Establishment of a normal reference value of parathyroid hormone in a large healthy Chinese population and evaluation of its relation to bone turnover and bone mineral density

Osteoporosis International

Volumn 27, Issue 5, 2016, Pages 1907-1916

  Li, M ^a   Lv, F ^a   Zhang, Z ^b   Deng, W ^c   Li, Y ^d   Deng, Z ^e   Jiang, Y ^a   Wang, O ^a   Xing, X ^a   Xu, L ^a   Xia, W ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^d RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^e THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

25OHD; BMD; Bone turnover; P1NP; PTH; CTX

Indexed keywords

25 HYDROXYVITAMIN D; BIOLOGICAL MARKER; CARBOXYL TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN; PARATHYROID GLAND HORMONE; PROCOLLAGEN I N TERMINAL PEPTIDE; UNCLASSIFIED DRUG; 25-HYDROXYVITAMIN D; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; PARATHYROID HORMONE; PEPTIDE; PEPTIDE FRAGMENT; PROCOLLAGEN; PROCOLLAGEN TYPE I N-TERMINAL PEPTIDE; PTH PROTEIN, HUMAN; VITAMIN D;

ADOLESCENT; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE TURNOVER; CHINESE; CONCENTRATION (PARAMETERS); CROSS-SECTIONAL STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HUMAN; MALE; MULTICENTER STUDY; NORMAL HUMAN; OSSIFICATION; PARATHYROID GLAND; PARATHYROID HORMONE BLOOD LEVEL; POPULATION RESEARCH; PRIORITY JOURNAL; REFERENCE VALUE; VITAMIN BLOOD LEVEL; X RAY BONE DENSITOMETER; ADULT; AGED; AGING; ANALOGS AND DERIVATIVES; ANTHROPOMETRY; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; BODY MASS; BONE REMODELING; CLINICAL TRIAL; MIDDLE AGED; PHYSIOLOGY; PROCEDURES; SEXUAL DEVELOPMENT; STATISTICS AND NUMERICAL DATA; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ANTHROPOMETRY; ASIAN CONTINENTAL ANCESTRY GROUP; BIOMARKERS; BODY MASS INDEX; BONE DENSITY; BONE REMODELING; COLLAGEN TYPE I; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; PEPTIDES; PROCOLLAGEN; REFERENCE VALUES; SEX CHARACTERISTICS; VITAMIN D; YOUNG ADULT;

EID: 84953203936     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-015-3475-5     Document Type: Article

References (41)

