Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats

Molecular and Cellular Biochemistry

Volumn 347, Issue 1-2, 2011, Pages 63-70

  Raaf, Lamia ^a,b   Noll, Christophe ^a   Cherifi, Mohamed El Hadi ^c   Samuel, Jane Lise ^a   Delcayre, Claude ^a   Delabar, Jean Maurice ^a   Benazzoug, Yasmina ^b   Janel, Nathalie ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

^c Parnet Hospital   (Algeria)

Author keywords

Fibrosis; Heart; Homocysteine; MMP TIMP; TGF 1; Ventricular cardiomyocyte hypertrophy

Indexed keywords

GELATINASE A; HOMOCYSTEINE; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DEGRADATION; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; HYPERHOMOCYSTEINEMIA; IMMUNOBLOTTING; MOLECULAR DYNAMICS; MORPHOMETRICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; STAINING; ZYMOGRAPHY;

RATTUS;

EID: 78651271244     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0612-5     Document Type: Article

References (39)

1. J Chen I Zhang L Cheng Y Li 2001 The effect of polymorphisms of MTHFR gene and vitamin B on hyperhomocysteinemia J Tongji Med Univ 21 17 20 10.1007/BF02888026 11523237
2. MD Tur E De Maistre P Franck MO Rolland S Fremont T Lecompte M Vidaihet 2004 Delayed diagnosis of homocystinuria by major deficiency in cystathionine beta synthase Rev Med Int 25 150 153 10.1016/j.revmed.2003.10.012 (Pubitemid 38115195)
3. DE Wilcken BB Wilcken 1998 Vitamins and homocysteine in cardiovascular disease and aging Ann NY Acad Sci 854 361 370 1:CAS:528:DyaK1MXjtVehsA%3D%3D 10.1111/j.1749-6632.1998.tb09916.x 9928444 (Pubitemid 29022816)
4. J Racek H Rusnáková L Trefil KK Siala 2005 The influence of folate and antioxidants on homocysteine levels and oxidative stress in patients with hyperlipidemia and hyperhomocysteinemia Physiol Res 54 87 95 1:CAS:528:DC%2BD2MXjtVGgs7c%3D 15717846
5. SJ Chan CN Chang JC Hsu YS Lee CH Shen 2002 Homocysteine, vitamin B6, and lipid in cardiovascular disease Nutrition 18 595 598 1:CAS:528: DC%2BD38XkvFyqtL0%3D 10.1016/S0899-9007(02)00778-5 12093437 (Pubitemid 34687097)
6. R Marcucci I Betti E Cecchi D Poli B Giusti S Fedi I Lapini R Abbate GF Gensini D Prisco 2004 Hyperhomocysteinemia and vitamin B6 deficiency: new risk markers for nonvalvular atrial fibrillation? Am Heart J 148 456 461 1:CAS:528:DC%2BD2cXnvVOju7k%3D 10.1016/j.ahj.2004.03.017 15389232 (Pubitemid 39265118)
7. Z Bagi Z Ungvari L Szollár A Koller 2001 Flow-induced constriction in arterioles of hyperhomocysteinemic rats is due to impaired nitric oxide and enhanced thromboxane A(2) mediation Arterioscler Thromb Vasc Biol 21 233 237 1:CAS:528:DC%2BD3MXhtVCnsbs%3D 11156858
8. A Miller V Mujumdar E Shek J Guillot M Angelo L Palmer SC Tyagi 2000 Hyperhomocyst(e)inemia induces multiorgan damage Heart Vessels 15 135 143 1:STN:280:DC%2BD3M7pvVCjsA%3D%3D 10.1007/s003800070030 11289502 (Pubitemid 32236954)
9. S Devi RH Kennedy L Joseph NS Shekhawat RB Melchert J Joseph 2006 Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats Cardiovasc Pathol 15 75 82 1:CAS:528:DC%2BD28Xit1Cmsr4%3D 10.1016/j.carpath.2005.11.001 16533695
10. S Kundu M Kumar U Sen PK Mishra N Tyagi N Metreveli D Lominadze W Rodriguez SC Tyagi 2009 Nitrotyrosinylation, remodeling and endothelial-myocyte uncoupling in iNOS, cystathionine beta synthase (CBS) knockouts and iNOS/CBS double knockout mice J Cell Biochem 106 119 126 1:CAS:528:DC%2BD1MXns1GgsQ%3D%3D 10.1002/jcb.21982 19021146
11. J Joseph L Joseph S Devi RH Kennedy 2008 Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction J Heart Lung Transplant 27 1237 1241 10.1016/j.healun.2008.07.024 18971097
