메뉴 건너뛰기




Volumn 1, Issue 3, 2016, Pages

Recent developments and translational aspects in targeted therapy for metastatic breast cancer

Author keywords

Breast; Breast Cancer; Metastatic Breast Cancer; Targeted Therapy; Translational Cancer Research

Indexed keywords


EID: 85015278180     PISSN: None     EISSN: 20597029     Source Type: Journal    
DOI: 10.1136/esmoopen-2016-000036     Document Type: Review
Times cited : (1)

References (81)
  • 1
    • 84872847361 scopus 로고    scopus 로고
    • The genomic landscape of breast cancer as a therapeutic roadmap
    • Ellis MJ, Perou CM. The genomic landscape of breast cancer as a therapeutic roadmap. Cancer Discov 2013;3:27-34.
    • (2013) Cancer Discov , vol.3 , pp. 27-34
    • Ellis, M.J.1    Perou, C.M.2
  • 2
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Koboldt DC, Fulton RS, McLellan MD, et al. Comprehensive molecular portraits of human breast tumours. Nature 2012;490:61-70.
    • (2012) Nature , vol.490 , pp. 61-70
    • Koboldt, D.C.1    Fulton, R.S.2    McLellan, M.D.3
  • 3
    • 84862526929 scopus 로고    scopus 로고
    • The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    • Shah SP, Roth A, Goya R, et al. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature 2012;486:395-9.
    • (2012) Nature , vol.486 , pp. 395-399
    • Shah, S.P.1    Roth, A.2    Goya, R.3
  • 4
    • 84861527388 scopus 로고    scopus 로고
    • The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups
    • Curtis C, Shah SP, Chin SF, et al. The genomic and transcriptomic architecture of 2, 000 breast tumours reveals novel subgroups. Nature 2012;486:346-52.
    • (2012) Nature , vol.486 , pp. 346-352
    • Curtis, C.1    Shah, S.P.2    Chin, S.F.3
  • 5
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji S, Cibulskis K, Rangel-Escareno C, et al. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 2012;486:405-9.
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1    Cibulskis, K.2    Rangel-Escareno, C.3
  • 6
    • 84862584058 scopus 로고    scopus 로고
    • Whole-genome analysis informs breast cancer response to aromatase inhibition
    • Ellis MJ, Ding L, Shen D, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature 2012;486:353-60.
    • (2012) Nature , vol.486 , pp. 353-360
    • Ellis, M.J.1    Ding, L.2    Shen, D.3
  • 7
    • 84890293042 scopus 로고    scopus 로고
    • Incorporating genomics into breast cancer clinical trials and care
    • Tabchy A, Ma CX, Bose R, et al. Incorporating genomics into breast cancer clinical trials and care. Clin Cancer Res 2013;19:6371-9.
    • (2013) Clin Cancer Res , vol.19 , pp. 6371-6379
    • Tabchy, A.1    Ma, C.X.2    Bose, R.3
  • 8
    • 84875752240 scopus 로고    scopus 로고
    • Emerging targeted agents in metastatic breast cancer
    • Zardavas D, Baselga J, Piccart M. Emerging targeted agents in metastatic breast cancer. Nat Rev Clin Oncol 2013;10:191-210.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 191-210
    • Zardavas, D.1    Baselga, J.2    Piccart, M.3
  • 9
    • 84890263741 scopus 로고    scopus 로고
    • Neoadjuvant therapy as a platform for drug development and approval in breast cancer
    • Bardia A, Baselga J. Neoadjuvant therapy as a platform for drug development and approval in breast cancer. Clin Cancer Res 2013;19:6360-70.
    • (2013) Clin Cancer Res , vol.19 , pp. 6360-6370
    • Bardia, A.1    Baselga, J.2
  • 10
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/ neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/ neu oncogene. Science 1987;235:177-82.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 11
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-92.
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 12
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group. J Clin Oncol 2005;23:4265-74.
