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Volumn 58, Issue 3, 2017, Pages 438-444

68Ga-PSMA-11 PET as a gatekeeper for the treatment of metastatic prostate cancer with 223Ra: Proof of concept

Author keywords

223Ra; Bone metastases; Bone scan; PET; Prostate cancer; PSMA; Radionuclide therapy

Indexed keywords

ABIRATERONE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; ENZALUTAMIDE; PROSTATE SPECIFIC ANTIGEN; PROSTATE SPECIFIC MEMBRANE ANTIGEN 11 GA 68; PROSTATE SPECIFIC MEMBRANE ANTIGEN LU 177; RADIUM CHLORIDE RA 223; TRACER; UNCLASSIFIED DRUG; (68GA)GLU-UREA-LYS(AHX)-HBED-CC; ORGANOMETALLIC COMPOUND; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; RADIUM;

EID: 85014814288     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.116.178533     Document Type: Article
Times cited : (51)

References (41)
  • 1
    • 82955162692 scopus 로고    scopus 로고
    • Internal radiotherapy of painful bone metastases
    • Liepe K, Kotzerke J. Internal radiotherapy of painful bone metastases. Methods. 2011;55:258-270
    • (2011) Methods , vol.55 , pp. 258-270
    • Liepe, K.1    Kotzerke, J.2
  • 2
    • 84908594586 scopus 로고    scopus 로고
    • Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: A prespecified subgroup analysis from the randomised, double-blind, phase 3 alsympca trial
    • Hoskin P, Sartor O, O'Sullivan JM, et al. Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial. Lancet Oncol. 2014;15:1397-1406
    • (2014) Lancet Oncol. , vol.15 , pp. 1397-1406
    • Hoskin, P.1    Sartor, O.2    O'Sullivan, J.M.3
  • 3
    • 34347244905 scopus 로고    scopus 로고
    • Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: A randomised, multicentre, placebo-controlled phase II study
    • Nilsson S, Franzen L, Parker C, et al. Bone-targeted radium-223 in symptomatic, hormone-refractory prostate cancer: a randomised, multicentre, placebo-controlled phase II study. Lancet Oncol. 2007;8:587-594
    • (2007) Lancet Oncol. , vol.8 , pp. 587-594
    • Nilsson, S.1    Franzen, L.2    Parker, C.3
  • 4
    • 84886298505 scopus 로고    scopus 로고
    • Radium-223 in prostate cancer
    • Parker C, Sartor O. Radium-223 in prostate cancer. N Engl JMed. 2013;369:1659-1660
    • (2013) N Engl JMed. , vol.369 , pp. 1659-1660
    • Parker, C.1    Sartor, O.2
  • 5
    • 84901638475 scopus 로고    scopus 로고
    • Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: Results from a phase 3, double-blind, randomised trial
    • Sartor O, Coleman R, Nilsson S, et al. Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial. Lancet Oncol. 2014;15:738-746
    • (2014) Lancet Oncol. , vol.15 , pp. 738-746
    • Sartor, O.1    Coleman, R.2    Nilsson, S.3
  • 6
    • 84920748709 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: AUA guideline amendment
    • Cookson MS, Lowrance WT, Murad MH, Kibel AS. Castration-resistant prostate cancer: AUA guideline amendment. J Urol. 2015;193:491-499
    • (2015) J Urol. , vol.193 , pp. 491-499
    • Cookson, M.S.1    Lowrance, W.T.2    Murad, M.H.3    Kibel, A.S.4
  • 7
    • 84908450488 scopus 로고    scopus 로고
    • Systemic therapy in men with metastatic castration-resistant prostate cancer: American Society of Clinical Oncology and Cancer Care Ontario clinical practice guideline
    • Basch E, Loblaw DA, Oliver TK, et al. Systemic therapy in men with metastatic castration-resistant prostate cancer: American Society of Clinical Oncology and Cancer Care Ontario clinical practice guideline. J Clin Oncol. 2014;32:3436-3448
    • (2014) J Clin Oncol. , vol.32 , pp. 3436-3448
    • Basch, E.1    Loblaw, D.A.2    Oliver, T.K.3
  • 8
    • 84941276341 scopus 로고    scopus 로고
    • Cancer of the prostate: ESMO clinical practice guidelines for diagnosis, treatment and follow-up
    • Parker C, Gillessen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):v69-v77
    • (2015) Ann Oncol. , vol.26 , pp. v69-v77
    • Parker, C.1    Gillessen, S.2    Heidenreich, A.3    Horwich, A.4
  • 9
    • 84960874462 scopus 로고    scopus 로고
    • Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer
    • Mikah P, Krabbe LM, Eminaga O, et al. Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer. BMC Cancer. 2016;16:214