12. H Li H Simon TM Bocan JT Peterson 2000 MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition Cardiovasc Res 46 298 306 1:CAS:528:DC%2BD3cXisFGqsrw%3D 10.1016/S0008-6363(00)00028-6 10773234 (Pubitemid 30204602)
13. EE Creemers JN Davis AM Parkhurst P Leenders KB Dowdy E Hapke AM Hauet PG Escobar JP Cleutjens JF Smits MJ Daemen MR Zile FG Spinale 2003 Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice Am J Physiol Heart Circ Physiol 284 H364 H371 1:CAS:528:DC%2BD3sXmvF2htg%3D%3D 12388239
14. S Van Linthout U Seeland A Riad O Eckhardt M Hohl N Dhayat U Richter JW Fischer M Böhm M Pauschinger HP Schultheiss C Tschöpe 2008 Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy Basic Res Cardiol 103 319 327 10.1007/s00395-008-0715-2 18347835
15. A Bescond T Augier C Chareyre D Garçon W Hornebeck P Charpiot 1999 Influence of homocysteine on matrix metalloproteinase-2: activation and activity Biochem Biophys Res Commun 263 498 503 1:CAS:528:DyaK1MXlvFanuro%3D 10.1006/bbrc.1999.1391 10491321 (Pubitemid 29467224)
16. S Shastry SC Tyagi 2004 Homocysteine induces metalloproteinase and shedding of beta-1 integrin in microvessel endothelial cells J Cell Biochem 93 207 213 1:CAS:528:DC%2BD2cXns1Siu70%3D 10.1002/jcb.20137 15352177
17. I Romero-Calvo B Ocón P Martínez-Moya MD Suárez A Zarzuelo O Martínez-Augustin FS de Medina 2010 Reversible Ponceau staining as a loading control alternative to actin in Western blots Anal Biochem 401 318 320 1:CAS:528:DC%2BC3cXlt1ahsb8%3D 10.1016/j.ab.2010.02.036 20206115
18. U Seeland C Haeuseler R Hinrichs S Rosenkranz T Pfitzner K Scharffetter-Kochanek M Böhm 2002 Myocardial fibrosis in transforming growth factor-beta(1) (TGF-beta(1)) transgenic mice is associated with inhibition of interstitial collagenase Eur J Clin Invest 32 295 303 1:CAS:528:DC%2BD38XkvF2msrY%3D 10.1046/j.1365-2362.2002.00985.x 12027867 (Pubitemid 36228387)
19. M Bujak NG Frangogiannis 2007 The role of TGF-beta signaling in myocardial infarction and cardiac remodeling Cardiovasc Res 74 184 195 1:CAS:528:DC%2BD2sXjvFehs7g%3D 10.1016/j.cardiores.2006.10.002 17109837 (Pubitemid 46517504)
20. MA Hofmann E Lalla Y Lu MR Gleason BM Wolf N Tanji LJ Ferran Jr B Kohl V Rao W Kisiel DM Stern AM Schmidt 2001 Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model J Clin Invest 107 675 683 1:CAS:528:DC%2BD3MXitVGns70%3D 10.1172/JCI10588 11254667
21. A Zulli DL Hare BF Buxton MJ Black 2006 The combination of high dietary methionine plus cholesterol induces myocardial fibrosis in rabbits Atherosclerosis 185 278 281 1:CAS:528:DC%2BD28XitVKgsbo%3D 10.1016/j. atherosclerosis.2005.06.036 16054151
22. KS Moshal SM Tipparaju TP Vacek M Kumar M Singh IE Frank PK Patibandla N Tyagi J Rai N Metreveli WE Rodriguez MT Tseng SC Tyagi 2008 Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia Am J Physiol Heart Circ Physiol 295 H890 H897 1:CAS:528:DC%2BD1cXhtVakt7vK 10.1152/ajpheart.00099.2008 18567713
23. J Joseph L Joseph NS Shekhawat S Devi J Wang RB Melchert M Hauer-Jensen RH Kennedy 2003 Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats Am J Physiol Heart Circ Physiol 285 H679 H686 1:CAS:528:DC%2BD3sXmsVagsL8%3D 12730062
24. K Robert J Nehmé E Bourdon G Pivert B Friguet C Delcayre JM Delabar N Janel 2005 Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver Gastroenterology 128 1405 1415 1:CAS:528:DC%2BD2MXlt1CisL4%3D 10.1053/j.gastro.2005.02.034 15887121 (Pubitemid 40712189)
25. J Hamelet N Maurin R Fulchiron JM Delabar N Janel 2007 Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement Exp Mol Pathol 83 249 253 1:CAS:528:DC%2BD2sXpvFKgsbc%3D 10.1016/j.yexmp.2007.04.005 17543941 (Pubitemid 47320660)
