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Volumn 7, Issue , 2017, Pages

Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating MIR-22 and BMP7

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMINOID; BIOLOGICAL MARKER; BMP7 PROTEIN, MOUSE; CREATININE; MICRORNA; MIRN22 MICRORNA, MOUSE; OSTEOGENIC PROTEIN 1; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; UROKINASE RECEPTOR;

EID: 85015220244     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep44584     Document Type: Article
Times cited : (30)

References (50)
  • 1
    • 76749103329 scopus 로고    scopus 로고
    • Diabetic kidney disease: Act now or pay later
    • Atkins, R. C. & Zimmet, P. Diabetic kidney disease: act now or pay later. Kidney international 77, 375-377, doi: 10.1038/ki.2009.509 (2010).
    • (2010) Kidney International , vol.77 , pp. 375-377
    • Atkins, R.C.1    Zimmet, P.2
  • 2
    • 84963525897 scopus 로고    scopus 로고
    • Diabetic nephropathy: Focus on current and future therapeutic strategies
    • Pofi, R. et al. Diabetic Nephropathy: Focus on Current and Future Therapeutic Strategies. Current drug metabolism 17, 497-502 (2016).
    • (2016) Current Drug Metabolism , vol.17 , pp. 497-502
    • Pofi, R.1
  • 4
    • 84979884860 scopus 로고    scopus 로고
    • Cardiac and renovascular complications in type 2 diabetes- is there hope?
    • Ingelfinger, J. R. & Rosen, C. J. Cardiac and Renovascular Complications in Type 2 Diabetes- Is There Hope? The New England journal of medicine, doi: 10.1056/NEJMe1607413 (2016).
    • (2016) The New England Journal of Medicine
    • Ingelfinger, J.R.1    Rosen, C.J.2
  • 5
    • 84927640087 scopus 로고    scopus 로고
    • Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy
    • discussion 2223, doi: 10.1097/hjh.0000000000000328
    • Sharkovska, Y. et al. Blood pressure and glucose independent renoprotective effects of dipeptidyl peptidase-4 inhibition in a mouse model of type-2 diabetic nephropathy. Journal of hypertension 32, 2211-2223, discussion 2223, doi: 10.1097/hjh.0000000000000328 (2014).
    • (2014) Journal of Hypertension , vol.32 , pp. 2211-2223
    • Sharkovska, Y.1
  • 6
    • 77954383099 scopus 로고    scopus 로고
    • Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice
    • Dong, Y. F. et al. Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. Journal of hypertension 28, 1554-1565, doi: 10.1097/HJH.0b013e328338bb11 (2010).
    • (2010) Journal of Hypertension , vol.28 , pp. 1554-1565
    • Dong, Y.F.1
  • 7
    • 84969801219 scopus 로고    scopus 로고
    • Significant natriuretic and antihypertensive action of the epithelial sodium channel blocker amiloride in diabetic patients with and without nephropathy
    • Andersen, H. et al. Significant natriuretic and antihypertensive action of the epithelial sodium channel blocker amiloride in diabetic patients with and without nephropathy. Journal of hypertension 34, 1621-1629, doi: 10.1097/hjh.0000000000000967 (2016).
    • (2016) Journal of Hypertension , vol.34 , pp. 1621-1629
    • Andersen, H.1
  • 8
    • 84943157206 scopus 로고    scopus 로고
    • Salutary cardiovascular effects of antidiabetic drugs: Myth or fact?
    • Ruiz-Hurtado, G. & Ruilope, L. M. Salutary cardiovascular effects of antidiabetic drugs: myth or fact? Journal of hypertension 33, 2198-2199, doi: 10.1097/hjh.0000000000000741 (2015).
    • (2015) Journal of Hypertension , vol.33 , pp. 2198-2199
    • Ruiz-Hurtado, G.1    Ruilope, L.M.2
  • 9
    • 75549083692 scopus 로고    scopus 로고
    • Endothelial dysfunction as a target for prevention of cardiovascular disease
    • Versari, D., Daghini, E., Virdis, A., Ghiadoni, L. & Taddei, S. Endothelial dysfunction as a target for prevention of cardiovascular disease. Diabetes care 32 Suppl 2, S314-321, doi: 10.2337/dc09-S330 (2009).
