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Volumn 131, Issue 1, 2017, Pages 69-86

Homocysteine deteriorates intrahepatic derangement and portal-systemic collaterals in cirrhotic rats

Author keywords

Angiogenesis; Homocysteine; Liver cirrhosis; Liver fibrosis; Portal hypertension; Vascular responsiveness

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ARGIPRESSIN; BILIRUBIN; COLLAGEN TYPE 1; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; THIOACETAMIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; COLLAGEN; VASCULOTROPIN A;

EID: 85014003967     PISSN: 01435221     EISSN: 14708736     Source Type: Journal    
DOI: 10.1042/CS20160470     Document Type: Article
Times cited : (6)

References (59)
  • 1
    • 15444362095 scopus 로고    scopus 로고
    • Increased hepatic resistance: a new target in the pharmacologic therapy of portal hypertension
    • Hernandez-Guerra, M., Garcia-Pagan, J.C. and Bosch, J. (2005) Increased hepatic resistance: a new target in the pharmacologic therapy of portal hypertension. J. Clin. Gastroenterol. 39, S131-S137.
    • (2005) J. Clin. Gastroenterol , vol.39 , pp. S131-S137
    • Hernandez-Guerra, M.1    Garcia-Pagan, J.C.2    Bosch, J.3
  • 2
    • 84926323391 scopus 로고    scopus 로고
    • Vascular pathobiology in chronic liver disease and cirrhosis-current status and future directions
    • Iwakiri, Y., Shah, V. and Rockey, D.C. (2014) Vascular pathobiology in chronic liver disease and cirrhosis-current status and future directions. J. Hepatol. 61, 912-924.
    • (2014) J. Hepatol , vol.61 , pp. 912-924
    • Iwakiri, Y.1    Shah, V.2    Rockey, D.C.3
  • 3
    • 0026737603 scopus 로고
    • The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats
    • Lee, F.Y., Albillos, A., Colombato, L.A. and Groszmann, R.J. (1992) The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats. Hepatology 16, 1043-1048.
    • (1992) Hepatology , vol.16 , pp. 1043-1048
    • Lee, F.Y.1    Albillos, A.2    Colombato, L.A.3    Groszmann, R.J.4
  • 4
    • 0024441739 scopus 로고
    • Prostacyclin mediates splanchnic vascular response to norepinephrine in portal hypertension
    • Sitzmann, J.V., Li, S.S. and Lin, P.W. (1989) Prostacyclin mediates splanchnic vascular response to norepinephrine in portal hypertension. J. Surg. Res. 47, 208-211.
    • (1989) J. Surg. Res , vol.47 , pp. 208-211
    • Sitzmann, J.V.1    Li, S.S.2    Lin, P.W.3
  • 5
    • 0032858372 scopus 로고    scopus 로고
    • Effects of vasopressin on portal-systemic collaterals in portal hypertensive rats: role of nitric oxide and prostaglandin
    • Chan, C.C., Lee, F.Y., Wang, S.S., Chang, F.Y., Lin, H.C., Chu, C.J., Tai, C.C., Lai, I.N. and Lee, S.D. (1999) Effects of vasopressin on portal-systemic collaterals in portal hypertensive rats: role of nitric oxide and prostaglandin. Hepatology 30, 630-635.
    • (1999) Hepatology , vol.30 , pp. 630-635
    • Chan, C.C.1    Lee, F.Y.2    Wang, S.S.3    Chang, F.Y.4    Lin, H.C.5    Chu, C.J.6    Tai, C.C.7    Lai, I.N.8    Lee, S.D.9
  • 6
  • 7
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain, R.K. (2003) Molecular regulation of vessel maturation. Nat. Med. 9, 685-693.
    • (2003) Nat. Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 8
    • 84926323391 scopus 로고    scopus 로고
    • Vascular pathobiology in chronic liver disease and cirrhosis-current status and future directions
    • Iwakiri, Y., Shah, V. and Rockey, D.C. (2014) Vascular pathobiology in chronic liver disease and cirrhosis-current status and future directions. J. Hepatol. 61, 912-924.