26. C Matté FM Stefanello V Mackedanz CD Pederzolli ML Lamers CS Dutra-Filho MF Dos Santos AT Wyse 2009 Homocysteine induces oxidative stress, inflammatory infiltration, fibrosis and reduces glycogen/glycoprotein content in liver of rats Int J Dev Neurosci 27 337 344 10.1016/j.ijdevneu.2009.03.005 19460627
27. F Yi M Xia N Li C Zhang L Tang PL Li 2009 Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats Hypertension 53 90 96 1:CAS:528:DC%2BD1cXhsVOgtL%2FO 10.1161/ HYPERTENSIONAHA.108.115675 19029489
28. J Dai W Li L Chang Z Zhang C Tang N Wang Y Zhu X Wang 2006 Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis Free Radic Biol Med 41 1566 1577 1:CAS:528:DC%2BD28XhtVyit77P 10.1016/j.freeradbiomed.2006.08.020 17045925 (Pubitemid 44528255)
29. HK Park SJ Park CS Kim YW Paek JU Lee WJ Lee 2001 Enhanced gene expression of renin-angiotensin system, TGF-beta1, endothelin-1 and nitric oxide synthase in right-ventricular hypertrophy Pharmacol Res 43 265 273 1:CAS:528:DC%2BD3MXisV2ksbg%3D 10.1006/phrs.2000.0777 11401419 (Pubitemid 32601434)
30. A Majors LA Ehrhart EH Pezacka 1997 Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells Arterioscler Thromb Vasc Biol 17 2074 2081 1:CAS:528:DyaK2sXntlKksb4%3D 9351374
31. ER García-Tevijano C Berasain JA Rodríguez FJ Corrales R Arias A Martín-Duce J Caballería JM Mato MA Avila 2001 Hyperhomocysteinemia in liver cirrhosis: mechanisms and role in vascular and hepatic fibrosis Hypertension 38 1217 1221 10.1161/hy1101.099499 11711526
32. CG Zou SY Gao YS Zhao SD Li XZ Cao Y Zhang KQ Zhang 2009 Homocysteine enhances cell proliferation in hepatic myofibroblastic stellate cells J Mol Med 87 75 84 1:CAS:528:DC%2BD1cXhsFSrurrE 10.1007/s00109-008-0407-2 18825355
33. Y Sakata AL Chancey VG Divakaran K Sekiguchi N Sivasubramanian DL Mann 2008 Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor Basic Res Cardiol 103 60 68 1:CAS:528:DC%2BD1cXotlKhtA%3D%3D 10.1007/s00395-007-0689-5 18034274 (Pubitemid 50005150)
34. Y Zhai X Gao Q Wu L Peng J Lin Z Zuo 2008 Fluvastatin decreases cardiac fibrosis possibly through regulation of TGF-beta(1)/Smad 7 expression in the spontaneously hypertensive rats Eur J Pharmacol 587 196 203 1:CAS:528: DC%2BD1cXmsFGlurY%3D 10.1016/j.ejphar.2008.03.006 18430418
35. P Stawowy C Margeta H Kallisch NG Seidah M Chrétien E Fleck K Graf 2004 Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase Cardiovasc Res 63 87 97 1:CAS:528:DC%2BD2cXkvV2it7Y%3D 10.1016/j.cardiores.2004.03.010 15194465 (Pubitemid 38759813)
36. A Solini E Santini M Nannipieri E Ferrannini 2006 High glucose and homocysteine synergistically affect the metalloproteinases-tissue inhibitors of metalloproteinases pattern, but not TGFB expression, in human fibroblasts Diabetologia 49 2499 2506 1:CAS:528:DC%2BD28XptF2ktb0%3D 10.1007/s00125-006- 0377-2 16896935 (Pubitemid 44362506)
37. G Doronzo I Russo L Mattiello M Trovati G Anfossi 2005 Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways Thromb Haemost 6 1285 1293
38. AV Ovechkin N Tyagi U Sen D Lominadze MM Steed KS Moshal SC Tyagi 2006 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice Am J Physiol Lung Cell Mol Physiol 5 L905 L9011 10.1152/ajplung.00543.2005 (Pubitemid 44772052)
39. GS Butler MJ Butler SJ Atkinson H Will T Tamura S Schade van Westrum T Crabbe J Clements MP d'Ortho G Murphy 1998 The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic study J Biol Chem 273 871 880 1:CAS:528:DyaK1cXksFeqtQ%3D%3D 10.1074/jbc.273.2.871 9422744 (Pubitemid 28049179)