    • (2009) Diabetes Care , vol.32 , pp. S314-321
    • Versari, D.1    Daghini, E.2    Virdis, A.3    Ghiadoni, L.4    Taddei, S.5
  • 10
    • 0032924098 scopus 로고    scopus 로고
    • Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney
    • Dousa, T. P. Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney. Kidney international 55, 29-62, doi: 10.1046/j.1523-1755.1999.00233.x (1999).
    • (1999) Kidney International , vol.55 , pp. 29-62
    • Dousa, T.P.1
  • 11
    • 0028039015 scopus 로고
    • Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response
    • Craven, P. A., Studer, R. K. & DeRubertis, F. R. Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats. Evidence for protein kinase C-mediated suppression of the cholinergic response. The Journal of clinical investigation 93, 311-320, doi: 10.1172/jci116961 (1994).
    • (1994) The Journal of Clinical Investigation , vol.93 , pp. 311-320
    • Craven, P.A.1    Studer, R.K.2    DeRubertis, F.R.3
  • 12
    • 33750577820 scopus 로고    scopus 로고
    • Mechanisms of diabetic nephropathy: Role of hypertension
    • Giunti, S., Barit, D. & Cooper, M. E. Mechanisms of diabetic nephropathy: role of hypertension. Hypertension 48, 519-526, doi: 10.1161/01.HYP.0000240331.32352.0c (2006).
    • (2006) Hypertension , vol.48 , pp. 519-526
    • Giunti, S.1    Barit, D.2    Cooper, M.E.3
  • 13
    • 84891633254 scopus 로고    scopus 로고
    • Potential therapeutic role of phosphodiesterase type 5 inhibition in hypertension and chronic kidney disease
    • Brown, K. E., Dhaun, N., Goddard, J. & Webb, D. J. Potential therapeutic role of phosphodiesterase type 5 inhibition in hypertension and chronic kidney disease. Hypertension 63, 5-11, doi: 10.1161/hypertensionaha.113.01774 (2014).
    • (2014) Hypertension , vol.63 , pp. 5-11
    • Brown, K.E.1    Dhaun, N.2    Goddard, J.3    Webb, D.J.4
  • 14
    • 52149122499 scopus 로고    scopus 로고
    • Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats
    • Jeong, K. H. et al. Effects of sildenafil on oxidative and inflammatory injuries of the kidney in streptozotocin-induced diabetic rats. American journal of nephrology 29, 274-282, doi: 10.1159/000158635 (2009).
    • (2009) American Journal of Nephrology , vol.29 , pp. 274-282
    • Jeong, K.H.1
  • 15
    • 79951979701 scopus 로고    scopus 로고
    • Sildenafil a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats
    • Kuno, Y., Iyoda, M., Shibata, T., Hirai, Y. & Akizawa, T. Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats. British journal of pharmacology 162, 1389-1400, doi: 10.1111/j.1476-5381.2010.01149.x (2011).
    • (2011) British Journal of Pharmacology , vol.162 , pp. 1389-1400
    • Kuno, Y.1    Iyoda, M.2    Shibata, T.3    Hirai, Y.4    Akizawa, T.5
  • 17
    • 84952886376 scopus 로고    scopus 로고
    • Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in STZ-induced diabetic rats
    • Tripathi, A. S., Mazumder, P. M. & Chandewar, A. V. Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in STZ-induced diabetic rats. Journal of basic and clinical physiology and pharmacology 27, 57-62, doi: 10.1515/jbcpp-2015-0035 (2016).
    • (2016) Journal of Basic and Clinical Physiology and Pharmacology , vol.27 , pp. 57-62
    • Tripathi, A.S.1    Mazumder, P.M.2    Chandewar, A.V.3
  • 18
    • 84930644447 scopus 로고    scopus 로고
    • Chronic inhibition of PDE5 limits pro-inflammatory monocyte-macrophage polarization in streptozotocin- induced diabetic mice
    • Venneri, M. A. et al. Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin- Induced Diabetic Mice. PloS one 10, e0126580, doi: 10.1371/journal.pone.0126580 (2015).
    • (2015) PloS One , vol.10 , pp. e0126580
    • Venneri, M.A.1
  • 19
    • 84923642102 scopus 로고    scopus 로고
    • Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: A meta-analysis
    • Santi, D. et al. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. European journal of endocrinology/European Federation of Endocrine Societies 172, R103-114, doi: 10.1530/eje-14-0700 (2015).