    • (2016) BMC Cancer. , vol.16 , pp. 214
    • Mikah, P.1    Krabbe, L.M.2    Eminaga, O.3
  • 10
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher HI, Fizazi K, Saad F, et al. Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med. 2012;367:1187-1197
    • (2012) N Engl J Med. , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3
  • 11
    • 84955585899 scopus 로고    scopus 로고
    • The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: A pilot phase II study
    • Mahammedi H, Planchat E, Pouget M, et al. The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study. Oncology. 2016;90:69-78
    • (2016) Oncology. , vol.90 , pp. 69-78
    • Mahammedi, H.1    Planchat, E.2    Pouget, M.3
  • 12
    • 41949104346 scopus 로고    scopus 로고
    • Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: Recommendations of the Prostate Cancer Clinical Trials Working Group
    • Scher HI, Halabi S, Tannock I, et al. Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group. J Clin Oncol. 2008;26:1148-1159
    • (2008) J Clin Oncol. , vol.26 , pp. 1148-1159
    • Scher, H.I.1    Halabi, S.2    Tannock, I.3
  • 13
    • 84880428467 scopus 로고    scopus 로고
    • Alpha emitter radium-223 and survival in metastatic prostate cancer
    • Parker C, Nilsson S, Heinrich D, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369:213-223
    • (2013) N Engl J Med. , vol.369 , pp. 213-223
    • Parker, C.1    Nilsson, S.2    Heinrich, D.3
  • 14
    • 84929940756 scopus 로고    scopus 로고
    • Radium-223 dichloride for metastatic castration-resistant prostate cancer: The urologist's perspective
    • Shore ND. Radium-223 dichloride for metastatic castration-resistant prostate cancer: the urologist's perspective. Urology. 2015;85:717-724
    • (2015) Urology. , vol.85 , pp. 717-724
    • Shore, N.D.1
  • 15
    • 84890590469 scopus 로고    scopus 로고
    • Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
    • Afshar-Oromieh A, Zechmann CM, Malcher A, et al. Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2014; 41:11-20
    • (2014) Eur J Nucl Med Mol Imaging. , vol.41 , pp. 11-20
    • Afshar-Oromieh, A.1    Zechmann, C.M.2    Malcher, A.3
  • 16
    • 84891699534 scopus 로고    scopus 로고
    • PET imaging with a [68Ga]galliumlabelled PSMA ligand for the diagnosis of prostate cancer: Biodistribution in humans and first evaluation of tumour lesions
    • Afshar-Oromieh A, Malcher A, Eder M, et al. PET imaging with a [68Ga]galliumlabelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging. 2013;40:486-495
    • (2013) Eur J Nucl Med Mol Imaging. , vol.40 , pp. 486-495
    • Afshar-Oromieh, A.1    Malcher, A.2    Eder, M.3
  • 17
    • 84963973453 scopus 로고    scopus 로고
    • Correlation of intraprostatic tumor extent with 68Ga-PSMA distribution in patients with prostate cancer
    • Rahbar K, Weckesser M, Huss S, et al. Correlation of intraprostatic tumor extent with 68Ga-PSMA distribution in patients with prostate cancer. J Nucl Med. 2016; 57:563-567
    • (2016) J Nucl Med. , vol.57 , pp. 563-567
    • Rahbar, K.1    Weckesser, M.2    Huss, S.3
  • 18
    • 84957837099 scopus 로고    scopus 로고
    • 68Ga-labeled anti-prostate-specific membrane antigen peptide as marker for androgen deprivation therapy response in prostate cancer
    • Schlenkhoff CD, Gaertner F, Essler M, Hauser S, Ahmadzadehfar H. 68Ga-labeled anti-prostate-specific membrane antigen peptide as marker for androgen deprivation therapy response in prostate cancer. Clin Nucl Med. 2016;41:423-425
    • (2016) Clin Nucl Med. , vol.41 , pp. 423-425
    • Schlenkhoff, C.D.1    Gaertner, F.2    Essler, M.3    Hauser, S.4    Ahmadzadehfar, H.5
  • 19
    • 84929493114 scopus 로고    scopus 로고
    • Evaluation of hybrid 68Ga-PSMA ligand PET/CT in 248 patients with biochemical recurrence after radical prostatectomy
    • Eiber M, Maurer T, Souvatzoglou M, et al. Evaluation of hybrid 68Ga-PSMA ligand PET/CT in 248 patients with biochemical recurrence after radical prostatectomy. J Nucl Med. 2015;56:668-674
    • (2015) J Nucl Med. , vol.56 , pp. 668-674
    • Eiber, M.1    Maurer, T.2    Souvatzoglou, M.3
  • 20
    • 84934918549 scopus 로고    scopus 로고
    • Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: A two-centre study
