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Volumn 45, Issue 5, 2017, Pages e493-e499

An unbalanced inflammatory cytokine response is not associated with mortality following sepsis: A prospective cohort study

Author keywords

Anti inflammatory; Balance; Host response; Proinflammatory; Sepsis

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 6; CYTOKINE; IL10 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN;

EID: 85014274124     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002292     Document Type: Article
Times cited : (41)

References (35)
  • 1
    • 0026285066 scopus 로고
    • Sepsis syndrome. New insights into its pathogenesis and treatment
    • Bone RC: Sepsis syndrome. New insights into its pathogenesis and treatment. Infect Dis Clin North Am 1991; 5:793-805.
    • (1991) Infect Dis Clin North Am , vol.5 , pp. 793-805
    • Bone, R.C.1
  • 2
    • 0026048714 scopus 로고
    • The pathogenesis of sepsis
    • Bone RC: The pathogenesis of sepsis. Ann Intern Med 1991; 115:457-469.
    • (1991) Ann Intern Med , vol.115 , pp. 457-469
    • Bone, R.C.1
  • 3
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101:1644-1655.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3
  • 5
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150.
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 6
    • 84897377065 scopus 로고    scopus 로고
    • Why have clinical trials in sepsis failed?
    • Marshall JC: Why have clinical trials in sepsis failed? Trends Mol Med 2014; 20:195-203.
    • (2014) Trends Mol Med , vol.20 , pp. 195-203
    • Marshall, J.C.1
  • 8
    • 84888325490 scopus 로고    scopus 로고
    • Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy
    • Hotchkiss RS, Monneret G, Payen D: Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013; 13:862-874.
    • (2013) Nat Rev Immunol , vol.13 , pp. 862-874
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 9
    • 84874256945 scopus 로고    scopus 로고
    • Immunosuppression in sepsis: A novel understanding of the disorder and a new therapeutic approach
    • Hotchkiss RS, Monneret G, Payen D: Immunosuppression in sepsis: A novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013; 13:260-268.
    • (2013) Lancet Infect Dis , vol.13 , pp. 260-268
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 10
    • 77951622976 scopus 로고    scopus 로고
    • Long-Term mortality and quality of life in sepsis: A systematic review
    • Winters BD, Eberlein M, Leung J, et al: Long-Term mortality and quality of life in sepsis: A systematic review. Crit Care Med 2010; 38:1276-1283.
    • (2010) Crit Care Med , vol.38 , pp. 1276-1283
    • Winters, B.D.1    Eberlein, M.2    Leung, J.3
  • 11
    • 44449160935 scopus 로고    scopus 로고
    • Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    • GenIMS Investigators
    • Yende S, D'Angelo G, Kellum JA, et al; GenIMS Investigators: Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med 2008; 177:1242-1247.
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 1242-1247
    • Yende, S.1    D'Angelo, G.2    Kellum, J.A.3
  • 12
    • 84884905541 scopus 로고    scopus 로고
    • Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients
    • Klein Klouwenberg PM, Ong DS, Bos LD, et al: Interobserver agreement of Centers for Disease Control and Prevention criteria for classifying infections in critically ill patients. Crit Care Med 2013; 41:2373-2378.
    • (2013) Crit Care Med , vol.41 , pp. 2373-2378
    • Klein Klouwenberg, P.M.1    Ong, D.S.2    Bos, L.D.3
  • 13
    • 84940970665 scopus 로고    scopus 로고
    • Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: A cohort study
    • Klein Klouwenberg PM, Cremer OL, van Vught LA, et al: Likelihood of infection in patients with presumed sepsis at the time of intensive care unit admission: A cohort study. Crit Care 2015; 19:319.
    • (2015) Crit Care , vol.19 , pp. 319
    • Klein Klouwenberg, P.M.1    Cremer, O.L.2    Van Vught, L.A.3
  • 14
    • 84959273475 scopus 로고    scopus 로고
    • The third international consensus definitions for sepsis and septic shock (sepsis-3)
    • Singer M, Deutschman CS, Seymour CW, et al: The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315:801-810.
    • (2016) JAMA , vol.315 , pp. 801-810
    • Singer, M.1    Deutschman, C.S.2    Seymour, C.W.3
  • 15
    • 84930007712 scopus 로고    scopus 로고
