Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 9, 2017, Pages 2271-2276

  Bargaje, Rhishikesh ^a   Trachana, Kalliopi ^a   Shelton, Martin N ^a   McGinnis, Christopher S ^a   Zhou, Joseph X ^a   Chadick, Cora ^a   Cook, Savannah ^b   Cavanaugh, Christopher ^b   Huang, Sui ^a   Hood, Leroy ^a  

^a INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Critical state transitions; Differentiation efficiency; IPSC to cardiomyocyte differentiation; Prediction; Single cell analysis

Indexed keywords

TRANSCRIPTION FACTOR; 6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; ACTIVIN; ACTIVIN A; BIOLOGICAL MARKER; BMP4 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 4; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRANSCRIPTOME;

ARTICLE; CARDIAC MUSCLE CELL; CELL DIFFERENTIATION; CELL HETEROGENEITY; CELL LINEAGE; CELL POPULATION; CELL STRUCTURE; DEVELOPMENTAL GENE; ENDODERM; GENE EXPRESSION; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MESODERMAL CELL; PHENOTYPE; PRIMITIVE STREAK; PRIORITY JOURNAL; SINGLE CELL ANALYSIS; CELL COUNT; CELL LINE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MESODERM; METABOLISM;

ACTIVINS; BIOMARKERS; BONE MORPHOGENETIC PROTEIN 4; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; ENDODERM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MESODERM; MYOCYTES, CARDIAC; PYRIDINES; PYRIMIDINES; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 85014249158     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1621412114     Document Type: Article

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