Aged neutrophils contribute to the first line of defense in the acute inflammatory response

Blood

Volumn 128, Issue 19, 2016, Pages 2327-2337

  Uhl, Bernd ^a   Vadlau, Yannick ^a   Zuchtriegel, Gabriele ^a   Nekolla, Katharina ^a   Sharaf, Kariem ^a   Gaertner, Florian ^a   Massberg, Steffen ^a   Krombach, Fritz ^a   Reichel, Christoph A ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD18 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 4; CD11B ANTIGEN; CYTOKINE; INTEGRIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL ADHESION; CELL AGING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOTOXEMIA; INFLAMMATION; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; ACUTE DISEASE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL MEMBRANE; CELL TRACKING; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHAGOCYTOSIS; SIGNAL TRANSDUCTION;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD11B; CELL ADHESION; CELL AGING; CELL MEMBRANE; CELL TRACKING; CYTOKINES; INFLAMMATION; INTEGRINS; MALE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; NEUTROPHILS; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 85014262346     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-05-718999     Document Type: Article

References (45)

1. Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014;9:181-218.
2. Nauseef WM, Borregaard N. Neutrophils at work. Nat Immunol. 2014;15(7):602-611.
3. Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol. 2010;10(6):427-439.
4. Basu S, Hodgson G, Katz M, Dunn AR. Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. Blood. 2002;100(3):854-861.
5. Pillay J, den Braber I, Vrisekoop N, et al. In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days. Blood. 2010;116(4):625-627.
6. Simon SI, Kim MH. A day (or 5) in a neutrophil's life. Blood. 2010;116(4):511-512.
7. Li KW, Turner SM, Emson CL, Hellerstein MK, Dale DC. Deuterium and neutrophil kinetics. Blood. 2011;117(22):6052-6053, author reply 6053-6054.
8. Tofts PS, Chevassut T, Cutajar M, Dowell NG, Peters AM. Doubts concerning the recently reported human neutrophil lifespan of 5.4 days. Blood. 2011;117(22):6050-6052, author reply 6053-6054.
9. Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, Frenette PS. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med. 2009;15(4): 384-391.
10. Taylor PR, Roy S, Leal SM Jr, et al. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORgt and dectin-2. Nat Immunol. 2014;15(2):143-151.
11. Woodfin A, Beyrau M, Voisin MB, et al. ICAM-1-expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. Blood. 2016;127(7):898-907.
12. Woodfin A, Voisin MB, Beyrau M, et al. The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol. 2011;12(8):761-769.
13. Zhang YP, Wang WL, Liu J, et al. Plasminogen activator inhibitor-1 promotes the proliferation and inhibits the apoptosis of pulmonary fibroblasts by Ca(21) signaling. Thromb Res. 2013;131(1): 64-71.
14. Silvestre-Roig C, Hidalgo A, Soehnlein O. Neutrophil heterogeneity: implications for homeostasis and pathogenesis. Blood. 2016; 127(18):2173-2181.
15. Casanova-Acebes M, Pitaval C, Weiss LA, et al. Rhythmic modulation of the hematopoietic niche through neutrophil clearance. Cell. 2013;153(5): 1025-1035.
16. Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 2005;22(3):285-294.
17. Adrover JM, Nicolas-Avila JA, Hidalgo A. Aging: a temporal dimension for neutrophils. Trends Immunol. 2016;37(5):334-345.
18. Zhang D, Chen G, Manwani D, et al. Neutrophil ageing is regulated by the microbiome. Nature. 2015;525(7570):528-532.
19. Martin C, Burdon PC, Bridger G, Gutierrez-Ramos JC, Williams TJ, Rankin SM. Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence. Immunity. 2003; 19(4):583-593.
20. Baez S. An open cremaster muscle preparation for the study of blood vessels by in vivo microscopy. Microvasc Res. 1973;5(3):384-394.
21. Mempel TR, Moser C, Hutter J, Kuebler WM, Krombach F. Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy. J Vasc Res. 2003;40(5): 435-441.
22. Stadtmann A, Germena G, Block H, et al. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med. 2013; 210(11):2171-2180.
23. Hyduk SJ, Oh J, Xiao H, Chen M, Cybulsky MI. Paxillin selectively associates with constitutive and chemoattractant-induced high-affinity alpha4beta1 integrins: implications for integrin signaling. Blood. 2004;104(9):2818-2824.
24. Hogg N, Patzak I, Willenbrock F. The insider's guide to leukocyte integrin signalling and function. Nat Rev Immunol. 2011;11(6):416-426.
25. Chung WS, Clarke LE, Wang GX, et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature. 2013; 504(7480):394-400.
26. Drechsler M, Megens RT, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation. 2010;122(18):1837-1845.
27. Nakamura A, Mori Y, Hagiwara K, et al. Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice. J Exp Med. 2003;197(5):669-674.
28. Roger T, Froidevaux C, Le Roy D, et al. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci USA. 2009;106(7):2348-2352.
29. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol. 2013;13(3):159-175.
30. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7(9):678-689.
31. Nourshargh S, Alon R. Leukocyte migration into inflamed tissues. Immunity. 2014;41(5):694-707.
32. Nourshargh S, Hordijk PL, Sixt M. Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol. 2010;11(5):366-378.
33. Reichel CA, Kanse SM, Krombach F. At the interface of fibrinolysis and inflammation: the role of urokinase-type plasminogen activator in the leukocyte extravasation cascade. Trends Cardiovasc Med. 2012;22(7):192-196.
34. Vestweber D. How leukocytes cross the vascular endothelium. Nat Rev Immunol. 2015;15(11): 692-704.
35. Kaufmann SH, Dorhoi A. Molecular determinants in phagocyte-bacteria interactions. Immunity. 2016;44(3):476-491.
36. Furze RC, Rankin SM. The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse. FASEB J. 2008;22(9): 3111-3119.
37. Rankin SM. The bone marrow: a site of neutrophil clearance. J Leukoc Biol. 2010;88(2):241-251.
38. Suratt BT, Young SK, Lieber J, Nick JA, Henson PM, Worthen GS. Neutrophil maturation and activation determine anatomic site of clearance from circulation. Am J Physiol Lung Cell Mol Physiol. 2001;281(4):L913-L921.
39. von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J Immunol. 2008; 181(8):5183-5188.
40. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282(5396): 2085-2088.
41. Knapp S, von Aulock S, Leendertse M, et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol. 2008;180(5):3478-3484.
42. Harris HE, Andersson U, Pisetsky DS. HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol. 2012; 8(4):195-202.
43. Triantafilou K, Triantafilou M, Dedrick RLA. A CD14-independent LPS receptor cluster. Nat Immunol. 2001;2(4):338-345.
44. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303(5663):1532-1535.
45. Curtis AM, Bellet MM, Sassone-Corsi P, O'Neill LA. Circadian clock proteins and immunity. Immunity. 2014;40(2):178-186.