1. Curtis JR, Ewing SK, Bauer DC, Cauley JA, Cawthon PM, Barrett-Connor E, Haney EM, Ishani A, Cremers S, Orwoll E (2012) Association of intact parathyroid hormone levels with subsequent hip BMD loss: the Osteoporotic Fractures in Men (MrOS) Study. J Clin Endocrinol Metab 97:1937–1944
2. Sai AJ, Walters RW, Fang X, Gallagher JC (2011) Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab 96:E436–E446
3. Vignali E, Viccica G, Diacinti D et al (2009) Morphometric vertebral fractures in postmenopausal women with primary hyperparathyroidism. J Clin Endocrinol Metab 94:2306–2312
4. Li Y, Chen C, Liu HL, Qian G (2015) Vitamin d, parathyroid hormone, and heart failure in a Chinese elderly population. Endocr Pract 21:30–40
5. Hagstrom E, Kilander L, Nylander R, Larsson EM, Michaelsson K, Melhus H, Ahlstrom H, Johansson L, Lind L, Arnlov J (2014) Plasma parathyroid hormone is associated with vascular dementia and cerebral hyperintensities in two community-based cohorts. J Clin Endocrinol Metab 99:4181–4189
6. Hagstrom E, Hellman P, Larsson TE et al (2009) Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation 119:2765–2771
7. Rejnmark L, Vestergaard P, Heickendorff L, Mosekilde L (2011) Determinants of plasma PTH and their implication for defining a reference interval. Clin Endocrinol (Oxf) 74:37–43
8. Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G (2010) Age but not gender modulates the relationship between PTH and vitamin D. Bone 47:408–412
9. Gallagher JC, Peacock M, Yalamanchili V, Smith LM (2013) Effects of vitamin D supplementation in older African American women. J Clin Endocrinol Metab 98:1137–1146
10. Joo NS, Dawson-Hughes B, Kim YS, Oh K, Yeum KJ (2013) Impact of calcium and vitamin D insufficiencies on serum parathyroid hormone and bone mineral density: analysis of the fourth and fifth Korea National Health and Nutrition Examination Survey (KNHANES IV-3, 2009 and KNHANES V-1, 2010). J Bone Miner Res 28:764–770
11. Souberbielle JC, Friedlander G, Cormier C (2006) Practical considerations in PTH testing. Clin Chim Acta 366:81–89
12. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM, Endocrine S (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930
13. Eastell R, Brandi ML, Costa AG, D’Amour P, Shoback DM, Thakker RV (2014) Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. J Clin Endocrinol Metab 99:3570–3579
14. Vasikaran S, Cooper C, Eastell R, Griesmacher A, Morris HA, Trenti T, Kanis JA (2011) International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis. Clin Chem Lab Med 49:1271–1274
15. Li M, Li Y, Deng W, Zhang Z, Deng Z, Hu Y, Xia W, Xu L (2014) Chinese bone turnover marker study: reference ranges for C-terminal telopeptide of type I collagen and procollagen I N-terminal peptide by age and gender. PLoS One 9:e103841
16. Genant HK (1995) Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results. J Bone Miner Res 10:997–998
17. Hernandez JL, Olmos JM, Pariente E, Nan D, Martinez J, Llorca J, Valero C, Obregon E, Gonzalez-Macias J (2013) Influence of vitamin D status on vertebral fractures, bone mineral density, and bone turnover markers in normocalcemic postmenopausal women with high parathyroid hormone levels. J Clin Endocrinol Metab 98:1711–1717
18. Touvier M, Deschasaux M, Montourcy M et al (2014) Interpretation of plasma PTH concentrations according to 25OHD status, gender, age, weight status, and calcium intake: importance of the reference values. J Clin Endocrinol Metab 99:1196–1203
19. Aloia JF, Dhaliwal R, Shieh A, Mikhail M, Fazzari M, Ragolia L, Abrams SA (2014) Vitamin D supplementation increases calcium absorption without a threshold effect. Am J Clin Nutr 99:624–631
20. Jamali Z, Asadikaram G, Mahmoodi M, Sayadi A, Jamalizadeh A, Saleh-Moghadam M, Sirati-Sabt M, Arababadi MK (2013) Vitamin D status in female students and its relation to calcium metabolism markers, lifestyles, and polymorphism in vitamin D receptor. Clin Lab 59:407–413
21. Shu L, Ji J, Zhu Q, Cao G, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D (2011) The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res 26:1057–1071
22. Lin CH, Su CH, Hwang PP (2014) Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology 155:56–67
23. Need AG, O’Loughlin PD, Morris HA, Coates PS, Horowitz M, Nordin BE (2008) Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res 23:1859–1863
24. Gallagher JC, Jindal PS, Smith LM (2014) Vitamin D does not increase calcium absorption in young women: a randomized clinical trial. J Bone Miner Res 29:1081–1087
25. Ritter CS, Brown AJ (2011) Direct suppression of PTH gene expression by the vitamin D prohormones doxercalciferol and calcidiol requires the vitamin D receptor. J Mol Endocrinol 46:63–66
26. Ebeling PR (2014) Vitamin D and bone health: epidemiologic studies. Bonekey Rep 3:511
27. Hu WW, Zhang Z, He JW, Fu WZ, Wang C, Zhang H, Yue H, Gu JM, Zhang ZL (2013) Establishing reference intervals for bone turnover markers in the healthy Shanghai population and the relationship with bone mineral density in postmenopausal women. Int J Endocrinol 2013:513925
28. Zhao J, Xia W, Nie M et al (2011) The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study. Menopause 18:1237–1243
29. Souberbielle JC, Fayol V, Sault C, Lawson-Body E, Kahan A, Cormier C (2005) Assay-specific decision limits for two new automated parathyroid hormone and 25-hydroxyvitamin D assays. Clin Chem 51:395–400
30. Souberbielle JC, Cormier C, Kindermans C, Gao P, Cantor T, Forette F, Baulieu EE (2001) Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. J Clin Endocrinol Metab 86:3086–3090
31. Fuleihan Gel H, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, Singh RJ (2015) Serum 25-hydroxyvitamin D levels: variability, knowledge gaps, and the concept of a desirable range. J Bone Miner Res 30:1119–1133
32. Metzger M, Houillier P, Gauci C et al (2013) Relation between circulating levels of 25(OH) vitamin D and parathyroid hormone in chronic kidney disease: quest for a threshold. J Clin Endocrinol Metab 98:2922–2928
33. Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh JK (2006) Optimal vitamin D status and serum parathyroid hormone concentrations in African American women. Am J Clin Nutr 84:602–609
34. Ross AC, Manson JE, Abrams SA et al (2011) The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58
35. Lips P, van Schoor NM, de Jongh RT (2014) Diet, sun, and lifestyle as determinants of vitamin D status. Ann N Y Acad Sci 1317:92–98
36. Valcour A, Blocki F, Hawkins DM, Rao SD (2012) Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab 97:3989–3995
37. Valina-Toth AL, Lai Z, Yoo W, Abou-Samra A, Gadegbeku CA, Flack JM (2010) Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans. Clin Endocrinol (Oxf) 72:595–603
38. Costa AG, Bilezikian JP (2013) Bone turnover markers in primary hyperparathyroidism. J Clin Densitom 16:22–27
39. Berger C, Almohareb O, Langsetmo L et al (2015) Characteristics of hyperparathyroid states in the Canadian Multicentre Osteoporosis Study (CaMos) and relationship to skeletal markers. Clin Endocrinol (Oxf) 82:359–368
40. Koumakis E, Souberbielle JC, Sarfati E, Meunier M, Maury E, Gallimard E, Borderie D, Kahan A, Cormier C (2013) Bone mineral density evolution after successful parathyroidectomy in patients with normocalcemic primary hyperparathyroidism. J Clin Endocrinol Metab 98:3213–3220
41. Lewiecki EM, Miller PD (2013) Skeletal effects of primary hyperparathyroidism: bone mineral density and fracture risk. J Clin Densitom 16:28–32