Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine

Cell Reports

Volumn 18, Issue 11, 2017, Pages 2547-2556

  Poursaitidis, Ioannis ^b   Wang, Xiaomeng ^b   Crighton, Thomas ^b   Labuschagne, Christiaan ^c   Mason, David ^b   Cramer, Shira L ^d   Triplett, Kendra ^d   Roy, Rajat ^e   Pardo, Olivier E ^e   Seckl, Michael J ^e   Rowlinson, Scott W ^f   Stone, Everett ^g   Lamb, Richard F ^a  

^a LIVERPOOL HOPE UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d The University of Texas at Austin   (United States)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f Aeglea BioTherapeutics   (United States)

^g UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

EGFR; ferroptosis; GPX4; MAPK; NOX4; oncogene; ROS

Indexed keywords

CATALASE; CYSTINE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; AMINO ACID; CYSTEINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IRON; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST EPITHELIUM CELL; CANCER GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FERROPTOSIS; HUMAN; HUMAN CELL; LIMIT OF QUANTITATION; MALE; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; SENSITIZATION; SIGNAL TRANSDUCTION; ANIMAL; BREAST; CELL DEATH; CELL SURVIVAL; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GENETICS; LUNG TUMOR; MAPK SIGNALING; METABOLISM; MUTATION; ONCOGENE; PATHOLOGY; SCID MOUSE; TUMOR CELL LINE;

AMINO ACIDS; ANIMALS; BREAST; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CYSTEINE; CYSTINE; DOWN-REGULATION; EPITHELIAL CELLS; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; IRON; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE, SCID; MUTATION; ONCOGENES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 85015254073     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.02.054     Document Type: Article

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