Chronic inhibition of PDE5 limits pro-inflammatory monocyte-macrophage polarization in streptozotocin-induced diabetic mice

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Venneri, Mary Anna ^a   Giannetta, Elisa ^a   Panio, Giuseppe ^a   De Gaetano, Rita ^a   Gianfrilli, Daniele ^a   Pofi, Riccardo ^a   Masciarelli, Silvia ^a   Fazi, Francesco ^a   Pellegrini, Manuela ^b   Lenzi, Andrea ^a   Naro, Fabio ^a   Isidori, Andrea M ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF MOLISE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN RECEPTOR; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; SILDENAFIL; VASCULAR CELL ADHESION MOLECULE 1; NOS2 PROTEIN, MOUSE; PDE5A PROTEIN, MOUSE; PHOSPHODIESTERASE V INHIBITOR; PROTECTIVE AGENT; PTGS2 PROTEIN, MOUSE; STREPTOZOCIN; TEK PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL ADHESION; CELL EXPANSION; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; POLARIZATION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TISSUE REPAIR; ANIMAL; CELL COMMUNICATION; CELL COUNT; CHEMICALLY INDUCED; COCULTURE; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

MURINAE; MUS;

ANIMALS; CELL ADHESION; CELL COMMUNICATION; CELL COUNT; COCULTURE TECHNIQUES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; CYCLOOXYGENASE 2; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; MACROPHAGES; MALE; MICE; MONOCYTES; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHODIESTERASE 5 INHIBITORS; PROTECTIVE AGENTS; RECEPTOR, TIE-2; SIGNAL TRANSDUCTION; SILDENAFIL CITRATE; STREPTOZOCIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84930644447     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0126580     Document Type: Article

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