    • (2015) European Journal of Endocrinology/European Federation of Endocrine Societies , vol.172 , pp. R103-114
    • Santi, D.1
  • 20
    • 84950160008 scopus 로고    scopus 로고
    • Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes
    • Mandosi, E. et al. Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes. Expert opinion on therapeutic targets 19, 1617-1622, doi: 10.1517/14728222.2015.1066337 (2015).
    • (2015) Expert Opinion on Therapeutic Targets , vol.19 , pp. 1617-1622
    • Mandosi, E.1
  • 21
    • 84937518988 scopus 로고    scopus 로고
    • Sildenafil improves renal function in patients with pulmonary arterial hypertension
    • Webb, D. J., Vachiery, J. L., Hwang, L. J. & Maurey, J. O. Sildenafil improves renal function in patients with pulmonary arterial hypertension. British journal of clinical pharmacology 80, 235-241, doi: 10.1111/bcp.12616 (2015).
    • (2015) British Journal of Clinical Pharmacology , vol.80 , pp. 235-241
    • Webb, D.J.1    Vachiery, J.L.2    Hwang, L.J.3    Maurey, J.O.4
  • 22
    • 34548443810 scopus 로고    scopus 로고
    • Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes
    • Grover-Paez, F., Villegas Rivera, G. & Guillen Ortiz, R. Sildenafil citrate diminishes microalbuminuria and the percentage of A1c in male patients with type 2 diabetes. Diabetes research and clinical practice 78, 136-140, doi: 10.1016/j.diabres.2007.02.006 (2007).
    • (2007) Diabetes Research and Clinical Practice , vol.78 , pp. 136-140
    • Grover-Paez, F.1    Villegas Rivera, G.2    Guillen Ortiz, R.3
  • 23
    • 56149085738 scopus 로고    scopus 로고
    • Associations of renal vascular resistance with albuminuria and other macroangiopathy in type 2 diabetic patients
    • Hamano, K., Nitta, A., Ohtake, T. & Kobayashi, S. Associations of renal vascular resistance with albuminuria and other macroangiopathy in type 2 diabetic patients. Diabetes care 31, 1853-1857, doi: 10.2337/dc08-0168 (2008).
    • (2008) Diabetes Care , vol.31 , pp. 1853-1857
    • Hamano, K.1    Nitta, A.2    Ohtake, T.3    Kobayashi, S.4
  • 24
    • 33746406403 scopus 로고    scopus 로고
    • Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?
    • MacIsaac, R. J. et al. Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease? Diabetes care 29, 1560-1566, doi: 10.2337/dc05-1788 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 1560-1566
    • MacIsaac, R.J.1
  • 26
    • 84884536502 scopus 로고    scopus 로고
    • Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy
    • Brouwers, B. et al. Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy. The Journal of biological chemistry 288, 27200-27207, doi: 10.1074/jbc.M113.469486 (2013).
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 27200-27207
    • Brouwers, B.1
  • 27
    • 0041766597 scopus 로고    scopus 로고
    • In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors
    • De Palma, M., Venneri, M. A. & Naldini, L. In vivo targeting of tumor endothelial cells by systemic delivery of lentiviral vectors. Human gene therapy 14, 1193-1206, doi: 10.1089/104303403322168028 (2003).
    • (2003) Human Gene Therapy , vol.14 , pp. 1193-1206
    • De Palma, M.1    Venneri, M.A.2    Naldini, L.3
  • 28
    • 34548442169 scopus 로고    scopus 로고
    • Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy
    • Kelly, D. J., Buck, D., Cox, A. J., Zhang, Y. & Gilbert, R. E. Effects on protein kinase C-beta inhibition on glomerular vascular endothelial growth factor expression and endothelial cells in advanced experimental diabetic nephropathy. American journal of physiology. Renal physiology 293, F565-574, doi: 10.1152/ajprenal.00397.2006 (2007).
    • (2007) American Journal of Physiology. Renal Physiology , vol.293 , pp. F565-574
    • Kelly, D.J.1    Buck, D.2    Cox, A.J.3    Zhang, Y.4    Gilbert, R.E.5
  • 29
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg, M. et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nature medicine 9, 964-968, doi: 10.1038/nm888 (2003).