    • Ahmadzadehfar H, Rahbar K, Kurpig S, et al. Early side effects and first results of radioligand therapy with 177Lu-DKFZ-617 PSMA of castrate-resistant metastatic prostate cancer: a two-centre study. EJNMMI Res. 2015;5:114
    • (2015) EJNMMI Res. , vol.5 , pp. 114
    • Ahmadzadehfar, H.1    Rahbar, K.2    Kurpig, S.3
  • 21
    • 84962905957 scopus 로고    scopus 로고
    • Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrateresistant metastatic prostate cancer
    • Ahmadzadehfar H, Eppard E, Kurpig S, et al. Therapeutic response and side effects of repeated radioligand therapy with 177Lu-PSMA-DKFZ-617 of castrateresistant metastatic prostate cancer. Oncotarget. 2016;7:12477-12488
    • (2016) Oncotarget. , vol.7 , pp. 12477-12488
    • Ahmadzadehfar, H.1    Eppard, E.2    Kurpig, S.3
  • 22
    • 84921846878 scopus 로고    scopus 로고
    • Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castrationresistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study
    • Ryan CJ, Smith MR, Fizazi K, et al. Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castrationresistant prostate cancer (COU-AA-302): final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol. 2015;16:152-160
    • (2015) Lancet Oncol. , vol.16 , pp. 152-160
    • Ryan, C.J.1    Smith, M.R.2    Fizazi, K.3
  • 23
    • 77957682309 scopus 로고    scopus 로고
    • Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: A randomised open-label trial
    • de Bono JS, Oudard S, Ozguroglu M, et al. Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial. Lancet. 2010;376:1147-1154
    • (2010) Lancet. , vol.376 , pp. 1147-1154
    • De Bono, J.S.1    Oudard, S.2    Ozguroglu, M.3
  • 25
    • 4744337716 scopus 로고    scopus 로고
    • Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
    • Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351:1513-1520
    • (2004) N Engl J Med. , vol.351 , pp. 1513-1520
    • Petrylak, D.P.1    Tangen, C.M.2    Hussain, M.H.3
  • 27
    • 84978426205 scopus 로고    scopus 로고
    • 177Lu-labeled prostate-specific membrane antigen radioligand therapy of metastatic castration-resistant prostate cancer: Safety and efficacy
    • Baum RP, Kulkarni HR, Schuchardt C, et al. 177Lu-labeled prostate-specific membrane antigen radioligand therapy of metastatic castration-resistant prostate cancer: safety and efficacy. J Nucl Med. 2016;57:1006-1013
    • (2016) J Nucl Med. , vol.57 , pp. 1006-1013
    • Baum, R.P.1    Kulkarni, H.R.2    Schuchardt, C.3
  • 28
    • 84963954521 scopus 로고    scopus 로고
    • Radioligand therapy with 177Lu-PSMA-617 as a novel therapeutic option in patients with metastatic castration resistant prostate cancer
    • Rahbar K, Bode A, Weckesser M, et al. Radioligand therapy with 177Lu-PSMA-617 as a novel therapeutic option in patients with metastatic castration resistant prostate cancer. Clin Nucl Med. 2016;41:522-528
    • (2016) Clin Nucl Med. , vol.41 , pp. 522-528
    • Rahbar, K.1    Bode, A.2    Weckesser, M.3
  • 29
    • 84989287555 scopus 로고    scopus 로고
    • Response and tolerability of a single dose of 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer: A multicenter retrospective analysis
    • Rahbar K, Schmidt M, Heinzel A, et al. Response and tolerability of a single dose of 177Lu-PSMA-617 in patients with metastatic castration-resistant prostate cancer: a multicenter retrospective analysis. J Nucl Med. 2016;57:1334-1338
    • (2016) J Nucl Med. , vol.57 , pp. 1334-1338
    • Rahbar, K.1    Schmidt, M.2    Heinzel, A.3
  • 30
    • 84980463813 scopus 로고    scopus 로고
    • PSMA-targeted radionuclide therapy of metastatic castration-resistant prostate cancer with Lu-177 labeled PSMA-617
    • Kratochwil C, Giesel FL, Stefanova M, et al. PSMA-targeted radionuclide therapy of metastatic castration-resistant prostate cancer with Lu-177 labeled PSMA-617. J Nucl Med. 2016;57:1170-1176
    • (2016) J Nucl Med. , vol.57 , pp. 1170-1176
    • Kratochwil, C.1    Giesel, F.L.2    Stefanova, M.3
  • 31
    • 84959115589 scopus 로고    scopus 로고
    • Positive influence of 177Lu PSMA-617 therapy on bone marrow depression caused by metastatic prostate cancer
