How the reference values for serum parathyroid hormone concentration are (or should be) established?

Journal of Endocrinological Investigation

Volumn 40, Issue 3, 2017, Pages 241-256

  Souberbielle, J C ^a,b   Brazier, F ^a,b   Piketty, M L ^a,b   Cormier, C ^c   Minisola, S ^d   Cavalier, E ^e  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Institut Cochin   (France)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Chronic kidney disease; Parathyroid hormone (PTH); Primary hyperparathyroidism; Reference values; Vitamin D

Indexed keywords

CALCIUM; PARATHYROID HORMONE; VITAMIN D;

AGE; BODY MASS; CHRONIC KIDNEY FAILURE; GENDER; HORMONE DETERMINATION; HUMAN; KIDNEY FUNCTION; MENOPAUSE; MULTICENTER STUDY (TOPIC); PARATHYROID HORMONE BLOOD LEVEL; PRACTICE GUIDELINE; PRIMARY HYPERPARATHYROIDISM; QUANTITATIVE ANALYSIS; RACE DIFFERENCE; REFERENCE VALUE; REVIEW; RISK ASSESSMENT; STANDARDIZATION; VITAMIN D DEFICIENCY; BLOOD; HYPERPARATHYROIDISM, PRIMARY;

HUMANS; HYPERPARATHYROIDISM, PRIMARY; PARATHYROID HORMONE; REFERENCE VALUES;

EID: 85014325998     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-016-0553-2     Document Type: Review

References (52)

