Dynamic changes of alkaline phosphatase are strongly associated with PSA-decline and predict best clinical benefit earlier than PSA-changes under therapy with abiraterone acetate in bone metastatic castration resistant prostate cancer

BMC Cancer

Volumn 16, Issue 1, 2016, Pages

  Mikah, Phillip ^a   Krabbe, Laura Maria ^a   Eminaga, Okyaz ^b   Herrmann, Edwin ^a   Papavassilis, Philipp ^a   Hinkelammert, Reemt ^a   Semjonow, Axel ^a   Schrader, Andres Jan ^a   Boegemann, Martin ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Abiraterone acetate; MCRPC; Outcomes; Prostate cancer; Surrogate biomarker

Indexed keywords

ABIRATERONE ACETATE; ALKALINE PHOSPHATASE; AMINOTRANSFERASE; DENOSUMAB; ENZALUTAMIDE; LACTATE DEHYDROGENASE; PROSTATE SPECIFIC ANTIGEN; ZOLEDRONIC ACID; ABIRATERONE; ANDROSTANE DERIVATIVE; ANTINEOPLASTIC AGENT; TUMOR MARKER;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; BONE METASTASIS; CANCER GROWTH; CANCER PROGNOSIS; CASTRATION RESISTANT PROSTATE CANCER; CONTROLLED STUDY; DRUG DOSE REDUCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PREDICTION; RETROSPECTIVE STUDY; SIDE EFFECT; BLOOD; BONE NEOPLASMS; DISEASE FREE SURVIVAL; KAPLAN MEIER METHOD; METASTASIS; MIDDLE AGED; PATHOLOGY; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; SECONDARY; TREATMENT OUTCOME;

AGED; ALKALINE PHOSPHATASE; ANDROSTENES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOMARKERS, TUMOR; BONE NEOPLASMS; DISEASE-FREE SURVIVAL; HUMANS; KAPLAN-MEIER ESTIMATE; L-LACTATE DEHYDROGENASE; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; TREATMENT OUTCOME;

EID: 84960874462     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-016-2260-y     Document Type: Article

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