TrpC5 regulates differentiation through the Ca2+/Wnt5a signalling pathway in colorectal cancer

Clinical Science

Volumn 131, Issue 3, 2017, Pages 227-237

  Chen, Zhen ^a   Tang, Chunlei ^a   Zhu, Yaodan ^a   Xie, Mingxu ^a   He, Dongxu ^a   Pan, Qiongxi ^a   Zhang, Peng ^a,b   Hua, Dong ^a   Wang, Teng ^a   Jin, Linfang ^a   Qi, Xiaowei ^a   Zhu, Yifei ^a   Yao, Xiaoqiang ^b   Jin, Jian ^a   Ma, Xin ^a  

^a JIANGNAN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Ca2+ Wnt5a signalling pathway; Cancer cell differentiation; Colorectal cancer; TrpC5 ion channel

Indexed keywords

BETA CATENIN; CALCIUM ION; CYCLIN D1; MYC PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; WNT5A PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC5 PROTEIN, HUMAN; WNT5A PROTEIN, HUMAN;

ADVERSE OUTCOME; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CANCER CELL; CANCER PROGNOSIS; CELL DIFFERENTIATION; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE FREE SURVIVAL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; BAGG ALBINO MOUSE; CACO-2 CELL LINE; CALCIUM SIGNALING; CANCER GRADING; CARCINOMA; COLORECTAL NEOPLASMS; HT-29 CELL LINE; METABOLISM; NUDE MOUSE; PATHOLOGY; PROGNOSIS; SECRETION (PROCESS);

ANIMALS; BETA CATENIN; CACO-2 CELLS; CALCIUM SIGNALING; CARCINOMA; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; HT29 CELLS; HUMANS; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM GRADING; PROGNOSIS; TRPC CATION CHANNELS; WNT-5A PROTEIN;

EID: 85014077927     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160759     Document Type: Article

References (41)

1. Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E. and Forman, D. (2011) Global cancer statistics. CA Cancer J. Clin. 61, 69-90
2. Park, S.H., Lee, D.H., Kim, J.L., Kim, B.R., Na, Y.J., Jo, M.J., Jeong, Y.A., Lee, S.Y., Lee, S.I., Lee, Y.Y. et al. (2016) Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells. Oncotarget 7, 59503-59518
3. Zhang, M., Zhao, Q.C., Liu, Y.P., Yang, L., Zhu, H.M. and Chhetri, J.K. (2014) Prognostic analysis and comparison of colon cancer in Han and Hui patients. World J. Gastroenterol. 20, 5082-5086
4. Bruun, J., Kolberg, M., Nesland, J.M., Svindland, A., Nesbakken, A. and Lothe, R.A. (2014) Prognostic significance of beta-catenin, E-cadherin, and SOX9 in colorectal cancer: results from a large population-representative series. Front. Oncol. 4, 118
5. Rakha, E.A., Reis-Filho, J.S. and Ellis, I.O. (2010) Combinatorial biomarker expression in breast cancer. Breast Cancer Res. Tr. 120, 293-308
6. Lamprechtand, S.A. and Lipkin, M. (2003) Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms. Nat. Rev. Cancer 3, 601-614
7. Sellers, T.A., Bazyk, A.E., Bostick, R.M., Kushi, L.H., Olson, J.E., Anderson, K.E., Lazovich, D. and Folsom, A.R. (1998) Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States). Cancer Causes Control 9, 357-367
8. Baron, J.A., Beach, M., Mandel, J.S., van Stolk, R.U., Haile, R.W., Sandler, R.S., Rothstein, R., Summers, R.W., Snover, D.C., Beck, G.J. et al. (1999) Calcium supplements for the prevention of colorectal adenomas. Calcium Polyp Prevention Study Group. N. Engl. J. Med. 340, 101-107
9. Lipkin, M. (1999) Preclinical and early human studies of calcium and colon cancer prevention. Ann. N.Y. Acad. Sci. 889, 120-127
10. Wu, K., Willett, W.C., Fuchs, C.S., Colditz, G.A. and Giovannucci, E.L. (2002) Calcium intake and risk of colon cancer in women and men. J. Natl. Cancer Inst. 94, 437-446
11. Venkatachalamand, K. and Montell, C. (2007) TRP channels. Annu. Rev. Biochem. 76, 387-417
12. Bezzerides, V.J., Ramsey, I.S., Kotecha, S., Greka, A. and Clapham, D.E. (2004) Rapid vesicular translocation and insertion of TRP channels. Nat. Cell Biol. 6, 709-720
13. Greka, A., Navarro, B., Oancea, E., Duggan, A. and Clapham, D.E. (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat. Neurosci. 6, 837-845
14. Xu, S.Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C.J. et al. (2008) TRPC channel activation by extracellular thioredoxin. Nature 451, 69-72
15. Voets, T., Owsianik, G., Janssens, A., Talavera, K. and Nilius, B. (2007) TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat. Chem. Biol. 3, 174-182
16. Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V. and Nilius, B. (2004) The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748-754
17. Lehen'kyiand, V. and Prevarskaya, N. (2011) Oncogenic TRP channels. Adv. Exp. Med. Biol. 704, 929-945
18. Richter, J.M., Schaefer, M. and Hill, K. (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol. Pharmacol. 86, 514-521
19. Ma, X., Cai, Y., He, D., Zou, C., Zhang, P., Lo, C.Y., Xu, Z., Chan, F.L., Yu, S., Chen, Y. et al. (2012) Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. Proc. Natl. Acad. Sci. U.S.A. 109, 16282-16287
20. Ma, X., Chen, Z., Hua, D., He, D., Wang, L., Zhang, P., Wang, J., Cai, Y., Gao, C., Zhang, X. et al. (2014) Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance. Proc. Natl. Acad. Sci. U.S.A. 111, 6389-6394
21. Euhus, D.M., Hudd, C., LaRegina, M.C. and Johnson, F.E. (1986) Tumor measurement in the nude mouse. J. Surg. Oncol. 31, 229-234
22. Botchkina, I.L., Rowehl, R.A., Rivadeneira, D.E., Karpeh, Jr, M.S., Crawford, H., Dufour, A., Ju, J., Wang, Y., Leyfman, Y. and Botchkina, G.I. (2009) Phenotypic subpopulations of metastatic colon cancer stem cells: genomic analysis. Cancer Genomics Proteomics 6, 19-29
23. Yeung, T.M., Gandhi, S.C., Wilding, J.L., Muschel, R. and Bodmer, W.F. (2010) Cancer stem cells from colorectal cancer-derived cell lines. Proc. Natl. Acad. Sci. U.S.A. 107, 3722-3727
24. 2+-ATPase expression during colon cancer cell line differentiation. Biochem. Biophys. Res. Commun. 355, 932-936
25. Arango, D., Al-Obaidi, S., Williams, D.S., Dopeso, H., Mazzolini, R., Corner, G., Byun, D.S., Carr, A.A., Murone, C., Tögel, L. et al. (2012) Villin expression is frequently lost in poorly differentiated colon cancer. Am. J. Pathol. 180, 1509-1521
26. Hu, R., Zuo, Y., Zuo, L., Liu, C., Zhang, S., Wu, Q., Zhou, Q., Gui, S., Wei, W. and Wang, Y. (2011) KLF4 expression correlates with the degree of differentiation in colorectal cancer. Gut Live. 5, 154-159
27. Saigusa, S., Tanaka, K., Toiyama, Y., Yokoe, T., Okugawa, Y., Ioue, Y., Miki, C. and Kusunoki, M. (2009) Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann. Surg. Oncol. 16, 3488-3498
28. Rich, T.C., Fagan, K.A., Tse, T.E., Schaack, J., Cooper, D.M. and Karpen, J.W. (2001) A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc. Natl. Acad. Sci. U.S.A. 98, 13049-13054
29. Dolfi, F., Garcia-Guzman, M., Ojaniemi, M., Nakamura, H., Matsuda, M. and Vuori, K. (1998) The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 95, 15394-15399
30. Kupzig, S., Walker, S.A. and Cullen, P.J. (2005) The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade. Proc. Natl. Acad. Sci. U.S.A. 102, 7577-7582
31. 2+: molecular determinants and functional consequences. Physiol. Rev. 86, 369-408
32. Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V. and Nilius, B. (2004) The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748-754
33. Berridge, M.J., Bootman, M.D. and Roderick, H.L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4, 517-529
34. Beech, D.J. (2007) Canonical transient receptor potential 5. Handb. Exp. Pharmacol. 179, 109-123
35. 2+ and Wnt/β-catenin pathways. J. Biol. Chem. 288, 35651-35659
36. Gerger, A., Zhang, W., Yang, D., Bohanes, P., Ning, Y., Winder, T., LaBonte, M.J., Wilson, P.M., Benhaim, L., Paez, D. et al. (2011) Common cancer stem cell gene variants predict colon cancer recurrence. Clin. Cancer Res. 17, 6934-6943
37. Zeki, S.S., Graham, T.A. and Wright, N.A. (2011) Stem cells and their implications for colorectal cancer. Nat. Rev. Gastroenterol. Hepatol. 8, 90-100
38. Jung, W., Hong, K.D., Jung, W.Y., Lee, E., Shin, B.K., Kim, H.K., Kim, A. and Kim, B.H. (2013) SIRT1 expression is associated with good prognosis in colorectal cancer. Korean J. Pathol. 47, 332-339
39. Torres, S., Bartolomé, R.A., Mendes, M., Barderas, R., Fernandez-Acenero, M.J., Pelaez-Garcia, A., Peña, C., Lopez-Lucendo, M., Villar-Vázquez, R., de Herreros, A.G. et al. (2013) Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin. Cancer Res. 19, 6006-6019
40. He, D.X. and Ma, X. (2016) Transient receptor potential channel C5 in cancer chemoresistance. Acta Pharmacol. Sin. 37, 19-24
41. Nilius, B., Owsianik, G., Voets, T. and Peters, J.A. (2007) Transient receptor potential cation channels in disease. Physiol. Rev. 87, 165-217