    • (2005) J Clin Oncol , vol.23 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 13
    • 77949893849 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer
    • Wardley AM, Pivot X, Morales-Vasquez F, et al. Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer. J Clin Oncol 2010;28:976-83.
    • (2010) J Clin Oncol , vol.28 , pp. 976-983
    • Wardley, A.M.1    Pivot, X.2    Morales-Vasquez, F.3
  • 14
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012;366:109-19.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 15
    • 84923052492 scopus 로고    scopus 로고
    • Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer
    • Swain SM, Baselga J, Kim SB, et al. Pertuzumab, trastuzumab, and docetaxel in HER2-positive metastatic breast cancer. N Engl J Med 2015;372:724-34.
    • (2015) N Engl J Med , vol.372 , pp. 724-734
    • Swain, S.M.1    Baselga, J.2    Kim, S.B.3
  • 16
    • 84868520609 scopus 로고    scopus 로고
    • Trastuzumab emtansine for HER2-positive advanced breast cancer
    • Verma S, Miles D, Gianni L, et al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012;367:1783-91.
    • (2012) N Engl J Med , vol.367 , pp. 1783-1791
    • Verma, S.1    Miles, D.2    Gianni, L.3
  • 17
    • 84901639476 scopus 로고    scopus 로고
    • Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): A randomised, open-label, phase 3 trial
    • Krop IE, Kim SB, González-Martín A, et al. Trastuzumab emtansine versus treatment of physician's choice for pretreated HER2-positive advanced breast cancer (TH3RESA): A randomised, open-label, phase 3 trial. Lancet Oncol 2014;15:689-99.
    • (2014) Lancet Oncol , vol.15 , pp. 689-699
    • Krop, I.E.1    Kim, S.B.2    González-Martín, A.3
  • 18
    • 84973115597 scopus 로고    scopus 로고
    • A phase i study of MM-302, a HER2-targeted PEGylated liposomal doxorubicin, in patients with HER2+ metastatic breast cancer
    • AbstractCT234
    • LoRusso PM, Krop I, Miller K, et al. A phase I study of MM-302, a HER2-targeted PEGylated liposomal doxorubicin, in patients with HER2+ metastatic breast cancer. AACR Annual Meeting, 2015. AbstractCT234.
    • (2015) AACR Annual Meeting
    • LoRusso, P.M.1    Krop, I.2    Miller, K.3
  • 19
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-43.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 20
    • 1842614245 scopus 로고    scopus 로고
    • Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
    • Tripathy D, Slamon DJ, Cobleigh M, et al. Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression. J Clin Oncol 2004;22:1063-70.
    • (2004) J Clin Oncol , vol.22 , pp. 1063-1070
    • Tripathy, D.1    Slamon, D.J.2    Cobleigh, M.3
  • 21
    • 34548543191 scopus 로고    scopus 로고
    • Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer
    • Bartsch R, Wenzel C, Altorjai G, et al. Capecitabine and trastuzumab in heavily pretreated metastatic breast cancer. J Clin Oncol 2007;25:3853-8.
    • (2007) J Clin Oncol , vol.25 , pp. 3853-3858
    • Bartsch, R.1    Wenzel, C.2    Altorjai, G.3
  • 22
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German breast group 26/ breast international group 03-05 study
    • von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German breast group 26/ breast international group 03-05 study. J Clin Oncol 2009;27:1999-2006.
    • (2009) J Clin Oncol , vol.27 , pp. 1999-2006
    • Von Minckwitz, G.1    Du Bois, A.2    Schmidt, M.3
  • 23
    • 84864066561 scopus 로고    scopus 로고
    • Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: Final results from the EGF104900 Study
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. J Clin Oncol 2012;30:2585-92.
