Race, genomics and chronic disease: What patients with African ancestry have to say

Journal of Health Care for the Poor and Underserved

Volumn 28, Issue 1, 2017, Pages 248-260

  Horowitz, Carol R ^a   Ferryman, Kadija ^b   Negron, Rennie ^c   Sabin, Tatiana ^a   Rodriguez, Mayra ^d   Zinberg, Randi F ^a   Böttinger, Erwin ^a,e   Robinson, Mimsie ^f  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NEW SCHOOL FOR SOCIAL RESEARCH   (United States)

^c YALE UNIVERSITY   (United States)

^d Essen Medical Associates   (United States)

^e BERLIN INSTITUTE OF HEALTH   (Germany)

^f The Bethel Gospel Assembly ^*  (United States)

Author keywords

African american; Ancestry; Genetics; Health disparities; Race; Risk; Testing

Indexed keywords

APOL1 PROTEIN, HUMAN; APOLIPOPROTEIN L1;

ADULT; AFRICAN AMERICAN; ANCESTRY GROUP; ATTITUDE TO HEALTH; CHRONIC DISEASE; ETHNOLOGY; FEMALE; GENETIC SCREENING; GENETICS; GENOMICS; HUMAN; HYPERTENSION; INTERVIEW; KIDNEY FAILURE; MALE; MIDDLE AGED; RISK FACTOR;

ADULT; AFRICAN AMERICANS; APOLIPOPROTEIN L1; CHRONIC DISEASE; CONTINENTAL POPULATION GROUPS; FEMALE; GENETIC TESTING; GENOMICS; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; HYPERTENSION; INTERVIEWS AS TOPIC; MALE; MIDDLE AGED; RENAL INSUFFICIENCY; RISK FACTORS;

EID: 85013911342     PISSN: 10492089     EISSN: 15486869     Source Type: Journal    
DOI: 10.1353/hpu.2017.0020     Document Type: Article

References (36)

