Pericardial Fluid Exosomes: A New Material to Treat Cardiovascular Disease

Molecular Therapy

Volumn 25, Issue 3, 2017, Pages 568-569

  Sahoo, Susmita ^a   Mathiyalagan, Prabhu ^a   Hajjar, Roger J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA;

ANGIOGENESIS; AORTA VALVE REPLACEMENT; BLOOD FLOW; CARDIAC MUSCLE; CONGESTIVE CARDIOMYOPATHY; DISEASE COURSE; ENDOTHELIUM CELL; EXOSOME; GENE EXPRESSION; HEART DEVELOPMENT; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HUMAN; LIMB ISCHEMIA; NONHUMAN; PERICARDIAL EFFUSION; SHORT SURVEY; CARDIOVASCULAR DISEASE;

CARDIOVASCULAR DISEASES; EXOSOMES; HUMANS; PERICARDIAL EFFUSION; PERICARDIAL FLUID;

EID: 85016245175     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2017.02.002     Document Type: Short Survey

References (16)

1. 1 Sahoo, S., Losordo, D.W., Exosomes and cardiac repair after myocardial infarction. Circ. Res. 114 (2014), 333–344.
2. 2 Liang, Y., Sahoo, S., Exosomes explosion for cardiac resuscitation. J. Am. Coll. Cardiol. 66 (2015), 612–615.
3. 3 Gallet, R., Dawkins, J., Valle, J., Simsolo, E., de Couto, G., Middleton, R., Tseliou, E., Luthringer, D., Kreke, M., Smith, R.R., et al. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur. Heart J., 2016, ehw240.
4. 4 Beltrami, C., Besnier, M., Shantikumar, S., Shearn, A.I.U., Rajakaruna, C., Laftah, A., Sessa, F., Spinetti, G., Petretto, E., Angelini, G.D., Emanueli, C., Huamn peridardial fluid contains exosomes enriched with cardiovascular-expressed microRNAs and promotes therapeutic angiogenesis. Mol Ther. 25 (2017), 679–693 this issue.
5. 5 Brand, T., Heart development: molecular insights into cardiac specification and early morphogenesis. Dev. Biol. 258 (2003), 1–19.
6. 6 He, L., Hannon, G.J., MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5 (2004), 522–531.
7. 7 Chen, J.F., Murchison, E.P., Tang, R., Callis, T.E., Tatsuguchi, M., Deng, Z., Rojas, M., Hammond, S.M., Schneider, M.D., Selzman, C.H., et al. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc. Natl. Acad. Sci. USA 105 (2008), 2111–2116.
8. 8 Wahlquist, C., Jeong, D., Rojas-Muñoz, A., Kho, C., Lee, A., Mitsuyama, S., van Mil, A., Park, W.J., Sluijter, J.P., Doevendans, P.A., et al. Inhibition of miR-25 improves cardiac contractility in the failing heart. Nature 508 (2014), 531–535.
9. 9 Cai, W.F., Liu, G.S., Lam, C.K., Florea, S., Qian, J., Zhao, W., Pritchard, T., Haghighi, K., Lebeche, D., Lu, L.J., et al. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur. J. Heart Fail. 17 (2015), 782–793.
10. 10 Mathiyalagan, P., Okabe, J., Chang, L., Su, Y., Du, X.J., El-Osta, A., The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res. 42 (2014), 790–803.
11. 11 Sahoo, S., Klychko, E., Thorne, T., Misener, S., Schultz, K.M., Millay, M., Ito, A., Liu, T., Kamide, C., Agrawal, H., et al. Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ. Res. 109 (2011), 724–728.
12. 12 Agarwal, U., George, A., Bhutani, S., Ghosh-Choudhary, S., Maxwell, J.T., Brown, M.E., Mehta, Y., Platt, M.O., Liang, Y., Sahoo, S., Davis, M.E., Experimental, systems and computational approaches to understanding the microRNA-mediated reparative potential of cardiac progenitor cell-derived exosomes from pediatric patients. Circ. Res., 2016, 10.1161/CIRCRESAHA.116.309935 Published online November 21, 2016.
13. 13 Mathiyalagan, P., Sahoo, S., Exosomes-based gene therapy for microrna delivery. Methods Mol. Biol. 1521 (2017), 139–152.
14. 14 Castañares, C., Redondo-Horcajo, M., Magán-Marchal, N., ten Dijke, P., Lamas, S., Rodríguez-Pascual, F., Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation. J. Cell Sci. 120 (2007), 1256–1266.
15. 15 Fujita, M., Komeda, M., Hasegawa, K., Kihara, Y., Nohara, R., Sasayama, S., Pericardial fluid as a new material for clinical heart research. Int. J. Cardiol. 77 (2001), 113–118.
16. 16 Kuosmanen, S.M., Hartikainen, J., Hippeläinen, M., Kokki, H., Levonen, A.L., Tavi, P., MicroRNA profiling of pericardial fluid samples from patients with heart failure. PLoS ONE, 10, 2015, e0119646.