    • (2012) J Clin Oncol , vol.30 , pp. 2585-2592
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 24
    • 84863715765 scopus 로고    scopus 로고
    • A phase II study of afatinib (BIBW 2992), an irreversible ERBB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab
    • Lin NU, Winer EP, Wheatley D, et al. A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab. Breast Cancer Res Treat 2012;133:1057-65.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 1057-1065
    • Lin, N.U.1    Winer, E.P.2    Wheatley, D.3
  • 25
    • 84959194134 scopus 로고    scopus 로고
    • Abstract P5-19-01: Randomized Phase III trial of afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one prior trastuzumab treatment: LUX-Breast 1
    • Harbeck N, Huang C-S, Hurvitz S, et al. Abstract P5-19-01: Randomized Phase III trial of afatinib plus vinorelbine versus trastuzumab plus vinorelbine in patients with HER2-overexpressing metastatic breast cancer who had progressed on one prior trastuzumab treatment: LUX-Breast 1. Cancer Res 2015;75:P5-19-0.
    • (2015) Cancer Res , vol.75 , pp. P5-190
    • Harbeck, N.1    Huang, C.-S.2    Hurvitz, S.3
  • 26
    • 84945115067 scopus 로고    scopus 로고
    • Phase 1b study of ONT-380, an oral HER2-specific inhibitor, in combination with capecitabine (C) and trastuzumab (T) in third line+treatment of HER2+ metastatic breast cancer (MBC)
    • abstract 602
    • Hamilton E, Yardley D. Phase 1b study of ONT-380, an oral HER2-specific inhibitor, in combination with capecitabine (C) and trastuzumab (T) in third line+treatment of HER2+ metastatic breast cancer (MBC). J Clin Oncol 2015;33;abstract 602.
    • (2015) J Clin Oncol , vol.33
    • Hamilton, E.1    Yardley, D.2
  • 27
    • 84948808453 scopus 로고    scopus 로고
    • Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): A randomised, open-label, multicentre, phase 2 trial
    • Cortés J, Dieras V, Ro J, et al. Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): A randomised, open-label, multicentre, phase 2 trial. Lancet Oncol 2015;16:1700-10.
    • (2015) Lancet Oncol , vol.16 , pp. 1700-1710
    • Cortés, J.1    Dieras, V.2    Ro, J.3
  • 28
    • 77950497981 scopus 로고    scopus 로고
    • Neratinib, an irreversible ERBB receptor tyrosine kinase inhibitor, in patients with advanced ERBB2-positive breast cancer
    • Burstein HJ, Sun Y, Dirix LY, et al. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2010;28:1301-7.
    • (2010) J Clin Oncol , vol.28 , pp. 1301-1307
    • Burstein, H.J.1    Sun, Y.2    Dirix, L.Y.3
  • 29
    • 84888004978 scopus 로고    scopus 로고
    • A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer
    • Martin M, Bonneterre J, Geyer CE Jr, et al. A phase two randomised trial of neratinib monotherapy versus lapatinib plus capecitabine combination therapy in patients with HER2+ advanced breast cancer. Eur J Cancer 2013;49:3763-72.
    • (2013) Eur J Cancer , vol.49 , pp. 3763-3772
    • Martin, M.1    Bonneterre, J.2    Geyer, C.E.3
  • 30
    • 84894807977 scopus 로고    scopus 로고
    • Phase i study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors
    • Gandhi L, Bahleda R, Tolaney SM, et al. Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. J Clin Oncol 2014;32:68-75.
    • (2014) J Clin Oncol , vol.32 , pp. 68-75
    • Gandhi, L.1    Bahleda, R.2    Tolaney, S.M.3
  • 31
    • 84960505735 scopus 로고    scopus 로고
    • Abstract P5-19-04: A phase I/II study of neratinib plus temsirolimus in HER2+ metastatic breast cancer reveals ongoing HER2 pathway dependence in many patients despite several lines of HER2 targeted therapy
    • Gajria D, Modi S, Saura C, et al. Abstract P5-19-04: A phase I/II study of neratinib plus temsirolimus in HER2+ metastatic breast cancer reveals ongoing HER2 pathway dependence in many patients despite several lines of HER2 targeted therapy. Cancer Res 2015;75:P5-19-04.