1. Xue JL, Eggers PW, Agodoa LY, et al. Longitudinal study of racial and ethnic differences in developing end-stage renal disease among aged Medicare beneficiaries. J Am Soc Nephrol. 2007 Apr; 18(4): 1299-306. Epub 2007 Feb 28. https://doi.org/10.1681/ASN.2006050524 PMid: 17329578
2. United States Renal Data System (USRDS). USRDS 2010 Annual Data Report: atlas of chronic kidney disease and end-stage renal disease in the United States. Bethesda, MD: National Institute of Health, 2010. Available at: www.usrds.org/atlas10.aspx.
3. Peralta CA, Bibbins-Domingo K, Vittinghoff E, et al. APOL1 genotype and race differences in incident albuminuria and renal function decline. J Am Soc Nephrol. 2015 Mar; 27(3): 887-93. Epub 2015 Jul 15. https://doi.org/10.1681/ASN.2015020124 PMid: 26180129
4. Johns TS, Estrella MM, Crews DC, et al. Neighborhood socioeconomic status, race, and mortality in young adult dialysis patients. J Am Soc Nephrol. 2014 Nov; 25(11): 2649-57. https://doi.org/10.1681/ASN.2013111207 PMid: 24925723 PMCid: PMC4214533
5. Norris KC, Agodoa LY. Unraveling the racial disparities associated with kidney disease. Kidney Int. 2005 Sep; 68(3): 914-24. https://doi.org/10.1111/j.1523-1755.2005.00485.x PMid: 16105022
6. Powe NR. To have and have not: health and health care disparities in chronic kidney disease. Kidney Int. 2003 Aug; 64(2): 763-72. https://doi.org/10.1046/j.1523-1755.2003.00138.x PMid: 12846781
7. Keith D, Ashby VB, Port FK, et al. Insurance type and minority status associated with large disparities in prelisting dialysis among candidates for kidney transplantation. Clin J Am Soc Nephrol. 2008 Mar; 3(2): 463-70. Epub 2008 Jan 16. https://doi.org/10.2215/CJN.02220507 PMid: 18199847 PMCid: PMC2390941
8. Vargas RB, Norris KC. Kidney disease progression and screening cost-effectiveness among African Americans. J Am Soc Nephrol. 2012 Dec; 23(12): 1915-6. Epub 2012 Nov 15. https://doi.org/10.1681/ASN.2012101028 PMid: 23160510 PMCid: PMC3507374
9. Peralta CA, Katz R, DeBoer I, et al. Racial and ethnic differences in kidney function decline among persons without chronic kidney disease. J Am Soc Nephrol. 2011 Jul; 22(7); 1327-34. Epub 2011 Jun 23. https://doi.org/10.1681/ASN.2010090960 PMid: 21700831 PMCid: PMC3137580
10. Hsu CY, Lin F, Vittinghoff E, et al. Racial differences in the progression from chronic renal insufficiency to end-stage renal disease in the United States. J Am Soc Nephrol. 2003 Nov; 14(11): 2902-7. https://doi.org/10.1097/01.ASN.0000091586.46532.B4 PMid: 14569100
11. Gao SW, Oliver DK, Das N, et al. Assessment of racial disparities in chronic kidney disease stage 3 and 4 care in the department of defense health system. Clin J Am Soc Nephrol. 2008 Mar; 3(2): 442-9. Epub 2008 Jan 16. https://doi.org/10.2215/CJN.03940907 PMid: 18199843 PMCid: PMC2390939
12. Norris K, Nissenson AR. Race, gender and socioeconomic disparities in CKD in the United States. J Am Soc Nephrol. 2008 Jul; 19(7): 1261-70. Epub 2008 Jun 4. https://doi.org/10.1681/ASN.2008030276 PMid: 18525000
13. Genovese G, Friedman DJ, Ross MD, et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13; 329(5993): 841-5. Epub 2010 Jul 15. https://doi.org/10.1126/science.1193032 PMid: 20647424 PMCid: PMC2980843
14. Parsa A, Kao WH, Xie D, et al. APOL1 risk variants, race, and progression of chronic kidney disease. N Engl J Med. 2013 Dec 5; 369(23): 2183-96. Epub 2013 Nov 9. https://doi.org/10.1056/NEJMoa1310345 PMid: 24206458 PMCid: PMC3969022
15. Ito K, Bick AG, Flannick J, et al. Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res. 2014 Feb 28; 114(5): 845-50. Epub 2013 Dec 30. https://doi.org/10.1161/CIRCRESAHA.114.302347 PMid: 24379297 PMCid: PMC3982584
16. Friedman DJ, Kozlitina J, Genovese G, et al. Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol. 2011 Nov; 22(11): 2098-105. Epub 2011 Oct 13. https://doi.org/10.1681/ASN.2011050519 PMid: 21997396 PMCid: PMC3231785
17. Friedman DJ, Pollak MR. Genetics of kidney failure and the evolving story of APOL1. J Clin Invest. 2011 Sep; 121(9): 3367-74. Epub 2011 Sep 1. https://doi.org/10.1172/JCI46263 PMid: 21881214 PMCid: PMC3163957
18. Boulware LE, Cooper LA, Ratner LE, et al. Race and trust in the health care system. Public Health Rep. 2003 Jul-Aug; 118(4): 358-65. https://doi.org/10.1016/S0033-3549(04)50262-5