1. Souberbielle JC, Cormier C, Cavalier E (2015) How to manage an isolated elevated PTH? Ann Endocrinol 76:134–141
2. Eastell R, Arnold A, Brandi ML, Brown EM, D’Amour P, Hanley D et al (2009) Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab 94:340–350
3. Bilezikian J, Brandi ML, Eastell R, Silverberg S, Udelsman R, Marcocci C et al (2014) Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the fourth international workshop. J Clin Endocrinol Metab 99:3561–3569
4. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY et al (1987) Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33:1364–1367
5. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C et al (1998) A non (1–84) circulating parathyroid hormone fragment interferes significantly with intact PTH commercial assay in uremic samples. Clin Chem 44:4287–4290
6. John M, Goodman W, Gao P, Cantor T, Salusky I, Juppner H (1999) A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab 84:4287–4290
7. Cavalier E, Daly AF, Betea D, Pruteanu-Apetrii P, Delanaye P, Stubbs P et al (2010) The ratio of parathyroid hormone as measured by third- and second-generation assays as a marker for parathyroid carcinoma. J Clin Endocrinol Metab 95:3745–3749
8. Souberbielle JC, Boutten A, Carlier MC, Chevenne D, Coumaros G, Lawson-Body E et al (2006) Inter-method variability in PTH measurement: implication for the care of CKD patients. Kidney Int 70:345–350
9. Joly D, Drueke T, Alberti C, Houillier P, Lawson-Body E, Martin K et al (2008) Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: a cross-sectional study. Am J Kidney Dis 51:987–995
10. Touvier M, Deschasaux M, Montourcy M, Sutton A, Charnuax N, Kess-Guyot E et al (2014) Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values. J Clin Endocrinol Metab 99:1196–1203
11. Björkman M, Sorva A, Tilvis R (2009) Responses of parathyroid hormone to vitamin D supplementation: a systematic review of clinical trials. Arch Gerontol Geriatr 48:160–166
12. Blind E, Schmidt-Gayk H, Scharla S, Flentje D, Fischer S, Göhring U et al (1988) Two-site assay of intact parathyroid hormone in the investigation of primary hyperparathyroidism and other disorders of calcium metabolism compared with a mid-region assay. J Clin Endocrinol Metab 67:353–360
13. Endres D, Villanueva R, Sharp C Jr, Singer F (1991) Immunochemiluminometric and immunoradiometric determinations of intact and total immunoreactive parathyrin: performance in the differential diagnosis of hypercalcemia and hypoparathyroidism. Clin Chem 37:162–168
14. Ratcliffe W, Heath D, Ryan M, Jones S (1989) Performance and diagnostic application of a two-site immunometric assay for parathyrin in serum. Clin Chem 35:1957–1961
15. Gao P, Scheibel S, D’Amour P, John M, Rao S, Schmidt-Gayk H et al (2001) Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1–84: implication for improvement of accurate assessment of parathyroid function. J Bone Miner Res 16:605–614
16. Souberbielle JC, Cormier C, Kindermans C, Gao P, Cantor T, Forette F et al (2001) Vitamin D status and redefining serum parathyroid hormone reference range. J Clin Endocrinol Metab 86:3086–3090
17. Glendenning P, Vasikaran S (2002) Comment on: Vitamin D status and redefining serum PTH reference range in the elderly. J Clin Endocrinol Metab 97:946–947
18. Souberbielle JC, Fayol V, Sault C, Lawson-Body E, Kahan A, Cormier A (2005) Assay-specific decision limits for two new automated parathyroid hormone and 25-hydroxyvitamin D assays. Clin Chem 51:395–400
19. Aloia J, Feuerman M, Yeh J (2006) Reference range for serum parathyroid hormone. Endocr Pract 12:137–144
20. La’ulu S, Roberts W (2010) Performance characteristics of six intact parathyroid hormone assays. Am J Clin Pathol 134:930–938
21. Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L (2011) Determinants of plasma PTH and their implication for defining a reference interval. Clin Endocrinol 74:37–43
22. Fillée C, Keller T, Mourad M, Brikman T, Ketelslegers JM (2012) Impact of vitamin D-related serum PTH reference values on the diagnosis of mild primary hyperparathyroidism, using bivariate calcium/PTH reference regions. Clin Endocrinol 76:785–789
23. Cavalier E, Delanaye P, Vranken L, Bekaert AC, Carlisi A, Chapelle JP et al (2012) Interpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values. Nephrol Dial Transpl 27:1950–1956
24. Deckers M, de Jongh R, Lips P, Penninx B, Milaschi Y, Smit J et al (2013) Prevalence of vitamin D deficiency and consequences for PTH reference values. Clin Chim Acta 426:41–45
25. Djennane M, Lebbah S, Roux C, Djoudi H, Cavalier E, Souberbielle JC (2014) Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency. Osteoporos Int 25:1493–1502
26. Li M, Lv F, Zhang Z, Deng W, Li Y, Deng Z et al (2016) Establishment of a normal reference value of parathyroid hormone in a large healthy Chinese population and evaluation of its relation to bone turnover and bone mineral density. Osteoporos Int 27:1907–1916