    • (2003) Nature Medicine , vol.9 , pp. 964-968
    • Zeisberg, M.1
  • 30
    • 84890904166 scopus 로고    scopus 로고
    • MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney
    • Long, J. et al. MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. The Journal of biological chemistry 288, 36202-36214, doi: 10.1074/jbc.M113.498634 (2013).
    • (2013) The Journal of Biological Chemistry , vol.288 , pp. 36202-36214
    • Long, J.1
  • 31
    • 84984690362 scopus 로고    scopus 로고
    • PDE5 inhibition ameliorates visceral adiposity targeting the MIR-22/SIRT1 pathway: Evidence from the CECSID trial
    • Fiore, D. et al. PDE5 Inhibition Ameliorates Visceral Adiposity Targeting the miR-22/SIRT1 Pathway: Evidence From the CECSID Trial. The Journal of clinical endocrinology and metabolism 101, 1525-1534, doi: 10.1210/jc.2015-4252 (2016).
    • (2016) The Journal of Clinical Endocrinology and Metabolism , vol.101 , pp. 1525-1534
    • Fiore, D.1
  • 32
    • 84861234413 scopus 로고    scopus 로고
    • Chronic inhibition of cgmp phosphodiesterase 5A improves diabetic cardiomyopathy: A randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging
    • Giannetta, E. et al. Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging. Circulation 125, 2323-2333, doi: 10.1161/ circulationaha.111.063412 (2012).
    • (2012) Circulation , vol.125 , pp. 2323-2333
    • Giannetta, E.1
  • 33
    • 79551580284 scopus 로고    scopus 로고
    • PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: Results of a 1-year, prospective, randomized, placebo-controlled study
    • Guazzi, M., Vicenzi, M., Arena, R. & Guazzi, M. D. PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study. Circulation. Heart failure 4, 8-17, doi: 10.1161/circheartfailure.110.944694 (2011).
    • (2011) Circulation. Heart Failure , vol.4 , pp. 8-17
    • Guazzi, M.1    Vicenzi, M.2    Arena, R.3    Guazzi, M.D.4
  • 34
    • 84922605537 scopus 로고    scopus 로고
    • Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials
    • Giannetta, E. et al. Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials. BMC Med 12, 185, doi: 10.1186/s12916-014-0185-3 (2014).
    • (2014) BMC Med , vol.12 , pp. 185
    • Giannetta, E.1
  • 35
    • 84896714161 scopus 로고    scopus 로고
    • Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension
    • Dias, A. T. et al. Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension. Journal of translational medicine 12, 35, doi: 10.1186/1479-5876-12-35 (2014).
    • (2014) Journal of Translational Medicine , vol.12 , pp. 35
    • Dias, A.T.1
  • 36
    • 30944437637 scopus 로고    scopus 로고
    • Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage
    • Rodriguez-Iturbe, B. et al. Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage. Kidney international 68, 2131-2142, doi: 10.1111/j.1523-1755.2005.00669.x (2005).
    • (2005) Kidney International , vol.68 , pp. 2131-2142
    • Rodriguez-Iturbe, B.1
  • 37
    • 85017347478 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibition reduces albuminuria in subjects with overt diabetic nephropathy
    • Scheele, W. et al. Phosphodiesterase Type 5 Inhibition Reduces Albuminuria in Subjects with Overt Diabetic Nephropathy. Journal of the American Society of Nephrology: JASN, doi: 10.1681/asn.2015050473 (2016).
    • (2016) Journal of the American Society of Nephrology: JASN
    • Scheele, W.1
  • 38
    • 0029052913 scopus 로고
    • Glomerular actions of nitric oxide
    • Raij, L. & Baylis, C. Glomerular actions of nitric oxide. Kidney international 48, 20-32 (1995).
    • (1995) Kidney International , vol.48 , pp. 20-32
    • Raij, L.1    Baylis, C.2
  • 39
    • 84887467090 scopus 로고    scopus 로고
    • Combined angiotensin inhibition for the treatment of diabetic nephropathy
    • Fried, L. F. et al. Combined angiotensin inhibition for the treatment of diabetic nephropathy. The New England journal of medicine 369, 1892-1903, doi: 10.1056/NEJMoa1303154 (2013).
