Demystifying the prothrombotic role of NETs

Blood

Volumn 129, Issue 8, 2017, Pages 925-926

  Schulz, Christian ^a   Massberg, Steffen ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HISTONE; THROMBIN;

BINDING AFFINITY; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CHROMATIN; EXTRACELLULAR TRAP; HUMAN; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; MEMBRANE MICROPARTICLE; NOTE; NUCLEOSOME; PRIORITY JOURNAL; THROMBOSIS;

EID: 85014932573     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-01-757328     Document Type: Note

References (10)

1. Noubouossie DF, Whelihan MF, Yu Y-B, et al. In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps. Blood. 2017;129(8):1021-1029.
2. Massberg S, Grahl L, von Bruehl ML, et al. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16(8):887-896.
3. Engelmann B, Massberg S. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34-45.
4. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532-1535.
5. Riegger J, Byrne RA, Joner M, et al; Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort (PRESTIGE) Investigators. Histopathological evaluation of thrombus in patients presenting with stent thrombosis. A multicenter European study: a report of the prevention of late stent thrombosis by an interdisciplinary global European effort consortium. Eur Heart J. 2016;37(19):1538-1549.
6. Knight JS, Luo W, O'Dell AA, et al. Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res. 2014;114(6):947-956.
7. von Brühl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209(4):819-835.
8. Hakkim A, Fürnrohr BG, Amann K, et al. Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci USA. 2010;107(21):9813-9818.
9. Korolev N, Lyubartsev AP, Nordenskiöld L. Computer modeling demonstrates that electrostatic attraction of nucleosomal DNA is mediated by histone tails. Biophys J. 2006;90(12):4305-4316.
10. Halverson TW, Wilton M, Poon KK, Petri B, Lewenza S. DNA is an antimicrobial component of neutrophil extracellular traps. PLoS Pathog. 2015;11(1):e1004593.