Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 10, 2016, Pages 2672-2677

  Li, Qin ^a   Wennborg, Anders ^a   Aurell, Erik ^b   Dekel, Erez ^c   Zou, Jie Zhi ^a   Xu, Yuting ^d   Huang, Sui ^e   Ernberg, Ingemar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ALBANOVA UNIVERSITY CENTER   (Sweden)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

Cancer cell attractor; Cell heterogeneity; Cell population dynamics; Edge cells; Gene regulatory network

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; CD23 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; IMMUNOGLOBULIN E RECEPTOR; MEMBRANE METALLOENDOPEPTIDASE; ORGANIC CATION TRANSPORTER; SLC22A2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CANCER CELL; CANCER CELL ATTRACTOR CONCEPTUAL MODEL; CELL CLONE; CELL FATE; CELL HETEROGENEITY; CELL POPULATION; CELL PROLIFERATION; CELL VIABILITY; COMPUTER MODEL; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FLOW CYTOMETRY; FOKKER PLANCK EQUATION; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATOR GENE; ALGORITHM; BIOLOGICAL MODEL; GENE EXPRESSION PROFILING; GENETICS; KINETICS; METABOLISM; NEOPLASM; PATHOLOGY; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TIME FACTOR; TRANSFORMED CELL LINE;

ALGORITHMS; APOPTOSIS; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; CELL PROLIFERATION; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; KINETICS; MODELS, GENETIC; NEOPLASMS; NEPRILYSIN; ORGANIC CATION TRANSPORT PROTEINS; RECEPTORS, IGE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TIME FACTORS;

EID: 84960944064     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1519210113     Document Type: Article

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