    • (2015) Cancer Res , vol.75 , pp. P5-1904
    • Gajria, D.1    Modi, S.2    Saura, C.3
  • 32
    • 84952636697 scopus 로고    scopus 로고
    • Neratinib after adjuvant chemotherapy and trastuzumab in HER2-positive early breast cancer: Primary analysis at 2 years of a phase 3, randomized, placebo-controlled trial (ExteNET)
    • abstract 508
    • Chan A. Neratinib after adjuvant chemotherapy and trastuzumab in HER2-positive early breast cancer: Primary analysis at 2 years of a phase 3, randomized, placebo-controlled trial (ExteNET). J Clin Oncol 2015;33:abstract 508.
    • (2015) J Clin Oncol , vol.33
    • Chan, A.1
  • 33
    • 85052719142 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3)
    • abstract 505
    • O'Reagen AM. Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3). J Clin Oncol 2015;33:abstract 505.
    • (2015) J Clin Oncol , vol.33
    • O'Reagen, A.M.1
  • 34
    • 84899992665 scopus 로고    scopus 로고
    • Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): A randomised, double-blind, placebo-controlled phase 3 trial
    • André F, O'Regan R, Ozguroglu M, et al. Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): A randomised, double-blind, placebo-controlled phase 3 trial. Lancet Oncol 2014;15:580-91.
    • (2014) Lancet Oncol , vol.15 , pp. 580-591
    • André, F.1    O'Regan, R.2    Ozguroglu, M.3
  • 35
    • 84945171997 scopus 로고    scopus 로고
    • Updated findings of a first-in-human, phase i study of margetuximab (M), an Fc-optimized chimeric monoclonal antibody (MAb), in patients (pts) with HER2-positive advanced solid tumors
    • abstract 523
    • Burris HA, Giaccone G. Updated findings of a first-in-human, phase I study of margetuximab (M), an Fc-optimized chimeric monoclonal antibody (MAb), in patients (pts) with HER2-positive advanced solid tumors. J Clin Oncol 2015;33:abstract 523.
    • (2015) J Clin Oncol , vol.33
    • Burris, H.A.1    Giaccone, G.2
  • 36
    • 21644438384 scopus 로고    scopus 로고
    • The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches
    • Zaczek A, Brandt B, Bielawski KP. The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches. Histol Histopathol 2005;20:1005-15.
    • (2005) Histol Histopathol , vol.20 , pp. 1005-1015
    • Zaczek, A.1    Brandt, B.2    Bielawski, K.P.3
  • 37
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • Sergina NV, Rausch M, Wang D, et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007;445:437-41.
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3
  • 38
    • 58149250652 scopus 로고    scopus 로고
    • Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors
    • Chen FL, Xia W, Spector NL. Acquired resistance to small molecule ErbB2 tyrosine kinase inhibitors. Clin Cancer Res 2008;14:6730-4.
    • (2008) Clin Cancer Res , vol.14 , pp. 6730-6734
    • Chen, F.L.1    Xia, W.2    Spector, N.L.3
  • 39
    • 84908216580 scopus 로고    scopus 로고
    • Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients
    • Berghoff AS, Bartsch R, Preusser M, et al. Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients. Breast 2014;23:637-43.
    • (2014) Breast , vol.23 , pp. 637-643
    • Berghoff, A.S.1    Bartsch, R.2    Preusser, M.3
  • 40
    • 85052692532 scopus 로고    scopus 로고
    • Phase i study of HER3 targeted antibody patritumab in combination with trastuzumab and paclitaxel in patients with HER2-overexpressing metastatic breast cancer (MBC)
    • abstract 584
    • Saeki T, Mukai H. Phase I study of HER3 targeted antibody patritumab in combination with trastuzumab and paclitaxel in patients with HER2-overexpressing metastatic breast cancer (MBC). J Clin Oncol 2015;33:abstract 584.