    • (2014) J. Hepatol , vol.61 , pp. 912-924
    • Iwakiri, Y.1    Shah, V.2    Rockey, D.C.3
  • 9
    • 0025362827 scopus 로고
    • Methionine metabolism in mammals
    • Finkelstein, J.D. (1990) Methionine metabolism in mammals. J. Nutr. Biochem. 1, 228-237.
    • (1990) J. Nutr. Biochem , vol.1 , pp. 228-237
    • Finkelstein, J.D.1
  • 11
    • 0028670786 scopus 로고
    • Homocysteine and arterial occlusive diseases
    • Malinow, M.R. (1994) Homocysteine and arterial occlusive diseases. J. Intern. Med. 236, 603-617.
    • (1994) J. Intern. Med , vol.236 , pp. 603-617
    • Malinow, M.R.1
  • 12
    • 0035018538 scopus 로고    scopus 로고
    • Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arterioles
    • Ungvari, Z. and Koller, A. (2001) Homocysteine reduces smooth muscle [Ca2+]i and constrictor responses of isolated arterioles. J. Cardiovasc. Pharmacol. 37, 705-712.
    • (2001) J. Cardiovasc. Pharmacol , vol.37 , pp. 705-712
    • Ungvari, Z.1    Koller, A.2
  • 14
    • 0031018333 scopus 로고
    • Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation in humans
    • Tawakol, A., Omland, T., Gerhard, M., Wu, J.T. and Creager, M.A. (1995) Hyperhomocysteinemia is associated with impaired endothelium-dependent vasodilatation in humans. Circulation 95, 1119-1121.
    • (1995) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 16
    • 0346787880 scopus 로고    scopus 로고
    • Chronic methionine load-induced hyperhomocysteinemia enhances rat carotid responsiveness for angiotensin II
    • Bonaventura, D., Tirapelli, C.R., Haddad, R., Höehr, N.F., Eberlin, M.N. and de Oliveira, A.M. (2004) Chronic methionine load-induced hyperhomocysteinemia enhances rat carotid responsiveness for angiotensin II. Pharmacology 70, 91-99.
    • (2004) Pharmacology , vol.70 , pp. 91-99
    • Bonaventura, D.1    Tirapelli, C.R.2    Haddad, R.3    Höehr, N.F.4    Eberlin, M.N.5    de Oliveira, A.M.6
  • 17
    • 0032787873 scopus 로고    scopus 로고
    • Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia
    • Ungvari, Z., Pacher, P., Rischak, K., Szollar, L. and Koller, A. (1999) Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocysteinemia. Arterioscler. Thromb. Vasc. Biol. 19, 1899-1904.
    • (1999) Arterioscler. Thromb. Vasc. Biol , vol.19 , pp. 1899-1904
    • Ungvari, Z.1    Pacher, P.2    Rischak, K.3    Szollar, L.4    Koller, A.5
  • 18
    • 0032832961 scopus 로고    scopus 로고
    • Effect of homocysteine on the production of nitric oxide in endothelial cells
    • Chow, K., Cheung, F., Lao, T.T. and O.K., T.T. (1999) Effect of homocysteine on the production of nitric oxide in endothelial cells. Clin. Exp. Pharmacol. Physiol. 26, 817-818.
    • (1999) Clin. Exp. Pharmacol. Physiol , vol.26 , pp. 817-818
    • Chow, K.1    Cheung, F.2    Lao, T.T.3    Karmin, O.4
  • 19
    • 1842411860 scopus 로고    scopus 로고
    • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
    • Upchurch, Jr, G.R., Welch, G.N., Fabian, A.J., Freedman, J.E., Johnson, J.L., Keaney, Jr, J.F. and Loscalzo, J. (1997) Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J. Biol. Chem. 272, 17012-17017.
    • (1997) J. Biol. Chem , vol.272 , pp. 17012-17017
    • Upchurch, G.R.1    Welch, G.N.2    Fabian, A.J.3    Freedman, J.E.4    Johnson, J.L.5    Keaney, J.F.6    Loscalzo, J.7
  • 20
    • 0002313552 scopus 로고    scopus 로고
    • Acute hyperhomocysteinaemia and endothelial dysfunction
    • Chambers, J.C., McGregor, A., Jean-Marie, J. and Kooner, J.S. (1998) Acute hyperhomocysteinaemia and endothelial dysfunction. Lancet 351, 36-37.