    • (2013) The New England Journal of Medicine , vol.369 , pp. 1892-1903
    • Fried, L.F.1
  • 40
    • 84946888250 scopus 로고    scopus 로고
    • Soluble urokinase receptor and chronic kidney disease
    • Hayek, S. S. et al. Soluble Urokinase Receptor and Chronic Kidney Disease. The New England journal of medicine 373, 1916-1925, doi: 10.1056/NEJMoa1506362 (2015).
    • (2015) The New England Journal of Medicine , vol.373 , pp. 1916-1925
    • Hayek, S.S.1
  • 42
    • 0036178291 scopus 로고    scopus 로고
    • Renal resistance index and progression of renal disease
    • Radermacher, J., Ellis, S. & Haller, H. Renal resistance index and progression of renal disease. Hypertension 39, 699-703 (2002).
    • (2002) Hypertension , vol.39 , pp. 699-703
    • Radermacher, J.1    Ellis, S.2    Haller, H.3
  • 43
    • 33644764917 scopus 로고    scopus 로고
    • Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria
    • Nosadini, R. et al. Increased renal arterial resistance predicts the course of renal function in type 2 diabetes with microalbuminuria. Diabetes 55, 234-239 (2006).
    • (2006) Diabetes , vol.55 , pp. 234-239
    • Nosadini, R.1
  • 44
    • 70349286126 scopus 로고    scopus 로고
    • Renal resistive index and long-term outcome in chronic nephropathies
    • Parolini, C. et al. Renal resistive index and long-term outcome in chronic nephropathies. Radiology 252, 888-896, doi: 10.1148/ radiol.2523080351 (2009).
    • (2009) Radiology , vol.252 , pp. 888-896
    • Parolini, C.1
  • 45
    • 84928582639 scopus 로고    scopus 로고
    • Doppler-based renal resistive index for prediction of renal dysfunction reversibility: A systematic review and metaanalysis
    • Ninet, S. et al. Doppler-based renal resistive index for prediction of renal dysfunction reversibility: A systematic review and metaanalysis. Journal of critical care 30, 629-635, doi: 10.1016/j.jcrc.2015.02.008 (2015).
    • (2015) Journal of Critical Care , vol.30 , pp. 629-635
    • Ninet, S.1
  • 46
    • 33750579081 scopus 로고    scopus 로고
    • Effect of regular phosphodiesterase type 5 inhibition in hypertension
    • Oliver, J. J., Melville, V. P. & Webb, D. J. Effect of regular phosphodiesterase type 5 inhibition in hypertension. Hypertension 48, 622-627, doi: 10.1161/01.HYP.0000239816.13007.c9 (2006).
    • (2006) Hypertension , vol.48 , pp. 622-627
    • Oliver, J.J.1    Melville, V.P.2    Webb, D.J.3
  • 47
    • 84938566208 scopus 로고    scopus 로고
    • Sildenafil improves vascular endothelial structure and function in renovascular hypertension
    • Fahning, B. M. et al. Sildenafil Improves Vascular Endothelial Structure and Function in Renovascular Hypertension. Current pharmaceutical biotechnology 16, 823-831 (2015).
    • (2015) Current Pharmaceutical Biotechnology , vol.16 , pp. 823-831
    • Fahning, B.M.1
  • 48
    • 33748062324 scopus 로고    scopus 로고
    • Renal bone morphogenetic protein-7 protects against diabetic nephropathy
    • Wang, S. et al. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. Journal of the American Society of Nephrology: JASN 17, 2504-2512, doi: 10.1681/asn.2006030278 (2006).
    • (2006) Journal of the American Society of Nephrology: JASN , vol.17 , pp. 2504-2512
    • Wang, S.1
  • 49
    • 34347375050 scopus 로고    scopus 로고
    • Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors
    • Sugimoto, H., Grahovac, G., Zeisberg, M. & Kalluri, R. Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes 56, 1825-1833, doi: 10.2337/db06-1226 (2007).
    • (2007) Diabetes , vol.56 , pp. 1825-1833
    • Sugimoto, H.1    Grahovac, G.2    Zeisberg, M.3    Kalluri, R.4
  • 50
    • 84883006525 scopus 로고    scopus 로고
    • MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: Functional and therapeutic implications for gene expression and the pathogenesis of hypertension
    • Friese, R. S. et al. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension. Human molecular genetics 22, 3624-3640, doi: 10.1093/hmg/ddt213 (2013).
    • (2013) Human Molecular Genetics , vol.22 , pp. 3624-3640
    • Friese, R.S.1


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