Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb

Circulation Research

Volumn 120, Issue 9, 2017, Pages 1466-1476

  Mathiyalagan, Prabhu ^a   Liang, Yaxuan ^a   Kim, David ^a,b   Misener, Sol ^b   Thorne, Tina ^b   Kamide, Christine E ^b   Klyachko, Ekaterina ^b   Losordo, Douglas W ^b,c   Hajjar, Roger J ^a   Sahoo, Susmita ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Caladrius Biosciences   (United States)

Author keywords

Cardiovascular disease; cell transplantation; exosomes; hindlimb; ischemia; microRNA; stem cells

Indexed keywords

ANGIOGENIC PROTEIN; ANGIOPOIETIN 1; ANGIOPOIETIN 2; CD34 ANTIGEN; CYCLIN A; CYCLIN B; GELATINASE B; LOCKED NUCLEIC ACID; MESSENGER RNA; MICRORNA; MICRORNA 126 3P; RIBOSOME RNA; RNA 18S; SPROUTY RELATED EVH1 DOMAIN CONTAINING PROTEIN 1; THROMBOSPONDIN 1; U6 RRNA; UNCLASSIFIED DRUG; VASCULOTROPIN; BIOLOGICAL MARKER; CONDITIONED MEDIUM; MIRN126 MICRORNA, HUMAN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL FUNCTION; CONDITIONED MEDIUM; CONTROLLED STUDY; EXOSOME; FIBROBLAST; GENE EXPRESSION REGULATION; GENE SILENCING; HINDLIMB; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LEG AMPUTATION; LEG ISCHEMIA; LIMB PERFUSION; LIMB SALVAGE; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; SMOOTH MUSCLE CELL; STABLE TRANSFECTION; STEM CELL; STEM CELL TRANSPLANTATION; TISSUE REPAIR; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; ANIMAL; BAGG ALBINO MOUSE; BLOOD FLOW; CELL CULTURE; CONVALESCENCE; DISEASE MODEL; ENDOTHELIAL PROGENITOR CELL; GENETIC TRANSFECTION; GENETICS; ISCHEMIA; METABOLISM; MOTOR ACTIVITY; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PHENOTYPE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TIME FACTOR; TRANSPLANTATION; VASCULARIZATION;

ANGIOGENIC PROTEINS; ANIMALS; ANTIGENS, CD34; BIOMARKERS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; ENDOTHELIAL PROGENITOR CELLS; EXOSOMES; GENE EXPRESSION REGULATION; HINDLIMB; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; ISCHEMIA; MICE, INBRED BALB C; MICRORNAS; MOTOR ACTIVITY; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; PARACRINE COMMUNICATION; PHENOTYPE; RECOVERY OF FUNCTION; REGIONAL BLOOD FLOW; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 85015663550     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.310557     Document Type: Article

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