    • (1998) Lancet , vol.351 , pp. 36-37
    • Chambers, J.C.1    McGregor, A.2    Jean-Marie, J.3    Kooner, J.S.4
  • 21
    • 77955891875 scopus 로고    scopus 로고
    • Chronic hyperhomocysteinemia impairs vascular function in ovariectomized rat carotid arteries
    • Celotto, A.C., Fukada, S.Y., Laurindo, F.R., Haddad, R., Eberlin, M.N. and de Oliveira, A. (2009) Chronic hyperhomocysteinemia impairs vascular function in ovariectomized rat carotid arteries. Amino Acids 38, 1515-1522.
    • (2009) Amino Acids , vol.38 , pp. 1515-1522
    • Celotto, A.C.1    Fukada, S.Y.2    Laurindo, F.R.3    Haddad, R.4    Eberlin, M.N.5    de Oliveira, A.6
  • 22
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler, J.S., Osborne, J.A., Jaraki, O., Rabbani, L.E., Mullins, M., Singel, D. and Loscalzo, J. (1993) Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J. Clin. Invest. 91, 308-318.
    • (1993) J. Clin. Invest , vol.91 , pp. 308-318
    • Stamler, J.S.1    Osborne, J.A.2    Jaraki, O.3    Rabbani, L.E.4    Mullins, M.5    Singel, D.6    Loscalzo, J.7
  • 23
    • 2442572249 scopus 로고    scopus 로고
    • Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4
    • Roybal, C.N., Yang, S., Sun, C.W., Hurtado, D., Vander Jaqt, D.L., Townes, T.M. and Abcouwer, S.F. (2004) Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J. Biol. Chem. 279, 14844-14852.
    • (2004) J. Biol. Chem , vol.279 , pp. 14844-14852
    • Roybal, C.N.1    Yang, S.2    Sun, C.W.3    Hurtado, D.4    Vander Jaqt, D.L.5    Townes, T.M.6    Abcouwer, S.F.7
  • 24
    • 0042733751 scopus 로고    scopus 로고
    • Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages
    • Maeda, M., Yamamoto, I., Fujio, Y. and Azuma, J. (2003) Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages. Biochim. Biophys. Acta 1623, 41-46.
    • (2003) Biochim. Biophys. Acta , vol.1623 , pp. 41-46
    • Maeda, M.1    Yamamoto, I.2    Fujio, Y.3    Azuma, J.4
  • 25
    • 34347380194 scopus 로고    scopus 로고
    • Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina
    • Lee, I., Lee, H., Kim, J.M., Chae, E.H., Kim, S.J. and Chang, N. (2007) Short-term hyperhomocysteinemia-induced oxidative stress activates retinal glial cells and increases vascular endothelial growth factor expression in rat retina. Biosci. Biotechnol. Biochem. 71, 1203-1210.
    • (2007) Biosci. Biotechnol. Biochem , vol.71 , pp. 1203-1210
    • Lee, I.1    Lee, H.2    Kim, J.M.3    Chae, E.H.4    Kim, S.J.5    Chang, N.6
  • 26
    • 0035104593 scopus 로고    scopus 로고
    • Homocysteine: a sulph'rous fire
    • Hajjar, K.A. (2001) Homocysteine: a sulph'rous fire. J. Clin. Invest. 107, 663-664.
    • (2001) J. Clin. Invest , vol.107 , pp. 663-664
    • Hajjar, K.A.1
  • 27
    • 84856801910 scopus 로고    scopus 로고
    • The effects of homocysteine and folic acid on angiogenesis and VEGF expression during chicken vascular development
    • Oosterbaan, A.M., Steegers, E.A. and Ursem, N.T. (2012) The effects of homocysteine and folic acid on angiogenesis and VEGF expression during chicken vascular development. Microvasc. Res. 83, 98-104.
