Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 gene mutation

Leukemia

Volumn 16, Issue 6, 2002, Pages 1131-1134

  Penther, D ^a   Preudhomme, C ^b   Talmant, P ^a   Roumier, C ^b   Godon, A ^a   Mechinaud F ^a   Milpied, N ^a   Bataille, R ^a   Avet Loiseau, H ^a  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

AML1 gene; Amplification; Childhood acute lymphoblastic leukemia; Mutation

Indexed keywords

COMPLEMENTARY DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; B CELL LEUKEMIA; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 12P; CHROMOSOME 21Q; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 21; CONTROLLED STUDY; DNA SEQUENCE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DOSAGE; GENE TRANSLOCATION; HUMAN; HUMAN TISSUE; HYPOTHESIS; INFANT; MAJOR CLINICAL STUDY; MOLECULAR GENETICS; POINT MUTATION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 85014216614     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402479     Document Type: Article

References (21)

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3. Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia
4. High incidence of biallelic point mutations in the Runt domain of the AML1/PEBP2αB gene in M0 acute myeloid leukemia and in myeloid malignancies with acquired trisomy 21
5. Biallelic and heterozygous point mutations in the Runt domain of the AML1/PEBP2αB gene associated with myeloblastic leukemias
6. Mutations of the AML1 gene in myelodysplastic syndrome and their functional implications in leukemogenesis
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11. Characterization of the c-myc amplicon in a case of acute myeloid leukemia with double minute chromosomes
12. Amplification of the 11q23 region in acute myeloid leukemia
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14. TEL/AML1 fusion gene is a rare event in adult acute lymphoblastic leukemia
15. Evaluation of minimal residual disease using reverse-transcription polymerase chain reaction in t(8;21) acute myeloid leukemia: A multicenter study of 51 patients
16. Gene amplification in humans cancers: Biological and clinical significance
17. Role of the transcription factor AML1 in acute leukemia and hematopoietic differentiation
18. Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivactor core binding factor beta
19. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
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21. AML1/CBFß transcription complex: Its role in normal hematopoiesis and leukemia