)

^b ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Familial mastocytosis; Imatinib; K509I; KIT

Indexed keywords

IMATINIB; KIT ENZYME; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; CLINICAL FEATURE; DRUG EFFECT; DRUG SENSITIVITY; ENZYME ANALYSIS; EXON; FEMALE; GENE AMPLIFICATION; GENE CLUSTER; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; HUMAN; IMMUNOPHENOTYPING; MALE; MASTOCYTOSIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MASTOCYTOSIS; MUTATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RNA SPLICING;

EID: 32844455834     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2005.08.015     Document Type: Article

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