    • Sepsis-induced immunoparalysis: Mechanisms, markers, and treatment options
    • Hamers L, Kox M, Pickkers P: Sepsis-induced immunoparalysis: Mechanisms, markers, and treatment options. Minerva Anestesiol 2015; 81:426-439.
    • (2015) Minerva Anestesiol , vol.81 , pp. 426-439
    • Hamers, L.1    Kox, M.2    Pickkers, P.3
  • 16
    • 84941941387 scopus 로고    scopus 로고
    • Rose-John S: Interleukin-6: Biology, signaling and strategies of blockade
    • Schaper F, Rose-John S: Interleukin-6: Biology, signaling and strategies of blockade. Cytokine Growth Factor Rev 2015; 26:475-487.
    • (2015) Cytokine Growth Factor Rev , vol.26 , pp. 475-487
    • Schaper, F.1
  • 17
    • 84856381402 scopus 로고    scopus 로고
    • A combined score of pro-And anti-inflammatory interleukins improves mortality prediction in severe sepsis
    • Andaluz-Ojeda D, Bobillo F, Iglesias V, et al: A combined score of pro-And anti-inflammatory interleukins improves mortality prediction in severe sepsis. Cytokine 2012; 57:332-336.
    • (2012) Cytokine , vol.57 , pp. 332-336
    • Andaluz-Ojeda, D.1    Bobillo, F.2    Iglesias, V.3
  • 18
    • 79961015817 scopus 로고    scopus 로고
    • Pro-And anti-inflammatory responses are regulated simultaneously from the first moments of septic shock
    • Tamayo E, Fernández A, Almansa R, et al: Pro-And anti-inflammatory responses are regulated simultaneously from the first moments of septic shock. Eur Cytokine Netw 2011; 22:82-87.
    • (2011) Eur Cytokine Netw , vol.22 , pp. 82-87
    • Tamayo, E.1    Fernández, A.2    Almansa, R.3
  • 19
    • 16944363557 scopus 로고    scopus 로고
    • Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: Sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13
    • van der Poll T, de Waal Malefyt R, Coyle SM, et al: Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: Sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis 1997; 175:118-122.
    • (1997) J Infect Dis , vol.175 , pp. 118-122
    • Van Der Poll, T.1    De Waal Malefyt, R.2    Coyle, S.M.3
  • 20
    • 34249318067 scopus 로고    scopus 로고
    • Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis
    • Bozza FA, Salluh JI, Japiassu AM, et al: Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis. Crit Care 2007; 11:R49.
    • (2007) Crit Care , vol.11 , pp. R49
    • Bozza, F.A.1    Salluh, J.I.2    Japiassu, A.M.3
  • 21
    • 0032939769 scopus 로고    scopus 로고
    • Pro-And anti-inflammatory cytokines during acute severe pancreatitis: An early and sustained response, although unpredictable of death
    • Parisian Study Group on Acute Pancreatitis
    • Brivet FG, Emilie D, Galanaud P: Pro-And anti-inflammatory cytokines during acute severe pancreatitis: An early and sustained response, although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Crit Care Med 1999; 27:749-755.
    • (1999) Crit Care Med , vol.27 , pp. 749-755
    • Brivet, F.G.1    Emilie, D.2    Galanaud, P.3
  • 22
    • 66749164669 scopus 로고    scopus 로고
    • The sepsis seesaw: Tilting toward immunosuppression
    • Hotchkiss RS, Coopersmith CM, McDunn JE, et al: The sepsis seesaw: Tilting toward immunosuppression. Nat Med 2009; 15:496-497.
    • (2009) Nat Med , vol.15 , pp. 496-497
    • Hotchkiss, R.S.1    Coopersmith, C.M.2    McDunn, J.E.3
  • 23
    • 1642420994 scopus 로고    scopus 로고
    • A modified poisson regression approach to prospective studies with binary data
    • Zou G: A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol 2004; 159:702-706.
    • (2004) Am J Epidemiol , vol.159 , pp. 702-706
    • Zou, G.1
  • 24
    • 34548022149 scopus 로고    scopus 로고
    • Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study
    • GenIMS Investigators
    • Kellum JA, Kong L, Fink MP, et al; GenIMS Investigators: Understanding the inflammatory cytokine response in pneumonia and sepsis: Results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167:1655-1663.
    • (2007) Arch Intern Med , vol.167 , pp. 1655-1663
    • Kellum, J.A.1    Kong, L.2    Fink, M.P.3
  • 25
    • 84896671549 scopus 로고    scopus 로고
    • Immunological characterization of compensatory anti-inflammatory response syndrome in patients with severe sepsis: A longitudinal study
    • Gomez HG, Gonzalez SM, Londoño JM, et al: Immunological characterization of compensatory anti-inflammatory response syndrome in patients with severe sepsis: A longitudinal study. Crit Care Med 2014; 42:771-780.