    • (2012) Microvasc. Res , vol.83 , pp. 98-104
    • Oosterbaan, A.M.1    Steegers, E.A.2    Ursem, N.T.3
  • 28
    • 0036238826 scopus 로고    scopus 로고
    • Plasma level of homocysteine is inversely-associated with the development of collateral circulation in patients with single-vessel coronary artery disease
    • Nagai, Y., Tasaki, H., Miyamoto, M., Nihei, S., Kobayashi, K., Yamashita, K., Tsutsui, M., Kouzuma, R., Okazaki, M. and Nakashima, Y. (2002) Plasma level of homocysteine is inversely-associated with the development of collateral circulation in patients with single-vessel coronary artery disease. Circ. J. 66, 158-162.
    • (2002) Circ. J , vol.66 , pp. 158-162
    • Nagai, Y.1    Tasaki, H.2    Miyamoto, M.3    Nihei, S.4    Kobayashi, K.5    Yamashita, K.6    Tsutsui, M.7    Kouzuma, R.8    Okazaki, M.9    Nakashima, Y.10
  • 30
    • 0018679769 scopus 로고
    • Portal hypertension after bile duct obstruction. Effect of the bile diversion on portal pressure in the rat
    • Franco, D., Gigou, M., Szekely, A.M. and Bismuth, H. (1979) Portal hypertension after bile duct obstruction. Effect of the bile diversion on portal pressure in the rat. Arch. Surg. 114, 1064-1067.
    • (1979) Arch. Surg , vol.114 , pp. 1064-1067
    • Franco, D.1    Gigou, M.2    Szekely, A.M.3    Bismuth, H.4
  • 31
    • 84862816204 scopus 로고
    • Disturbances of structure and function in the liver as the result of biliary obstruction
    • Cameron, G.R. and Hasan, S.M. (1958) Disturbances of structure and function in the liver as the result of biliary obstruction. J. Pathol. Bacteriol. 75, 33-49.
    • (1958) J. Pathol. Bacteriol , vol.75 , pp. 33-49
    • Cameron, G.R.1    Hasan, S.M.2
  • 32
    • 0021238490 scopus 로고
    • Prolonged bile duct ligation obstruction: a new experimental model of cirrhosis in the rat
    • Kountouras, J., Billing, B.H. and Scheuer, P.J. (1984) Prolonged bile duct ligation obstruction: a new experimental model of cirrhosis in the rat. Br. J. Exp. Pathol. 65, 305-311
    • (1984) Br. J. Exp. Pathol , vol.65 , pp. 305-311
    • Kountouras, J.1    Billing, B.H.2    Scheuer, P.J.3
  • 33
    • 0016281945 scopus 로고
    • The porto-systemic collateral pattern in the rat
    • Halvorsen, J.F. and Myking, A.O. (1974) The porto-systemic collateral pattern in the rat. Eur. Surg. Res. 6, 183-195.
    • (1974) Eur. Surg. Res , vol.6 , pp. 183-195
    • Halvorsen, J.F.1    Myking, A.O.2
  • 35
    • 0025966706 scopus 로고
    • Influence of anesthesia, postanesthetic state, and restraint on superior mesenteric arterial flow in normal rats
    • Colombato, L.A., Sabba, C., Polio, J. and Groszmann, R.J. (1991) Influence of anesthesia, postanesthetic state, and restraint on superior mesenteric arterial flow in normal rats. Am. J. Physiol. 260, G1-G6
    • (1991) Am. J. Physiol , vol.260 , pp. G1-G6
    • Colombato, L.A.1    Sabba, C.2    Polio, J.3    Groszmann, R.J.4
  • 36
    • 0026583936 scopus 로고
    • Vasodilatation and sodium retention in prehepatic portal hypertension
    • Albillos, A., Colombato, L.A. and Groszmann, R.J. (1992) Vasodilatation and sodium retention in prehepatic portal hypertension. Gastroenterology 102, 931-935.