    • (2015) J Clin Oncol , vol.33
    • Saeki, T.1    Mukai, H.2
  • 41
    • 50549123220 scopus 로고
    • On the treatment of inoperable cases of carcinoma of the mamma: Suggestions for a new method of treatment, with illustrative cases
    • Beatson GT. On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases. Lancet 1896;148:104-7.
    • (1896) Lancet , vol.148 , pp. 104-107
    • Beatson, G.T.1
  • 42
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative G
    • Early Breast Cancer Trialists' Collaborative G. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet 2005;365:1687-717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 43
    • 70350485056 scopus 로고    scopus 로고
    • NCCN breast cancer clinical practice guidelines in oncology: An update
    • Carlson RW. NCCN breast cancer clinical practice guidelines in oncology: An update. J Natl Compr Canc Netw 2003;1(Suppl 1): S61-3.
    • (2003) J Natl Compr Canc Netw , vol.1 , pp. S61-S63
    • Carlson, R.W.1
  • 44
    • 0027280084 scopus 로고
    • Expression and amplification of cyclin genes in human breast cancer
    • Buckley MF, Sweeney KJ, Hamilton JA, et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene 1993;8:2127-33.
    • (1993) Oncogene , vol.8 , pp. 2127-2133
    • Buckley, M.F.1    Sweeney, K.J.2    Hamilton, J.A.3
  • 45
    • 84859189826 scopus 로고    scopus 로고
    • Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: A TransATAC study
    • Lundgren K, Brown M, Pineda S, et al. Effects of cyclin D1 gene amplification and protein expression on time to recurrence in postmenopausal breast cancer patients treated with anastrozole or tamoxifen: A TransATAC study. Breast Cancer Res 2012;14:R57.
    • (2012) Breast Cancer Res , vol.14 , pp. R57
    • Lundgren, K.1    Brown, M.2    Pineda, S.3
  • 46
    • 84888381937 scopus 로고    scopus 로고
    • Activating ESR1 mutations in hormone-resistant metastatic breast cancer
    • Robinson DR, Wu YM, Vats P, et al. Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet 2013;45:1446-51.
    • (2013) Nat Genet , vol.45 , pp. 1446-1451
    • Robinson, D.R.1    Wu, Y.M.2    Vats, P.3
  • 47
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne CK, Shou J, Massarweh S, et al. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005;11(Pt 2):865s-70s.
    • (2005) Clin Cancer Res , vol.11 , pp. 865s-870s
    • Osborne, C.K.1    Shou, J.2    Massarweh, S.3
  • 48
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012;366:520-9.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 49
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • Bachelot T, Bourgier C, Cropet C, et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study. J Clin Oncol 2012;30:2718-24.
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 50
    • 84872518645 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer
    • Wolff AC, Lazar AA, Bondarenko I, et al. Randomized phase III placebo-controlled trial of letrozole plus oral temsirolimus as first-line endocrine therapy in postmenopausal women with locally advanced or metastatic breast cancer. J Clin Oncol 2013;31:195-202.
    • (2013) J Clin Oncol , vol.31 , pp. 195-202
    • Wolff, A.C.1    Lazar, A.A.2    Bondarenko, I.3
  • 51
    • 11144358645 scopus 로고    scopus 로고
    • High frequency of mutations of the PIK3CA gene in human cancers
    • Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004;304:554.
    • (2004) Science , vol.304 , pp. 554
    • Samuels, Y.1    Wang, Z.2    Bardelli, A.3
  • 52
    • 66849136781 scopus 로고    scopus 로고
    • Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    • Baselga J, Semiglazov V, van Dam P, et al. Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer. J Clin Oncol 2009;27:2630-7.
    • (2009) J Clin Oncol , vol.27 , pp. 2630-2637
    • Baselga, J.1    Semiglazov, V.2    Van Dam, P.3
  • 53
    • 22344446415 scopus 로고    scopus 로고
    • Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    • Boulay A, Rudloff J, Ye J, et al. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer. Clin Cancer Res 2005;11:5319-28.