    • Schlenkhoff CD, Gaertner F, Essler M, Schmidt M, Ahmadzadehfar H. Positive influence of 177Lu PSMA-617 therapy on bone marrow depression caused by metastatic prostate cancer. Clin Nucl Med. 2016;41:478-480
    • (2016) Clin Nucl Med. , vol.41 , pp. 478-480
    • Schlenkhoff, C.D.1    Gaertner, F.2    Essler, M.3    Schmidt, M.4    Ahmadzadehfar, H.5
  • 32
    • 84959094706 scopus 로고    scopus 로고
    • Metastatic prostate cancer with restored hormone-response after radioligand therapy with 177Lu-PSMA-617
    • Schlenkhoff CD, Knupfer E, Essler M, Ahmadzadehfar H.Metastatic prostate cancer with restored hormone-response after radioligand therapy with 177Lu-PSMA-617. Clin Nucl Med. 2016;41:572-573
    • (2016) Clin Nucl Med. , vol.41 , pp. 572-573
    • Schlenkhoff, C.D.1    Knupfer, E.2    Essler, M.3    Ahmadzadehfar, H.4
  • 34
    • 84868247267 scopus 로고    scopus 로고
    • 18F-fluoride PET/CT is highly effective for excluding bone metastases even in patients with equivocal bone scintigraphy
    • Bortot DC, Amorim BJ, Oki GC, et al. 18F-fluoride PET/CT is highly effective for excluding bone metastases even in patients with equivocal bone scintigraphy. Eur J Nucl Med Mol Imaging. 2012;39:1730-1736
    • (2012) Eur J Nucl Med Mol Imaging. , vol.39 , pp. 1730-1736
    • Bortot, D.C.1    Amorim, B.J.2    Oki, G.C.3
  • 36
    • 84961405267 scopus 로고    scopus 로고
    • Skeletal tumor burden on baseline 18F-fluoride PET/CT predicts bone marrow failure after 223Ra therapy
    • Etchebehere EC, Araujo JC, Milton DR, et al. Skeletal tumor burden on baseline 18F-fluoride PET/CT predicts bone marrow failure after 223Ra therapy. Clin Nucl Med. 2016;41:268-273
    • (2016) Clin Nucl Med. , vol.41 , pp. 268-273
    • Etchebehere, E.C.1    Araujo, J.C.2    Milton, D.R.3
  • 37
    • 84938871510 scopus 로고    scopus 로고
    • Prognostic factors in patients treated with 223Ra: The role of skeletal tumor burden on baseline 18F-fluoride PET/CT in predicting overall survival
    • Etchebehere EC, Araujo JC, Fox PS, Swanston NM, Macapinlac HA, Rohren EM. Prognostic factors in patients treated with 223Ra: the role of skeletal tumor burden on baseline 18F-fluoride PET/CT in predicting overall survival. J Nucl Med. 2015;56:1177-1184
    • (2015) J Nucl Med. , vol.56 , pp. 1177-1184
    • Etchebehere, E.C.1    Araujo, J.C.2    Fox, P.S.3    Swanston, N.M.4    Macapinlac, H.A.5    Rohren, E.M.6
  • 38
    • 84948969313 scopus 로고    scopus 로고
    • Haematopoietic toxicity of radium-223 in patients with high skeletal tumour burden
    • Miederer M, Thomas C, Beck J, et al. Haematopoietic toxicity of radium-223 in patients with high skeletal tumour burden. Nuklearmedizin. 2015;54:197-203
    • (2015) Nuklearmedizin. , vol.54 , pp. 197-203
    • Miederer, M.1    Thomas, C.2    Beck, J.3
  • 39
    • 84925481651 scopus 로고    scopus 로고
    • The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer
    • Afshar-Oromieh A, Avtzi E, Giesel FL, et al. The diagnostic value of PET/CT imaging with the 68Ga-labelled PSMA ligand HBED-CC in the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2015;42:197-209
    • (2015) Eur J Nucl Med Mol Imaging. , vol.42 , pp. 197-209
    • Afshar-Oromieh, A.1    Avtzi, E.2    Giesel, F.L.3
  • 40
    • 84862670770 scopus 로고    scopus 로고
    • [68Ga]galliumlabelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: Comparison with 18F-FECH
    • Afshar-Oromieh A, Haberkorn U, EderM, EisenhutM, Zechmann CM. [68Ga]galliumlabelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH. Eur J Nucl Med Mol Imaging. 2012;39:1085-1086
    • (2012) Eur J Nucl Med Mol Imaging. , vol.39 , pp. 1085-1086
    • Afshar-Oromieh, A.1    Haberkorn, U.2    Eder, M.3    Eisenhut, M.4    Zechmann, C.M.5
  • 41
    • 84925300464 scopus 로고    scopus 로고
    • Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: Morphologic and molecular backgrounds and future promises
    • Santoni M, Scarpelli M, Mazzucchelli R, et al. Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises. J Biol Regul Homeost Agents. 2014;28:555-563.
    • (2014) J Biol Regul Homeost Agents. , vol.28 , pp. 555-563
    • Santoni, M.1    Scarpelli, M.2    Mazzucchelli, R.3


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