    • (1992) Gastroenterology , vol.102 , pp. 931-935
    • Albillos, A.1    Colombato, L.A.2    Groszmann, R.J.3
  • 37
    • 0015953660 scopus 로고
    • A simple and inexpensive membrane "lung" for small organ perfusion
    • Hamilton, R.L., Berry, M.N., Williams, M.C. and Severinghaus, E.M. (1974) A simple and inexpensive membrane "lung" for small organ perfusion. J. Lipid Res. 15, 182-186
    • (1974) J. Lipid Res , vol.15 , pp. 182-186
    • Hamilton, R.L.1    Berry, M.N.2    Williams, M.C.3    Severinghaus, E.M.4
  • 39
    • 0019522762 scopus 로고
    • Measurement of portal-systemic shunting in the rat by using ?-labeled microspheres
    • Chojkier, M. and Groszmann, R.J. (1981) Measurement of portal-systemic shunting in the rat by using ?-labeled microspheres. Am. J. Physiol. 240, G371-G375
    • (1981) Am. J. Physiol , vol.240 , pp. G371-G375
    • Chojkier, M.1    Groszmann, R.J.2
  • 40
    • 0032929606 scopus 로고    scopus 로고
    • On the validity of blood flow measurement using colored microspheres
    • Hodeige, D., de Pauw, M., Eechaute, W., Weyne, J. and Heyndrickx, G.R. (1999) On the validity of blood flow measurement using colored microspheres. Am. J. Physiol. 276, H1150-H1158
    • (1999) Am. J. Physiol , vol.276 , pp. H1150-H1158
    • Hodeige, D.1    de Pauw, M.2    Eechaute, W.3    Weyne, J.4    Heyndrickx, G.R.5
  • 41
    • 84919654991 scopus 로고    scopus 로고
    • Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats
    • Chuang, C.L., Huang, H.C., Chang, C.C., Lee, F.Y., Wu, J.C., Lee, J.Y., Hsieh, H.G. and Lee, S.D. (2015) Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats. J. Gastroenterol. Hepatol. 30, 199-207.
    • (2015) J. Gastroenterol. Hepatol , vol.30 , pp. 199-207
    • Chuang, C.L.1    Huang, H.C.2    Chang, C.C.3    Lee, F.Y.4    Wu, J.C.5    Lee, J.Y.6    Hsieh, H.G.7    Lee, S.D.8
  • 43
    • 84859424328 scopus 로고    scopus 로고
    • Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
    • Kajimoto, H., Kai, H., Aoki, H., Yasuoka, S., Anegawa, T., Aoki, Y., Ueda, S., Okuda, S. and Imaizumi, T. (2012) Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine. Kidney Int 81, 762-768.
    • (2012) Kidney Int , vol.81 , pp. 762-768
    • Kajimoto, H.1    Kai, H.2    Aoki, H.3    Yasuoka, S.4    Anegawa, T.5    Aoki, Y.6    Ueda, S.7    Okuda, S.8    Imaizumi, T.9
  • 44
    • 84930945062 scopus 로고    scopus 로고
    • L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery
    • Xuan, C., Lun, L.M., Zhao, J.X., Wang, H.W., Wang, J., Ning, C.P., Liu, Z., Zhang, B.B. and He, G.W. (2015) L-citrulline for protection of endothelial function from ADMA-induced injury in porcine coronary artery. Sci. Rep. 5, 10987.
    • (2015) Sci. Rep , vol.5 , pp. 10987
    • Xuan, C.1    Lun, L.M.2    Zhao, J.X.3    Wang, H.W.4    Wang, J.5    Ning, C.P.6    Liu, Z.7    Zhang, B.B.8    He, G.W.9
  • 47
    • 84941299788 scopus 로고    scopus 로고
    • Homocysteine induces collagen I expression by downregulating histone methyltransferase G9a
    • Lei, W., Long, Y., Li, S., Liu, Z., Zhu, F., Hou, F.F. and Nie, J. (2015) Homocysteine induces collagen I expression by downregulating histone methyltransferase G9a. PLoS One 10, e0130421.
    • (2015) PLoS One , vol.10
    • Lei, W.1    Long, Y.2    Li, S.3    Liu, Z.4    Zhu, F.5    Hou, F.F.6    Nie, J.7
  • 49
  • 50
    • 84990913373 scopus 로고    scopus 로고
    • Swertiamarin attenuates experimental rat hepatic fibrosis by suppressing angiotensin II-angiotensin type 1 receptor-extracellular signal-regulated kinase signaling
    • Li, S., Wang, Q., Tao, Y. and Liu, C. (2016) Swertiamarin attenuates experimental rat hepatic fibrosis by suppressing angiotensin II-angiotensin type 1 receptor-extracellular signal-regulated kinase signaling. J. Pharmacol. Exp. Ther. 359, 247-255.