    • (2005) Clin Cancer Res , vol.11 , pp. 5319-5328
    • Boulay, A.1    Rudloff, J.2    Ye, J.3
  • 54
    • 85052680823 scopus 로고    scopus 로고
    • Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive, HER2-negative advanced breast cancer: Results from BOLERO-2
    • abstract LBA509
    • Hortobagyi GN, Piccart M. Correlation of molecular alterations with efficacy of everolimus in hormone receptor-positive, HER2-negative advanced breast cancer: results from BOLERO-2. J Clin Oncol 2015;33:abstract LBA509.
    • (2015) J Clin Oncol , vol.33
    • Hortobagyi, G.N.1    Piccart, M.2
  • 55
    • 84891868991 scopus 로고    scopus 로고
    • Predictive markers of everolimus efficacy in hormone receptor positive (HR+) metastatic breast cancer (MBC): Final results of the TAMRAD trial translational study
    • abstract 510
    • Treilleux I, Arnedos M. Predictive markers of everolimus efficacy in hormone receptor positive (HR+) metastatic breast cancer (MBC): final results of the TAMRAD trial translational study. J Clin Oncol 2013;31:abstract 510.
    • (2013) J Clin Oncol , vol.31
    • Treilleux, I.1    Arnedos, M.2
  • 56
    • 84975753526 scopus 로고    scopus 로고
    • PIK3CA status in circulating tumor DNA (ctDNA) predicts efficacy of buparlisib (BUP) plus fulvestrant (FULV) in postmenopausal women with endocrine-resistant HR+/HER2-advanced breast cancer (BC): First results from the randomized, phase III BELLE-2 trial
    • Abstract S6-01
    • Baselga J, Im SA, Iwata H, et al. PIK3CA status in circulating tumor DNA (ctDNA) predicts efficacy of buparlisib (BUP) plus fulvestrant (FULV) in postmenopausal women with endocrine-resistant HR+/HER2-advanced breast cancer (BC): first results from the randomized, phase III BELLE-2 trial. SABCS, 2015. Abstract S6-01.
    • (2015) SABCS
    • Baselga, J.1    Im, S.A.2    Iwata, H.3
  • 57
    • 84922369296 scopus 로고    scopus 로고
    • The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study
    • Finn RS, Crown JP, Lang I, et al. The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): A randomised phase 2 study. Lancet Oncol 2015;16:25-35.
    • (2015) Lancet Oncol , vol.16 , pp. 25-35
    • Finn, R.S.1    Crown, J.P.2    Lang, I.3
  • 58
    • 84937042338 scopus 로고    scopus 로고
    • Palbociclib in hormone-receptor-positive advanced breast cancer
    • Turner NC, Ro J, André F, et al. Palbociclib in hormone-receptor-positive advanced breast cancer. N Engl J Med 2015;373:209-19.
    • (2015) N Engl J Med , vol.373 , pp. 209-219
    • Turner, N.C.1    Ro, J.2    André, F.3
  • 59
    • 84939864061 scopus 로고    scopus 로고
    • Chemohormonal therapy in metastatic hormone-sensitive prostate cancer
    • Sweeney CJ, Chen YH, Carducci M, et al. Chemohormonal therapy in metastatic hormone-sensitive prostate cancer. N Engl J Med 2015;373:737-46.
    • (2015) N Engl J Med , vol.373 , pp. 737-746
    • Sweeney, C.J.1    Chen, Y.H.2    Carducci, M.3
  • 60
    • 84960402176 scopus 로고    scopus 로고
    • Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1-positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer enrolled in KEYNOTE-028
    • Abstract S5-07
    • Rugo H, Delord J, Im SA. Preliminary efficacy and safety of pembrolizumab (MK-3475) in patients with PD-L1-positive, estrogen receptor-positive (ER+)/HER2-negative advanced breast cancer enrolled in KEYNOTE-028. SABCS, 2015. Abstract S5-07.