27. Souberbielle JC, Massart C, Brailly-Tabard S, Cormier C, Cavalier E, Delanaye P et al (2016) Serum PTH reference values established by an automated third-generation assay in vitamin D-replete subjects with normal renal function: consequences of diagnosing primary hyperparathyroidism and the classification of dialysis patients. Eu J Endocrinol 174:315–323
28. Ross C, Manson JE, Abrams S, Aloia J, Brannon P, Clinton S et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58
29. Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R et al (2011) Evaluation, treatment and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930
30. KDIGO C-M (2009) Work Group KDIGO Clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone disorder (CKD-MBD). Kidney Int 76(Suppl 113):S1–130
31. Bell NH, Greene A, Epstein S, Oexmann MJ, Shaw S, Shary JR (1985) Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest 76:470–473
32. Quesada JM, Coopmans W, Ruiz B, Aljam P, Jans I, Bouillon R (1992) Influence of vitamin D on parathyroid hormone in the elderly. J Clin Endocrinol Metab 75:494–501
33. Valcour A, Blocki F, Hawkins DM, Rao SD (2012) Effects of age and serum 25OHD-vitamin D levels on serum parathyroid hormone levels. J Clin Endocrinol Metab 97:3989–3995
34. Bailey D, Colantino D, Kuriakopoulou L, Cohen A, Chan MK, Armbruster D et al (2013) Marked biological variance in endocrine and biochemical markers in childhood: establishment of pediatric reference intervals using healthy community children from CALIPER cohort. Clin Chem 59:1393–1405
35. Soldin O, Dahlin J, Gresham E, King J, Soldin S (2008) Immulite 2000 age and sex-specific reference intervals for alpha fetoprotein, homocysteine, insulin, insulin-like growth factor-1, insulin-like growth factor binding protein-3, C-peptide, immunoglobulin E and intact parathyroid hormone. Clin Biochem 41:937–942
36. Kovacs C, Kronenberg H (1997) Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev 18:832–872
37. Frolich A, Rudnicki M, Fischer-Rasmussen W, Olofsson K (1991) Serum concentration of intact parathyroid hormone during late human pregnancy: a longitudinal study. Eur J Obstet Gynecol Reprod Biol 42:85–87
38. Seely EW, Brown E, DeMaggio D, Weldon D, Graves S (1997) A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Obstet Gynecol 176:214–217
39. Saggese G, Baroncelli GI, Bertelloni S, Cipolloni C (1991) Intact parathyroid hormone levels during pregnancy, in healthy term neonates and in hypocalcemic preterm infants. Acta Paediatr Scand 80:36–41
40. Cross N, Hillman L, Allen S, Krause G, Vieira N (1995) Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr 61:514–523
41. More C, Bhattoa HP, Bettembuk P, Balogh A (2003) The effect of pregnancy and lactation on hormonal status and biochemical markers of bone turnover. Eur J Obstet Gynecol Reprod Biol 106:209–213
42. Uemura H, Yasui T, Kiyokawa M, Kuwahara A, Ikawa H, Matsuzaki T et al (2002) Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers. J Endocrinol 174:353–359
43. Kramer C, Ye C, Hanley A, Connelly P, Sermer M, Zinman B et al (2016) The relationship between parathyroid hormone and 25-hydroxyvitamin D during and after pregnancy. J Clin Endocrinol Metab 101:1729–1736
44. Fuleihan GEH, Klerman E, Brown E, Choe Y, Brown E, Czeisler C (1997) The parathyroid hormone circadian rhythm is truly endogenous—a general clinical research center study. J Clin Endocrinol Metab 82:281–286
45. Rejnmark L, Lauridsen A, Vestergaard P, Heickendorff L, Andreasen F, Mosekilde L (2002) Diurnal rhythm of plasma 1,25-dihydroxyvitamin D and vitamin D-binding protein in postmenopausal women: relationship to plasma parathyroid hormone and calcium and phosphate metabolism. Eur J Endocrinol 146:635–642
46. Smith E, Cai M, McMahon L, Holt S (2012) Biological variability of plasma intact and C-terminal FGF23 measurements. J Clin Endocrinol Metab 97:3501–3504
47. Horn PS, Feng L, Li Y, Pesce AJ (2001) Effect of outliers and nonhealthy individuals on reference interval estimation. Clin Chem 47:2137–2145
48. Souberbielle JC, Lawson-Body E, Hammadi B, Sarfati E, Kahan A, Cormier C (2003) The use in clinical practice of parathyroid hormone normative values established in vitamin D-sufficient subjects. J Clin Endocrinol Metab 88:3501–3504
49. Koumakis E, Souberbielle JC, Sarfati E, Meunier M, Maury E, Gallimard E et al (2013) Bone mineral density evolution after successful parathyroidectomy in patients with normocalcemic primary hyperparathyroidism. J Clin Endocrinol Metab 98:3213–3220
50. van Ballegooijen A, Reinders I, Visser M, Brouwer I (2013) Parathyroid hormone and cardiovascular disease events: a systematic review and meta-analysis of prospective studies. Am Heart J 165:655–664
51. Yang B, Lu C, Wu Q, Zhang J, Zhao H, Cao Y (2016) Parathyroid hormone, cardiovascular and all-cause mortality: a meta-analysis. Clin Chim Acta 455:154–160
52. Minisola S, Pepe J, Piemonte S, Cipriani C (2015) The diagnosis and management of hypercalcemia. BMJ 2(350):h2723. doi:10.1136/bmj.h2723