    • (2016) J. Pharmacol. Exp. Ther , vol.359 , pp. 247-255
    • Li, S.1    Wang, Q.2    Tao, Y.3    Liu, C.4
  • 51
    • 84929185403 scopus 로고    scopus 로고
    • Superior mesenteric artery flow changes in liver cirrhosis
    • Tamoiunas, A.E., Irnius, A. and Grabauskienë, V. (2003) Superior mesenteric artery flow changes in liver cirrhosis. Semin. Cardiol. 9, 53-57
    • (2003) Semin. Cardiol , vol.9 , pp. 53-57
    • Tamoiunas, A.E.1    Irnius, A.2    Grabauskienë, V.3
  • 52
    • 0037339694 scopus 로고    scopus 로고
    • Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase
    • Ungvari, Z., Csiszar, A., Edwards, J.G., Kaminski, P.M., Wolin, M.S., Kaley, G. and Koller, A. (2003) Increased superoxide production in coronary arteries in hyperhomocysteinemia: role of tumor necrosis factor-alpha, NAD(P)H oxidase, and inducible nitric oxide synthase. Arterioscler. Thromb. Vasc. Biol. 23, 418-424.
    • (2003) Arterioscler. Thromb. Vasc. Biol , vol.23 , pp. 418-424
    • Ungvari, Z.1    Csiszar, A.2    Edwards, J.G.3    Kaminski, P.M.4    Wolin, M.S.5    Kaley, G.6    Koller, A.7
  • 53
    • 84925271214 scopus 로고    scopus 로고
    • Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes
    • Chien, S.J., Chen, T.C., Kuo, H.C., Chen, C.N. and Chang, S.F. (2015) Fulvic acid attenuates homocysteine-induced cyclooxygenase-2 expression in human monocytes. BMC Complement Altern. Med. 15, 61.
    • (2015) BMC Complement Altern. Med , vol.15 , pp. 61
    • Chien, S.J.1    Chen, T.C.2    Kuo, H.C.3    Chen, C.N.4    Chang, S.F.5
  • 54
    • 84876218090 scopus 로고    scopus 로고
    • Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways
    • Lee, Y.S., Lee, S.J., Seo, K.W., Bae, J.U., Park, S.Y. and Kim, C.D. (2013) Homocysteine induces COX-2 expression in macrophages through ROS generated by NMDA receptor-calcium signaling pathways. Free Radical Res 47, 422-431.
    • (2013) Free Radical Res , vol.47 , pp. 422-431
    • Lee, Y.S.1    Lee, S.J.2    Seo, K.W.3    Bae, J.U.4    Park, S.Y.5    Kim, C.D.6
  • 55
    • 84859429176 scopus 로고    scopus 로고
    • Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis
    • Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y. and Chiu, C.H. (2012) Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. J. Sci. Food Agric. 92, 1441-1447.
    • (2012) J. Sci. Food Agric , vol.92 , pp. 1441-1447
    • Chen, I.S.1    Chen, Y.C.2    Chou, C.H.3    Chuang, R.F.4    Sheen, L.Y.5    Chiu, C.H.6
  • 58
    • 0036231538 scopus 로고    scopus 로고
    • Increased homocysteine in liver cirrhosis: a result of renal impairment?
    • Woitas, R.P., Stoffel-Wagner, B., Poege, U. and Sauerbruch, T. (2002) Increased homocysteine in liver cirrhosis: a result of renal impairment? Clin. Chem 48, 796-797
    • (2002) Clin. Chem , vol.48 , pp. 796-797
    • Woitas, R.P.1    Stoffel-Wagner, B.2    Poege, U.3    Sauerbruch, T.4
  • 59
    • 84949008799 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is associated with severity of cirrhosis and negative impact after liver transplantation
    • Bhanji, R.A., Ma, M., Bain, V.G. and Montano-Loza, A.J. (2015) Hyperhomocysteinemia is associated with severity of cirrhosis and negative impact after liver transplantation. Liver Int 36, 696-704.
    • (2015) Liver Int , vol.36 , pp. 696-704
    • Bhanji, R.A.1    Ma, M.2    Bain, V.G.3    Montano-Loza, A.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.