    • (2015) SABCS
    • Rugo, H.1    Delord, J.2    Im, S.A.3
  • 61
    • 84904188903 scopus 로고    scopus 로고
    • Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis
    • Cortazar P, Zhang L, Untch M, et al. Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis. Lancet 2014;384:164-72.
    • (2014) Lancet , vol.384 , pp. 164-172
    • Cortazar, P.1    Zhang, L.2    Untch, M.3
  • 62
    • 52049086689 scopus 로고    scopus 로고
    • Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer
    • Atchley DP, Albarracin CT, Lopez A, et al. Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. J Clin Oncol 2008;26:4282-8.
    • (2008) J Clin Oncol , vol.26 , pp. 4282-4288
    • Atchley, D.P.1    Albarracin, C.T.2    Lopez, A.3
  • 63
    • 17544403741 scopus 로고    scopus 로고
    • Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer
    • Krainer M, Silva-Arrieta S, FitzGerald MG, et al. Differential contributions of BRCA1 and BRCA2 to early-onset breast cancer. N Engl J Med 1997;336:1416-21.
    • (1997) N Engl J Med , vol.336 , pp. 1416-1421
    • Krainer, M.1    Silva-Arrieta, S.2    FitzGerald, M.G.3
  • 64
    • 13344260688 scopus 로고    scopus 로고
    • Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer
    • FitzGerald MG, MacDonald DJ, Krainer M, et al. Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer. N Engl J Med 1996;334:143-9.
    • (1996) N Engl J Med , vol.334 , pp. 143-149
    • FitzGerald, M.G.1    MacDonald, D.J.2    Krainer, M.3
  • 65
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 66
    • 77149171459 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer
    • Comen EA, Robson M. Poly(ADP-ribose) polymerase inhibitors in triple-negative breast cancer. Cancer J 2010;16:48-52.
    • (2010) Cancer J , vol.16 , pp. 48-52
    • Comen, E.A.1    Robson, M.2
  • 67
    • 84921771510 scopus 로고    scopus 로고
    • Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation
    • Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 2015;33:244-50.
    • (2015) J Clin Oncol , vol.33 , pp. 244-250
    • Kaufman, B.1    Shapira-Frommer, R.2    Schmutzler, R.K.3
  • 68
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H, et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 2011;12:852-61.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 69
    • 79952253747 scopus 로고    scopus 로고
    • Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer
    • Gonzalez-Angulo AM, Timms KM, Liu S, et al. Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res 2011;17:1082-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 1082-1089
    • Gonzalez-Angulo, A.M.1    Timms, K.M.2    Liu, S.3
  • 70
    • 84964293321 scopus 로고    scopus 로고
    • Cabozantinib (XL184) inhibits growth and invasion of preclinical TNBC models
    • Sameni M, Tovar EA, Essenburg CJ, et al. Cabozantinib (XL184) inhibits growth and invasion of preclinical TNBC models. Clin Cancer Res 2016;22:923-34.
    • (2016) Clin Cancer Res , vol.22 , pp. 923-934
    • Sameni, M.1    Tovar, E.A.2    Essenburg, C.J.3
  • 71
    • 84873835254 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in metastatic breast cancer (MBC): Results from a phase II randomized discontinuation trial (RDT)
    • abstract 535
    • Winer EP. Activity of cabozantinib (XL184) in metastatic breast cancer (MBC): results from a phase II randomized discontinuation trial (RDT). J Clin Oncol 2012;30:abstract 535.
    • (2012) J Clin Oncol , vol.30
    • Winer, E.P.1
  • 72
    • 84898901879 scopus 로고    scopus 로고
    • A phase II study of foretinib in triple-negative, recurrent/ metastatic breast cancer: NCIC CTG trial IND. 197 (NCT01147484)
    • abstract 1036
    • Rayson D. A phase II study of foretinib in triple-negative, recurrent/ metastatic breast cancer: NCIC CTG trial IND. 197 (NCT01147484). J Clin Oncol 2012;30:abstract 1036.