19. Henderson G, Garrett J, Bussey-Jones J, et al. Great expectations: views of genetic research participants regarding current and future genetic studies. Genet Med. 2008 Mar; 10(3): 193-200. https://doi.org/10.1097/GIM.0b013e318164e4f5 PMid: 18344709
20. Singer E, Antonucci T, Van Hoewyk J. Racial and ethnic variations in knowledge and attitudes about genetic testing. Genet Test. 2004 Spring; 8(1): 31-43. https://doi.org/10.1089/109065704323016012 PMid: 15140372
21. Suther S, Kiros GE. Barriers to the use of genetic testing: a study of racial and ethnic disparities. Genet Med. 2009 Sep; 11(9): 655-62. https://doi.org/10.1097/GIM.0b013e3181ab22aa PMid: 19752639
22. Bates MD, Griffin MT, Killion CM, et al. African American males’ knowledge and attitudes toward genetic testing and willingness to participate in genetic testing: a pilot study. J Natl Black Nurses Assoc. 2011 Jul; 22(1)1-7. PMid: 21888145
23. Taylor JY, Peternell B, Smith JA. Attitudes toward genetic testing for hypertension among African American women and girls. Nurs Res Pract. 2013; 2013: 341374. Epub 2013 Nov 2.
24. Millon Underwood S, Buseh AG, Kelber ST, et al. Enhancing the participation of African Americans in health-related genetic research: findings of a collaborative academic and community-based research study. Nurs Res Pract. 2013; 2013: 749563. Epub 2013 Dec 4.
25. Akinleye I, Roberts JS, Royal CD, et al. Differences between African American and White research volunteers in their attitudes, beliefs and knowledge regarding genetic testing for Alzheimer’s disease. J Genet Couns. 2011 Dec; 20(6): 650-9. Epub 2011 Jun 9. https://doi.org/10.1007/s10897-011-9377-6 PMid: 21656311 PMCid: PMC3223287
26. Freedman BI, Fletcher AJ, Sanghani VR, et al. Perceptions regarding genetic testing in populations at risk for nephropathy. Am J Nephrol. 2013; 38(6): 453-7. Epub 2013 Nov 21. https://doi.org/10.1159/000356244 PMid: 24280773 PMCid: PMC3914164
27. Horowitz CR, Abul-Husn NS, Ellis S, et al. Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry. Contemp Clin Trials. 2016 Mar; 47: 101-8. Epub 2015 Dec 30. https://doi.org/10.1016/j.cct.2015.12.020 PMid: 26747051
28. Glaser BG. The constant comparative method of qualitative analysis. Soc Probl. 1965: 12: 436-45. https://doi.org/10.2307/798843 https://doi.org/10.1525/sp.1965.12.4.03a00070
29. Gottesman O, Scott SA, Ellis SB, et al. The CLIPMERGE PGx Program: clinical implementation of personalized medicine through electronic health records and genomics-pharmacogenomics. Clin Pharmacol Ther. 2013 Aug; 94(2): 214-7. Epub 2013 Apr 3. https://doi.org/10.1038/clpt.2013.72 PMid: 23588317 PMCid: PMC3720762
30. Kopp JB. Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder. Curr Opin Nephrol Hypertens. 2013 May; 22(3): 266-72. https://doi.org/10.1097/MNH.0b013e3283600f8c PMid: 23470819 PMCid: PMC4165431
31. Lewis KL, Hooker GW, Connors PD, et al. Participant use and communication of findings from exome sequencing: a mixed-methods study. Genet Med. 2016 Jun; 18(6): 577-83. Epub 2015 Nov 5. https://doi.org/10.1038/gim.2015.133 PMid: 26540156 PMCid: PMC4860179
32. Berlowitz DR, Ash AS, Hickey EC, et al. Inadequate management of blood pressure in a hypertensive population. N Engl J Med. 1998 Dec 31; 339(27): 1957-63. https://doi.org/10.1056/NEJM199812313392701 PMid: 9869666
33. Rodondi N, Peng T, Karter AJ, et al. Therapy modifications in response to poorly controlled hypertension, dyslipidemia, and diabetes mellitus. Ann Intern Med. 2006 Apr 4; 144(7): 475-84. https://doi.org/10.7326/0003-4819-144-7-200604040-00006 PMid: 16585661 PMCid: PMC2577322
34. Strain WD, Cos X, Hirst M, et al. Time to do more: addressing clinical inertia in the management of type 2 diabetes mellitus. Diabetes Res Clin Pract. 2014 Sep; 105(3): 302-12. Epub 2014 May 27. https://doi.org/10.1016/j.diabres.2014.05.005 PMid: 24956964
35. Grams ME, Matsushita K, Sang Y, et al. Explaining the racial difference in AKI incidence. J Am Soc Nephrol. 2014 Aug; 25(8): 1834-41. Epub 2014 Apr 10. https://doi.org/10.1681/ASN.2013080867 PMid: 24722442 PMCid: PMC4116065
36. Kaul R, Cohen CR, Chege D, et al. Biological factors that may contribute to regional and racial disparities in HIV prevalence. Am J Reprod Immunol. 2011 Mar; 65(3): 317-24. Epub 2011 Jan 12. https://doi.org/10.1111/j.1600-0897.2010.00962.x PMid: 21223426