    • (2014) Crit Care Med , vol.42 , pp. 771-780
    • Gomez, H.G.1    Gonzalez, S.M.2    Londoño, J.M.3
  • 26
    • 77952630881 scopus 로고    scopus 로고
    • Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection
    • Gogos C, Kotsaki A, Pelekanou A, et al: Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit Care 2010; 14:R96.
    • (2010) Crit Care , vol.14 , pp. R96
    • Gogos, C.1    Kotsaki, A.2    Pelekanou, A.3
  • 28
    • 84922476780 scopus 로고    scopus 로고
    • PSHREG: A SAS macro for proportional and nonproportional subdistribution hazards regression
    • Kohl M, Plischke M, Leffondré K, et al: PSHREG: A SAS macro for proportional and nonproportional subdistribution hazards regression. Comput Methods Programs Biomed 2015; 118:218-233.
    • (2015) Comput Methods Programs Biomed , vol.118 , pp. 218-233
    • Kohl, M.1    Plischke, M.2    Leffondré, K.3
  • 29
    • 84879562427 scopus 로고    scopus 로고
    • Immunotherapy for the adjunctive treatment of sepsis: From immunosuppression to immunostimulation. Time for a paradigm change?
    • Leentjens J, Kox M, van der Hoeven JG, et al: Immunotherapy for the adjunctive treatment of sepsis: From immunosuppression to immunostimulation. Time for a paradigm change? Am J Respir Crit Care Med 2013; 187:1287-1293.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 1287-1293
    • Leentjens, J.1    Kox, M.2    Van Der Hoeven, J.G.3
  • 30
    • 4544231442 scopus 로고    scopus 로고
    • The anti-inflammatory response dominates after septic shock: Association of low monocyte HLADR expression and high interleukin-10 concentration
    • Monneret G, Finck ME, Venet F, et al: The anti-inflammatory response dominates after septic shock: Association of low monocyte HLADR expression and high interleukin-10 concentration. Immunol Lett 2004; 95:193-198.
    • (2004) Immunol Lett , vol.95 , pp. 193-198
    • Monneret, G.1    Finck, M.E.2    Venet, F.3
  • 31
    • 34548482285 scopus 로고    scopus 로고
    • Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia
    • Leonidou L, Mouzaki A, Michalaki M, et al: Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia. J Infect 2007; 55:340-346.
    • (2007) J Infect , vol.55 , pp. 340-346
    • Leonidou, L.1    Mouzaki, A.2    Michalaki, M.3
  • 32
    • 33746190736 scopus 로고    scopus 로고
    • Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    • Osuchowski MF, Welch K, Siddiqui J, et al: Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 2006; 177:1967-1974.
    • (2006) J Immunol , vol.177 , pp. 1967-1974
    • Osuchowski, M.F.1    Welch, K.2    Siddiqui, J.3
  • 33
    • 84867903811 scopus 로고    scopus 로고
    • Sepsis chronically in MARS: Systemic cytokine responses are always mixed regardless of the outcome, magnitude, or phase of sepsis
    • Osuchowski MF, Craciun F, Weixelbaumer KM, et al: Sepsis chronically in MARS: Systemic cytokine responses are always mixed regardless of the outcome, magnitude, or phase of sepsis. J Immunol 2012; 189:4648-4656.
    • (2012) J Immunol , vol.189 , pp. 4648-4656
    • Osuchowski, M.F.1    Craciun, F.2    Weixelbaumer, K.M.3
  • 34
    • 84923052923 scopus 로고    scopus 로고
    • Exaggerated plasma interleukin 6, interleukin 10, and subsequent development of health care-Associated infections in patients with sepsis
    • Umberger R, Thompson CL, Cashion AK, et al: Exaggerated plasma interleukin 6, interleukin 10, and subsequent development of health care-Associated infections in patients with sepsis. Dimens Crit Care Nurs 2015; 34:100-111.
    • (2015) Dimens Crit Care Nurs , vol.34 , pp. 100-111
    • Umberger, R.1    Thompson, C.L.2    Cashion, A.K.3
  • 35
    • 79955483742 scopus 로고    scopus 로고
    • Dutch SOD-SDD Trialists Group: The role of intestinal colonization with gram-negative bacteria as a source for intensive care unit-Acquired bacteremia
    • Oostdijk EA, de Smet AM, Kesecioglu J, et al; Dutch SOD-SDD Trialists Group: The role of intestinal colonization with gram-negative bacteria as a source for intensive care unit-Acquired bacteremia. Crit Care Med 2011; 39:961-966.
    • (2011) Crit Care Med , vol.39 , pp. 961-966
    • Oostdijk, E.A.1    De Smet, A.M.2    Kesecioglu, J.3


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