    • (2012) J Clin Oncol , vol.30
    • Rayson, D.1
  • 73
    • 84941643538 scopus 로고    scopus 로고
    • Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer
    • Diéras V, Campone M, Yardley DA, et al. Randomized, phase II, placebo-controlled trial of onartuzumab and/or bevacizumab in combination with weekly paclitaxel in patients with metastatic triple-negative breast cancer. Ann Oncol 2015;26:1904-10.
    • (2015) Ann Oncol , vol.26 , pp. 1904-1910
    • Diéras, V.1    Campone, M.2    Yardley, D.A.3
  • 74
    • 84879859652 scopus 로고    scopus 로고
    • Targeting FGFR with dovitinib (TKI258): Preclinical and clinical data in breast cancer
    • André F, Bachelot T, Campone M, et al. Targeting FGFR with dovitinib (TKI258): preclinical and clinical data in breast cancer. Clin Cancer Res 2013;19:3693-702.
    • (2013) Clin Cancer Res , vol.19 , pp. 3693-3702
    • André, F.1    Bachelot, T.2    Campone, M.3
  • 75
    • 84858210768 scopus 로고    scopus 로고
    • A multicenter, open-label phase II trial of dovitinib, an FGFR1 inhibitor, in FGFR1 amplified and non-amplified metastatic breast cancer
    • abstract 508
    • Andre F, Bachelot TD, Campone M, et al. A multicenter, open-label phase II trial of dovitinib, an FGFR1 inhibitor, in FGFR1 amplified and non-amplified metastatic breast cancer. J Clin Oncol 2011;29: Abstract 508.
    • (2011) J Clin Oncol , vol.29
    • Andre, F.1    Bachelot, T.D.2    Campone, M.3
  • 76
    • 84925408760 scopus 로고    scopus 로고
    • Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors
    • Soria JC, DeBraud F, Bahleda R, et al. Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors. Ann Oncol 2014;25: 2244-51.
    • (2014) Ann Oncol , vol.25 , pp. 2244-2251
    • Soria, J.C.1    DeBraud, F.2    Bahleda, R.3
  • 77
    • 84908360684 scopus 로고    scopus 로고
    • Phase i clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study)
    • Quintela-Fandino M, Urruticoechea A, Guerra J, et al. Phase I clinical trial of nintedanib plus paclitaxel in early HER-2-negative breast cancer (CNIO-BR-01-2010/GEICAM-2010-10 study). Br J Cancer 2014;111:1060-4.
    • (2014) Br J Cancer , vol.111 , pp. 1060-1064
    • Quintela-Fandino, M.1    Urruticoechea, A.2    Guerra, J.3
  • 78
    • 84899836282 scopus 로고    scopus 로고
    • Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival
    • Brown SD, Warren RL, Gibb EA, et al. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival. Genome Res 2014;24:743-50.
    • (2014) Genome Res , vol.24 , pp. 743-750
    • Brown, S.D.1    Warren, R.L.2    Gibb, E.A.3
  • 79
    • 84937961692 scopus 로고    scopus 로고
    • A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer
    • Abstract S1-09
    • Nanda R, Chow LQ. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer. SABCS, 2014. Abstract S1-09.
    • (2014) SABCS
    • Nanda, R.1    Chow, L.Q.2
  • 80
    • 84951782867 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer
    • Abstract 2859
    • Emans LA, Braiteh FS. Inhibition of PD-L1 by MPDL3280A leads to clinical activity in patients with metastatic triple-negative breast cancer. AACR Annual Meeting, 2015. Abstract 2859.
    • (2015) AACR Annual Meeting
    • Emans, L.A.1    Braiteh, F.S.2
  • 81
    • 84994036086 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: A phase Ib JAVELIN solid tumor trial
    • Abstract S1-04
    • Dirix LY, Nikolinakos P. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: A phase Ib JAVELIN solid tumor trial. SABCS, 2015. Abstract S1-04.
    • (2015) SABCS
    • Dirix, L.Y.1    Nikolinakos, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.